 Connection
Thomas Cech to Protein Binding
This is a "connection" page, showing publications Thomas Cech has written about Protein Binding.
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Connection Strength |
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2.979 |
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Davidovich C, Wang X, Cifuentes-Rojas C, Goodrich KJ, Gooding AR, Lee JT, Cech TR. Toward a consensus on the binding specificity and promiscuity of PRC2 for RNA. Mol Cell. 2015 Feb 05; 57(3):552-8.
Score: 0.332
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Song J, Gooding AR, Hemphill WO, Love BD, Robertson A, Yao L, Zon LI, North TE, Kasinath V, Cech TR. Structural basis for inactivation of PRC2 by G-quadruplex RNA. Science. 2023 09 22; 381(6664):1331-1337.
Score: 0.152
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Hemphill WO, Fenske R, Gooding AR, Cech TR. PRC2 direct transfer from G-quadruplex RNA to dsDNA has implications for RNA-binding chromatin modifiers. Proc Natl Acad Sci U S A. 2023 06 06; 120(23):e2220528120.
Score: 0.148
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Zaug AJ, Lim CJ, Olson CL, Carilli MT, Goodrich KJ, Wuttke DS, Cech TR. CST does not evict elongating telomerase but prevents initiation by ssDNA binding. Nucleic Acids Res. 2021 11 18; 49(20):11653-11665.
Score: 0.133
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Youmans DT, Gooding AR, Dowell RD, Cech TR. Competition between PRC2.1 and 2.2 subcomplexes regulates PRC2 chromatin occupancy in human stem cells. Mol Cell. 2021 02 04; 81(3):488-501.e9.
Score: 0.125
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Long Y, Hwang T, Gooding AR, Goodrich KJ, Rinn JL, Cech TR. RNA is essential for PRC2 chromatin occupancy and function in human pluripotent stem cells. Nat Genet. 2020 09; 52(9):931-938.
Score: 0.121
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Lim CJ, Barbour AT, Zaug AJ, Goodrich KJ, McKay AE, Wuttke DS, Cech TR. The structure of human CST reveals a decameric assembly bound to telomeric DNA. Science. 2020 06 05; 368(6495):1081-1085.
Score: 0.121
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Youmans DT, Schmidt JC, Cech TR. Live-cell imaging reveals the dynamics of PRC2 and recruitment to chromatin by SUZ12-associated subunits. Genes Dev. 2018 06 01; 32(11-12):794-805.
Score: 0.105
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Stern JL, Paucek RD, Huang FW, Ghandi M, Nwumeh R, Costello JC, Cech TR. Allele-Specific DNA Methylation and Its Interplay with Repressive Histone Marks at Promoter-Mutant TERT Genes. Cell Rep. 2017 12 26; 21(13):3700-3707.
Score: 0.102
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Wang X, Paucek RD, Gooding AR, Brown ZZ, Ge EJ, Muir TW, Cech TR. Molecular analysis of PRC2 recruitment to DNA in chromatin and its inhibition by RNA. Nat Struct Mol Biol. 2017 Dec; 24(12):1028-1038.
Score: 0.101
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Lim CJ, Zaug AJ, Kim HJ, Cech TR. Reconstitution of human shelterin complexes reveals unexpected stoichiometry and dual pathways to enhance telomerase processivity. Nat Commun. 2017 10 20; 8(1):1075.
Score: 0.101
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Long Y, Wang X, Youmans DT, Cech TR. How do lncRNAs regulate transcription? Sci Adv. 2017 09; 3(9):eaao2110.
Score: 0.100
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Stern JL, Theodorescu D, Vogelstein B, Papadopoulos N, Cech TR. Mutation of the TERT promoter, switch to active chromatin, and monoallelic TERT expression in multiple cancers. Genes Dev. 2015 Nov 01; 29(21):2219-24.
Score: 0.088
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Wang X, Schwartz JC, Cech TR. Nucleic acid-binding specificity of human FUS protein. Nucleic Acids Res. 2015 Sep 03; 43(15):7535-43.
Score: 0.086
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Dalby AB, Hofr C, Cech TR. Contributions of the TEL-patch amino acid cluster on TPP1 to telomeric DNA synthesis by human telomerase. J Mol Biol. 2015 Mar 27; 427(6 Pt B):1291-1303.
Score: 0.083
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Schmidt JC, Dalby AB, Cech TR. Identification of human TERT elements necessary for telomerase recruitment to telomeres. Elife. 2014 Oct 01; 3.
Score: 0.081
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McKay DB, Xi L, Barthel KKB, Cech TR. Structure and function of steroid receptor RNA activator protein, the proposed partner of SRA noncoding RNA. J Mol Biol. 2014 Apr 17; 426(8):1766-1785.
Score: 0.078
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Schwartz JC, Wang X, Podell ER, Cech TR. RNA seeds higher-order assembly of FUS protein. Cell Rep. 2013 Nov 27; 5(4):918-25.
Score: 0.077
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Davidovich C, Zheng L, Goodrich KJ, Cech TR. Promiscuous RNA binding by Polycomb repressive complex 2. Nat Struct Mol Biol. 2013 Nov; 20(11):1250-7.
Score: 0.076
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Nandakumar J, Cech TR. Finding the end: recruitment of telomerase to telomeres. Nat Rev Mol Cell Biol. 2013 Feb; 14(2):69-82.
Score: 0.072
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Schwartz JC, Ebmeier CC, Podell ER, Heimiller J, Taatjes DJ, Cech TR. FUS binds the CTD of RNA polymerase II and regulates its phosphorylation at Ser2. Genes Dev. 2012 Dec 15; 26(24):2690-5.
Score: 0.072
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Nandakumar J, Bell CF, Weidenfeld I, Zaug AJ, Leinwand LA, Cech TR. The TEL patch of telomere protein TPP1 mediates telomerase recruitment and processivity. Nature. 2012 Dec 13; 492(7428):285-9.
Score: 0.071
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Taylor DJ, Podell ER, Taatjes DJ, Cech TR. Multiple POT1-TPP1 proteins coat and compact long telomeric single-stranded DNA. J Mol Biol. 2011 Jul 01; 410(1):10-7.
Score: 0.064
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Jacobs SA, Podell ER, Cech TR. Crystal structure of the essential N-terminal domain of telomerase reverse transcriptase. Nat Struct Mol Biol. 2006 Mar; 13(3):218-25.
Score: 0.045
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Lei M, Podell ER, Cech TR. Structure of human POT1 bound to telomeric single-stranded DNA provides a model for chromosome end-protection. Nat Struct Mol Biol. 2004 Dec; 11(12):1223-9.
Score: 0.041
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Aigner S, Cech TR. The Euplotes telomerase subunit p43 stimulates enzymatic activity and processivity in vitro. RNA. 2004 Jul; 10(7):1108-18.
Score: 0.040
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Bryan TM, Goodrich KJ, Cech TR. Tetrahymena telomerase is active as a monomer. Mol Biol Cell. 2003 Dec; 14(12):4794-804.
Score: 0.038
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Livengood AJ, Zaug AJ, Cech TR. Essential regions of Saccharomyces cerevisiae telomerase RNA: separate elements for Est1p and Est2p interaction. Mol Cell Biol. 2002 Apr; 22(7):2366-74.
Score: 0.034
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Heenan PR, Wang X, Gooding AR, Cech TR, Perkins TT. Bending and looping of long DNA by Polycomb repressive complex 2 revealed by AFM imaging in liquid. Nucleic Acids Res. 2020 04 06; 48(6):2969-2981.
Score: 0.030
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Froelich-Ammon SJ, Dickinson BA, Bevilacqua JM, Schultz SC, Cech TR. Modulation of telomerase activity by telomere DNA-binding proteins in Oxytricha. Genes Dev. 1998 May 15; 12(10):1504-14.
Score: 0.026
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Hammond PW, Cech TR. Euplotes telomerase: evidence for limited base-pairing during primer elongation and dGTP as an effector of translocation. Biochemistry. 1998 Apr 14; 37(15):5162-72.
Score: 0.026
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Long Y, Bolanos B, Gong L, Liu W, Goodrich KJ, Yang X, Chen S, Gooding AR, Maegley KA, Gajiwala KS, Brooun A, Cech TR, Liu X. Conserved RNA-binding specificity of polycomb repressive complex 2 is achieved by dispersed amino acid patches in EZH2. Elife. 2017 11 29; 6.
Score: 0.025
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Wang X, Goodrich KJ, Gooding AR, Naeem H, Archer S, Paucek RD, Youmans DT, Cech TR, Davidovich C. Targeting of Polycomb Repressive Complex 2 to RNA by Short Repeats of Consecutive Guanines. Mol Cell. 2017 Mar 16; 65(6):1056-1067.e5.
Score: 0.024
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Shukla S, Schmidt JC, Goldfarb KC, Cech TR, Parker R. Inhibition of telomerase RNA decay rescues telomerase deficiency caused by dyskerin or PARN defects. Nat Struct Mol Biol. 2016 Apr; 23(4):286-92.
Score: 0.022
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Weeks KM, Cech TR. Protein facilitation of group I intron splicing by assembly of the catalytic core and the 5' splice site domain. Cell. 1995 Jul 28; 82(2):221-30.
Score: 0.022
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Gampel A, Cech TR. Binding of the CBP2 protein to a yeast mitochondrial group I intron requires the catalytic core of the RNA. Genes Dev. 1991 Oct; 5(10):1870-80.
Score: 0.017
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Pyle AM, Cech TR. Ribozyme recognition of RNA by tertiary interactions with specific ribose 2'-OH groups. Nature. 1991 Apr 18; 350(6319):628-31.
Score: 0.016
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Raghuraman MK, Cech TR. Effect of monovalent cation-induced telomeric DNA structure on the binding of Oxytricha telomeric protein. Nucleic Acids Res. 1990 Aug 11; 18(15):4543-52.
Score: 0.015
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Raghuraman MK, Cech TR. Assembly and self-association of oxytricha telomeric nucleoprotein complexes. Cell. 1989 Nov 17; 59(4):719-28.
Score: 0.015
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Wang F, Podell ER, Zaug AJ, Yang Y, Baciu P, Cech TR, Lei M. The POT1-TPP1 telomere complex is a telomerase processivity factor. Nature. 2007 Feb 01; 445(7127):506-10.
Score: 0.012
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Opresko PL, Mason PA, Podell ER, Lei M, Hickson ID, Cech TR, Bohr VA. POT1 stimulates RecQ helicases WRN and BLM to unwind telomeric DNA substrates. J Biol Chem. 2005 Sep 16; 280(37):32069-80.
Score: 0.011
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Pardue ML, Fostel JM, Cech TR. DNA-protein interactions in the Drosophila virilis mitochondrial chromosome. Nucleic Acids Res. 1984 Feb 24; 12(4):1991-9.
Score: 0.010
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F?rstemann K, Zaug AJ, Cech TR, Lingner J. Yeast telomerase is specialized for C/A-rich RNA templates. Nucleic Acids Res. 2003 Mar 15; 31(6):1646-55.
Score: 0.009
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Potter DA, Fostel JM, Berninger M, Pardue ML, Cech TR. DNA-protein interactions in the Drosophila melanogaster mitochondrial genome as deduced from trimethylpsoralen crosslinking patterns. Proc Natl Acad Sci U S A. 1980 Jul; 77(7):4118-22.
Score: 0.008
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Willis MC, Hicke BJ, Uhlenbeck OC, Cech TR, Koch TH. Photocrosslinking of 5-iodouracil-substituted RNA and DNA to proteins. Science. 1993 Nov 19; 262(5137):1255-7.
Score: 0.005
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Connection Strength
The connection strength for concepts is the sum of the scores for each matching publication.
Publication scores are based on many factors, including how long ago they were written and whether the person is a first or senior author.
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