 Connection
Thomas Cech to Mutation
This is a "connection" page, showing publications Thomas Cech has written about Mutation.
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2.521 |
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Stern JL, Paucek RD, Huang FW, Ghandi M, Nwumeh R, Costello JC, Cech TR. Allele-Specific DNA Methylation and Its Interplay with Repressive Histone Marks at Promoter-Mutant TERT Genes. Cell Rep. 2017 12 26; 21(13):3700-3707.
Score: 0.288
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Stern JL, Theodorescu D, Vogelstein B, Papadopoulos N, Cech TR. Mutation of the TERT promoter, switch to active chromatin, and monoallelic TERT expression in multiple cancers. Genes Dev. 2015 Nov 01; 29(21):2219-24.
Score: 0.248
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Theodorescu D, Cech TR. Telomerase in bladder cancer: back to a better future? Eur Urol. 2014 Feb; 65(2):370-1.
Score: 0.216
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Zaug AJ, Podell ER, Cech TR. Mutation in TERT separates processivity from anchor-site function. Nat Struct Mol Biol. 2008 Aug; 15(8):870-2.
Score: 0.150
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Zaug AJ, Lim CJ, Olson CL, Carilli MT, Goodrich KJ, Wuttke DS, Cech TR. CST does not evict elongating telomerase but prevents initiation by ssDNA binding. Nucleic Acids Res. 2021 11 18; 49(20):11653-11665.
Score: 0.094
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Agarwal N, Rinaldetti S, Cheikh BB, Zhou Q, Hass EP, Jones RT, Joshi M, LaBarbera DV, Knott SRV, Cech TR, Theodorescu D. TRIM28 is a transcriptional activator of the mutant TERT promoter in human bladder cancer. Proc Natl Acad Sci U S A. 2021 09 21; 118(38).
Score: 0.093
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Youmans DT, Gooding AR, Dowell RD, Cech TR. Competition between PRC2.1 and 2.2 subcomplexes regulates PRC2 chromatin occupancy in human stem cells. Mol Cell. 2021 02 04; 81(3):488-501.e9.
Score: 0.089
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Stern JL, Hibshman G, Hu K, Ferrara SE, Costello JC, Kim W, Tamayo P, Cech TR, Huang FW. Mesenchymal and MAPK Expression Signatures Associate with Telomerase Promoter Mutations in Multiple Cancers. Mol Cancer Res. 2020 07; 18(7):1050-1062.
Score: 0.084
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Jabri E, Cech TR. In vitro selection of the Naegleria GIR1 ribozyme identifies three base changes that dramatically improve activity. RNA. 1998 Dec; 4(12):1481-92.
Score: 0.077
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Shoffner GM, Wang R, Podell E, Cech TR, Guo F. In Crystallo Selection to Establish New?RNA?Crystal?Contacts. Structure. 2018 09 04; 26(9):1275-1283.e3.
Score: 0.074
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Goldfarb KC, Cech TR. Targeted CRISPR disruption reveals a role for RNase MRP RNA in human preribosomal RNA processing. Genes Dev. 2017 01 01; 31(1):59-71.
Score: 0.067
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Campbell TB, Cech TR. Mutations in the Tetrahymena ribozyme internal guide sequence: effects on docking of the P1 helix into the catalytic core and correlation with catalytic activity. Biochemistry. 1996 Sep 03; 35(35):11493-502.
Score: 0.066
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Xi L, Schmidt JC, Zaug AJ, Ascarrunz DR, Cech TR. A novel two-step genome editing strategy with CRISPR-Cas9 provides new insights into telomerase action and TERT gene expression. Genome Biol. 2015 Nov 10; 16:231.
Score: 0.062
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Schmidt JC, Dalby AB, Cech TR. Identification of human TERT elements necessary for telomerase recruitment to telomeres. Elife. 2014 Oct 01; 3.
Score: 0.058
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Nakashima M, Nandakumar J, Sullivan KD, Espinosa JM, Cech TR. Inhibition of telomerase recruitment and cancer cell death. J Biol Chem. 2013 Nov 15; 288(46):33171-80.
Score: 0.054
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Zaug AJ, Crary SM, Jesse Fioravanti M, Campbell K, Cech TR. Many disease-associated variants of hTERT retain high telomerase enzymatic activity. Nucleic Acids Res. 2013 Oct; 41(19):8969-78.
Score: 0.053
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Dalby AB, Goodrich KJ, Pfingsten JS, Cech TR. RNA recognition by the DNA end-binding Ku heterodimer. RNA. 2013 Jun; 19(6):841-51.
Score: 0.052
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Nandakumar J, Bell CF, Weidenfeld I, Zaug AJ, Leinwand LA, Cech TR. The TEL patch of telomere protein TPP1 mediates telomerase recruitment and processivity. Nature. 2012 Dec 13; 492(7428):285-9.
Score: 0.050
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Pyle AM, McSwiggen JA, Cech TR. Direct measurement of oligonucleotide substrate binding to wild-type and mutant ribozymes from Tetrahymena. Proc Natl Acad Sci U S A. 1990 Nov; 87(21):8187-91.
Score: 0.044
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Berman AJ, Gooding AR, Cech TR. Tetrahymena telomerase protein p65 induces conformational changes throughout telomerase RNA (TER) and rescues telomerase reverse transcriptase and TER assembly mutants. Mol Cell Biol. 2010 Oct; 30(20):4965-76.
Score: 0.043
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Zaug AJ, Podell ER, Nandakumar J, Cech TR. Functional interaction between telomere protein TPP1 and telomerase. Genes Dev. 2010 Mar 15; 24(6):613-22.
Score: 0.042
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Qiao F, Goodrich KJ, Cech TR. Engineering cis-telomerase RNAs that add telomeric repeats to themselves. Proc Natl Acad Sci U S A. 2010 Mar 16; 107(11):4914-8.
Score: 0.042
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Jacobs SA, Podell ER, Cech TR. Crystal structure of the essential N-terminal domain of telomerase reverse transcriptase. Nat Struct Mol Biol. 2006 Mar; 13(3):218-25.
Score: 0.032
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Guo F, Gooding AR, Cech TR. Comparison of crystal structure interactions and thermodynamics for stabilizing mutations in the Tetrahymena ribozyme. RNA. 2006 Mar; 12(3):387-95.
Score: 0.032
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Jacobs SA, Podell ER, Wuttke DS, Cech TR. Soluble domains of telomerase reverse transcriptase identified by high-throughput screening. Protein Sci. 2005 Aug; 14(8):2051-8.
Score: 0.030
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Lei M, Podell ER, Baumann P, Cech TR. DNA self-recognition in the structure of Pot1 bound to telomeric single-stranded DNA. Nature. 2003 Nov 13; 426(6963):198-203.
Score: 0.027
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Seto AG, Umansky K, Tzfati Y, Zaug AJ, Blackburn EH, Cech TR. A template-proximal RNA paired element contributes to Saccharomyces cerevisiae telomerase activity. RNA. 2003 Nov; 9(11):1323-32.
Score: 0.027
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Guo F, Cech TR. In vivo selection of better self-splicing introns in Escherichia coli: the role of the P1 extension helix of the Tetrahymena intron. RNA. 2002 May; 8(5):647-58.
Score: 0.024
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Juneau K, Podell E, Harrington DJ, Cech TR. Structural basis of the enhanced stability of a mutant ribozyme domain and a detailed view of RNA--solvent interactions. Structure. 2001 Mar 07; 9(3):221-31.
Score: 0.022
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Silverman SK, Cech TR. An early transition state for folding of the P4-P6 RNA domain. RNA. 2001 Feb; 7(2):161-6.
Score: 0.022
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Bryan TM, Goodrich KJ, Cech TR. A mutant of Tetrahymena telomerase reverse transcriptase with increased processivity. J Biol Chem. 2000 Aug 04; 275(31):24199-207.
Score: 0.022
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Haering CH, Nakamura TM, Baumann P, Cech TR. Analysis of telomerase catalytic subunit mutants in vivo and in vitro in Schizosaccharomycespombe. Proc Natl Acad Sci U S A. 2000 Jun 06; 97(12):6367-72.
Score: 0.021
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Friedman KL, Cech TR. Essential functions of amino-terminal domains in the yeast telomerase catalytic subunit revealed by selection for viable mutants. Genes Dev. 1999 Nov 01; 13(21):2863-74.
Score: 0.020
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Silverman SK, Cech TR. Energetics and cooperativity of tertiary hydrogen bonds in RNA structure. Biochemistry. 1999 Jul 06; 38(27):8691-702.
Score: 0.020
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Tanner MA, Anderson EM, Gutell RR, Cech TR. Mutagenesis and comparative sequence analysis of a base triple joining the two domains of group I ribozymes. RNA. 1997 Sep; 3(9):1037-51.
Score: 0.018
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Szewczak AA, Cech TR. An RNA internal loop acts as a hinge to facilitate ribozyme folding and catalysis. RNA. 1997 Aug; 3(8):838-49.
Score: 0.018
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Rusconi CP, Cech TR. The anticodon is the signal sequence for mitochondrial import of glutamine tRNA in Tetrahymena. Genes Dev. 1996 Nov 15; 10(22):2870-80.
Score: 0.017
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Tang M, Li Y, Zhang Y, Chen Y, Huang W, Wang D, Zaug AJ, Liu D, Zhao Y, Cech TR, Ma W, Songyang Z. Disease mutant analysis identifies a new function of DAXX in telomerase regulation and telomere maintenance. J Cell Sci. 2015 Jan 15; 128(2):331-41.
Score: 0.015
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Laggerbauer B, Murphy FL, Cech TR. Two major tertiary folding transitions of the Tetrahymena catalytic RNA. EMBO J. 1994 Jun 01; 13(11):2669-76.
Score: 0.014
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Flor PJ, Flanegan JB, Cech TR. A conserved base pair within helix P4 of the Tetrahymena ribozyme helps to form the tertiary structure required for self-splicing. EMBO J. 1989 Nov; 8(11):3391-9.
Score: 0.010
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Barfod ET, Cech TR. The conserved U.G pair in the 5' splice site duplex of a group I intron is required in the first but not the second step of self-splicing. Mol Cell Biol. 1989 Sep; 9(9):3657-66.
Score: 0.010
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Price JV, Cech TR. Determinants of the 3' splice site for self-splicing of the Tetrahymena pre-rRNA. Genes Dev. 1988 Nov; 2(11):1439-47.
Score: 0.010
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Barfod ET, Cech TR. Deletion of nonconserved helices near the 3' end of the rRNA intron of Tetrahymena thermophila alters self-splicing but not core catalytic activity. Genes Dev. 1988 Jun; 2(6):652-63.
Score: 0.009
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Been MD, Barfod ET, Burke JM, Price JV, Tanner NK, Zaug AJ, Cech TR. Structures involved in Tetrahymena rRNA self-splicing and RNA enzyme activity. Cold Spring Harb Symp Quant Biol. 1987; 52:147-57.
Score: 0.008
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Zaug AJ, Been MD, Cech TR. The Tetrahymena ribozyme acts like an RNA restriction endonuclease. Nature. 1986 Dec 4-10; 324(6096):429-33.
Score: 0.008
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Been MD, Cech TR. One binding site determines sequence specificity of Tetrahymena pre-rRNA self-splicing, trans-splicing, and RNA enzyme activity. Cell. 1986 Oct 24; 47(2):207-16.
Score: 0.008
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Burke JM, Irvine KD, Kaneko KJ, Kerker BJ, Oettgen AB, Tierney WM, Williamson CL, Zaug AJ, Cech TR. Role of conserved sequence elements 9L and 2 in self-splicing of the Tetrahymena ribosomal RNA precursor. Cell. 1986 Apr 25; 45(2):167-76.
Score: 0.008
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Opresko PL, Mason PA, Podell ER, Lei M, Hickson ID, Cech TR, Bohr VA. POT1 stimulates RecQ helicases WRN and BLM to unwind telomeric DNA substrates. J Biol Chem. 2005 Sep 16; 280(37):32069-80.
Score: 0.008
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Price JV, Kieft GL, Kent JR, Sievers EL, Cech TR. Sequence requirements for self-splicing of the Tetrahymena thermophila pre-ribosomal RNA. Nucleic Acids Res. 1985 Mar 25; 13(6):1871-89.
Score: 0.007
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F?rstemann K, Zaug AJ, Cech TR, Lingner J. Yeast telomerase is specialized for C/A-rich RNA templates. Nucleic Acids Res. 2003 Mar 15; 31(6):1646-55.
Score: 0.006
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Connection Strength
The connection strength for concepts is the sum of the scores for each matching publication.
Publication scores are based on many factors, including how long ago they were written and whether the person is a first or senior author.
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