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Connection

Charles Dinarello to Cytokines

This is a "connection" page, showing publications Charles Dinarello has written about Cytokines.

 
Connection Strength
 
 
 
10.026
 
  1. Ghezzi P, Fantuzzi G, Dinarello CA. Perspective: Daniela Novick, cytokines and their receptors. Front Immunol. 2023; 14:1160651.
    View in: PubMed
    Score: 0.501
  2. de Graaf DM, Jaeger M, van den Munckhof ICL, Ter Horst R, Schraa K, Zwaag J, Kox M, Fujita M, Yamauchi T, Mercurio L, Madonna S, Rutten JHW, de Graaf J, Riksen NP, van de Veerdonk FL, Netea MG, Joosten LAB, Dinarello CA. Reduced concentrations of the B cell cytokine interleukin 38 are associated with cardiovascular disease risk in overweight subjects. Eur J Immunol. 2021 03; 51(3):662-671.
    View in: PubMed
    Score: 0.422
  3. Ballak DB, Li S, Cavalli G, Stahl JL, Tengesdal IW, van Diepen JA, Kl?ck V, Swartzwelter B, Azam T, Tack CJ, Stienstra R, Mandrup-Poulsen T, Seals DR, Dinarello CA. Interleukin-37 treatment of mice with metabolic syndrome improves insulin sensitivity and reduces pro-inflammatory cytokine production in adipose tissue. J Biol Chem. 2018 09 14; 293(37):14224-14236.
    View in: PubMed
    Score: 0.358
  4. Cavalli G, Hayashi M, Jin Y, Yorgov D, Santorico SA, Holcomb C, Rastrou M, Erlich H, Tengesdal IW, Dagna L, Neff CP, Palmer BE, Spritz RA, Dinarello CA. MHC class II super-enhancer increases surface expression of HLA-DR and HLA-DQ and affects cytokine production in autoimmune vitiligo. Proc Natl Acad Sci U S A. 2016 Feb 02; 113(5):1363-8.
    View in: PubMed
    Score: 0.302
  5. Li S, Fossati G, Marchetti C, Modena D, Pozzi P, Reznikov LL, Moras ML, Azam T, Abbate A, Mascagni P, Dinarello CA. Specific inhibition of histone deacetylase 8 reduces gene expression and production of proinflammatory cytokines in vitro and in vivo. J Biol Chem. 2015 Jan 23; 290(4):2368-78.
    View in: PubMed
    Score: 0.279
  6. Furlan A, Monzani V, Reznikov LL, Leoni F, Fossati G, Modena D, Mascagni P, Dinarello CA. Pharmacokinetics, safety and inducible cytokine responses during a phase 1 trial of the oral histone deacetylase inhibitor ITF2357 (givinostat). Mol Med. 2011 May-Jun; 17(5-6):353-62.
    View in: PubMed
    Score: 0.215
  7. Nold-Petry CA, Nold MF, Nielsen JW, Bustamante A, Zepp JA, Storm KA, Hong JW, Kim SH, Dinarello CA. Increased cytokine production in interleukin-18 receptor alpha-deficient cells is associated with dysregulation of suppressors of cytokine signaling. J Biol Chem. 2009 Sep 18; 284(38):25900-11.
    View in: PubMed
    Score: 0.192
  8. van der Meer JH, Netea MG, Dinarello CA. Modulation of muramyl dipeptide stimulation of cytokine production by blood components. Clin Exp Immunol. 2009 Jun; 156(3):428-33.
    View in: PubMed
    Score: 0.191
  9. Dinarello CA. Hyperosmolar sodium chloride, p38 mitogen activated protein and cytokine-mediated inflammation. Semin Dial. 2009 May-Jun; 22(3):256-9.
    View in: PubMed
    Score: 0.189
  10. Dinarello CA. Inflammation in human disease: anticytokine therapy. Biol Blood Marrow Transplant. 2009 Jan; 15(1 Suppl):134-6.
    View in: PubMed
    Score: 0.185
  11. Nold MF, Nold-Petry CA, Pott GB, Zepp JA, Saavedra MT, Kim SH, Dinarello CA. Endogenous IL-32 controls cytokine and HIV-1 production. J Immunol. 2008 Jul 01; 181(1):557-65.
    View in: PubMed
    Score: 0.179
  12. Dinarello CA. Historical insights into cytokines. Eur J Immunol. 2007 Nov; 37 Suppl 1:S34-45.
    View in: PubMed
    Score: 0.171
  13. Dinarello CA. The paradox of pro-inflammatory cytokines in cancer. Cancer Metastasis Rev. 2006 Sep; 25(3):307-13.
    View in: PubMed
    Score: 0.158
  14. Kim SH, Han SY, Azam T, Yoon DY, Dinarello CA. Interleukin-32: a cytokine and inducer of TNFalpha. Immunity. 2005 Jan; 22(1):131-42.
    View in: PubMed
    Score: 0.140
  15. Dinarello CA. Anti-cytokine therapeutics and infections. Vaccine. 2003 Jun 01; 21 Suppl 2:S24-34.
    View in: PubMed
    Score: 0.126
  16. Dinarello CA. Setting the cytokine trap for autoimmunity. Nat Med. 2003 Jan; 9(1):20-2.
    View in: PubMed
    Score: 0.122
  17. de Graaf DM, Wang RX, Amo-Aparicio J, Lee JS, Dowdell AS, Tengesdal IW, Marchetti C, Colgan SP, Joosten LAB, Dinarello CA. IL-38 Gene Deletion Worsens Murine Colitis. Front Immunol. 2022; 13:840719.
    View in: PubMed
    Score: 0.117
  18. Netea MG, Stuyt RJ, Kim SH, Van der Meer JW, Kullberg BJ, Dinarello CA. The role of endogenous interleukin (IL)-18, IL-12, IL-1beta, and tumor necrosis factor-alpha in the production of interferon-gamma induced by Candida albicans in human whole-blood cultures. J Infect Dis. 2002 Apr 01; 185(7):963-70.
    View in: PubMed
    Score: 0.115
  19. Teufel LU, Arts RJW, Netea MG, Dinarello CA, Joosten LAB. IL-1 family cytokines as drivers and inhibitors of trained immunity. Cytokine. 2022 02; 150:155773.
    View in: PubMed
    Score: 0.113
  20. van Deuren RC, Arts P, Cavalli G, Jaeger M, Steehouwer M, van de Vorst M, Gilissen C, Joosten LAB, Dinarello CA, Mhlanga MM, Kumar V, Netea MG, van de Veerdonk FL, Hoischen A. Impact of rare and common genetic variation in the interleukin-1 pathway on human cytokine responses. Genome Med. 2021 05 25; 13(1):94.
    View in: PubMed
    Score: 0.109
  21. Pizarro TT, Dinarello CA, Cominelli F. Editorial: Cytokines and Intestinal Mucosal Immunity. Front Immunol. 2021; 12:698693.
    View in: PubMed
    Score: 0.109
  22. Dinarello CA, Pomerantz BJ. Proinflammatory cytokines in heart disease. Blood Purif. 2001; 19(3):314-21.
    View in: PubMed
    Score: 0.106
  23. Netea MG, Selzman CH, Kullberg BJ, Galama JM, Weinberg A, Stalenhoef AF, Van der Meer JW, Dinarello CA. Acellular components of Chlamydia pneumoniae stimulate cytokine production in human blood mononuclear cells. Eur J Immunol. 2000 Feb; 30(2):541-9.
    View in: PubMed
    Score: 0.100
  24. Mantovani A, Dinarello CA, Molgora M, Garlanda C. Interleukin-1 and Related Cytokines in the Regulation of Inflammation and Immunity. Immunity. 2019 04 16; 50(4):778-795.
    View in: PubMed
    Score: 0.094
  25. Dinarello CA. Cytokines as endogenous pyrogens. J Infect Dis. 1999 Mar; 179 Suppl 2:S294-304.
    View in: PubMed
    Score: 0.094
  26. Li S, Amo-Aparicio J, Neff CP, Tengesdal IW, Azam T, Palmer BE, L?pez-Vales R, Bufler P, Dinarello CA. Role for nuclear interleukin-37 in the suppression of innate immunity. Proc Natl Acad Sci U S A. 2019 03 05; 116(10):4456-4461.
    View in: PubMed
    Score: 0.093
  27. Cleophas MCP, Crisan TO, Kl?ck V, Hoogerbrugge N, Netea-Maier RT, Dinarello CA, Netea MG, Joosten LAB. Romidepsin suppresses monosodium urate crystal-induced cytokine production through upregulation of suppressor of cytokine signaling 1 expression. Arthritis Res Ther. 2019 02 06; 21(1):50.
    View in: PubMed
    Score: 0.093
  28. Reznikov LL, Puren AJ, Fantuzzi G, M?hl H, Shapiro L, Yoon DY, Cutler DL, Dinarello CA. Spontaneous and inducible cytokine responses in healthy humans receiving a single dose of IFN-alpha2b: increased production of interleukin-1 receptor antagonist and suppression of IL-1-induced IL-8. J Interferon Cytokine Res. 1998 Oct; 18(10):897-903.
    View in: PubMed
    Score: 0.091
  29. Dinarello CA, Novick D, Puren AJ, Fantuzzi G, Shapiro L, M?hl H, Yoon DY, Reznikov LL, Kim SH, Rubinstein M. Overview of interleukin-18: more than an interferon-gamma inducing factor. J Leukoc Biol. 1998 Jun; 63(6):658-64.
    View in: PubMed
    Score: 0.089
  30. Fantuzzi G, Puren AJ, Harding MW, Livingston DJ, Dinarello CA. Interleukin-18 regulation of interferon gamma production and cell proliferation as shown in interleukin-1beta-converting enzyme (caspase-1)-deficient mice. Blood. 1998 Mar 15; 91(6):2118-25.
    View in: PubMed
    Score: 0.088
  31. Fantuzzi G, Dinarello CA. Stem cell factor-deficient mice have a dysregulation of cytokine production during local inflammation. Eur Cytokine Netw. 1998 Mar; 9(1):85-92.
    View in: PubMed
    Score: 0.087
  32. Puren AJ, Fantuzzi G, Gu Y, Su MS, Dinarello CA. Interleukin-18 (IFNgamma-inducing factor) induces IL-8 and IL-1beta via TNFalpha production from non-CD14+ human blood mononuclear cells. J Clin Invest. 1998 Feb 01; 101(3):711-21.
    View in: PubMed
    Score: 0.087
  33. Roubenoff R, Harris TB, Abad LW, Wilson PW, Dallal GE, Dinarello CA. Monocyte cytokine production in an elderly population: effect of age and inflammation. J Gerontol A Biol Sci Med Sci. 1998 Jan; 53(1):M20-6.
    View in: PubMed
    Score: 0.086
  34. Dinarello CA. Proinflammatory and anti-inflammatory cytokines as mediators in the pathogenesis of septic shock. Chest. 1997 Dec; 112(6 Suppl):321S-329S.
    View in: PubMed
    Score: 0.086
  35. Fantuzzi G, Sacco S, Ghezzi P, Dinarello CA. Physiological and cytokine responses in IL-1 beta-deficient mice after zymosan-induced inflammation. Am J Physiol. 1997 Jul; 273(1 Pt 2):R400-6.
    View in: PubMed
    Score: 0.083
  36. Dos Santos JC, Heinhuis B, Gomes RS, Damen MS, Real F, Mortara RA, Keating ST, Dinarello CA, Joosten LA, Ribeiro-Dias F. Cytokines and microbicidal molecules regulated by IL-32 in THP-1-derived human macrophages infected with New World Leishmania species. PLoS Negl Trop Dis. 2017 02; 11(2):e0005413.
    View in: PubMed
    Score: 0.081
  37. Ter Horst R, Jaeger M, Smeekens SP, Oosting M, Swertz MA, Li Y, Kumar V, Diavatopoulos DA, Jansen AFM, Lemmers H, Toenhake-Dijkstra H, van Herwaarden AE, Janssen M, van der Molen RG, Joosten I, Sweep FCGJ, Smit JW, Netea-Maier RT, Koenders MMJF, Xavier RJ, van der Meer JWM, Dinarello CA, Pavelka N, Wijmenga C, Notebaart RA, Joosten LAB, Netea MG. Host and Environmental Factors Influencing Individual Human Cytokine Responses. Cell. 2016 11 03; 167(4):1111-1124.e13.
    View in: PubMed
    Score: 0.080
  38. Cavalli G, Koenders M, Kalabokis V, Kim J, Tan AC, Garlanda C, Mantovani A, Dagna L, Joosten LA, Dinarello CA. Treating experimental arthritis with the innate immune inhibitor interleukin-37 reduces joint and systemic inflammation. Rheumatology (Oxford). 2016 Dec; 55(12):2220-2229.
    View in: PubMed
    Score: 0.079
  39. Fantuzzi G, Dinarello CA. The inflammatory response in interleukin-1 beta-deficient mice: comparison with other cytokine-related knock-out mice. J Leukoc Biol. 1996 Apr; 59(4):489-93.
    View in: PubMed
    Score: 0.077
  40. Iannitti RG, Napolioni V, Oikonomou V, De Luca A, Galosi C, Pariano M, Massi-Benedetti C, Borghi M, Puccetti M, Lucidi V, Colombo C, Fiscarelli E, Lass-Fl?rl C, Majo F, Cariani L, Russo M, Porcaro L, Ricciotti G, Ellemunter H, Ratclif L, De Benedictis FM, Talesa VN, Dinarello CA, van de Veerdonk FL, Romani L. IL-1 receptor antagonist ameliorates inflammasome-dependent inflammation in murine and human cystic fibrosis. Nat Commun. 2016 Mar 14; 7:10791.
    View in: PubMed
    Score: 0.076
  41. Tzanetakou V, Kanni T, Giatrakou S, Katoulis A, Papadavid E, Netea MG, Dinarello CA, van der Meer JWM, Rigopoulos D, Giamarellos-Bourboulis EJ. Safety and Efficacy of Anakinra in Severe Hidradenitis Suppurativa: A Randomized Clinical Trial. JAMA Dermatol. 2016 Jan; 152(1):52-59.
    View in: PubMed
    Score: 0.075
  42. Dinarello CA. Cytokines as mediators in the pathogenesis of septic shock. Curr Top Microbiol Immunol. 1996; 216:133-65.
    View in: PubMed
    Score: 0.075
  43. Dinarello CA, Margolis NH. Cytokine-processing enzymes. Stopping the cuts. Curr Biol. 1995 Jun 01; 5(6):587-90.
    View in: PubMed
    Score: 0.072
  44. Pereira BJ, Dinarello CA. Role of cytokines in patients on dialysis. Int J Artif Organs. 1995 Jun; 18(6):293-304.
    View in: PubMed
    Score: 0.072
  45. Carta S, Penco F, Lavieri R, Martini A, Dinarello CA, Gattorno M, Rubartelli A. Cell stress increases ATP release in NLRP3 inflammasome-mediated autoinflammatory diseases, resulting in cytokine imbalance. Proc Natl Acad Sci U S A. 2015 Mar 03; 112(9):2835-40.
    View in: PubMed
    Score: 0.071
  46. Cleophas MC, Crisan TO, Lemmers H, Toenhake-Dijkstra H, Fossati G, Jansen TL, Dinarello CA, Netea MG, Joosten LA. Suppression of monosodium urate crystal-induced cytokine production by butyrate is mediated by the inhibition of class I histone deacetylases. Ann Rheum Dis. 2016 Mar; 75(3):593-600.
    View in: PubMed
    Score: 0.070
  47. Netea MG, van de Veerdonk FL, van der Meer JW, Dinarello CA, Joosten LA. Inflammasome-independent regulation of IL-1-family cytokines. Annu Rev Immunol. 2015; 33:49-77.
    View in: PubMed
    Score: 0.070
  48. Shapiro L, Panayotatos N, Meydani SN, Wu D, Dinarello CA. Ciliary neurotrophic factor combined with soluble receptor inhibits synthesis of proinflammatory cytokines and prostaglandin-E2 in vitro. Exp Cell Res. 1994 Nov; 215(1):51-6.
    View in: PubMed
    Score: 0.069
  49. Pereira BJ, Dinarello CA. Production of cytokines and cytokine inhibitory proteins in patients on dialysis. Nephrol Dial Transplant. 1994; 9 Suppl 2:60-71.
    View in: PubMed
    Score: 0.065
  50. Dinarello CA, Cannon JG. Cytokine measurements in septic shock. Ann Intern Med. 1993 Oct 15; 119(8):853-4.
    View in: PubMed
    Score: 0.065
  51. Cannon JG, Nerad JL, Poutsiaka DD, Dinarello CA. Measuring circulating cytokines. J Appl Physiol (1985). 1993 Oct; 75(4):1897-902.
    View in: PubMed
    Score: 0.064
  52. Granowitz EV, Porat R, Mier JW, Orencole SF, Kaplanski G, Lynch EA, Ye K, Vannier E, Wolff SM, Dinarello CA. Intravenous endotoxin suppresses the cytokine response of peripheral blood mononuclear cells of healthy humans. J Immunol. 1993 Aug 01; 151(3):1637-45.
    View in: PubMed
    Score: 0.064
  53. Dinarello CA, Gelfand JA, Wolff SM. Anticytokine strategies in the treatment of the systemic inflammatory response syndrome. JAMA. 1993 Apr 14; 269(14):1829-35.
    View in: PubMed
    Score: 0.062
  54. Meydani SN, Dinarello CA. Influence of dietary fatty acids on cytokine production and its clinical implications. Nutr Clin Pract. 1993 Apr; 8(2):65-72.
    View in: PubMed
    Score: 0.062
  55. Gresnigt MS, Joosten LA, Verschueren I, van der Meer JW, Netea MG, Dinarello CA, van de Veerdonk FL. Neutrophil-mediated inhibition of proinflammatory cytokine responses. J Immunol. 2012 Nov 15; 189(10):4806-15.
    View in: PubMed
    Score: 0.060
  56. Granowitz EV, Clark BD, Vannier E, Callahan MV, Dinarello CA. Effect of interleukin-1 (IL-1) blockade on cytokine synthesis: I. IL-1 receptor antagonist inhibits IL-1-induced cytokine synthesis and blocks the binding of IL-1 to its type II receptor on human monocytes. Blood. 1992 May 01; 79(9):2356-63.
    View in: PubMed
    Score: 0.058
  57. Granowitz EV, Vannier E, Poutsiaka DD, Dinarello CA. Effect of interleukin-1 (IL-1) blockade on cytokine synthesis: II. IL-1 receptor antagonist inhibits lipopolysaccharide-induced cytokine synthesis by human monocytes. Blood. 1992 May 01; 79(9):2364-9.
    View in: PubMed
    Score: 0.058
  58. Dinarello CA. Cytokines: agents provocateurs in hemodialysis? Kidney Int. 1992 Mar; 41(3):683-94.
    View in: PubMed
    Score: 0.058
  59. Dinarello CA. Anti-cytokine strategies. Eur Cytokine Netw. 1992 Jan-Feb; 3(1):7-17.
    View in: PubMed
    Score: 0.057
  60. Dinarello CA. A clinical perspective of IL-1? as the gatekeeper of inflammation. Eur J Immunol. 2011 May; 41(5):1203-17.
    View in: PubMed
    Score: 0.054
  61. Netea MG, Dinarello CA. More than inflammation: interleukin-1beta polymorphisms and the lipid metabolism. J Clin Endocrinol Metab. 2011 May; 96(5):1279-81.
    View in: PubMed
    Score: 0.054
  62. Kamari Y, Shaish A, Shemesh S, Vax E, Grosskopf I, Dotan S, White M, Voronov E, Dinarello CA, Apte RN, Harats D. Reduced atherosclerosis and inflammatory cytokines in apolipoprotein-E-deficient mice lacking bone marrow-derived interleukin-1a. Biochem Biophys Res Commun. 2011 Feb 11; 405(2):197-203.
    View in: PubMed
    Score: 0.053
  63. Endres S, Meydani SN, Dinarello CA. Effects of omega 3 fatty acid supplements on ex vivo synthesis of cytokines in human volunteers. Comparison with oral aspirin and ibuprofen. World Rev Nutr Diet. 1991; 66:401-6.
    View in: PubMed
    Score: 0.053
  64. Lewis EC, Blaabjerg L, St?rling J, Ronn SG, Mascagni P, Dinarello CA, Mandrup-Poulsen T. The oral histone deacetylase inhibitor ITF2357 reduces cytokines and protects islet ? cells in vivo and in vitro. Mol Med. 2011 May-Jun; 17(5-6):369-77.
    View in: PubMed
    Score: 0.053
  65. Lundh M, Christensen DP, Rasmussen DN, Mascagni P, Dinarello CA, Billestrup N, Grunnet LG, Mandrup-Poulsen T. Lysine deacetylases are produced in pancreatic beta cells and are differentially regulated by proinflammatory cytokines. Diabetologia. 2010 Dec; 53(12):2569-78.
    View in: PubMed
    Score: 0.052
  66. Abbate A, Van Tassell BW, Seropian IM, Toldo S, Robati R, Varma A, Salloum FN, Smithson L, Dinarello CA. Interleukin-1beta modulation using a genetically engineered antibody prevents adverse cardiac remodelling following acute myocardial infarction in the mouse. Eur J Heart Fail. 2010 Apr; 12(4):319-22.
    View in: PubMed
    Score: 0.050
  67. Dinarello CA. Cytokines and biocompatibility. Blood Purif. 1990; 8(4):208-13.
    View in: PubMed
    Score: 0.050
  68. Dinarello CA. The pathophysiology of the pro-inflammatory cytokines. Biotherapy. 1990; 2(3):189-91.
    View in: PubMed
    Score: 0.050
  69. Lewis EC, Mizrahi M, Toledano M, Defelice N, Wright JL, Churg A, Shapiro L, Dinarello CA. alpha1-Antitrypsin monotherapy induces immune tolerance during islet allograft transplantation in mice. Proc Natl Acad Sci U S A. 2008 Oct 21; 105(42):16236-41.
    View in: PubMed
    Score: 0.046
  70. Sharma S, Kulk N, Nold MF, Gr?f R, Kim SH, Reinhardt D, Dinarello CA, Bufler P. The IL-1 family member 7b translocates to the nucleus and down-regulates proinflammatory cytokines. J Immunol. 2008 Apr 15; 180(8):5477-82.
    View in: PubMed
    Score: 0.044
  71. Tan ZS, Beiser AS, Vasan RS, Roubenoff R, Dinarello CA, Harris TB, Benjamin EJ, Au R, Kiel DP, Wolf PA, Seshadri S. Inflammatory markers and the risk of Alzheimer disease: the Framingham Study. Neurology. 2007 May 29; 68(22):1902-8.
    View in: PubMed
    Score: 0.041
  72. Larsen L, Tonnesen M, Ronn SG, St?rling J, J?rgensen S, Mascagni P, Dinarello CA, Billestrup N, Mandrup-Poulsen T. Inhibition of histone deacetylases prevents cytokine-induced toxicity in beta cells. Diabetologia. 2007 Apr; 50(4):779-89.
    View in: PubMed
    Score: 0.041
  73. Netea MG, Azam T, Ferwerda G, Girardin SE, Kim SH, Dinarello CA. Triggering receptor expressed on myeloid cells-1 (TREM-1) amplifies the signals induced by the NACHT-LRR (NLR) pattern recognition receptors. J Leukoc Biol. 2006 Dec; 80(6):1454-61.
    View in: PubMed
    Score: 0.039
  74. Dinarello CA. Inhibitors of histone deacetylases as anti-inflammatory drugs. Ernst Schering Res Found Workshop. 2006; (56):45-60.
    View in: PubMed
    Score: 0.038
  75. Rodriguez RM, Abdullah R, Miller R, Barry L, Lungstras-Bufler K, Bufler P, Dinarello CA, Abraham E. A pilot study of cytokine levels and white blood cell counts in the diagnosis of necrotizing fasciitis. Am J Emerg Med. 2006 Jan; 24(1):58-61.
    View in: PubMed
    Score: 0.038
  76. Numerof RP, Dinarello CA, Asadullah K. Cytokines as potential therapeutic targets for inflammatory skin diseases. Eur Cytokine Netw. 2005 Jun; 16(2):101-3.
    View in: PubMed
    Score: 0.036
  77. Kumar A, Zanotti S, Bunnell G, Habet K, A?el R, Neumann A, Cheang M, Dinarello CA, Cutler D, Parrillo JE. Interleukin-10 blunts the human inflammatory response to lipopolysaccharide without affecting the cardiovascular response. Crit Care Med. 2005 Feb; 33(2):331-40.
    View in: PubMed
    Score: 0.035
  78. Leoni F, Fossati G, Lewis EC, Lee JK, Porro G, Pagani P, Modena D, Moras ML, Pozzi P, Reznikov LL, Siegmund B, Fantuzzi G, Dinarello CA, Mascagni P. The histone deacetylase inhibitor ITF2357 reduces production of pro-inflammatory cytokines in vitro and systemic inflammation in vivo. Mol Med. 2005 Jan-Dec; 11(1-12):1-15.
    View in: PubMed
    Score: 0.035
  79. Dinarello CA. Interleukin-18 and the treatment of rheumatoid arthritis. Rheum Dis Clin North Am. 2004 May; 30(2):417-34, ix.
    View in: PubMed
    Score: 0.033
  80. Lungstras-Bufler K, Bufler P, Abdullah R, Rutherford C, Endres S, Abraham E, Dinarello CA, Rodriguez RM. High cytokine levels at admission are associated with fatal outcome in patients with necrotizing fasciitis. Eur Cytokine Netw. 2004 Apr-Jun; 15(2):135-8.
    View in: PubMed
    Score: 0.033
  81. Wang M, Sankula R, Tsai BM, Meldrum KK, Turrentine M, March KL, Brown JW, Dinarello CA, Meldrum DR. P38 MAPK mediates myocardial proinflammatory cytokine production and endotoxin-induced contractile suppression. Shock. 2004 Feb; 21(2):170-4.
    View in: PubMed
    Score: 0.033
  82. Dinarello CA. Infection, fever, and exogenous and endogenous pyrogens: some concepts have changed. J Endotoxin Res. 2004; 10(4):201-22.
    View in: PubMed
    Score: 0.033
  83. Roubenoff R, Parise H, Payette HA, Abad LW, D'Agostino R, Jacques PF, Wilson PW, Dinarello CA, Harris TB. Cytokines, insulin-like growth factor 1, sarcopenia, and mortality in very old community-dwelling men and women: the Framingham Heart Study. Am J Med. 2003 Oct 15; 115(6):429-35.
    View in: PubMed
    Score: 0.032
  84. Feezor RJ, Oberholzer C, Baker HV, Novick D, Rubinstein M, Moldawer LL, Pribble J, Souza S, Dinarello CA, Ertel W, Oberholzer A. Molecular characterization of the acute inflammatory response to infections with gram-negative versus gram-positive bacteria. Infect Immun. 2003 Oct; 71(10):5803-13.
    View in: PubMed
    Score: 0.032
  85. Vasan RS, Sullivan LM, Roubenoff R, Dinarello CA, Harris T, Benjamin EJ, Sawyer DB, Levy D, Wilson PW, D'Agostino RB. Inflammatory markers and risk of heart failure in elderly subjects without prior myocardial infarction: the Framingham Heart Study. Circulation. 2003 Mar 25; 107(11):1486-91.
    View in: PubMed
    Score: 0.031
  86. Teufel LU, Netea MG, van de Veerdonk FL, Dinarello CA, Joosten LAB, Arts RJW. Opposing Effects of Interleukin-36? and Interleukin-38 on Trained Immunity. Int J Mol Sci. 2023 Jan 24; 24(3).
    View in: PubMed
    Score: 0.031
  87. Lonnemann G, Novick D, Rubinstein M, Passlick-Deetjen J, Lang D, Dinarello CA. A switch to high-flux helixone membranes reverses suppressed interferon-gamma production in patients on low-flux dialysis. Blood Purif. 2003; 21(3):225-31.
    View in: PubMed
    Score: 0.031
  88. Lonnemann N, Hosseini S, Ohm M, Geffers R, Hiller K, Dinarello CA, Korte M. IL-37 expression reduces acute and chronic neuroinflammation and rescues cognitive impairment in an Alzheimer's disease mouse model. Elife. 2022 08 30; 11.
    View in: PubMed
    Score: 0.030
  89. Netea MG, Kullberg BJ, Galama JM, Stalenhoef AF, Dinarello CA, Van der Meer JW. Non-LPS components of Chlamydia pneumoniae stimulate cytokine production through Toll-like receptor 2-dependent pathways. Eur J Immunol. 2002 04; 32(4):1188-95.
    View in: PubMed
    Score: 0.029
  90. Leoni F, Zaliani A, Bertolini G, Porro G, Pagani P, Pozzi P, Don? G, Fossati G, Sozzani S, Azam T, Bufler P, Fantuzzi G, Goncharov I, Kim SH, Pomerantz BJ, Reznikov LL, Siegmund B, Dinarello CA, Mascagni P. The antitumor histone deacetylase inhibitor suberoylanilide hydroxamic acid exhibits antiinflammatory properties via suppression of cytokines. Proc Natl Acad Sci U S A. 2002 Mar 05; 99(5):2995-3000.
    View in: PubMed
    Score: 0.029
  91. Perales MA, Fantuzzi G, Goldberg SM, Turk MJ, Mortazavi F, Busam K, Houghton AN, Dinarello CA, Wolchok JD. GM-CSF DNA induces specific patterns of cytokines and chemokines in the skin: implications for DNA vaccines. Cytokines Cell Mol Ther. 2002; 7(3):125-33.
    View in: PubMed
    Score: 0.028
  92. Dinarello CA. Novel targets for interleukin 18 binding protein. Ann Rheum Dis. 2001 Nov; 60 Suppl 3:iii18-24.
    View in: PubMed
    Score: 0.028
  93. Schr?der A, Lunding LP, Zissler UM, Vock C, Webering S, Ehlers JC, Orinska Z, Chaker A, Schmidt-Weber CB, Lang NJ, Schiller HB, Mall MA, Fehrenbach H, Dinarello CA, Wegmann M. IL-37 regulates allergic inflammation by counterbalancing pro-inflammatory IL-1 and IL-33. Allergy. 2022 03; 77(3):856-869.
    View in: PubMed
    Score: 0.028
  94. Javan H, Li L, Schaaf CL, Lee YS, Salama ME, Dinarello CA, Selzman CH. Interleukin-1 Receptor Antagonism Abrogates Acute Pressure Overload-Induced Murine Heart Failure. Ann Thorac Surg. 2022 07; 114(1):98-107.
    View in: PubMed
    Score: 0.028
  95. Briukhovetska D, D?rr J, Endres S, Libby P, Dinarello CA, Kobold S. Interleukins in cancer: from biology to therapy. Nat Rev Cancer. 2021 08; 21(8):481-499.
    View in: PubMed
    Score: 0.027
  96. van der Heijden WA, Van de Wijer L, Keramati F, Trypsteen W, Rutsaert S, Horst RT, Jaeger M, Koenen HJ, Stunnenberg HG, Joosten I, Verweij PE, van Lunzen J, Dinarello CA, Joosten LA, Vandekerckhove L, Netea MG, van der Ven AJ, de Mast Q. Chronic HIV infection induces transcriptional and functional reprogramming of innate immune cells. JCI Insight. 2021 04 08; 6(7).
    View in: PubMed
    Score: 0.027
  97. de Graaf DM, Maas RJA, Smeekens SP, Eisenmesser E, Redzic JS, Helsen MM, Powers NE, Li S, Kalabokis V, Gresnigt MS, Joosten LAB, Dinarello CA, van de Veerdonk FL. Human recombinant interleukin-38 suppresses inflammation in mouse models of local and systemic disease. Cytokine. 2021 01; 137:155334.
    View in: PubMed
    Score: 0.026
  98. Amo-Aparicio J, Sanchez-Fernandez A, Li S, Eisenmesser EZ, Garlanda C, Dinarello CA, Lopez-Vales R. Extracellular and nuclear roles of IL-37 after spinal cord injury. Brain Behav Immun. 2021 01; 91:194-201.
    View in: PubMed
    Score: 0.026
  99. Grander C, Schaefer B, Schw?rzler J, Grabherr F, de Graaf DM, Enrich B, Oberhuber G, Mayr L, Sangineto M, Jaschke N, Adolph TE, Effenberger M, Moschen AR, Dinarello CA, Zoller H, Tilg H. Alpha-1 antitrypsin governs alcohol-related liver disease in mice and humans. Gut. 2021 03; 70(3):585-594.
    View in: PubMed
    Score: 0.026
  100. Reznikov LL, Shames BD, Barton HA, Selzman CH, Fantuzzi G, Kim SH, Johnson SM, Dinarello CA. Interleukin-1beta deficiency results in reduced NF-kappaB levels in pregnant mice. Am J Physiol Regul Integr Comp Physiol. 2000 Jan; 278(1):R263-70.
    View in: PubMed
    Score: 0.025
  101. Donath MY, Dinarello CA, Mandrup-Poulsen T. Targeting innate immune mediators in type 1 and type 2 diabetes. Nat Rev Immunol. 2019 12; 19(12):734-746.
    View in: PubMed
    Score: 0.024
  102. Dinarello CA. Interleukin-18. Methods. 1999 Sep; 19(1):121-32.
    View in: PubMed
    Score: 0.024
  103. Hernandez G, Mills TS, Rabe JL, Chavez JS, Kuldanek S, Kirkpatrick G, Noetzli L, Jubair WK, Zanche M, Myers JR, Stevens BM, Fleenor CJ, Adane B, Dinarello CA, Ashton J, Jordan CT, Di Paola J, Hagman JR, Holers VM, Kuhn KA, Pietras EM. Pro-inflammatory cytokine blockade attenuates myeloid expansion in a murine model of rheumatoid arthritis. Haematologica. 2020 03; 105(3):585-597.
    View in: PubMed
    Score: 0.024
  104. Dinarello CA, Gatti S, Bartfai T. Fever: links with an ancient receptor. Curr Biol. 1999 Feb 25; 9(4):R147-50.
    View in: PubMed
    Score: 0.023
  105. Novick D, Kim SH, Fantuzzi G, Reznikov LL, Dinarello CA, Rubinstein M. Interleukin-18 binding protein: a novel modulator of the Th1 cytokine response. Immunity. 1999 Jan; 10(1):127-36.
    View in: PubMed
    Score: 0.023
  106. Rubinstein M, Dinarello CA, Oppenheim JJ, Hertzog P. Recent advances in cytokines, cytokine receptors and signal transduction. Cytokine Growth Factor Rev. 1998 Jun; 9(2):175-81.
    View in: PubMed
    Score: 0.022
  107. Kerstholt M, Vrijmoeth H, Lachmandas E, Oosting M, Lupse M, Flonta M, Dinarello CA, Netea MG, Joosten LAB. Role of glutathione metabolism in host defense against Borrelia burgdorferi infection. Proc Natl Acad Sci U S A. 2018 03 06; 115(10):E2320-E2328.
    View in: PubMed
    Score: 0.022
  108. Dinarello CA. Interleukin-1, interleukin-1 receptors and interleukin-1 receptor antagonist. Int Rev Immunol. 1998; 16(5-6):457-99.
    View in: PubMed
    Score: 0.022
  109. Jaber BL, Gonski JA, Cendoroglo M, Balakrishnan VS, Razeghi P, Dinarello CA, Pereira BJ. New polyether sulfone dialyzers attenuate passage of cytokine-inducing substances from pseudomonas aeruginosa contaminated dialysate. Blood Purif. 1998; 16(4):210-9.
    View in: PubMed
    Score: 0.022
  110. Hoeke G, Khedoe PPSJ, van Diepen JA, Pike-Overzet K, van de Ven B, Vazirpanah N, Mol I, Hiemstra PS, Staal FJT, Stienstra R, Netea MG, Dinarello CA, Rensen PCN, Berb?e JFP. The Effects of Selective Hematopoietic Expression of Human IL-37 on Systemic Inflammation and Atherosclerosis in LDLr-Deficient Mice. Int J Mol Sci. 2017 Aug 09; 18(8).
    View in: PubMed
    Score: 0.021
  111. Schauer AE, Klassert TE, von Lachner C, Riebold D, Schneewei? A, Stock M, M?ller MM, Hammerschmidt S, Bufler P, Seifert U, Dietert K, Dinarello CA, Nold MF, Gruber AD, Nold-Petry CA, Slevogt H. IL-37 Causes Excessive Inflammation and Tissue Damage in Murine Pneumococcal Pneumonia. J Innate Immun. 2017; 9(4):403-418.
    View in: PubMed
    Score: 0.021
  112. Dinarello CA, Bunn PA. Fever. Semin Oncol. 1997 Jun; 24(3):288-98.
    View in: PubMed
    Score: 0.021
  113. Le Tulzo Y, Shenkar R, Kaneko D, Moine P, Fantuzzi G, Dinarello CA, Abraham E. Hemorrhage increases cytokine expression in lung mononuclear cells in mice: involvement of catecholamines in nuclear factor-kappaB regulation and cytokine expression. J Clin Invest. 1997 Apr 01; 99(7):1516-24.
    View in: PubMed
    Score: 0.020
  114. Alheim K, Chai Z, Fantuzzi G, Hasanvan H, Malinowsky D, Di Santo E, Ghezzi P, Dinarello CA, Bartfai T. Hyperresponsive febrile reactions to interleukin (IL) 1alpha and IL-1beta, and altered brain cytokine mRNA and serum cytokine levels, in IL-1beta-deficient mice. Proc Natl Acad Sci U S A. 1997 Mar 18; 94(6):2681-6.
    View in: PubMed
    Score: 0.020
  115. Li J, Zhai Y, Ao L, Hui H, Fullerton DA, Dinarello CA, Meng X. Interleukin-37 suppresses the inflammatory response to protect cardiac function in old endotoxemic mice. Cytokine. 2017 07; 95:55-63.
    View in: PubMed
    Score: 0.020
  116. Fantuzzi G, Ku G, Harding MW, Livingston DJ, Sipe JD, Kuida K, Flavell RA, Dinarello CA. Response to local inflammation of IL-1 beta-converting enzyme- deficient mice. J Immunol. 1997 Feb 15; 158(4):1818-24.
    View in: PubMed
    Score: 0.020
  117. Bekkering S, van den Munckhof I, Nielen T, Lamfers E, Dinarello C, Rutten J, de Graaf J, Joosten LA, Netea MG, Gomes ME, Riksen NP. Innate immune cell activation and epigenetic remodeling in symptomatic and asymptomatic atherosclerosis in humans in?vivo. Atherosclerosis. 2016 11; 254:228-236.
    View in: PubMed
    Score: 0.020
  118. Fantuzzi G, Zheng H, Faggioni R, Benigni F, Ghezzi P, Sipe JD, Shaw AR, Dinarello CA. Effect of endotoxin in IL-1 beta-deficient mice. J Immunol. 1996 Jul 01; 157(1):291-6.
    View in: PubMed
    Score: 0.019
  119. Dinarello CA. Thermoregulation and the pathogenesis of fever. Infect Dis Clin North Am. 1996 Jun; 10(2):433-49.
    View in: PubMed
    Score: 0.019
  120. Thea DM, Porat R, Nagimbi K, Baangi M, St Louis ME, Kaplan G, Dinarello CA, Keusch GT. Plasma cytokines, cytokine antagonists, and disease progression in African women infected with HIV-1. Ann Intern Med. 1996 Apr 15; 124(8):757-62.
    View in: PubMed
    Score: 0.019
  121. Dinarello CA. Biologic basis for interleukin-1 in disease. Blood. 1996 Mar 15; 87(6):2095-147.
    View in: PubMed
    Score: 0.019
  122. Benigni F, Fantuzzi G, Sacco S, Sironi M, Pozzi P, Dinarello CA, Sipe JD, Poli V, Cappelletti M, Paonessa G, Pennica D, Panayotatos N, Ghezzi P. Six different cytokines that share GP130 as a receptor subunit, induce serum amyloid A and potentiate the induction of interleukin-6 and the activation of the hypothalamus-pituitary-adrenal axis by interleukin-1. Blood. 1996 Mar 01; 87(5):1851-4.
    View in: PubMed
    Score: 0.019
  123. Coll-Mir? M, Francos-Quijorna I, Santos-Nogueira E, Torres-Espin A, Bufler P, Dinarello CA, L?pez-Vales R. Beneficial effects of IL-37 after spinal cord injury in mice. Proc Natl Acad Sci U S A. 2016 Feb 02; 113(5):1411-6.
    View in: PubMed
    Score: 0.019
  124. Dinarello CA. Controlling the production of interleukin-1 and tumor necrosis factor in disease. Nutrition. 1995 Sep-Oct; 11(5 Suppl):695-7.
    View in: PubMed
    Score: 0.018
  125. Chernoff AE, Granowitz EV, Shapiro L, Vannier E, Lonnemann G, Angel JB, Kennedy JS, Rabson AR, Wolff SM, Dinarello CA. A randomized, controlled trial of IL-10 in humans. Inhibition of inflammatory cytokine production and immune responses. J Immunol. 1995 May 15; 154(10):5492-9.
    View in: PubMed
    Score: 0.018
  126. Tunjungputri RN, van der Ven AJ, Riksen N, Rongen G, Tacke S, van den Berg TN, Fijnheer R, Gomes ME, Dinarello CA, van de Veerdonk FL, Gasem MH, Netea MG, Joosten LA, de Groot PG, de Mast Q. Differential effects of platelets and platelet inhibition by ticagrelor on TLR2- and TLR4-mediated inflammatory responses. Thromb Haemost. 2015 May; 113(5):1035-45.
    View in: PubMed
    Score: 0.018
  127. Chomarat P, Vannier E, Dechanet J, Rissoan MC, Banchereau J, Dinarello CA, Miossec P. Balance of IL-1 receptor antagonist/IL-1 beta in rheumatoid synovium and its regulation by IL-4 and IL-10. J Immunol. 1995 Feb 01; 154(3):1432-9.
    View in: PubMed
    Score: 0.018
  128. Choi SW, Gatza E, Hou G, Sun Y, Whitfield J, Song Y, Oravecz-Wilson K, Tawara I, Dinarello CA, Reddy P. Histone deacetylase inhibition regulates inflammation and enhances Tregs after allogeneic hematopoietic cell transplantation in humans. Blood. 2015 Jan 29; 125(5):815-9.
    View in: PubMed
    Score: 0.017
  129. Luo Y, Cai X, Liu S, Wang S, Nold-Petry CA, Nold MF, Bufler P, Norris D, Dinarello CA, Fujita M. Suppression of antigen-specific adaptive immunity by IL-37 via induction of tolerogenic dendritic cells. Proc Natl Acad Sci U S A. 2014 Oct 21; 111(42):15178-83.
    View in: PubMed
    Score: 0.017
  130. Tilg H, Shapiro L, Vannier E, Poutsiaka DD, Trehu E, Atkins MB, Dinarello CA, Mier JW. Induction of circulating antagonists to IL-1 and TNF by IL-2 administration and their effects on IL-2 induced cytokine production in vitro. J Immunol. 1994 Mar 15; 152(6):3189-98.
    View in: PubMed
    Score: 0.017
  131. Gresnigt MS, Bozza S, Becker KL, Joosten LA, Abdollahi-Roodsaz S, van der Berg WB, Dinarello CA, Netea MG, Fontaine T, De Luca A, Moretti S, Romani L, Latge JP, van de Veerdonk FL. A polysaccharide virulence factor from Aspergillus fumigatus elicits anti-inflammatory effects through induction of Interleukin-1 receptor antagonist. PLoS Pathog. 2014 Mar; 10(3):e1003936.
    View in: PubMed
    Score: 0.017
  132. Schir? R, Longoni D, Rossi V, Maglia O, Doni A, Arsura M, Carrara G, Masera G, Vannier E, Dinarello CA, et al. Suppression of juvenile chronic myelogenous leukemia colony growth by interleukin-1 receptor antagonist. Blood. 1994 Jan 15; 83(2):460-5.
    View in: PubMed
    Score: 0.016
  133. Christensen DP, Gysemans C, Lundh M, Dahll?f MS, Noesgaard D, Schmidt SF, Mandrup S, Birkbak N, Workman CT, Piemonti L, Blaabjerg L, Monzani V, Fossati G, Mascagni P, Paraskevas S, Aikin RA, Billestrup N, Grunnet LG, Dinarello CA, Mathieu C, Mandrup-Poulsen T. Lysine deacetylase inhibition prevents diabetes by chromatin-independent immunoregulation and ?-cell protection. Proc Natl Acad Sci U S A. 2014 Jan 21; 111(3):1055-9.
    View in: PubMed
    Score: 0.016
  134. Erroi A, Fantuzzi G, Mengozzi M, Sironi M, Orencole SF, Clark BD, Dinarello CA, Isetta A, Gnocchi P, Giovarelli M, et al. Differential regulation of cytokine production in lipopolysaccharide tolerance in mice. Infect Immun. 1993 Oct; 61(10):4356-9.
    View in: PubMed
    Score: 0.016
  135. Hara N, Alkanani AK, Dinarello CA, Zipris D. Histone deacetylase inhibitor suppresses virus-induced proinflammatory responses and type 1 diabetes. J Mol Med (Berl). 2014 Jan; 92(1):93-102.
    View in: PubMed
    Score: 0.016
  136. Jonigk D, Al-Omari M, Maegel L, M?ller M, Izykowski N, Hong J, Hong K, Kim SH, Dorsch M, Mahadeva R, Laenger F, Kreipe H, Braun A, Shahaf G, Lewis EC, Welte T, Dinarello CA, Janciauskiene S. Anti-inflammatory and immunomodulatory properties of a1-antitrypsin without inhibition of elastase. Proc Natl Acad Sci U S A. 2013 Sep 10; 110(37):15007-12.
    View in: PubMed
    Score: 0.016
  137. Collins CB, Aherne CM, Ehrentraut SF, Gerich ME, McNamee EN, McManus MC, Lebsack MD, Jedlicka P, Azam T, de Zoeten EF, Dinarello CA, Rivera-Nieves J. Alpha-1-antitrypsin therapy ameliorates acute colitis and chronic murine ileitis. Inflamm Bowel Dis. 2013 Aug; 19(9):1964-73.
    View in: PubMed
    Score: 0.016
  138. Meydani SN, Lichtenstein AH, Cornwall S, Meydani M, Goldin BR, Rasmussen H, Dinarello CA, Schaefer EJ. Immunologic effects of national cholesterol education panel step-2 diets with and without fish-derived N-3 fatty acid enrichment. J Clin Invest. 1993 Jul; 92(1):105-13.
    View in: PubMed
    Score: 0.016
  139. Lee S, Lee Y, Hong K, Hong J, Bae S, Choi J, Jhun H, Kwak A, Kim E, Jo S, Dinarello CA, Kim S. Effect of recombinant a1-antitrypsin Fc-fused (AAT-Fc)protein on the inhibition of inflammatory cytokine production and streptozotocin-induced diabetes. Mol Med. 2013 May 20; 19:65-71.
    View in: PubMed
    Score: 0.016
  140. Carmi Y, Dotan S, Rider P, Kaplanov I, White MR, Baron R, Abutbul S, Huszar M, Dinarello CA, Apte RN, Voronov E. The role of IL-1? in the early tumor cell-induced angiogenic response. J Immunol. 2013 Apr 01; 190(7):3500-9.
    View in: PubMed
    Score: 0.015
  141. Santos AA, Scheltinga MR, Lynch E, Brown EF, Lawton P, Chambers E, Browning J, Dinarello CA, Wolff SM, Wilmore DW. Elaboration of interleukin 1-receptor antagonist is not attenuated by glucocorticoids after endotoxemia. Arch Surg. 1993 Feb; 128(2):138-43; discussion 143-4.
    View in: PubMed
    Score: 0.015
  142. Granowitz EV, Porat R, Mier JW, Pribble JP, Stiles DM, Bloedow DC, Catalano MA, Wolff SM, Dinarello CA. Pharmacokinetics, safety and immunomodulatory effects of human recombinant interleukin-1 receptor antagonist in healthy humans. Cytokine. 1992 Sep; 4(5):353-60.
    View in: PubMed
    Score: 0.015
  143. Lundh M, Christensen DP, Damgaard Nielsen M, Richardson SJ, Dahll?f MS, Skovgaard T, Berthelsen J, Dinarello CA, Stevenazzi A, Mascagni P, Grunnet LG, Morgan NG, Mandrup-Poulsen T. Histone deacetylases 1 and 3 but not 2 mediate cytokine-induced beta cell apoptosis in INS-1 cells and dispersed primary islets from rats and are differentially regulated in the islets of type 1 diabetic children. Diabetologia. 2012 Sep; 55(9):2421-31.
    View in: PubMed
    Score: 0.015
  144. Cavelti-Weder C, Babians-Brunner A, Keller C, Stahel MA, Kurz-Levin M, Zayed H, Solinger AM, Mandrup-Poulsen T, Dinarello CA, Donath MY. Effects of gevokizumab on glycemia and inflammatory markers in type 2 diabetes. Diabetes Care. 2012 Aug; 35(8):1654-62.
    View in: PubMed
    Score: 0.015
  145. Dinarello CA. Interleukin-1 and tumor necrosis factor: effector cytokines in autoimmune diseases. Semin Immunol. 1992 Jun; 4(3):133-45.
    View in: PubMed
    Score: 0.015
  146. Van Tassell BW, Arena RA, Toldo S, Mezzaroma E, Azam T, Seropian IM, Shah K, Canada J, Voelkel NF, Dinarello CA, Abbate A. Enhanced interleukin-1 activity contributes to exercise intolerance in patients with systolic heart failure. PLoS One. 2012; 7(3):e33438.
    View in: PubMed
    Score: 0.014
  147. Wang J, Nikrad MP, Travanty EA, Zhou B, Phang T, Gao B, Alford T, Ito Y, Nahreini P, Hartshorn K, Wentworth D, Dinarello CA, Mason RJ. Innate immune response of human alveolar macrophages during influenza A infection. PLoS One. 2012; 7(3):e29879.
    View in: PubMed
    Score: 0.014
  148. Avraham H, Vannier E, Chi SY, Dinarello CA, Groopman JE. Cytokine gene expression and synthesis by human megakaryocytic cells. Int J Cell Cloning. 1992 Mar; 10(2):70-9.
    View in: PubMed
    Score: 0.014
  149. Tawara I, Sun Y, Lewis EC, Toubai T, Evers R, Nieves E, Azam T, Dinarello CA, Reddy P. Alpha-1-antitrypsin monotherapy reduces graft-versus-host disease after experimental allogeneic bone marrow transplantation. Proc Natl Acad Sci U S A. 2012 Jan 10; 109(2):564-9.
    View in: PubMed
    Score: 0.014
  150. Rambaldi A, Torcia M, Bettoni S, Vannier E, Barbui T, Shaw AR, Dinarello CA, Cozzolino F. Modulation of cell proliferation and cytokine production in acute myeloblastic leukemia by interleukin-1 receptor antagonist and lack of its expression by leukemic cells. Blood. 1991 Dec 15; 78(12):3248-53.
    View in: PubMed
    Score: 0.014
  151. Toldo S, Seropian IM, Mezzaroma E, Van Tassell BW, Salloum FN, Lewis EC, Voelkel N, Dinarello CA, Abbate A. Alpha-1 antitrypsin inhibits caspase-1 and protects from acute myocardial ischemia-reperfusion injury. J Mol Cell Cardiol. 2011 Aug; 51(2):244-51.
    View in: PubMed
    Score: 0.014
  152. Meydani SN, Endres S, Woods MM, Goldin BR, Soo C, Morrill-Labrode A, Dinarello CA, Gorbach SL. Oral (n-3) fatty acid supplementation suppresses cytokine production and lymphocyte proliferation: comparison between young and older women. J Nutr. 1991 Apr; 121(4):547-55.
    View in: PubMed
    Score: 0.014
  153. Meydani SN, Endres S, Woods MM, Goldin BR, Soo C, Morrill-Labrode A, Dinarello CA, Gorbach SL. Effect of oral n-3 fatty acid supplementation on the immune response of young and older women. Adv Prostaglandin Thromboxane Leukot Res. 1991; 21A:245-8.
    View in: PubMed
    Score: 0.013
  154. Choi J, Bae S, Hong J, Ryoo S, Jhun H, Hong K, Yoon D, Lee S, Her E, Choi W, Kim J, Azam T, Dinarello CA, Kim S. Paradoxical effects of constitutive human IL-32{gamma} in transgenic mice during experimental colitis. Proc Natl Acad Sci U S A. 2010 Dec 07; 107(49):21082-6.
    View in: PubMed
    Score: 0.013
  155. Heinhuis B, Koenders MI, van de Loo FA, van Lent PL, Kim SH, Dinarello CA, Joosten LA, van den Berg WB. IL-32gamma and Streptococcus pyogenes cell wall fragments synergise for IL-1-dependent destructive arthritis via upregulation of TLR-2 and NOD2. Ann Rheum Dis. 2010 Oct; 69(10):1866-72.
    View in: PubMed
    Score: 0.013
  156. Schindler R, Dinarello CA. Ultrafiltration to remove endotoxins and other cytokine-inducing materials from tissue culture media and parenteral fluids. Biotechniques. 1990 Apr; 8(4):408-13.
    View in: PubMed
    Score: 0.013
  157. Bai X, Kim SH, Azam T, McGibney MT, Huang H, Dinarello CA, Chan ED. IL-32 is a host protective cytokine against Mycobacterium tuberculosis in differentiated THP-1 human macrophages. J Immunol. 2010 Apr 01; 184(7):3830-40.
    View in: PubMed
    Score: 0.013
  158. van de Veerdonk FL, Smeekens SP, Joosten LA, Kullberg BJ, Dinarello CA, van der Meer JW, Netea MG. Reactive oxygen species-independent activation of the IL-1beta inflammasome in cells from patients with chronic granulomatous disease. Proc Natl Acad Sci U S A. 2010 Feb 16; 107(7):3030-3.
    View in: PubMed
    Score: 0.012
  159. Endres S, Cannon JG, Ghorbani R, Dempsey RA, Sisson SD, Lonnemann G, Van der Meer JW, Wolff SM, Dinarello CA. In vitro production of IL 1 beta, IL 1 alpha, TNF and IL2 in healthy subjects: distribution, effect of cyclooxygenase inhibition and evidence of independent gene regulation. Eur J Immunol. 1989 Dec; 19(12):2327-33.
    View in: PubMed
    Score: 0.012
  160. Endres S, van der Meer JW, Dinarello CA. [Cytokines in the pathogenesis of fever]. Internist (Berl). 1989 Jun; 30(6):358-61.
    View in: PubMed
    Score: 0.012
  161. Dinarello CA. Interleukin-1 and its biologically related cytokines. Adv Immunol. 1989; 44:153-205.
    View in: PubMed
    Score: 0.012
  162. Dinarello CA. Interleukin-1 and the effects of cyclooxygenase inhibitors on its biological activities. Bull N Y Acad Med. 1989 Jan; 65(1):80-92.
    View in: PubMed
    Score: 0.012
  163. Dinarello CA, Savage N. Interleukin-1 and its receptor. Crit Rev Immunol. 1989; 9(1):1-20.
    View in: PubMed
    Score: 0.012
  164. Bosisio D, Vulcano M, Del Prete A, Sironi M, Salvi V, Salogni L, Riboldi E, Leoni F, Dinarello CA, Girolomoni G, Sozzani S. Blocking TH17-polarizing cytokines by histone deacetylase inhibitors in vitro and in vivo. J Leukoc Biol. 2008 Dec; 84(6):1540-8.
    View in: PubMed
    Score: 0.011
  165. Choi JD, Bae SY, Hong JW, Azam T, Dinarello CA, Her E, Choi WS, Kim BK, Lee CK, Yoon DY, Kim SJ, Kim SH. Identification of the most active interleukin-32 isoform. Immunology. 2009 Apr; 126(4):535-42.
    View in: PubMed
    Score: 0.011
  166. He Z, Lu L, Altmann C, Hoke TS, Ljubanovic D, Jani A, Dinarello CA, Faubel S, Edelstein CL. Interleukin-18 binding protein transgenic mice are protected against ischemic acute kidney injury. Am J Physiol Renal Physiol. 2008 Nov; 295(5):F1414-21.
    View in: PubMed
    Score: 0.011
  167. Reddy P, Sun Y, Toubai T, Duran-Struuck R, Clouthier SG, Weisiger E, Maeda Y, Tawara I, Krijanovski O, Gatza E, Liu C, Malter C, Mascagni P, Dinarello CA, Ferrara JL. Histone deacetylase inhibition modulates indoleamine 2,3-dioxygenase-dependent DC functions and regulates experimental graft-versus-host disease in mice. J Clin Invest. 2008 Jul; 118(7):2562-73.
    View in: PubMed
    Score: 0.011
  168. Tagaya Y, Okada M, Sugie K, Kasahara T, Kondo N, Hamuro J, Matsushima K, Dinarello CA, Yodoi J. IL-2 receptor(p55)/Tac-inducing factor. Purification and characterization of adult T cell leukemia-derived factor. J Immunol. 1988 Apr 15; 140(8):2614-20.
    View in: PubMed
    Score: 0.011
  169. Netea MG, Lewis EC, Azam T, Joosten LA, Jaekal J, Bae SY, Dinarello CA, Kim SH. Interleukin-32 induces the differentiation of monocytes into macrophage-like cells. Proc Natl Acad Sci U S A. 2008 Mar 04; 105(9):3515-20.
    View in: PubMed
    Score: 0.011
  170. Glauben R, Batra A, Stroh T, Erben U, Fedke I, Lehr HA, Leoni F, Mascagni P, Dinarello CA, Zeitz M, Siegmund B. Histone deacetylases: novel targets for prevention of colitis-associated cancer in mice. Gut. 2008 May; 57(5):613-22.
    View in: PubMed
    Score: 0.011
  171. Dinarello CA. Interleukin-1--its multiple biological effects and its association with hemodialysis. Blood Purif. 1988; 6(3):164-72.
    View in: PubMed
    Score: 0.011
  172. Pott GB, Sailer CA, Porat R, Peskind RL, Fuchs AC, Angel JB, Skolnik PR, Jacobson MA, Giordano MF, Lebeaut A, Grint PC, Dinarello CA, Shapiro L. Effect of a four-week course of interleukin-10 on cytokine production in a placebo-controlled study of HIV-1-infected subjects. Eur Cytokine Netw. 2007 Jun; 18(2):49-58.
    View in: PubMed
    Score: 0.010
  173. Dinarello CA, Dempsey RA, Allegretta M, LoPreste G, Dainiak N, Parkinson DR, Mier JW. Inhibitory effects of elevated temperature on human cytokine production and natural killer activity. Cancer Res. 1986 Dec; 46(12 Pt 1):6236-41.
    View in: PubMed
    Score: 0.010
  174. Glauben R, Batra A, Fedke I, Zeitz M, Lehr HA, Leoni F, Mascagni P, Fantuzzi G, Dinarello CA, Siegmund B. Histone hyperacetylation is associated with amelioration of experimental colitis in mice. J Immunol. 2006 Apr 15; 176(8):5015-22.
    View in: PubMed
    Score: 0.010
  175. Mazodier K, Marin V, Novick D, Farnarier C, Robitail S, Schleinitz N, Veit V, Paul P, Rubinstein M, Dinarello CA, Harl? JR, Kaplanski G. Severe imbalance of IL-18/IL-18BP in patients with secondary hemophagocytic syndrome. Blood. 2005 Nov 15; 106(10):3483-9.
    View in: PubMed
    Score: 0.009
  176. Sennello JA, Fayad R, Morris AM, Eckel RH, Asilmaz E, Montez J, Friedman JM, Dinarello CA, Fantuzzi G. Regulation of T cell-mediated hepatic inflammation by adiponectin and leptin. Endocrinology. 2005 May; 146(5):2157-64.
    View in: PubMed
    Score: 0.009
  177. Reddy P, Maeda Y, Hotary K, Liu C, Reznikov LL, Dinarello CA, Ferrara JL. Histone deacetylase inhibitor suberoylanilide hydroxamic acid reduces acute graft-versus-host disease and preserves graft-versus-leukemia effect. Proc Natl Acad Sci U S A. 2004 Mar 16; 101(11):3921-6.
    View in: PubMed
    Score: 0.008
  178. Park JW, Taube C, Swasey C, Kodama T, Joetham A, Balhorn A, Takeda K, Miyahara N, Allen CB, Dakhama A, Kim SH, Dinarello CA, Gelfand EW. Interleukin-1 receptor antagonist attenuates airway hyperresponsiveness following exposure to ozone. Am J Respir Cell Mol Biol. 2004 Jun; 30(6):830-6.
    View in: PubMed
    Score: 0.008
  179. Wieland CW, Siegmund B, Senaldi G, Vasil ML, Dinarello CA, Fantuzzi G. Pulmonary inflammation induced by Pseudomonas aeruginosa lipopolysaccharide, phospholipase C, and exotoxin A: role of interferon regulatory factor 1. Infect Immun. 2002 Mar; 70(3):1352-8.
    View in: PubMed
    Score: 0.007
  180. Joosten LA, van De Loo FA, Lubberts E, Helsen MM, Netea MG, van Der Meer JW, Dinarello CA, van Den Berg WB. An IFN-gamma-independent proinflammatory role of IL-18 in murine streptococcal cell wall arthritis. J Immunol. 2000 Dec 01; 165(11):6553-8.
    View in: PubMed
    Score: 0.007
  181. Faggioni R, Fantuzzi G, Gabay C, Moser A, Dinarello CA, Feingold KR, Grunfeld C. Leptin deficiency enhances sensitivity to endotoxin-induced lethality. Am J Physiol. 1999 01; 276(1):R136-42.
    View in: PubMed
    Score: 0.006
  182. Pfeffer LM, Dinarello CA, Herberman RB, Williams BR, Borden EC, Bordens R, Walter MR, Nagabhushan TL, Trotta PP, Pestka S. Biological properties of recombinant alpha-interferons: 40th anniversary of the discovery of interferons. Cancer Res. 1998 Jun 15; 58(12):2489-99.
    View in: PubMed
    Score: 0.006
  183. Tilg H, Dinarello CA, Mier JW. IL-6 and APPs: anti-inflammatory and immunosuppressive mediators. Immunol Today. 1997 Sep; 18(9):428-32.
    View in: PubMed
    Score: 0.005
  184. Roubenoff R, Freeman LM, Smith DE, Abad LW, Dinarello CA, Kehayias JJ. Adjuvant arthritis as a model of inflammatory cachexia. Arthritis Rheum. 1997 Mar; 40(3):534-9.
    View in: PubMed
    Score: 0.005
  185. Rall LC, Roubenoff R, Cannon JG, Abad LW, Dinarello CA, Meydani SN. Effects of progressive resistance training on immune response in aging and chronic inflammation. Med Sci Sports Exerc. 1996 Nov; 28(11):1356-65.
    View in: PubMed
    Score: 0.005
  186. Granowitz EV, Saget BM, Angel JB, Wang MZ, Wang A, Dinarello CA, Skolnik PR. Soluble tumor necrosis factor receptors inhibit phorbol myristate acetate and cytokine-induced HIV-1 expression chronically infected U1 cells. J Acquir Immune Defic Syndr Hum Retrovirol. 1996 Apr 15; 11(5):430-7.
    View in: PubMed
    Score: 0.005
  187. Rambaldi A, Torcia M, Dinarello CA, Barbui T, Cozzolino F. Modulation of cell proliferation and cytokine production in AML by recombinant interleukin-1 receptor antagonist. Leukemia. 1993 Aug; 7 Suppl 2:S10-2.
    View in: PubMed
    Score: 0.004
  188. Re F, Mengozzi M, Muzio M, Dinarello CA, Mantovani A, Colotta F. Expression of interleukin-1 receptor antagonist (IL-1ra) by human circulating polymorphonuclear cells. Eur J Immunol. 1993 Feb; 23(2):570-3.
    View in: PubMed
    Score: 0.004
  189. Molina JM, Schindler R, Ferriani R, Sakaguchi M, Vannier E, Dinarello CA, Groopman JE. Production of cytokines by peripheral blood monocytes/macrophages infected with human immunodeficiency virus type 1 (HIV-1). J Infect Dis. 1990 May; 161(5):888-93.
    View in: PubMed
    Score: 0.003
  190. Feingold KR, Soued M, Serio MK, Moser AH, Dinarello CA, Grunfeld C. Multiple cytokines stimulate hepatic lipid synthesis in vivo. Endocrinology. 1989 Jul; 125(1):267-74.
    View in: PubMed
    Score: 0.003
  191. White CW, Ghezzi P, McMahon S, Dinarello CA, Repine JE. Cytokines increase rat lung antioxidant enzymes during exposure to hyperoxia. J Appl Physiol (1985). 1989 Feb; 66(2):1003-7.
    View in: PubMed
    Score: 0.003
  192. Ranges GE, Zlotnik A, Espevik T, Dinarello CA, Cerami A, Palladino MA. Tumor necrosis factor alpha/cachectin is a growth factor for thymocytes. Synergistic interactions with other cytokines. J Exp Med. 1988 Apr 01; 167(4):1472-8.
    View in: PubMed
    Score: 0.003
  193. Folks TM, Justement J, Kinter A, Dinarello CA, Fauci AS. Cytokine-induced expression of HIV-1 in a chronically infected promonocyte cell line. Science. 1987 Nov 06; 238(4828):800-2.
    View in: PubMed
    Score: 0.003
  194. Van Damme J, De Ley M, Van Snick J, Dinarello CA, Billiau A. The role of interferon-beta 1 and the 26-kDa protein (interferon-beta 2) as mediators of the antiviral effect of interleukin 1 and tumor necrosis factor. J Immunol. 1987 Sep 15; 139(6):1867-72.
    View in: PubMed
    Score: 0.003
  195. Sauder DN, Mounessa NL, Katz SI, Dinarello CA, Gallin JI. Chemotactic cytokines: the role of leukocytic pyrogen and epidermal cell thymocyte-activating factor in neutrophil chemotaxis. J Immunol. 1984 Feb; 132(2):828-32.
    View in: PubMed
    Score: 0.002
Connection Strength

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