 Methotrexate
"Methotrexate" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An antineoplastic antimetabolite with immunosuppressant properties. It is an inhibitor of TETRAHYDROFOLATE DEHYDROGENASE and prevents the formation of tetrahydrofolate, necessary for synthesis of thymidylate, an essential component of DNA.
| Descriptor ID |
D008727
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| MeSH Number(s) |
D03.633.100.733.631.192.500
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| Concept/Terms |
Methotrexate Sodium- Methotrexate Sodium
- Sodium, Methotrexate
- Methotrexate, Sodium Salt
- Methotrexate, Disodium Salt
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Below are MeSH descriptors whose meaning is more general than "Methotrexate".
Below are MeSH descriptors whose meaning is more specific than "Methotrexate".
This graph shows the total number of publications written about "Methotrexate" by people in this website by year, and whether "Methotrexate" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1995 | 5 | 1 | 6 | | 1996 | 2 | 3 | 5 | | 1997 | 2 | 1 | 3 | | 1998 | 2 | 3 | 5 | | 1999 | 4 | 0 | 4 | | 2000 | 2 | 4 | 6 | | 2001 | 1 | 2 | 3 | | 2002 | 3 | 3 | 6 | | 2003 | 3 | 1 | 4 | | 2004 | 4 | 4 | 8 | | 2005 | 1 | 2 | 3 | | 2006 | 3 | 7 | 10 | | 2008 | 1 | 2 | 3 | | 2009 | 2 | 3 | 5 | | 2010 | 3 | 3 | 6 | | 2011 | 1 | 0 | 1 | | 2012 | 1 | 4 | 5 | | 2013 | 7 | 1 | 8 | | 2014 | 3 | 2 | 5 | | 2015 | 0 | 4 | 4 | | 2016 | 5 | 6 | 11 | | 2017 | 6 | 2 | 8 | | 2018 | 2 | 3 | 5 | | 2019 | 4 | 1 | 5 | | 2020 | 1 | 1 | 2 | | 2021 | 3 | 5 | 8 | | 2022 | 2 | 3 | 5 | | 2023 | 1 | 4 | 5 | | 2024 | 5 | 5 | 10 | | 2025 | 1 | 3 | 4 |
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Below are the most recent publications written about "Methotrexate" by people in Profiles.
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Miyamae T, Okamoto N, Inoue Y, Kubota T, Ebato T, Irabu H, Kameda H, Kaneko Y, Kubo H, Mitsunaga K, Mori M, Nakajima A, Nishimura K, Ohkubo N, Sato T, Sugita Y, Takanashi S, Tanaka T, Umebayashi H, Yashiro M, Yamanishi S, Fusama M, Hirata S, Kishimoto M, Kohno M, Kojima M, Kojima T, Morinobu A, Sugihara T, Tanaka E, Yajima N, Yanai R, Kawahito Y, Harigai M. Recommendations for the treatment of juvenile idiopathic arthritis with oligoarthritis or polyarthritis from the 2024 update of the Japan College of Rheumatology Clinical Practice Guidelines for the management of rheumatoid arthritis including juvenile idiopathic arthritis with oligoarthritis or polyarthritis - secondary publication. Mod Rheumatol. 2025 Sep 02; 35(5):894-908.
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Lee JG, Petraccione J, Trese KA, Hughes AC, Ausec TR, Salzmann-Sullivan M, Su LJ, Kim MT, Roh S, Goodwin AP, Feng FX, Flaig TW, Shields CW. Soft Extrudable Dendritic Particles with Nanostructured Tendrils for Local Adhesion and Drug Release to Bladder Cancers. Adv Mater. 2025 Sep; 37(38):e2505231.
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Gupta S, Kaunfer SA, Chen KL, Dias JA, Vijayan A, Rajasekaran A, Prosek JM, Truong HL, Wood A, Bassil C, Renaghan AD, Shah CV, Zhang J, Glezerman I, Carlos C, Kelly K, Passero CJ, Drappatz J, Abudayyeh A, Shin DS, Sperati CJ, Yelvington BJ, Kanduri SR, Neyra JA, Edmonston D, Shirali AC, Bansal A, Geara A, Mithani Z, Ziolkowski SL, Rashidi A, Jakubowski J, Pujari A, Bond DA, Dotson E, Wall S, Patton J, Barreto JN, Herrmann SM, Sheikh MS, Baz R, Lee J, Lucchesi N, Kolman M, Rasheed MA, Afzal A, Kang D, Mahesh A, Hsu RK, Nicolaysen A, Tefera K, Schretlen C, Miller RM, Velez JC, Flannery AH, Aklilu AM, Anand S, Chandrasekhara S, Donley V, Patel A, Ni J, Krishnamurthy S, Ali R, Yilmam OA, Wells SL, Ortega JL, Green-Lingren OL, Leaf RK, Sise ME, Nayak L, LaCasce AS, Leung N, Leaf DE. Glucarpidase for treatment of high-dose methotrexate toxicity. Blood. 2025 Apr 24; 145(17):1858-1869.
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Deane KD, Holers VM, Emery P, Mankia K, El-Gabalawy H, Sparks JA, Costenbader KH, Schett G, van der Helm-van Mil A, van Schaardenburg D, Thomas R, Cope AP. Therapeutic interception in individuals at risk of rheumatoid arthritis to prevent clinically impactful disease. Ann Rheum Dis. 2025 Jan; 84(1):14-28.
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Sundararajan M, Rathinam SR, Thundikandy R, Kanakath A, Balamurugan S, Vedhanayaki R, Miller DC, Lim LL, Suhler EB, Al-Dhibi HA, Arellanes-Garcia L, Reddy AK, Feng S, Doan T, Porco TC, Shantha JG, Acharya NR, Gonzales JA. Association Between Baseline Macular Morphologic Features on Optical Coherence Tomography and Visual Outcomes in Patients with Vogt-Koyanagi-Harada Disease. Ocul Immunol Inflamm. 2025 Feb; 33(2):263-270.
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Mandel M, Elhusseiny AM, Davidson SL, Rockter A, Levin AV, Huang LC, Cheung CSY, Stahl ED, Cooper AM, Jin J, Inger HE, Jordan CO, Jung JL, Utz VM, Angeles-Han ST, Oke I, Nihalani BR. Clinical outcomes in paediatric tubulointerstitial nephritis and uveitis syndrome (TINU). Eye (Lond). 2024 Dec; 38(17):3318-3324.
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Chavana AN, Taylor ZL, DeGroote N, Lindsay HB, Sauer HE, Mason EJ, Schafer ES, Miller TP, Castellino SM, Pommert L, O'Brien MM, Ramsey LB, Bernhardt MB, Brown AL. Toxicity profile of high-dose methotrexate in young children with central nervous system tumors. Pediatr Blood Cancer. 2024 Oct; 71(10):e31213.
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Fang N, Wong JMK, Reid JA. Letter to the editor for "Hysteroscopic subchorionic injection of methotrexate followed by laparoscopic excision of the gestational sac for the management of cesarean scar ectopic pregnancy: an innovative dual approach of a challenging pathology". Fertil Steril. 2024 Sep; 122(3):552.
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Eule CJ, Warren A, Molina Kuna E, Callihan EB, Kim SP, Flaig TW. Neoadjuvant Cisplatin-based Chemotherapy in Nonmetastatic Muscle-invasive Bladder Cancer: A Systematic Review and Pooled Meta-analysis to Determine the Preferred Regimen. Urology. 2024 06; 188:118-124.
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Walter JR, Barnhart KT, Koelper NC, Santoro NF, Zhang H, Thomas TR, Huang H, Harvie HS. Cost-effectiveness analysis of expectant vs active management for treatment of persistent pregnancies of unknown location. Am J Obstet Gynecol. 2024 Sep; 231(3):328.e1-328.e11.
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