 Cyclooxygenase 1
"Cyclooxygenase 1" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A constitutively-expressed subtype of prostaglandin-endoperoxide synthase. It plays an important role in many cellular processes.
| Descriptor ID |
D051545
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| MeSH Number(s) |
D08.811.600.720.500
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| Concept/Terms |
Cyclooxygenase 1- Cyclooxygenase 1
- Cyclo-Oxygenase I
- Cyclo Oxygenase I
- Prostaglandin H Synthase-1
- Prostaglandin H Synthase 1
- COX-1 Prostaglandin Synthase
- COX 1 Prostaglandin Synthase
- Prostaglandin Synthase, COX-1
- Synthase, COX-1 Prostaglandin
- Cyclooxygenase-1
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Below are MeSH descriptors whose meaning is more general than "Cyclooxygenase 1".
Below are MeSH descriptors whose meaning is more specific than "Cyclooxygenase 1".
This graph shows the total number of publications written about "Cyclooxygenase 1" by people in this website by year, and whether "Cyclooxygenase 1" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1997 | 0 | 1 | 1 | | 2001 | 0 | 3 | 3 | | 2003 | 0 | 1 | 1 | | 2004 | 0 | 2 | 2 | | 2006 | 2 | 1 | 3 | | 2007 | 0 | 2 | 2 | | 2008 | 0 | 2 | 2 | | 2009 | 0 | 1 | 1 | | 2014 | 1 | 0 | 1 | | 2015 | 0 | 1 | 1 | | 2019 | 0 | 1 | 1 | | 2021 | 0 | 1 | 1 | | 2025 | 1 | 0 | 1 |
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Below are the most recent publications written about "Cyclooxygenase 1" by people in Profiles.
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Mills WA, Savory NA, Lopez-Ortiz AO, Lentferink DH, González Ibáñez F, Agochi P, Rastegar E, Gupta A, Gupta D, Suram A, Isakson BE, Tremblay MÈ, Eyo UB. Microglial cyclooxygenase-1 modulates cerebral capillary basal tone in vivo in mice. Nat Commun. 2025 Jul 01; 16(1):5704.
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Marentette JO, Anderson CC, Prutton KM, Jennings EQ, Rauniyar AK, Galligan JJ, Roede JR. Trisomy 21 impairs PGE2 production in dermal fibroblasts. Prostaglandins Other Lipid Mediat. 2021 Apr; 153:106524.
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Nakade UP, Sharma A, Kumari P, Bhatiya S, Nair SV, Karikaran KN, Sharma V, Choudhury S, Garg SK. Functional and molecular characterization of endothelium-dependent and endothelium-independent relaxant pathways in uterine artery of non-pregnant buffaloes. Naunyn Schmiedebergs Arch Pharmacol. 2020 02; 393(2):225-241.
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Aldrovandi M, Hinz C, Lauder SN, Podmore H, Hornshaw M, Slatter DA, Tyrrell VJ, Clark SR, Marnett LJ, Collins PW, Murphy RC, O'Donnell VB. DioxolaneA3-phosphatidylethanolamines are generated by human platelets and stimulate neutrophil integrin expression. Redox Biol. 2017 04; 11:663-672.
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Hinz C, Aldrovandi M, Uhlson C, Marnett LJ, Longhurst HJ, Warner TD, Alam S, Slatter DA, Lauder SN, Allen-Redpath K, Collins PW, Murphy RC, Thomas CP, O'Donnell VB. Human Platelets Utilize Cycloxygenase-1 to Generate Dioxolane A3, a Neutrophil-activating Eicosanoid. J Biol Chem. 2016 Jun 24; 291(26):13448-64.
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Yun B, Lee H, Jayaraja S, Suram S, Murphy RC, Leslie CC. Prostaglandins from Cytosolic Phospholipase A2a/Cyclooxygenase-1 Pathway and Mitogen-activated Protein Kinases Regulate Gene Expression in Candida albicans-infected Macrophages. J Biol Chem. 2016 Mar 25; 291(13):7070-86.
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Turan GA, Eskicioglu F, Sivrikoz ON, Cengiz H, Adakan S, Gur EB, Tatar S, Sahin N, Yilmaz O. Myo-inositol is a promising treatment for the prevention of ovarian hyperstimulation syndrome (OHSS): an animal study. Arch Gynecol Obstet. 2015 Nov; 292(5):1163-71.
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Qayyum R, Becker DM, Yanek LR, Faraday N, Vaidya D, Mathias R, Kral BG, Becker LC. Greater collagen-induced platelet aggregation following cyclooxygenase 1 inhibition predicts incident acute coronary syndromes. Clin Transl Sci. 2015 Feb; 8(1):17-22.
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Aldrovandi M, Hammond VJ, Podmore H, Hornshaw M, Clark SR, Marnett LJ, Slatter DA, Murphy RC, Collins PW, O'Donnell VB. Human platelets generate phospholipid-esterified prostaglandins via cyclooxygenase-1 that are inhibited by low dose aspirin supplementation. J Lipid Res. 2013 Nov; 54(11):3085-97.
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Avagliano L, Falleni M, Marconi AM, Bulfoni C, Prada A, Barbera AF, Doi P, Bulfamante GP. An imbalance of COX level is not related to placental abruption. J Clin Pathol. 2011 Jul; 64(7):605-9.
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