 Tolbutamide
"Tolbutamide" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A sulphonylurea hypoglycemic agent with actions and uses similar to those of CHLORPROPAMIDE. (From Martindale, The Extra Pharmacopoeia, 30th ed, p290)
| Descriptor ID |
D014044
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| MeSH Number(s) |
D02.886.590.795.896 D02.948.828.896
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Tolbutamide".
Below are MeSH descriptors whose meaning is more specific than "Tolbutamide".
This graph shows the total number of publications written about "Tolbutamide" by people in this website by year, and whether "Tolbutamide" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1997 | 0 | 1 | 1 | | 1999 | 0 | 1 | 1 | | 2016 | 0 | 1 | 1 | | 2020 | 0 | 1 | 1 |
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Below are the most recent publications written about "Tolbutamide" by people in Profiles.
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Sharma A, Pagidipati NJ, Califf RM, McGuire DK, Green JB, Demets D, George JT, Gerstein HC, Hobbs T, Holman RR, Lawson FC, Leiter LA, Pfeffer MA, Reusch J, Riesmeyer JS, Roe MT, Rosenberg Y, Temple R, Wiviott S, McMurray J, Granger C. Impact of Regulatory Guidance on Evaluating Cardiovascular Risk of New Glucose-Lowering Therapies to Treat Type 2 Diabetes Mellitus: Lessons Learned and Future Directions. Circulation. 2020 03 10; 141(10):843-862.
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Yee AG, Freestone PS, Bai JZ, Lipski J. Paradoxical lower sensitivity of Locus Coeruleus than Substantia Nigra pars compacta neurons to acute actions of rotenone. Exp Neurol. 2017 Jan; 287(Pt 1):34-43.
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Wang Y, Jarrard RE, Pratt EP, Guerra ML, Salyer AE, Lange AM, Soderling IM, Hockerman GH. Uncoupling of Cav1.2 from Ca(2+)-induced Ca(2+) release and SK channel regulation in pancreatic ?-cells. Mol Endocrinol. 2014 Apr; 28(4):458-76.
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Jarrard RE, Wang Y, Salyer AE, Pratt EP, Soderling IM, Guerra ML, Lange AM, Broderick HJ, Hockerman GH. Potentiation of sulfonylurea action by an EPAC-selective cAMP analog in INS-1 cells: comparison of tolbutamide and gliclazide and a potential role for EPAC activation of a 2-APB-sensitive Ca2+ influx. Mol Pharmacol. 2013 Jan; 83(1):191-205.
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Herson PS, Ashford ML. Reduced glutathione inhibits beta-NAD+-activated non-selective cation currents in the CRI-G1 rat insulin-secreting cell line. J Physiol. 1999 Jan 01; 514 ( Pt 1):47-57.
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Harvey J, McKenna F, Herson PS, Spanswick D, Ashford ML. Leptin activates ATP-sensitive potassium channels in the rat insulin-secreting cell line, CRI-G1. J Physiol. 1997 Nov 01; 504 ( Pt 3):527-35.
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Sheridan BC, McIntyre RC, Meldrum DR, Fullerton DA. KATP channels contribute to beta- and adenosine receptor-mediated pulmonary vasorelaxation. Am J Physiol. 1997 11; 273(5):L950-6.
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Babu BV, Moorti R, Pugazhenthi S, Prabhu KM, Murthy PS. Alloxan recovered rabbits as animal model for screening for hypoglycaemic activity of compounds. Indian J Biochem Biophys. 1988 Dec; 25(6):714-8.
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Lee KC, Wilson RA, Randall DC, Altiere RJ, Kiritsy-Roy JA. An analysis of the haemodynamic effects of tolbutamide in conscious dogs. Clin Exp Pharmacol Physiol. 1988 May; 15(5):379-90.
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