 4-Aminopyridine
"4-Aminopyridine" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
One of the POTASSIUM CHANNEL BLOCKERS with secondary effect on calcium currents which is used mainly as a research tool and to characterize channel subtypes.
| Descriptor ID |
D015761
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| MeSH Number(s) |
D02.092.080.060 D03.383.725.050.060
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "4-Aminopyridine".
Below are MeSH descriptors whose meaning is more specific than "4-Aminopyridine".
This graph shows the total number of publications written about "4-Aminopyridine" by people in this website by year, and whether "4-Aminopyridine" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 0 | 1 | 1 | | 1998 | 0 | 2 | 2 | | 1999 | 0 | 2 | 2 | | 2000 | 0 | 1 | 1 | | 2003 | 0 | 1 | 1 | | 2009 | 0 | 1 | 1 | | 2011 | 0 | 1 | 1 | | 2012 | 1 | 0 | 1 | | 2014 | 0 | 1 | 1 | | 2015 | 1 | 1 | 2 | | 2016 | 1 | 0 | 1 | | 2017 | 1 | 0 | 1 | | 2018 | 0 | 1 | 1 | | 2019 | 1 | 0 | 1 | | 2020 | 0 | 1 | 1 | | 2024 | 0 | 1 | 1 | | 2025 | 2 | 0 | 2 |
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Below are the most recent publications written about "4-Aminopyridine" by people in Profiles.
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Kushner JK, Hoffman PB, Brzezinski CR, O'Neill BR, Hankinson TC, Wilkinson CC, Handler MH, Hoeffer CA, Alexander AL. 4-Aminopyridine induced hyperpolarizing oscillations in pediatric human epileptic tissue are network-driven potassium currents that are abolished by activation of KCNQ2-5 (Kv7.2-Kv7.5) channels. Neurobiol Dis. 2026 01; 218:107252.
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Ruiz-Pick YI, Richey RE, Garfield TC, Kichloo A, Olivencia-Yurvati AH, Dick GM, Romero SA. KV channel antagonism blunts vasodilatation in skeletal muscle of humans. J Physiol. 2025 11; 603(22):6801-6810.
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Mohamed NMM, Meredith FL, Rennie KJ. Inhibition of Ionic Currents by Fluoxetine in Vestibular Calyces in Different Epithelial Loci. Int J Mol Sci. 2024 Aug 13; 25(16).
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Bhatiya S, Choudhury S, Gari M, Singh P, Shukla A, Garg SK. Myometrial Calcium and Potassium Channels Play a Pivotal Role in Chromium-Induced Relaxation in Rat Uterus: an In Vitro Study. Biol Trace Elem Res. 2020 Nov; 198(1):198-205.
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Modrak M, Sundem L, Gupta R, Zuscik MJ, Elfar J. Pharmacological Attenuation of Electrical Effects in a Model of Compression Neuropathy. J Bone Joint Surg Am. 2019 Mar 20; 101(6):523-530.
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Gupta RK, Swain DK, Singh V, Anand M, Choudhury S, Yadav S, Saxena A, Garg SK. Molecular characterization of voltage-gated potassium channel (Kv) and its importance in functional dynamics in bull spermatozoa. Theriogenology. 2018 Jul 01; 114:229-236.
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Guo A, Niyazov A, Macaulay D, Terasawa E, Schmerold L, Wu EQ, Krieger S. Inpatient Admissions and Costs Associated with Persistent Use of Dalfampridine Extended-Release in Multiple Sclerosis: A Claims Database Analysis. J Manag Care Spec Pharm. 2017 Jul; 23(7):771-780.
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Tseng KC, Li H, Clark A, Sundem L, Zuscik M, Noble M, Elfar J. 4-Aminopyridine promotes functional recovery and remyelination in acute peripheral nerve injury. EMBO Mol Med. 2016 12; 8(12):1409-1420.
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Simpson DM, Goldenberg J, Kasner S, Nash M, Reding MJ, Zweifler RM, Suarez G, Zhao P, Henney HR, Rabinowicz AL, Carrazana E. Dalfampridine in chronic sensorimotor deficits after ischemic stroke: A proof of concept study. J Rehabil Med. 2015 11; 47(10):924-31.
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Dabertrand F, Krøigaard C, Bonev AD, Cognat E, Dalsgaard T, Domenga-Denier V, Hill-Eubanks DC, Brayden JE, Joutel A, Nelson MT. Potassium channelopathy-like defect underlies early-stage cerebrovascular dysfunction in a genetic model of small vessel disease. Proc Natl Acad Sci U S A. 2015 Feb 17; 112(7):E796-805.
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