 Podophyllotoxin
"Podophyllotoxin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A lignan (LIGNANS) found in PODOPHYLLIN resin from the roots of PODOPHYLLUM plants. It is a potent spindle poison, toxic if taken internally, and has been used as a cathartic. It is very irritating to skin and mucous membranes, has keratolytic actions, has been used to treat warts and keratoses, and may have antineoplastic properties, as do some of its congeners and derivatives.
| Descriptor ID |
D011034
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| MeSH Number(s) |
D02.455.426.559.389.140.450.777 D02.455.426.559.847.638.960.675 D04.615.638.960.675
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Podophyllotoxin".
Below are MeSH descriptors whose meaning is more specific than "Podophyllotoxin".
This graph shows the total number of publications written about "Podophyllotoxin" by people in this website by year, and whether "Podophyllotoxin" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2003 | 0 | 1 | 1 | | 2023 | 0 | 1 | 1 |
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Below are the most recent publications written about "Podophyllotoxin" by people in Profiles.
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Im C, Sharafeldin N, Yuan Y, Wang Z, Sapkota Y, Lu Z, Spector LG, Howell RM, Arnold MA, Hudson MM, Ness KK, Robison LL, Bhatia S, Armstrong GT, Neglia JP, Yasui Y, Turcotte LM. Polygenic Risk and Chemotherapy-Related Subsequent Malignancies in Childhood Cancer Survivors: A Childhood Cancer Survivor Study and St Jude Lifetime Cohort Study Report. J Clin Oncol. 2023 09 20; 41(27):4381-4393.
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Simon GR, Bunn PA. Taxanes in the treatment of advanced (stage III and IV) non-small cell lung cancer (NSCLC): recent developments. Cancer Invest. 2003; 21(1):87-104.
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Schaack J, Schedl P, Shenk T. Topoisomerase I and II cleavage of adenovirus DNA in vivo: both topoisomerase activities appear to be required for adenovirus DNA replication. J Virol. 1990 Jan; 64(1):78-85.
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Antman K, Pomfret E, Karp G, Skarin A, Canellos G. Phase II trial of etoposide in previously treated small cell carcinoma of the lung. Cancer Treat Rep. 1984 Nov; 68(11):1413-4.
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Thomas MR, Robinson WA, Mughal TI, Glode LM. Tumor lysis syndrome following VP-16-213 in chronic myeloid leukemia in blast crisis. Am J Hematol. 1984 Feb; 16(2):185-8.
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Thant M, Hawley RJ, Smith MT, Cohen MH, Minna JD, Bunn PA, Ihde DC, West W, Matthews MJ. Possible enhancement of vincristine neuropathy by VP-16. Cancer. 1982 Mar 01; 49(5):859-64.
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Radice PA, Bunn PA, Ihde DC. Therapeutic trials with VP-16-213 and VM-26: active agents in small cell lung cancer, non-Hodgkin's lymphomas, and other malignancies. Cancer Treat Rep. 1979 Aug; 63(8):1231-9.
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Slater GE, Rumack BH, Peterson RG. Podophyllin poisoning. Systemic toxicity following cutaneous application. Obstet Gynecol. 1978 Jul; 52(1):94-6.
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