 Darier Disease
"Darier Disease" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An autosomal dominantly inherited skin disorder characterized by warty malodorous papules that coalesce into plaques. It is caused by mutations in the ATP2A2 gene encoding SERCA2 protein, one of the SARCOPLASMIC RETICULUM CALCIUM-TRANSPORTING ATPASES. The condition is similar, clinically and histologically, to BENIGN FAMILIAL PEMPHIGUS, another autosomal dominant skin disorder. Both diseases have defective calcium pumps (CALCIUM-TRANSPORTING ATPASES) and unstable desmosomal adhesion junctions (DESMOSOMES) between KERATINOCYTES.
| Descriptor ID |
D007644
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| MeSH Number(s) |
C16.320.850.190 C17.800.428.275 C17.800.827.190
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| Concept/Terms |
Darier Disease- Darier Disease
- Disease, Darier
- Darier's Disease
- Dariers Disease
- Disease, Darier's
- Keratosis Follicularis
- Darier-White Disease
- Darier White Disease
- Darier-White Diseases
- Disease, Darier-White
- Diseases, Darier-White
Acrokeratosis Verruciformis of Hopf- Acrokeratosis Verruciformis of Hopf
- Hopf Acrokeratosis Verruciformis
- Hopf Disease
- Disease, Hopf
- Diseases, Hopf
- Hopf Diseases
- Acrokeratosis Verruciformis
- Verruciformis, Acrokeratosis
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Below are MeSH descriptors whose meaning is more general than "Darier Disease".
Below are MeSH descriptors whose meaning is more specific than "Darier Disease".
This graph shows the total number of publications written about "Darier Disease" by people in this website by year, and whether "Darier Disease" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2005 | 0 | 1 | 1 | | 2010 | 1 | 0 | 1 |
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Below are the most recent publications written about "Darier Disease" by people in Profiles.
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Berk DR, Taube JM, Bruckner AL, Lane AT. A sporadic patient with acrokeratosis verruciformis of Hopf and a novel ATP2A2 mutation. Br J Dermatol. 2010 Sep; 163(3):653-4.
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Chen J, Roop DR. Mouse models in preclinical studies for pachyonychia congenita. J Investig Dermatol Symp Proc. 2005 Oct; 10(1):37-46.
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