 Systemic Inflammatory Response Syndrome
"Systemic Inflammatory Response Syndrome" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A systemic inflammatory response to a variety of clinical insults, characterized by two or more of the following conditions: (1) fever >38 degrees C or HYPOTHERMIA <36 degrees C; (2) TACHYCARDIA >90 beat/minute; (3) tachypnea >24 breaths/minute; (4) LEUKOCYTOSIS >12,000 cells/cubic mm or 10% immature forms. While usually related to infection, SIRS can also be associated with noninfectious insults such as TRAUMA; BURNS; or PANCREATITIS. If infection is involved, a patient with SIRS is said to have SEPSIS.
| Descriptor ID |
D018746
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| MeSH Number(s) |
C23.550.470.790 C23.550.835.900
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Systemic Inflammatory Response Syndrome".
Below are MeSH descriptors whose meaning is more specific than "Systemic Inflammatory Response Syndrome".
- Systemic Inflammatory Response Syndrome
- Sepsis
This graph shows the total number of publications written about "Systemic Inflammatory Response Syndrome" by people in this website by year, and whether "Systemic Inflammatory Response Syndrome" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1999 | 2 | 1 | 3 | | 2002 | 1 | 0 | 1 | | 2003 | 1 | 0 | 1 | | 2004 | 0 | 1 | 1 | | 2005 | 0 | 1 | 1 | | 2006 | 2 | 0 | 2 | | 2008 | 1 | 1 | 2 | | 2010 | 2 | 0 | 2 | | 2011 | 0 | 1 | 1 | | 2012 | 1 | 0 | 1 | | 2014 | 4 | 2 | 6 | | 2015 | 2 | 1 | 3 | | 2016 | 1 | 1 | 2 | | 2017 | 2 | 0 | 2 | | 2018 | 1 | 1 | 2 | | 2019 | 0 | 1 | 1 | | 2020 | 2 | 0 | 2 | | 2021 | 7 | 5 | 12 | | 2022 | 1 | 9 | 10 | | 2023 | 3 | 6 | 9 | | 2024 | 2 | 3 | 5 | | 2025 | 1 | 0 | 1 |
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Below are the most recent publications written about "Systemic Inflammatory Response Syndrome" by people in Profiles.
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Lopez KN, Truong D, Anderson BR, Baker-Smith CM, Bradford TT, Dionne A, Dummer K, Forsha DE, Franklin WJ, Handler S, Harahsheh AS, Hasbani K, Liu I, Jone PN, Lang SM, McHugh KE, Oster M, Portman MA, Preminger T, Russell M, Sanil Y, Sexson Tejtel KS, Shakti D, Shea R, Trachtenberg F, Wang S, Wong JPP, Newburger JW. Sociodemographic Disparities in Severity of Multisystem Inflammatory Syndrome in Children: The National Cross-Sectional MUltisystem Inflammatory Syndrome In Children (MUSIC) Study. J Pediatr. 2025 Oct; 285:114670.
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Zhang A, Haywood NS, Money DT, Byler MR, Osuru HP, Atluri N, Laubach VE, Mehaffey JH, Charlton JR, Lunardi N, Kron IL, Teman NR. Rodent Model of Cardiopulmonary Bypass Demonstrates Systemic Inflammation and Neuromarker Changes. J Surg Res. 2024 Nov; 303:780-787.
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Roh DJ, Poyraz FC, Mao E, Shen Q, Kansara V, Cottarelli A, Song S, Nemkov T, Kumar A, Hudson KE, Ghoshal S, Park S, Agarwal S, Connolly ES, Claassen J, Kreuziger LB, Hod E, Yeatts S, Foster LD, Selim M. Anemia From Inflammation After Intracerebral Hemorrhage and Relationships With Outcome. J Am Heart Assoc. 2024 Jul 16; 13(14):e035524.
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Francoeur C, Alcamo AM, Robertson CL, Wainwright MS, Roa JD, Lovett ME, Stulce C, Yacoub M, Potera RM, Zivick E, Holloway A, Nagpal A, Wellnitz K, Even KM, Brunow de Carvalho W, Rodriguez IS, Schwartz SP, Walker TC, Campos-Miño S, Dervan LA, Geneslaw AS, Sewell TB, Pryce P, Silver WG, Lin JE, Vargas WS, Topjian A, McGuire JL, Domínguez Rojas JA, Tasayco-Muñoz J, Hong SJ, Muller WJ, Doerfler M, Williams CN, Drury K, Bhagat D, Nelson A, Price D, Dapul H, Santos L, Kahoud R, Appavu B, Guilliams KP, Agner SC, Walson KH, Rasmussen L, Pal R, Janas A, Ferrazzano P, Farias-Moeller R, Snooks KC, Chang CH, Iolster T, Erklauer JC, Jorro Baron F, Wassmer E, Yoong M, Jardine M, Mohammad Z, Deep A, Kendirli T, Lidsky K, Dallefeld S, Flockton H, Agrawal S, Siruguppa KS, Waak M, Gutiérrez-Mata A, Butt W, Bogantes-Ledezma S, Sevilla-Acosta F, Umaña-Calderón A, Ulate-Campos A, Yock-Corrales A, Talisa VB, Kanthimathinathan HK, Schober ME, Fink EL. Severe Pediatric Neurological Manifestations With SARS-CoV-2 or MIS-C Hospitalization and New Morbidity. JAMA Netw Open. 2024 06 03; 7(6):e2414122.
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Rao S, Gross RS, Mohandas S, Stein CR, Case A, Dreyer B, Pajor NM, Bunnell HT, Warburton D, Berg E, Overdevest JB, Gorelik M, Milner J, Saxena S, Jhaveri R, Wood JC, Rhee KE, Letts R, Maughan C, Guthe N, Castro-Baucom L, Stockwell MS. Postacute Sequelae of SARS-CoV-2 in Children. Pediatrics. 2024 Mar 01; 153(3).
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Schlapbach LJ, Watson RS, Sorce LR, Argent AC, Menon K, Hall MW, Akech S, Albers DJ, Alpern ER, Balamuth F, Bembea M, Biban P, Carrol ED, Chiotos K, Chisti MJ, DeWitt PE, Evans I, Flauzino de Oliveira C, Horvat CM, Inwald D, Ishimine P, Jaramillo-Bustamante JC, Levin M, Lodha R, Martin B, Nadel S, Nakagawa S, Peters MJ, Randolph AG, Ranjit S, Rebull MN, Russell S, Scott HF, de Souza DC, Tissieres P, Weiss SL, Wiens MO, Wynn JL, Kissoon N, Zimmerman JJ, Sanchez-Pinto LN, Bennett TD. International Consensus Criteria for Pediatric Sepsis and Septic Shock. JAMA. 2024 02 27; 331(8):665-674.
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Kaneko S, Noguchi Y, Hatano M, Shimbo A, Irabu H, Furuno K, Iwata N, Fujimura J, Akamine K, Kobayashi A, Endo T, Morio T, Shimizu M. Clinical Usefulness of T-Cell Receptor Vß Repertoire Analysis for Differentiating Multisystem Inflammatory Syndrome in Japanese Children From Toxic Shock Syndrome and Kawasaki Disease. Pediatr Infect Dis J. 2024 Apr 01; 43(4):e125-e127.
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Rao S, Jing N, Liu X, Lorman V, Maltenfort M, Schuchard J, Wu Q, Tong J, Razzaghi H, Mejias A, Lee GM, Pajor NM, Schulert GS, Thacker D, Jhaveri R, Christakis DA, Bailey LC, Forrest CB, Chen Y. Spectrum of severity of multisystem inflammatory syndrome in children: an EHR-based cohort study from the RECOVER program. Sci Rep. 2023 11 28; 13(1):21005.
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Lorman V, Razzaghi H, Song X, Morse K, Utidjian L, Allen AJ, Rao S, Rogerson C, Bennett TD, Morizono H, Eckrich D, Jhaveri R, Huang Y, Ranade D, Pajor N, Lee GM, Forrest CB, Bailey LC. A machine learning-based phenotype for long COVID in children: An EHR-based study from the RECOVER program. PLoS One. 2023; 18(8):e0289774.
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Kaneko S, Shimizu M, Shimbo A, Irabu H, Yokoyama K, Furuno K, Tanaka T, Ueno K, Fujita S, Iwata N, Fujimura J, Akamine K, Mizuta M, Nakagishi Y, Minato T, Watanabe K, Kobayashi A, Endo T, Tabata K, Mori M, Morio T. Clinical significance of serum cytokine profiles for differentiating between Kawasaki disease and its mimickers. Cytokine. 2023 09; 169:156280.
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