 1-Methyl-4-phenylpyridinium
"1-Methyl-4-phenylpyridinium" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An active neurotoxic metabolite of 1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE. The compound reduces dopamine levels, inhibits the biosynthesis of catecholamines, depletes cardiac norepinephrine and inactivates tyrosine hydroxylase. These and other toxic effects lead to cessation of oxidative phosphorylation, ATP depletion, and cell death. The compound, which is related to PARAQUAT, has also been used as an herbicide.
| Descriptor ID |
D015655
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| MeSH Number(s) |
D03.383.725.762.550
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| Concept/Terms |
1-Methyl-4-phenylpyridinium- 1-Methyl-4-phenylpyridinium
- 1 Methyl 4 phenylpyridinium
- 1-Methyl-4-phenylpyridine
- 1 Methyl 4 phenylpyridine
- N-Methyl-4-phenylpyridinium
- N-Methyl-4-phenylpyridine
- N Methyl 4 phenylpyridine
- 1-Methyl-4-phenylpyridinium Ion
- 1 Methyl 4 phenylpyridinium Ion
- Cyperquat
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Below are MeSH descriptors whose meaning is more general than "1-Methyl-4-phenylpyridinium".
Below are MeSH descriptors whose meaning is more specific than "1-Methyl-4-phenylpyridinium".
This graph shows the total number of publications written about "1-Methyl-4-phenylpyridinium" by people in this website by year, and whether "1-Methyl-4-phenylpyridinium" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2006 | 0 | 1 | 1 | | 2007 | 0 | 1 | 1 | | 2011 | 1 | 0 | 1 | | 2013 | 0 | 1 | 1 | | 2014 | 1 | 0 | 1 |
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Below are the most recent publications written about "1-Methyl-4-phenylpyridinium" by people in Profiles.
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Yee AG, Lee SM, Hunter MR, Glass M, Freestone PS, Lipski J. Effects of the Parkinsonian toxin MPP+ on electrophysiological properties of nigral dopaminergic neurons. Neurotoxicology. 2014 Dec; 45:1-11.
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Decker AR, McNeill MS, Lambert AM, Overton JD, Chen YC, Lorca RA, Johnson NA, Brockerhoff SE, Mohapatra DP, MacArthur H, Panula P, Masino MA, Runnels LW, Cornell RA. Abnormal differentiation of dopaminergic neurons in zebrafish trpm7 mutant larvae impairs development of the motor pattern. Dev Biol. 2014 Feb 15; 386(2):428-39.
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Zawada WM, Banninger GP, Thornton J, Marriott B, Cantu D, Rachubinski AL, Das M, Griffin WS, Jones SM. Generation of reactive oxygen species in 1-methyl-4-phenylpyridinium (MPP+) treated dopaminergic neurons occurs as an NADPH oxidase-dependent two-wave cascade. J Neuroinflammation. 2011 Oct 05; 8:129.
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H?glinger GU, Breunig JJ, Depboylu C, Rouaux C, Michel PP, Alvarez-Fischer D, Boutillier AL, Degregori J, Oertel WH, Rakic P, Hirsch EC, Hunot S. The pRb/E2F cell-cycle pathway mediates cell death in Parkinson's disease. Proc Natl Acad Sci U S A. 2007 Feb 27; 104(9):3585-90.
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Gasser PJ, Lowry CA, Orchinik M. Corticosterone-sensitive monoamine transport in the rat dorsomedial hypothalamus: potential role for organic cation transporter 3 in stress-induced modulation of monoaminergic neurotransmission. J Neurosci. 2006 Aug 23; 26(34):8758-66.
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Clarkson ED, Edwards-Prasad J, Freed CR, Prasad KN. Immortalized dopamine neurons: A model to study neurotoxicity and neuroprotection. Proc Soc Exp Biol Med. 1999 Nov; 222(2):157-63.
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