 Apolipoprotein L1
"Apolipoprotein L1" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An ApoL protein highly expressed by the liver. It has anti-trypanosomal activity through its ability to permeabilize TRYPANOSOMA membranes. Mutations in the APOL1 gene are associated with type 4 FOCAL SEGMENTAL GLOMERULOSCLEROSIS .
| Descriptor ID |
D000075944
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| MeSH Number(s) |
D10.532.091.750.500 D12.776.070.400.750.500 D12.776.521.120.750.500
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Apolipoprotein L1".
Below are MeSH descriptors whose meaning is more specific than "Apolipoprotein L1".
This graph shows the total number of publications written about "Apolipoprotein L1" by people in this website by year, and whether "Apolipoprotein L1" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
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| 2014 | 0 | 1 | 1 | | 2015 | 0 | 1 | 1 | | 2017 | 1 | 1 | 2 | | 2018 | 1 | 0 | 1 | | 2019 | 1 | 0 | 1 | | 2020 | 1 | 0 | 1 | | 2021 | 1 | 0 | 1 | | 2022 | 1 | 1 | 2 | | 2023 | 0 | 1 | 1 |
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Below are the most recent publications written about "Apolipoprotein L1" by people in Profiles.
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Gupta Y, Friedman DJ, McNulty MT, Khan A, Lane B, Wang C, Ke J, Jin G, Wooden B, Knob AL, Lim TY, Appel GB, Huggins K, Liu L, Mitrotti A, Stangl MC, Bomback A, Westland R, Bodria M, Marasa M, Shang N, Cohen DJ, Crew RJ, Morello W, Canetta P, Radhakrishnan J, Martino J, Liu Q, Chung WK, Espinoza A, Luo Y, Wei WQ, Feng Q, Weng C, Fang Y, Kullo IJ, Naderian M, Limdi N, Irvin MR, Tiwari H, Mohan S, Rao M, Dube GK, Chaudhary NS, Guti?rrez OM, Judd SE, Cushman M, Lange LA, Lange EM, Bivona DL, Verbitsky M, Winkler CA, Kopp JB, Santoriello D, Batal I, Pinheiro SVB, Oliveira EA, Simoes E Silva AC, Pisani I, Fiaccadori E, Lin F, Gesualdo L, Amoroso A, Ghiggeri GM, D'Agati VD, Magistroni R, Kenny EE, Loos RJF, Montini G, Hildebrandt F, Paul DS, Petrovski S, Goldstein DB, Kretzler M, Gbadegesin R, Gharavi AG, Kiryluk K, Sampson MG, Pollak MR, Sanna-Cherchi S. Strong protective effect of the APOL1 p.N264K variant against G2-associated focal segmental glomerulosclerosis and kidney disease. Nat Commun. 2023 Nov 30; 14(1):7836.
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Riella CV, McNulty M, Ribas GT, Tattersfield CF, Perez-Gill C, Eichinger F, Kelly J, Chun J, Subramanian B, Guizelini D, Alper SL, Pollak MR, Sampson MG, Friedman DJ. ADAR regulates APOL1 via A-to-I RNA editing by inhibition of MDA5 activation in a paradoxical biological circuit. Proc Natl Acad Sci U S A. 2022 11; 119(44):e2210150119.
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Chaudhary NS, Tiwari HK, Hidalgo BA, Limdi NA, Reynolds RJ, Cushman M, Zakai NA, Lange L, Judd SE, Winkler CA, Kopp JB, Guti?rrez OM, Irvin MR. APOL1 Risk Variants Associated with Serum Albumin in a Population-Based Cohort Study. Am J Nephrol. 2022; 53(2-3):182-190.
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Schaub C, Lee P, Racho-Jansen A, Giovinazzo J, Terra N, Raper J, Thomson R. Coiled-coil binding of the leucine zipper domains of APOL1 is necessary for the open cation channel conformation. J Biol Chem. 2021 09; 297(3):101009.
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Pant J, Giovinazzo JA, Tuka LS, Pe?a D, Raper J, Thomson R. Apolipoproteins L1-6 share key cation channel-regulating residues but have different membrane insertion and ion conductance properties. J Biol Chem. 2021 Aug; 297(2):100951.
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Chen DP, Zaky ZS, Schold JD, Herlitz LC, El-Rifai R, Drawz PE, Bruggeman LA, Barisoni L, Hogan SL, Hu Y, O'Toole JF, Poggio ED, Sedor JR. Podocyte density is reduced in kidney allografts with high-risk APOL1 genotypes at transplantation. Clin Transplant. 2021 04; 35(4):e14234.
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Reiner AP, Raffield LM, Franceschini N, Auer PL, Lange EM, Nickerson DA, Zakai NA, Correa A, Olson N. Effect of Sickle Cell Trait and APOL1 Genotype on the Association of Soluble uPAR with Kidney Function Measures in Black Americans. Clin J Am Soc Nephrol. 2021 Feb 08; 16(2):287-289.
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Giovinazzo JA, Thomson RP, Khalizova N, Zager PJ, Malani N, Rodriguez-Boulan E, Raper J, Schreiner R. Apolipoprotein L-1 renal risk variants form active channels at the plasma membrane driving cytotoxicity. Elife. 2020 05 19; 9.
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Chaudhary NS, Moore JX, Zakai NA, Judd SE, Naik RP, Limou S, Cushman M, Lange LA, Wang HE, Winkler CA, Irvin MR, Kopp JB, Guti?rrez OM. APOL1 Nephropathy Risk Alleles and Risk of Sepsis in Blacks. Clin J Am Soc Nephrol. 2019 12 06; 14(12):1733-1740.
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Nadkarni GN, Gignoux CR, Sorokin EP, Daya M, Rahman R, Barnes KC, Wassel CL, Kenny EE. Worldwide Frequencies of APOL1 Renal Risk Variants. N Engl J Med. 2018 12 27; 379(26):2571-2572.
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