 Minimal Clinically Important Difference
"Minimal Clinically Important Difference" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A statistically significant minimum set of clinical outcomes that demonstrates a clinical benefit of an intervention or treatment.
| Descriptor ID |
D000071081
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| MeSH Number(s) |
N04.761.559.590.399.750 N05.715.360.575.575.399.750
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Minimal Clinically Important Difference".
Below are MeSH descriptors whose meaning is more specific than "Minimal Clinically Important Difference".
This graph shows the total number of publications written about "Minimal Clinically Important Difference" by people in this website by year, and whether "Minimal Clinically Important Difference" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
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| 2018 | 0 | 1 | 1 | | 2019 | 1 | 0 | 1 | | 2020 | 1 | 0 | 1 | | 2021 | 0 | 2 | 2 | | 2022 | 0 | 1 | 1 | | 2023 | 1 | 0 | 1 | | 2024 | 1 | 1 | 2 | | 2025 | 0 | 1 | 1 | | 2026 | 1 | 1 | 2 |
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Below are the most recent publications written about "Minimal Clinically Important Difference" by people in Profiles.
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Major A, Ma E, Masaquel A, Tsang M, Di M, Kaur S, Pophali P, Werner S, Bungay R, Latrémouille-Viau D, Guerin A, Reyes C, Wu M, Cassoli L, Torka P. Patient-reported time toxicity with bispecific antibody therapies in relapsed/refractory follicular lymphoma and diffuse large B-cell lymphoma. Oncologist. 2026 Jun 06; 31(7).
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Maoz SL, Lee M, Fischer JL, Choby G, Hwang PH, Wang EW, Kuan EC, Adappa ND, Geltzeiler M, Getz AE, Humphreys IM, Le CH, Pinheiro-Neto CD, Chan EP, Roozdar P, Abuzeid WM, Chang EH, Jafari A, Kingdom TT, Kohanski MA, Lee JT, Lazor J, Nabavizadeh A, Nayak JV, Palmer JN, Patel ZM, Resnick AC, Smith TL, Snyderman CH, St John MA, Storm PB, Suh JD, Wang MB, Sim MS, Beswick DM. Minimal Clinically Important Difference of the Sinonasal Outcome Test in Sinonasal Malignancy. Ann Otol Rhinol Laryngol. 2026 Jul; 135(7):543-549.
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Williams KG, Constantine EP, Whitney KE, Keeter CL, Hirpara A, Fry SA, Boublik M, Frank R, Genuario JW, Mayer BK, McCarty EC, Noonan TJ, Dragoo JL. Arthroscopic partial meniscectomy outcomes are comparable in patients with synovitis treated by synovectomy and those without synovitis. Knee Surg Sports Traumatol Arthrosc. 2026 Apr; 34(4):1234-1244.
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Beswick DM, Liu CM, Overdevest JB, Zemke A, Khatiwada A, Gudis DA, Miller JE, Kimple A, Tervo JP, DiMango E, Goralski JL, Keating C, Senior B, Stapleton AL, Eshaghian PH, Mace JC, Markarian K, Alt JA, Bodner TE, Chowdhury NI, Getz AE, Hwang PH, Khanwalker A, Lee JT, Li DA, Norris M, Nayak JV, Owens C, Patel ZM, Poch K, Schlosser RJ, Smith KA, Smith TL, Soler ZM, Suh JD, Turner GA, Wang MB, Saavedra MT, Taylor Cousar JL. Predictors of Sinonasal Improvement After Highly Effective Modulator Therapy in Adults with Cystic Fibrosis. Laryngoscope. 2024 09; 134(9):3965-3973.
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Dhillon J, Keeter C, Kraeutler MJ. Does Calculation of the Minimal Clinically Important Difference Make Sense? Ways to Improve. Arthroscopy. 2024 04; 40(4):1039-1040.
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Miller JE, Taylor-Cousar JL, Overdevest JB, Khatiwada A, Mace JC, Alt JA, Bodner TE, Chowdhury NI, DiMango EA, Eshaghian PH, Getz AE, Gudis DA, Han EJ, Hwang PH, Keating CL, Khanwalkar A, Kimple AJ, Lee JT, Li D, Markarian K, Norris M, Nayak JV, Owens C, Patel ZM, Poch K, Schlosser RJ, Smith KA, Smith TL, Soler ZM, Suh JD, Tervo JP, Turner GA, Wang MB, Saavedra MT, Beswick DM. Determining the minimal clinically important difference for the questionnaire of olfactory disorders in people with cystic fibrosis and factors associated with improvement after highly effective modulator therapy. Int Forum Allergy Rhinol. 2024 Jun; 14(6):1079-1087.
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Kolin DA, Moverman MA, Pagani NR, Puzzitiello RN, Dubin J, Menendez ME, Jawa A, Kirsch JM. Substantial Inconsistency and Variability Exists Among Minimum Clinically Important Differences for Shoulder Arthroplasty Outcomes: A Systematic Review. Clin Orthop Relat Res. 2022 07 01; 480(7):1371-1383.
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Aronson KI, Swigris JJ. How Do We Define a Meaningful Change in Quality of Life for Patients with Sarcoidosis? Ann Am Thorac Soc. 2021 03; 18(3):417-418.
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Baughman RP, Judson MA, Beaumont JL, Maier LA, Sweiss NJ, Culver DA, Chen ES, Singh N, Lower EE, Reeves R, Hamzeh N, Grutters JC, Valeyre D, Birring SS. Evaluating the Minimal Clinically Important Difference of the King's Sarcoidosis Questionnaire in a Multicenter Prospective Study. Ann Am Thorac Soc. 2021 03; 18(3):477-485.
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Noe MH, Gelfand JM, Bryer JS, Price SN, Judson MA, Rosenbach M. Responsiveness to Change and Establishment of the Minimal Clinically Important Difference for the Cutaneous Sarcoidosis Activity and Morphology Instrument. JAMA Dermatol. 2020 01 01; 156(1):98-99.
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