 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid
"12-Hydroxy-5,8,10,14-eicosatetraenoic Acid" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A lipoxygenase metabolite of ARACHIDONIC ACID. It is a highly selective ligand used to label mu-opioid receptors in both membranes and tissue sections. The 12-S-HETE analog has been reported to augment tumor cell metastatic potential through activation of protein kinase C. (J Pharmacol Exp Ther 1995; 274(3):1545-51; J Natl Cancer Inst 1994; 86(15):1145-51)
| Descriptor ID |
D019377
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| MeSH Number(s) |
D10.251.355.255.100.300.425 D10.251.355.310.166.550.425
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| Concept/Terms |
12-S-HETE- 12-S-HETE
- 12-S-Hydroxyeicosatetraenoic Acid
- 12 S Hydroxyeicosatetraenoic Acid
- Acid, 12-S-Hydroxyeicosatetraenoic
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Below are MeSH descriptors whose meaning is more general than "12-Hydroxy-5,8,10,14-eicosatetraenoic Acid".
Below are MeSH descriptors whose meaning is more specific than "12-Hydroxy-5,8,10,14-eicosatetraenoic Acid".
This graph shows the total number of publications written about "12-Hydroxy-5,8,10,14-eicosatetraenoic Acid" by people in this website by year, and whether "12-Hydroxy-5,8,10,14-eicosatetraenoic Acid" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2011 | 1 | 0 | 1 | | 2015 | 0 | 1 | 1 |
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Below are the most recent publications written about "12-Hydroxy-5,8,10,14-eicosatetraenoic Acid" by people in Profiles.
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Klawitter J, McFann K, Pennington AT, Wang W, Klawitter J, Christians U, Schrier RW, Gitomer B, Cadnapaphornchai MA. Pravastatin Therapy and Biomarker Changes in Children and Young Adults with Autosomal Dominant Polycystic Kidney Disease. Clin J Am Soc Nephrol. 2015 Sep 04; 10(9):1534-41.
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Farias SE, Heidenreich KA, Wohlauer MV, Murphy RC, Moore EE. Lipid mediators in cerebral spinal fluid of traumatic brain injured patients. J Trauma. 2011 Nov; 71(5):1211-8.
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Thomas CP, Morgan LT, Maskrey BH, Murphy RC, K?hn H, Hazen SL, Goodall AH, Hamali HA, Collins PW, O'Donnell VB. Phospholipid-esterified eicosanoids are generated in agonist-activated human platelets and enhance tissue factor-dependent thrombin generation. J Biol Chem. 2010 Mar 05; 285(10):6891-903.
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Zarbock A, Distasi MR, Smith E, Sanders JM, Kronke G, Harry BL, von Vietinghoff S, Buscher K, Nadler JL, Ley K. Improved survival and reduced vascular permeability by eliminating or blocking 12/15-lipoxygenase in mouse models of acute lung injury (ALI). J Immunol. 2009 Oct 01; 183(7):4715-22.
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Gatlin JC, Estrada-Bernal A, Sanford SD, Pfenninger KH. Myristoylated, alanine-rich C-kinase substrate phosphorylation regulates growth cone adhesion and pathfinding. Mol Biol Cell. 2006 Dec; 17(12):5115-30.
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Murphy RC, Falck JR, Lumin S, Yadagiri P, Zirrolli JA, Balazy M, Masferrer JL, Abraham NG, Schwartzman ML. 12(R)-hydroxyeicosatrienoic acid: a vasodilator cytochrome P-450-dependent arachidonate metabolite from the bovine corneal epithelium. J Biol Chem. 1988 Nov 15; 263(32):17197-202.
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Westcott JY, Murphy RC, Stenmark K. Eicosanoids in human ventricular cerebrospinal fluid following severe brain injury. Prostaglandins. 1987 Dec; 34(6):877-87.
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Romero R, Quintero R, Emamian M, Wan M, Grzyboski C, Hobbins JC, Mitchell MD. Arachidonate lipoxygenase metabolites in amniotic fluid of women with intra-amniotic infection and preterm labor. Am J Obstet Gynecol. 1987 Dec; 157(6):1454-60.
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Romero R, Emamian M, Wan M, Grzyboski C, Hobbins JC, Mitchell MD. Increased concentrations of arachidonic acid lipoxygenase metabolites in amniotic fluid during parturition. Obstet Gynecol. 1987 Dec; 70(6):849-51.
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