 Neoplasms, Second Primary
"Neoplasms, Second Primary" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Abnormal growths of tissue that follow a previous neoplasm but are not metastases of the latter. The second neoplasm may have the same or different histological type and can occur in the same or different organs as the previous neoplasm but in all cases arises from an independent oncogenic event. The development of the second neoplasm may or may not be related to the treatment for the previous neoplasm since genetic risk or predisposing factors may actually be the cause.
| Descriptor ID |
D016609
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| MeSH Number(s) |
C04.692
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| Concept/Terms |
Neoplasms, Second Primary- Neoplasms, Second Primary
- Neoplasm, Second Primary
- Second Primary Neoplasm
- Metachronous Second Primary Neoplasms
- Neoplasms, Metachronous
- Second Primary Neoplasms, Metachronous
- Second Malignancy
- Malignancies, Second
- Malignancy, Second
- Second Malignancies
- Second Neoplasm
- Neoplasm, Second
- Neoplasms, Second
- Second Neoplasms
- Second Primary Neoplasms
- Metachronous Neoplasms
- Metachronous Neoplasm
- Neoplasm, Metachronous
- Neoplasms, Metachronous Second Primary
Neoplasms, Therapy-Associated- Neoplasms, Therapy-Associated
- Neoplasm, Therapy-Associated
- Neoplasms, Therapy Associated
- Therapy-Associated Neoplasm
- Neoplasms, Treatment-Associated
- Neoplasm, Treatment-Associated
- Neoplasms, Treatment Associated
- Treatment-Associated Neoplasm
- Neoplasms, Treatment-Related
- Neoplasm, Treatment-Related
- Neoplasms, Treatment Related
- Treatment-Related Neoplasm
- Therapy-Related Neoplasms
- Therapy Related Neoplasms
- Treatment-Associated Neoplasms
- Treatment Associated Neoplasms
- Treatment-Related Neoplasms
- Treatment Related Neoplasms
- Neoplasms, Therapy-Related
- Neoplasm, Therapy-Related
- Neoplasms, Therapy Related
- Therapy-Related Neoplasm
- Therapy-Associated Neoplasms
- Therapy Associated Neoplasms
Therapy-Associated Cancer- Therapy-Associated Cancer
- Cancer, Therapy-Associated
- Cancers, Therapy-Associated
- Therapy Associated Cancer
- Therapy-Associated Cancers
- Therapy-Related Cancer
- Cancer, Therapy-Related
- Cancers, Therapy-Related
- Therapy Related Cancer
- Therapy-Related Cancers
- Treatment-Related Cancer
- Cancer, Treatment-Related
- Cancers, Treatment-Related
- Treatment Related Cancer
- Treatment-Related Cancers
- Treatment-Associated Cancer
- Cancer, Treatment-Associated
- Cancers, Treatment-Associated
- Treatment Associated Cancer
- Treatment-Associated Cancers
Cancer, Second Primary- Cancer, Second Primary
- Cancers, Second Primary
- Second Primary Cancer
- Second Primary Cancers
- Second Cancer
- Cancer, Second
- Cancers, Second
- Second Cancers
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Below are MeSH descriptors whose meaning is more general than "Neoplasms, Second Primary".
Below are MeSH descriptors whose meaning is more specific than "Neoplasms, Second Primary".
This graph shows the total number of publications written about "Neoplasms, Second Primary" by people in this website by year, and whether "Neoplasms, Second Primary" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1995 | 1 | 1 | 2 | | 1997 | 1 | 1 | 2 | | 1998 | 0 | 1 | 1 | | 2000 | 1 | 0 | 1 | | 2001 | 3 | 1 | 4 | | 2002 | 1 | 0 | 1 | | 2006 | 3 | 3 | 6 | | 2007 | 1 | 1 | 2 | | 2008 | 1 | 0 | 1 | | 2009 | 1 | 0 | 1 | | 2010 | 1 | 0 | 1 | | 2011 | 1 | 0 | 1 | | 2012 | 2 | 1 | 3 | | 2013 | 1 | 0 | 1 | | 2014 | 1 | 0 | 1 | | 2015 | 5 | 1 | 6 | | 2016 | 5 | 0 | 5 | | 2017 | 2 | 0 | 2 | | 2019 | 5 | 0 | 5 | | 2020 | 3 | 1 | 4 | | 2021 | 6 | 2 | 8 | | 2022 | 8 | 0 | 8 | | 2023 | 5 | 0 | 5 | | 2024 | 5 | 1 | 6 | | 2025 | 2 | 0 | 2 |
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Below are the most recent publications written about "Neoplasms, Second Primary" by people in Profiles.
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Galvin RT, Chen Y, Yuan Y, Cooney T, Howell R, Smith S, Arnold MA, Conces M, Leisenring W, Armstrong GT, Neglia JP, Turcotte LM. Temporal trends of subsequent central nervous system malignancies among survivors of childhood cancer. J Natl Cancer Inst. 2025 May 01; 117(5):1036-1045.
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Im C, Hasan H, Stene E, Monick S, Rader RK, Sheade J, Wolfe H, Lu Z, Spector LG, McDonald AJ, Nolan V, Arnold MA, Conces MR, Moskowitz CS, Henderson TO, Robison LL, Armstrong GT, Yasui Y, Nanda R, Oeffinger KC, Neglia JP, Blaes A, Turcotte LM. Treatment, toxicity, and mortality after subsequent breast cancer in female survivors of childhood cancer. Nat Commun. 2025 Mar 31; 16(1):3088.
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Ghosh T, Hyun G, Dhaduk R, Conces M, Arnold MA, Howell RM, Henderson TO, McDonald A, Robison LL, Yasui Y, Ness KK, Armstrong GT, Neglia JP, Turcotte LM. Late subsequent leukemia after childhood cancer: A report from the Childhood Cancer Survivor Study (CCSS). Cancer Med. 2024 Oct; 13(20):e70086.
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Zhang BX, Brantley KD, Rosenberg SM, Kirkner GJ, Collins LC, Ruddy KJ, Tamimi RM, Schapira L, Borges VF, Warner E, Come SE, Winer EP, Bellon JR, Partridge AH. Second primary non-breast cancers in young breast cancer survivors. Breast Cancer Res Treat. 2024 Oct; 207(3):587-597.
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Brantley KD, Rosenberg SM, Collins LC, Ruddy KJ, Tamimi RM, Schapira L, Borges VF, Warner E, Come SE, Zheng Y, Kirkner GJ, Snow C, Winer EP, Partridge AH. Second Primary Breast Cancer in Young Breast Cancer Survivors. JAMA Oncol. 2024 Jun 01; 10(6):718-725.
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Schaeffer EM, Srinivas S, Adra N, An Y, Bitting R, Chapin B, Cheng HH, D'Amico AV, Desai N, Dorff T, Eastham JA, Farrington TA, Gao X, Gupta S, Guzzo T, Ippolito JE, Karnes RJ, Kuettel MR, Lang JM, Lotan T, McKay RR, Morgan T, Pow-Sang JM, Reiter R, Roach M, Robin T, Rosenfeld S, Shabsigh A, Spratt D, Szmulewitz R, Teply BA, Tward J, Valicenti R, Wong JK, Snedeker J, Freedman-Cass DA. NCCN Guidelines? Insights: Prostate Cancer, Version 3.2024. J Natl Compr Canc Netw. 2024 04; 22(3):140-150.
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Slatnick LR, Cost C, Garrington T, Donaldson N, Macy ME. Central Nervous System Metastases in Pediatric Patients With Ewing Sarcoma. J Pediatr Hematol Oncol. 2024 03 01; 46(2):e180-e183.
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Stinchcombe TE, Wang X, Damman B, Mentlick J, Landreneau R, Wigle D, Jones DR, Conti M, Ashrafi AS, Liberman M, de Perrot M, Mitchell JD, Keenan R, Bauer T, Miller D, Altorki N. Secondary Analysis of the Rate of Second Primary Lung Cancer From Cancer and Leukemia Group B 140503 (Alliance) Trial of Lobar Versus Sublobar Resection for T1aN0 Non-Small-Cell Lung Cancer. J Clin Oncol. 2024 Apr 01; 42(10):1110-1113.
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Florou V, Floudas CS, Maoz A, Naqash AR, Norton C, Tan AC, Sokol ES, Frampton G, Soares HP, Puri S, Swami U, Wilky B, Hosein P, Trent J, Lopes GL, Park W, Garrido-Laguna I. Real-world pan-cancer landscape of frameshift mutations and their role in predicting responses to immune checkpoint inhibitors in cancers with low tumor mutational burden. J Immunother Cancer. 2023 08; 11(8).
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Im C, Sharafeldin N, Yuan Y, Wang Z, Sapkota Y, Lu Z, Spector LG, Howell RM, Arnold MA, Hudson MM, Ness KK, Robison LL, Bhatia S, Armstrong GT, Neglia JP, Yasui Y, Turcotte LM. Polygenic Risk and Chemotherapy-Related Subsequent Malignancies in Childhood Cancer Survivors: A Childhood Cancer Survivor Study and St Jude Lifetime Cohort Study Report. J Clin Oncol. 2023 09 20; 41(27):4381-4393.
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