Histamine H1 Antagonists
"Histamine H1 Antagonists" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Drugs that selectively bind to but do not activate histamine H1 receptors, thereby blocking the actions of endogenous histamine. Included here are the classical antihistaminics that antagonize or prevent the action of histamine mainly in immediate hypersensitivity. They act in the bronchi, capillaries, and some other smooth muscles, and are used to prevent or allay motion sickness, seasonal rhinitis, and allergic dermatitis and to induce somnolence. The effects of blocking central nervous system H1 receptors are not as well understood.
Descriptor ID |
D006634
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MeSH Number(s) |
D27.505.519.625.375.425.400 D27.505.696.577.375.425.400
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Concept/Terms |
Histamine H1 Antagonists- Histamine H1 Antagonists
- H1 Antagonists, Histamine
- Antagonists, Histamine H1 Receptor
- Antihistaminics, H1
- H1 Antihistaminics
- Receptor Blockaders, H1
- H1 Receptor Blockaders
- Histamine H1 Blockers
- Histamine H1 Receptor Antagonists
- Histamine H1 Receptor Blockaders
- Antagonists, Histamine H1
- Blockaders, Histamine H1 Receptor
Antihistamines, Classical- Antihistamines, Classical
- Classical Antihistamines
- Antihistaminics, Classical
- Classical Antihistaminics
- First Generation H1 Antagonists
- Antihistamines, Sedating
- Sedating Antihistamines
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Below are MeSH descriptors whose meaning is more general than "Histamine H1 Antagonists".
Below are MeSH descriptors whose meaning is more specific than "Histamine H1 Antagonists".
This graph shows the total number of publications written about "Histamine H1 Antagonists" by people in this website by year, and whether "Histamine H1 Antagonists" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
Year | Major Topic | Minor Topic | Total |
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1997 | 1 | 0 | 1 | 2001 | 0 | 1 | 1 | 2002 | 0 | 2 | 2 | 2003 | 1 | 0 | 1 | 2004 | 0 | 2 | 2 | 2005 | 0 | 3 | 3 | 2006 | 0 | 2 | 2 | 2007 | 0 | 1 | 1 | 2008 | 0 | 2 | 2 | 2009 | 0 | 1 | 1 | 2012 | 2 | 0 | 2 | 2016 | 0 | 1 | 1 | 2017 | 1 | 0 | 1 |
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Below are the most recent publications written about "Histamine H1 Antagonists" by people in Profiles.
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Diaz-Artiles A, Priesol AJ, Clark TK, Sherwood DP, Oman CM, Young LR, Karmali F. The Impact of Oral Promethazine on Human Whole-Body Motion Perceptual Thresholds. J Assoc Res Otolaryngol. 2017 Aug; 18(4):581-590.
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Okland T, Shirazi M, Rylander M, Holland J. A Case of Aggressive Psychosis in the Setting of Regular Dextromethorphan Abuse. Psychosomatics. 2016 Nov - Dec; 57(6):655-656.
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Oleson EB, Ferris MJ, Espa?a RA, Harp J, Jones SR. Effects of the histamine H1 receptor antagonist and benztropine analog diphenylpyraline on dopamine uptake, locomotion and reward. Eur J Pharmacol. 2012 May 15; 683(1-3):161-5.
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Vande Griend JP, Anderson SL. Histamine-1 receptor antagonism for treatment of insomnia. J Am Pharm Assoc (2003). 2012; 52(6):e210-9.
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Greenhawt MJ, McMorris MS, Furlong TJ. Self-reported allergic reactions to peanut and tree nuts occurring on commercial airlines. J Allergy Clin Immunol. 2009 Sep; 124(3):598-9.
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Amar SM, Dreskin SC. Urticaria. Prim Care. 2008 Mar; 35(1):141-57, vii-viii.
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Cumbler E, Guerrasio J, Kim J, Glasheen J. Use of medications for insomnia in the hospitalized geriatric population. J Am Geriatr Soc. 2008 Mar; 56(3):579-81.
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Thurmond RL, Gelfand EW, Dunford PJ. The role of histamine H1 and H4 receptors in allergic inflammation: the search for new antihistamines. Nat Rev Drug Discov. 2008 Jan; 7(1):41-53.
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Abaza MM, Levy S, Hawkshaw MJ, Sataloff RT. Effects of medications on the voice. Otolaryngol Clin North Am. 2007 Oct; 40(5):1081-90, viii.
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Kelsay K. Management of sleep disturbance associated with atopic dermatitis. J Allergy Clin Immunol. 2006 Jul; 118(1):198-201.
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