 Histamine H1 Antagonists, Non-Sedating
"Histamine H1 Antagonists, Non-Sedating" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A class of non-sedating drugs that bind to but do not activate histamine receptors (DRUG INVERSE AGONISM), thereby blocking the actions of histamine or histamine agonists. These antihistamines represent a heterogenous group of compounds with differing chemical structures, adverse effects, distribution, and metabolism. Compared to the early (first generation) antihistamines, these non-sedating antihistamines have greater receptor specificity, lower penetration of BLOOD-BRAIN BARRIER, and are less likely to cause drowsiness or psychomotor impairment.
| Descriptor ID |
D039563
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| MeSH Number(s) |
D27.505.519.625.375.425.400.500 D27.505.696.577.375.425.400.500
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| Concept/Terms |
Histamine H1 Antagonists, Non-Sedating- Histamine H1 Antagonists, Non-Sedating
- Histamine H1 Antagonists, Non Sedating
- Second Generation H1 Antagonists
- H1 Antihistamines, Non-Sedating
- H1 Antihistamines, Non Sedating
- Non-Sedating H1 Antihistamines
- Second Generation Antihistamines
- Antihistamines, Second Generation
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Below are MeSH descriptors whose meaning is more general than "Histamine H1 Antagonists, Non-Sedating".
Below are MeSH descriptors whose meaning is more specific than "Histamine H1 Antagonists, Non-Sedating".
This graph shows the total number of publications written about "Histamine H1 Antagonists, Non-Sedating" by people in this website by year, and whether "Histamine H1 Antagonists, Non-Sedating" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2003 | 1 | 0 | 1 |
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Below are the most recent publications written about "Histamine H1 Antagonists, Non-Sedating" by people in Profiles.
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Drummond PD, Lester B. Loratadine augments emotional blushing. Eur Neuropsychopharmacol. 2018 11; 28(11):1284-1288.
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Mindell JA, Kuhn B, Lewin DS, Meltzer LJ, Sadeh A. Behavioral treatment of bedtime problems and night wakings in infants and young children. Sleep. 2006 Oct; 29(10):1263-76.
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Gelfand EW. Pediatric allergic rhinitis: factors affecting treatment choice. Ear Nose Throat J. 2005 Mar; 84(3):163-8.
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Bender BG, Berning S, Dudden R, Milgrom H, Tran ZV. Sedation and performance impairment of diphenhydramine and second-generation antihistamines: a meta-analysis. J Allergy Clin Immunol. 2003 Apr; 111(4):770-6.
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