 Osteoprotegerin
"Osteoprotegerin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A secreted member of the TNF receptor superfamily that negatively regulates osteoclastogenesis. It is a soluble decoy receptor of RANK LIGAND that inhibits both CELL DIFFERENTIATION and function of OSTEOCLASTS by inhibiting the interaction between RANK LIGAND and RECEPTOR ACTIVATOR OF NUCLEAR FACTOR-KAPPA B.
| Descriptor ID |
D053244
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| MeSH Number(s) |
D12.776.543.750.705.852.760.949.249
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| Concept/Terms |
Osteoprotegerin- Osteoprotegerin
- Osteoclastogenesis Inhibitory Factor
- Receptors, Tumor Necrosis Factor, Member 11b
- Follicular Dendritic Cell-Derived Receptor-1
- Follicular Dendritic Cell Derived Receptor 1
- Tumor Necrosis Factor Receptor Superfamily, Member 11b
- FDCR-1 Protein
- FDCR 1 Protein
- OCIF Protein
- Tumor Necrosis Factor Receptor 11b
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Below are MeSH descriptors whose meaning is more general than "Osteoprotegerin".
Below are MeSH descriptors whose meaning is more specific than "Osteoprotegerin".
This graph shows the total number of publications written about "Osteoprotegerin" by people in this website by year, and whether "Osteoprotegerin" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2000 | 0 | 1 | 1 | | 2002 | 0 | 1 | 1 | | 2003 | 0 | 1 | 1 | | 2007 | 1 | 0 | 1 | | 2008 | 3 | 0 | 3 | | 2009 | 2 | 1 | 3 | | 2012 | 1 | 0 | 1 | | 2013 | 1 | 1 | 2 | | 2014 | 1 | 0 | 1 | | 2015 | 1 | 0 | 1 | | 2017 | 1 | 0 | 1 | | 2019 | 1 | 0 | 1 | | 2022 | 0 | 1 | 1 |
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Below are the most recent publications written about "Osteoprotegerin" by people in Profiles.
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Payne KA, Shaw NM, Erickson CB, Yarger P, Yu Y, Baldini T, Kleck CJ, Patel VV, Burger EL. Blockade of Osteoclast-Mediated Bone Resorption With a RANKL-Inhibitor Enhances Bone Formation in a Rat Spinal Fusion Model. Spine (Phila Pa 1976). 2022 Aug 15; 47(16):1165-1171.
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Wu W, Song K, Chen G, Liu N, Cao T. Ganoderic acid A improves osteoarthritis by regulating RANKL/OPG ratio. Chem Biol Drug Des. 2022 09; 100(3):313-319.
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Mensah KA, Chen JW, Schickel JN, Isnardi I, Yamakawa N, Vega-Loza A, Anolik JH, Gatti RA, Gelfand EW, Montgomery RR, Horowitz MC, Craft JE, Meffre E. Impaired ATM activation in B cells is associated with bone resorption in rheumatoid arthritis. Sci Transl Med. 2019 11 20; 11(519).
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Arnold ND, Pickworth JA, West LE, Dawson S, Carvalho JA, Casbolt H, Braithwaite AT, Iremonger J, Renshall L, Germaschewski V, McCourt M, Bland-Ward P, Kowash H, Hameed AG, Rothman AMK, Frid MG, Roger Thompson AA, Evans HR, Southwood M, Morrell NW, Crossman DC, Whyte MKB, Stenmark KR, Newman CM, Kiely DG, Francis SE, Lawrie A. A therapeutic antibody targeting osteoprotegerin attenuates severe experimental pulmonary arterial hypertension. Nat Commun. 2019 11 15; 10(1):5183.
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Yamagishi T, Kawashima H, Ogose A, Ariizumi T, Oike N, Sasaki T, Hatano H, Ohashi R, Umezu H, Ajioka Y, Endo N. Expression Profiling of Receptor-Activator of Nuclear Factor-Kappa B Ligand in Soft Tissue Tumors. Tohoku J Exp Med. 2019 06; 248(2):87-97.
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Turcotte AF, Grenier-Larouche T, Ung RV, Simonyan D, Carreau AM, Carpentier AC, Mac-Way F, Michou L, Tchernof A, Biertho L, Lebel S, Marceau S, Gagnon C. Effects of Biliopancreatic Diversion on Bone Turnover Markers and Association with Hormonal Factors in Patients with Severe Obesity. Obes Surg. 2019 03; 29(3):990-998.
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Kamimura D, Suzuki T, Furniss AL, Griswold ME, Kullo IJ, Lindsey ML, Winniford MD, Butler KR, Mosley TH, Hall ME. Elevated serum osteoprotegerin is associated with increased left ventricular mass index and myocardial stiffness. J Cardiovasc Med (Hagerstown). 2017 Dec; 18(12):954-961.
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Moran CS, Rush CM, Dougan T, Jose RJ, Biros E, Norman PE, Gera L, Golledge J. Modulation of Kinin B2 Receptor Signaling Controls Aortic Dilatation and Rupture in the Angiotensin II-Infused Apolipoprotein E-Deficient Mouse. Arterioscler Thromb Vasc Biol. 2016 05; 36(5):898-907.
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Lloyd SA, Morony SE, Ferguson VL, Simske SJ, Stodieck LS, Warmington KS, Livingston EW, Lacey DL, Kostenuik PJ, Bateman TA. Osteoprotegerin is an effective countermeasure for spaceflight-induced bone loss in mice. Bone. 2015 Dec; 81:562-572.
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Kwan JS, Hsu YH, Cheung CL, Dupuis J, Saint-Pierre A, Eriksson J, Handelman SK, Aragaki A, Karasik D, Pramstaller PP, Kooperberg C, Lacroix AZ, Larson MG, Lau KS, Lorentzon M, Pichler I, Sham PC, Taliun D, Vandenput L, Kiel DP, Hicks AA, Jackson RD, Ohlsson C, Benjamin EJ, Kung AW. Meta-analysis of genome-wide association studies identifies two loci associated with circulating osteoprotegerin levels. Hum Mol Genet. 2014 Dec 15; 23(24):6684-93.
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