 Comparative Effectiveness Research
"Comparative Effectiveness Research" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Conduct and synthesis of systematic research comparing interventions and strategies to prevent, diagnose, treat, and monitor health conditions. The purpose of this research is to inform patients, providers, and decision-makers, responding to their expressed needs, about which interventions are most effective for which patients under specific circumstances. (hhs.gov/recovery/programs/cer/draftdefinition.html accessed 6/12/2009)
| Descriptor ID |
D057186
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| MeSH Number(s) |
H01.770.644.145.360.500 N05.425.157
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Comparative Effectiveness Research".
Below are MeSH descriptors whose meaning is more specific than "Comparative Effectiveness Research".
This graph shows the total number of publications written about "Comparative Effectiveness Research" by people in this website by year, and whether "Comparative Effectiveness Research" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2010 | 2 | 1 | 3 | | 2011 | 4 | 0 | 4 | | 2012 | 4 | 14 | 18 | | 2013 | 5 | 3 | 8 | | 2014 | 4 | 3 | 7 | | 2015 | 1 | 4 | 5 | | 2016 | 3 | 9 | 12 | | 2017 | 0 | 3 | 3 | | 2018 | 2 | 3 | 5 | | 2019 | 2 | 10 | 12 | | 2020 | 1 | 5 | 6 | | 2021 | 1 | 5 | 6 | | 2022 | 0 | 1 | 1 | | 2023 | 1 | 0 | 1 | | 2024 | 3 | 4 | 7 | | 2025 | 0 | 4 | 4 |
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Below are the most recent publications written about "Comparative Effectiveness Research" by people in Profiles.
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Presley CA, Butera NM, Krause-Steinrauf H, Desouza CV, Hollander PA, Hoogendoorn CJ, Lagari VS, Legowski EA, Martin CL, Rasouli N, Gonzalez JS, Cherrington AL. Lack of Association of Emotional Distress With Insulin Initiation in the GRADE Randomized Diabetes Comparative Effectiveness Trial. Sci Diabetes Self Manag Care. 2025 Aug; 51(4):382-393.
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Zemplenyi AT, Chen NC, Anderson KE, Adamson B, DiStefano MJ, Nair KV, McQueen RB. Key Considerations for Assessing Real-World Comparative Effectiveness in the Context of the Drug Price Negotiation Program: A Case Study of Pembrolizumab. Pharmacoeconomics. 2025 Sep; 43(9):1147-1160.
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Zemek R, Albrecht LM, Johnston S, Leddy J, Ledoux AA, Reed N, Silverberg N, Yeates K, Lamoureux M, Anderson C, Barrowman N, Beauchamp MH, Chen K, Chintoh A, Cortel-LeBlanc A, Cortel-LeBlanc M, Corwin DJ, Cowle S, Dalton K, Dawson J, Dodd A, El Emam K, Emery C, Fox E, Fuselli P, Gagnon IJ, Giza C, Hicks S, Howell DR, Kutcher SA, Lalonde C, Mannix RC, Master CL, Mayer AR, Osmond MH, Robillard R, Schneider KJ, Tanuseputro P, Terekhov I, Webster R, Wellington CL. TRANSCENDENT (Transforming Research by Assessing Neuroinformatics across the Spectrum of Concussion by Embedding iNterdisciplinary Data-collection to Enable Novel Treatments): protocol for a prospective observational cohort study of concussion patients with embedded comparative effectiveness research within a network of learning health system concussion clinics in Canada. BMJ Open. 2025 Apr 22; 15(4):e095292.
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Ozmen O, Rush E, Park BH, Jones M, Trafton J, Brenner L, Rupper RW, Ward M, Nebeker JR, Pizer SD. Combining Machine Learning and Comparative Effectiveness Methodology to Study Primary Care Pharmacotherapy Pathways for Veterans With Depression. Med Care. 2025 Jun 01; 63(6):422-429.
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Ananthakrishnan AN, Murad MH, Scott FI, Agrawal M, Haydek JP, Limketkai BN, Loftus EV, Singh S. Comparative Efficacy of Advanced Therapies for Management of Moderate-to-Severe Ulcerative Colitis: 2024 American Gastroenterological Association Evidence Synthesis. Gastroenterology. 2024 Dec; 167(7):1460-1482.
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Zittleman L, Westfall JM, Sofie B, Lutgen C, Fernald D, Hall TL, Hochheimer CJ, Murphy M, Felzien M, Dickinson LM, Manning BK, LeMaster J, Nease DE. The Odyssey of HOMER: Comparative Effectiveness Research on Medication for Opioid Use Disorder During the COVID-19 Pandemic. Ann Fam Med. 2024 Sep-Oct; 22(5):444-450.
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Kwan BM, Dickinson LM, Dailey-Vail J, Glasgow RE, Gritz RM, Gurfinkel D, Hester CM, Holtrop JS, Hosokawa P, Lanigan A, Nease DE, Nederveld A, Phimphasone-Brady P, Ritchie ND, Sajatovic M, Wearner R, Begum A, Carter M, Carrigan T, Clay B, Downey D, Koren R, Trujillo SA, Waxmonsky JA. Comparative Effectiveness of Patient-Driven versus Standardized Diabetes Shared Medical Appointments: A Pragmatic Cluster Randomized Trial. J Gen Intern Med. 2024 Nov; 39(15):2970-2979.
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Fortney JC, Kaysen DL, Engel CC, Cerimele JM, Nolan JP, Chase E, Blanchard BE, Hauge S, Bechtel J, Moore DL, Taylor A, Acierno R, Nagel N, Sripada RK, Painter JT, DeBeer BB, Bluett E, Teo AR, Morland LA, Heagerty PJ. Sequenced Treatment Effectiveness for Posttraumatic Stress (STEPS) Trial: A protocol for a pragmatic comparative effectiveness trial with baseline results. Contemp Clin Trials. 2024 Sep; 144:107606.
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DiStefano MJ, Pearson SD, Rind DM, Zemplenyi A. How Do the Institute for Clinical and Economic Review's Assessments of Comparative Effectiveness Compare With the German Federal Joint Committee's Assessments of Added Benefit? A Qualitative Study. Value Health. 2024 08; 27(8):1066-1072.
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Christine PJ, Lodi S, Hsu HE, Bovell-Ammon B, Yan S, Bernson D, Novo P, Lee JD, Rotrosen J, Liebschutz J, Walley AY, Larochelle MR. Target trial emulation for comparative effectiveness research with observational data: Promise and challenges for studying medications for opioid use disorder. Addiction. 2024 07; 119(7):1313-1321.
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