 Mitomycins
"Mitomycins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A group of methylazirinopyrroloindolediones obtained from certain Streptomyces strains. They are very toxic antibiotics used as ANTINEOPLASTIC AGENTS in some solid tumors. PORFIROMYCIN and MITOMYCIN are the most useful members of the group.
| Descriptor ID |
D008937
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| MeSH Number(s) |
D02.806.400.249 D03.383.097.500 D03.633.100.473.412.249
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Mitomycins".
Below are MeSH descriptors whose meaning is more specific than "Mitomycins".
This graph shows the total number of publications written about "Mitomycins" by people in this website by year, and whether "Mitomycins" was a major or minor topic of these publications.
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Below are the most recent publications written about "Mitomycins" by people in Profiles.
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Siegel D, Beall H, Senekowitsch C, Kasai M, Arai H, Gibson NW, Ross D. Bioreductive activation of mitomycin C by DT-diaphorase. Biochemistry. 1992 Sep 01; 31(34):7879-85.
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Gibson NW, Siegel D, Ross D. Mitomycin C. Cancer Chemother Biol Response Modif. 1992; 13:59-68.
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Siegel D, Gibson NW, Preusch PC, Ross D. Metabolism of mitomycin C by DT-diaphorase: role in mitomycin C-induced DNA damage and cytotoxicity in human colon carcinoma cells. Cancer Res. 1990 Dec 01; 50(23):7483-9.
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Doyle LA, Ihde DC, Carney DN, Bunn PA, Cohen MH, Matthews MJ, Puffenbarger R, Cordes RS, Minna JD. Combination chemotherapy with doxorubicin and mitomycin C in non-small cell bronchogenic carcinoma. Severe pulmonary toxicity from q 3 weekly mitomycin C. Am J Clin Oncol. 1984 Dec; 7(6):719-24.
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Beer DJ, Dinarello CA, Rosenwasser LJ, Rocklin RE. Human monocyte-derived soluble product(s) has an accessory function in the generation of histamine- and concanavalin A-induced suppressor T cells. J Clin Invest. 1982 Aug; 70(2):393-400.
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Parente A, Arking R, Kalata K. Effect of DNA inhibitors upon DNA synthesis and development of Drosophila embryos. J Exp Zool. 1980 May; 212(2):195-204.
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Stewart CR, Click B, Tole MF. DNA replication and late protein synthesis during SP82 infection of Bacillus subtilis. Virology. 1972 Dec; 50(3):653-63.
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