 Dicumarol
"Dicumarol" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An oral anticoagulant that interferes with the metabolism of vitamin K. It is also used in biochemical experiments as an inhibitor of reductases.
| Descriptor ID |
D001728
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| MeSH Number(s) |
D03.383.663.283.446.520.203 D03.633.100.150.446.520.203
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| Concept/Terms |
Dicumarol- Dicumarol
- Bishydroxycoumarin
- Dicoumarol
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Below are MeSH descriptors whose meaning is more general than "Dicumarol".
Below are MeSH descriptors whose meaning is more specific than "Dicumarol".
This graph shows the total number of publications written about "Dicumarol" by people in this website by year, and whether "Dicumarol" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2006 | 1 | 0 | 1 | | 2008 | 0 | 1 | 1 |
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Below are the most recent publications written about "Dicumarol" by people in Profiles.
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Voynow JA, Fischer BM, Zheng S, Potts EN, Grover AR, Jaiswal AK, Ghio AJ, Foster WM. NAD(P)H quinone oxidoreductase 1 is essential for ozone-induced oxidative stress in mice and humans. Am J Respir Cell Mol Biol. 2009 Jul; 41(1):107-13.
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Nolan KA, Zhao H, Faulder PF, Frenkel AD, Timson DJ, Siegel D, Ross D, Burke TR, Stratford IJ, Bryce RA. Coumarin-based inhibitors of human NAD(P)H:quinone oxidoreductase-1. Identification, structure-activity, off-target effects and in vitro human pancreatic cancer toxicity. J Med Chem. 2007 Dec 13; 50(25):6316-25.
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Du J, Daniels DH, Asbury C, Venkataraman S, Liu J, Spitz DR, Oberley LW, Cullen JJ. Mitochondrial production of reactive oxygen species mediate dicumarol-induced cytotoxicity in cancer cells. J Biol Chem. 2006 Dec 08; 281(49):37416-26.
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van Muiswinkel FL, Riemers FM, Peters GJ, LaFleur MV, Siegel D, Jongenelen CA, Drukarch B. L-Dopa stimulates expression of the antioxidant enzyme NAD(P)H:quinone oxidoreductase (NQO) in cultured astroglial cells. Free Radic Biol Med. 2000 Sep 01; 29(5):442-53.
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Pink JJ, Planchon SM, Tagliarino C, Varnes ME, Siegel D, Boothman DA. NAD(P)H:Quinone oxidoreductase activity is the principal determinant of beta-lapachone cytotoxicity. J Biol Chem. 2000 Feb 25; 275(8):5416-24.
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Gustafson DL, Beall HD, Bolton EM, Ross D, Waldren CA. Expression of human NAD(P)H: quinone oxidoreductase (DT-diaphorase) in Chinese hamster ovary cells: effect on the toxicity of antitumor quinones. Mol Pharmacol. 1996 Oct; 50(4):728-35.
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Lee CS, Hartley JA, Berardini MD, Butler J, Siegel D, Ross D, Gibson NW. Alteration in DNA cross-linking and sequence selectivity of a series of aziridinylbenzoquinones after enzymatic reduction by DT-diaphorase. Biochemistry. 1992 Mar 24; 31(11):3019-25.
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Preusch PC, Siegel D, Gibson NW, Ross D. A note on the inhibition of DT-diaphorase by dicoumarol. Free Radic Biol Med. 1991; 11(1):77-80.
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Siegel D, Gibson NW, Preusch PC, Ross D. Metabolism of mitomycin C by DT-diaphorase: role in mitomycin C-induced DNA damage and cytotoxicity in human colon carcinoma cells. Cancer Res. 1990 Dec 01; 50(23):7483-9.
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