Clinical Trials Data Monitoring Committees
"Clinical Trials Data Monitoring Committees" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Committees established to review interim data and efficacy outcomes in clinical trials. The findings of these committees are used in deciding whether a trial should be continued as designed, changed, or terminated. Government regulations regarding federally-funded research involving human subjects (the "Common Rule") require (45 CFR 46.111) that research ethics committees reviewing large-scale clinical trials monitor the data collected using a mechanism such as a data monitoring committee. FDA regulations (21 CFR 50.24) require that such committees be established to monitor studies conducted in emergency settings.
Descriptor ID |
D026661
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MeSH Number(s) |
N05.700.685.149
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Concept/Terms |
Clinical Trials Data Monitoring Committees- Clinical Trials Data Monitoring Committees
- Data Monitoring Committees
- Committee, Data Monitoring
- Committees, Data Monitoring
- Data Monitoring Committee
- Monitoring Committee, Data
- Monitoring Committees, Data
- Safety Monitoring Boards
- Board, Safety Monitoring
- Boards, Safety Monitoring
- Monitoring Board, Safety
- Monitoring Boards, Safety
- Safety Monitoring Board
- Data and Safety Monitoring Boards
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Below are MeSH descriptors whose meaning is more general than "Clinical Trials Data Monitoring Committees".
Below are MeSH descriptors whose meaning is more specific than "Clinical Trials Data Monitoring Committees".
This graph shows the total number of publications written about "Clinical Trials Data Monitoring Committees" by people in this website by year, and whether "Clinical Trials Data Monitoring Committees" was a major or minor topic of these publications.
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Year | Major Topic | Minor Topic | Total |
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2009 | 0 | 1 | 1 | 2010 | 1 | 0 | 1 | 2014 | 0 | 1 | 1 | 2016 | 1 | 0 | 1 |
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Below are the most recent publications written about "Clinical Trials Data Monitoring Committees" by people in Profiles.
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Holbein B, Rape MT, Hammack BN, Melvin A, Reider C, Knox TA. Institutionally chartered Data and Safety Monitoring Boards: structured approaches to assuring participant safety in clinical research. J Investig Med. 2021 06; 69(5):1050-1055.
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Shavadia JS, Sharma A, Gu X, Neaton J, DeLeve L, Holmes D, Home P, Eckel RH, Watkins PB, Granger CB. Determination of fasiglifam-induced liver toxicity: Insights from the data monitoring committee of the fasiglifam clinical trials program. Clin Trials. 2019 06; 16(3):253-262.
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Bristow MR, Sharma K, Assmann SF, Linas S, Gersh BJ, Grady C, Rice MM, Singh S, Boineau R, McKinlay SM, Greenberg BH. Data and Safety Monitoring Board evaluation and management of a renal adverse event signal in TOPCAT. Eur J Heart Fail. 2017 04; 19(4):457-465.
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Hess CN, Roe MT, Gibson CM, Temple RJ, Pencina MJ, Zarin DA, Anstrom KJ, Alexander JH, Sherman RE, Fiedorek FT, Mahaffey KW, Lee KL, Chow SC, Armstrong PW, Califf RM. Independent data monitoring committees: preparing a path for the future. Am Heart J. 2014 Aug; 168(2):135-41.e1.
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Wetherill L, Kapoor M, Agrawal A, Bucholz K, Koller D, Bertelsen SE, Le N, Wang JC, Almasy L, Hesselbrock V, Kramer J, Nurnberger JI, Schuckit M, Tischfield JA, Xuei X, Porjesz B, Edenberg HJ, Goate AM, Foroud T. Family-based association analysis of alcohol dependence criteria and severity. Alcohol Clin Exp Res. 2014 Feb; 38(2):354-66.
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Goldenberg NA, Spyropoulos AC, Halperin JL, Kessler CM, Schulman S, Turpie AG, Skene AM, Cutler NR, Hiatt WR. Improving academic leadership and oversight in large industry-sponsored clinical trials: the ARO-CRO model. Blood. 2011 Feb 17; 117(7):2089-92.
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Carson P, Fiuzat M, O'Connor C, Anand I, Plehn J, Lindenfeld JA, Silver M, White M, Miller A, Davis G, Robertson AD, Bristow M, Gottlieb S. Determination of hospitalization type by investigator case report form or adjudication committee in a large heart failure clinical trial (?-Blocker Evaluation of Survival Trial [BEST]). Am Heart J. 2010 Oct; 160(4):649-54.
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Sangha R, Lara PN, Adjei AA, Baas P, Choy H, Gaspar LE, Goss G, Saijo N, Schiller JH, Vokes EE, Gandara DR. Cooperative group research endeavors in small-cell lung cancer: current and future directions. Clin Lung Cancer. 2009 Sep; 10(5):322-30.
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McDuffie R, Summerson J, Reilly P, Blackwell C, Goff D, Kimel AR, Crago L, Fonseca V. The Action to Control Cardiovascular Risk in Diabetes (ACCORD) Trial and Hurricane Katrina: lessons for managing clinical trials during and after a natural disaster. Contemp Clin Trials. 2008 Sep; 29(5):756-61.
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Emerson SS, Kittelson JM, Gillen DL. Frequentist evaluation of group sequential clinical trial designs. Stat Med. 2007 Dec 10; 26(28):5047-80.
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