 alpha-MSH
"alpha-MSH" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A 13-amino acid peptide derived from proteolytic cleavage of ADRENOCORTICOTROPIC HORMONE, the N-terminal segment of ACTH. ACTH (1-13) is amidated at the C-terminal to form ACTH (1-13)NH2 which in turn is acetylated to form alpha-MSH in the secretory granules. Alpha-MSH stimulates the synthesis and distribution of MELANIN in MELANOCYTES in mammals and MELANOPHORES in lower vertebrates.
| Descriptor ID |
D000521
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| MeSH Number(s) |
D06.472.699.327.935.179 D06.472.699.327.935.531.750.050 D06.472.699.631.525.600.179 D06.472.699.631.525.600.531.750.050 D12.644.400.400.935.179 D12.644.400.400.935.531.750.050 D12.644.400.460.050 D12.644.548.365.935.179 D12.644.548.365.935.531.750.050 D12.644.548.691.525.690.179 D12.644.548.691.525.690.531.750.050 D12.776.631.650.405.935.179 D12.776.631.650.405.935.531.750.050 D12.776.631.650.460.050
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| Concept/Terms |
alpha-MSH- alpha-MSH
- alpha MSH
- alpha-Melanotropin
- alpha Melanotropin
- Acetylated ACTH (1-13)NH2
- alpha-Melanocyte-Stimulating Hormone
- Hormone, alpha-Melanocyte-Stimulating
- alpha Melanocyte Stimulating Hormone
- MSH, alpha
ACTH (1-13)NH2- ACTH (1-13)NH2
- (Desacetyl)alpha-MSH
- DE-alpha-MSH
- MSH, (Desacetyl)alpha-
- Des-Acetyl MSH
- MSH, Des-Acetyl
- Desacetyl alpha-MSH
- Desacetyl alpha MSH
- alpha-MSH, Desacetyl
- Desacetyl alpha-Melanocyte-Stimulating Hormone
- Desacetyl alpha Melanocyte Stimulating Hormone
- Hormone, Desacetyl alpha-Melanocyte-Stimulating
- alpha-Melanocyte-Stimulating Hormone, Desacetyl
- (Des-Acetyl)-alpha-MSH
- Adrenocorticotropin (1-13)NH2
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Below are MeSH descriptors whose meaning is more general than "alpha-MSH".
Below are MeSH descriptors whose meaning is more specific than "alpha-MSH".
This graph shows the total number of publications written about "alpha-MSH" by people in this website by year, and whether "alpha-MSH" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1998 | 1 | 1 | 2 | | 2024 | 2 | 0 | 2 | | 2026 | 0 | 1 | 1 |
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Below are the most recent publications written about "alpha-MSH" by people in Profiles.
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Miller JL, van Santen HM, Phillips SA, Hamilton J, Aberle J, Sathyapalan T, Mohamed Z, McCormack SE, Shoemaker AH, Kelsey MM, Ghalib L, Stalla G, Thaker VV, Habiby R, Ode KL, Wabitsch M, Dattani M, Abuzzahab MJ, Abdullatif H, Morgan R, Stefater-Richards M, Aroda VR, Friedrich C, Han JC, Ono H, Nagasaki K, Tanaka T, Isojima T, Arima H, Scimia C, Yuan G, Müller HL, Roth CL. Setmelanotide for the Treatment of Acquired Hypothalamic Obesity. N Engl J Med. 2026 Jul 09; 395(2):138-150.
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Argente J, Verge CF, Okorie U, Fennoy I, Kelsey MM, Cokkinias C, Scimia C, Lee HM, Farooqi IS. Setmelanotide in patients aged 2-5 years with rare MC4R pathway-associated obesity (VENTURE): a 1 year, open-label, multicenter, phase 3 trial. Lancet Diabetes Endocrinol. 2025 01; 13(1):29-37.
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Qiao Z, Xu J, Gallazzi F, Fisher DR, Gonzalez R, Kwak J, Miao Y. Effect of Ibuprofen as an Albumin Binder on Melanoma-Targeting Properties of 177Lu-Labeled Ibuprofen-Conjugated Alpha-Melanocyte-Stimulating Hormone Peptides. Mol Pharm. 2024 08 05; 21(8):4004-4011.
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Qiao Z, Xu J, Gonzalez R, Miao Y. Effects of Polyethylene Glycol and 8-Aminooctanoic Acid Linkers on Melanoma Uptake of [99mTc]Tc-Tricarbonyl-NOTA-Conjugated Lactam-Cyclized a-MSH Peptides. Bioconjug Chem. 2023 05 17; 34(5):934-940.
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Qiao Z, Xu J, Gonzalez R, Miao Y. Novel 64Cu-Labeled NOTA-Conjugated Lactam-Cyclized Alpha-Melanocyte-Stimulating Hormone Peptides with Enhanced Tumor to Kidney Uptake Ratios. Mol Pharm. 2022 07 04; 19(7):2535-2541.
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Qiao Z, Xu J, Gonzalez R, Miao Y. Novel Al18F-NOTA-Conjugated Lactam-Cyclized a-Melanocyte-Stimulating Hormone Peptides with Enhanced Melanoma Uptake. Bioconjug Chem. 2022 05 18; 33(5):982-990.
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Xu J, Gallazzi F, Fisher DR, Gonzalez R, Miao Y. The Effect of Albumin-Binding Moiety on Tumor Targeting and Biodistribution Properties of 67Ga-Labeled Albumin Binder-Conjugated Alpha-Melanocyte-Stimulating Hormone Peptides. Cancer Biother Radiopharm. 2022 Feb; 37(1):47-55.
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Xu J, Qiao Z, Gonzalez R, Miao Y. Facile preparation of a novel Ga-67-labeled NODAGA-conjugated lactam-cyclized alpha-MSH peptide at room temperature for melanoma targeting. Bioorg Med Chem Lett. 2020 12 15; 30(24):127627.
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Qiao Z, Xu J, Gonzalez R, Miao Y. Novel [99mTc]-Tricarbonyl-NOTA-Conjugated Lactam-Cyclized Alpha-MSH Peptide with Enhanced Melanoma Uptake and Reduced Renal Uptake. Mol Pharm. 2020 09 08; 17(9):3581-3588.
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Xu J, Yang J, Gonzalez R, Fisher DR, Miao Y. Melanoma-Targeting Property of Y-90-Labeled Lactam-Cyclized a-Melanocyte-Stimulating Hormone Peptide. Cancer Biother Radiopharm. 2019 Nov; 34(9):597-603.
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