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																		 Muscle Hypotonia
 
																		 
																		
																	 
																		 
																		
																	 
																			
																					
	"Muscle Hypotonia" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, 
	MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, 
	which enables searching at various levels of specificity.
 
	
	
		
			
			
				A diminution of the skeletal muscle tone marked by a diminished resistance to passive stretching.
    
			 
				
				
					
						| Descriptor ID | D009123 |  
						| MeSH Number(s) | C10.597.613.575 C23.888.592.608.575 |  
						| Concept/Terms | Muscle HypotoniaMuscle HypotoniaHypotonia, MuscleDecreased Muscle ToneMuscle Tone, DecreasedMuscle Tone PoorTone Poor, MuscleHypotoniaHypotony, MuscleMuscle HypotonyMuscular HypotoniaHypotonia, MuscularHypomyotonia
 Neonatal HypotoniaNeonatal HypotoniaHypotonia, NeonatalHypotonias, NeonatalNeonatal Hypotonias
 Flaccid Muscle ToneFlaccid Muscle ToneMuscle Tone, FlaccidMuscular FlaccidityFlaccidity, MuscularMuscular FlacciditiesMuscle FlaccidityFlaccidity, Muscle
 Floppy MusclesFloppy MusclesFloppy MuscleMuscle, FloppyMuscles, Floppy
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				Below are MeSH descriptors whose meaning is more general than "Muscle Hypotonia". 
				Below are MeSH descriptors whose meaning is more specific than "Muscle Hypotonia". 
	
	
		
			
			
					
				This graph shows the total number of publications written about "Muscle Hypotonia" by people in this website by year, and whether "Muscle Hypotonia" was a major or minor topic of these publications.  
					  To see the data from this visualization as text, click here. 
		            | Year | Major Topic | Minor Topic | Total | 
|---|
 | 2003 | 1 | 0 | 1 |  | 2010 | 0 | 1 | 1 |  | 2012 | 0 | 1 | 1 |  | 2013 | 0 | 2 | 2 |  | 2015 | 3 | 1 | 4 |  | 2016 | 1 | 0 | 1 |  | 2017 | 1 | 1 | 2 |  | 2018 | 1 | 2 | 3 |  | 2019 | 0 | 3 | 3 |  | 2020 | 1 | 0 | 1 |  | 2021 | 0 | 3 | 3 |  | 2023 | 0 | 1 | 1 |  | 2024 | 0 | 1 | 1 |  | 2025 | 1 | 0 | 1 | 
 
                    To return to the timeline, click here. 
				Below are the most recent publications written about "Muscle Hypotonia" by people in Profiles. 		
					
								
								Ryan MV, Blasco S, Olson KE, Sawyer K, Oleszek J, Sundar S, LeBeau S, Wilkinson CC. Cyclic Hypertonia and Hypotonia Associated with Intrathecal Baclofen Pumps: Findings and Treatments. Pediatr Neurosurg. 2025; 60(3):51-63.
								Mullegama SV, Kiernan KA, Torti E, Pavlovsky E, Tilton N, Sekula A, Gao H, Alaimo JT, Engleman K, Rush ET, Blocker K, Dipple KM, Fettig VM, Hare H, Glass I, Grange DK, Griffin M, Phornphutkul C, Massingham L, Mehta L, Miller DE, Thies J, Merritt JL, Muller E, Osmond M, Sawyer SL, Slaugh R, Hickey RE, Wolf B, Choudhary S, Simonovic M, Zhang Y, Palculict TB, Telegrafi A, Carere DA, Wentzensen IM, Morrow MM, Monaghan KG, Yang J, Juusola J. De novo missense variants in exon 9 of SEPHS1 cause a neurodevelopmental condition with developmental delay, poor growth, hypotonia, and dysmorphic features. Am J Hum Genet. 2024 04 04; 111(4):778-790.
								Daniels C, Greene C, Smith L, Pestana-Knight E, Demarest S, Zhang B, Benke TA, Poduri A, Olson HE. CDKL5 deficiency disorder and other infantile-onset genetic epilepsies. Dev Med Child Neurol. 2024 Apr; 66(4):456-468.
								Petkova SP, Adhikari A, Berg EL, Fenton TA, Duis J, Silverman JL. Gait as a quantitative translational outcome measure in Angelman syndrome. Autism Res. 2022 05; 15(5):821-833.
								Kumble S, Levy AM, Punetha J, Gao H, Ah Mew N, Anyane-Yeboa K, Benke PJ, Berger SM, Bjerglund L, Campos-Xavier B, Ciliberto M, Cohen JS, Comi AM, Curry C, Damaj L, Denomm?-Pichon AS, Emrick L, Faivre L, Fasano MB, Fi?vet A, Finkel RS, Garc?a-Mi?a?r S, Gerard A, Gomez-Puertas P, Guillen Sacoto MJ, Hoffman TL, Howard L, Iglesias AD, Izumi K, Larson A, Leiber A, Lozano R, Marcos-Alcalde I, Mintz CS, Mullegama SV, M?ller RS, Odent S, Oppermann H, Ostergaard E, Pacio-M?guez M, Palomares-Bralo M, Parikh S, Paulson AM, Platzer K, Posey JE, Potocki L, Revah-Politi A, Rio M, Ritter AL, Robinson S, Rosenfeld JA, Santos-Simarro F, Sousa SB, W?ber M, Xie Y, Chung WK, Brown NJ, T?mer Z. The clinical and molecular spectrum of QRICH1 associated neurodevelopmental disorder. Hum Mutat. 2022 02; 43(2):266-282.
								Schirwani S, Albaba S, Carere DA, Guillen Sacoto MJ, Milan Zamora F, Si Y, Rabin R, Pappas J, Renaud DL, Hauser N, Reid E, Blanchet P, Foulds N, Dixit A, Fisher R, Armstrong R, Isidor B, Cogne B, Schrier Vergano S, Demirdas S, Dykzeul N, Cohen JS, Grand K, Morel D, Slavotinek A, Albassam HF, Naik S, Dean J, Ragge N, Costa C, Tedesco MG, Harrison RE, Bouman A, Palen E, Challman TD, Willemsen MH, Vogt J, Cunniff C, Bergstrom K, Walia JS, Bruel AL, Kini U, Alkuraya FS, Slegesky V, Meeks N, Girotto P, Johnson D, Newbury-Ecob R, Ockeloen CW, Prontera P, Lynch SA, Li D, Graham JM, Pierson TM, Balasubramanian M. Expanding the phenotype of ASXL3-related syndrome: A comprehensive description of 45 unpublished individuals with inherited and de novo pathogenic variants in ASXL3. Am J Med Genet A. 2021 11; 185(11):3446-3458.
								Muir AM, Gardner JF, van Jaarsveld RH, de Lange IM, van der Smagt JJ, Wilson GN, Dubbs H, Goldberg EM, Zitano L, Bupp C, Martinez J, Srour M, Accogli A, Alhakeem A, Meltzer M, Gropman A, Brewer C, Caswell RC, Montgomery T, McKenna C, McKee S, Powell C, Vasudevan PC, Brady AF, Joss S, Tysoe C, Noh G, Tarnopolsky M, Brady L, Zafar M, Schrier Vergano SA, Murray B, Sawyer L, Hainline BE, Sapp K, DeMarzo D, Huismann DJ, Wentzensen IM, Schnur RE, Monaghan KG, Juusola J, Rhodes L, Dobyns WB, Lecoquierre F, Goldenberg A, Polster T, Axer-Schaefer S, Platzer K, Klöckner C, Hoffman TL, MacArthur DG, O'Leary MC, VanNoy GE, England E, Varghese VC, Mefford HC. Variants in GNAI1 cause a syndrome associated with variable features including developmental delay, seizures, and hypotonia. Genet Med. 2021 05; 23(5):881-887.
								Murphy OC, Messacar K, Benson L, Bove R, Carpenter JL, Crawford T, Dean J, DeBiasi R, Desai J, Elrick MJ, Farias-Moeller R, Gombolay GY, Greenberg B, Harmelink M, Hong S, Hopkins SE, Oleszek J, Otten C, Sadowsky CL, Schreiner TL, Thakur KT, Van Haren K, Carballo CM, Chong PF, Fall A, Gowda VK, Helfferich J, Kira R, Lim M, Lopez EL, Wells EM, Yeh EA, Pardo CA. Acute flaccid myelitis: cause, diagnosis, and management. Lancet. 2021 01 23; 397(10271):334-346.
								Ramirez N, Olivella G, Rodriguez O, Marrero P, Smith J, Garg S, Vitale M, St Hilaire T, Betz R. Incidence of complications in the management of non-ambulatory neuromuscular early-onset scoliosis with a rib-based growing system: high- versus low-tone patients. Eur J Orthop Surg Traumatol. 2020 May; 30(4):621-627.
								Beck DB, Subramanian T, Vijayalingam S, Ezekiel UR, Donkervoort S, Yang ML, Dubbs HA, Ortiz-Gonzalez XR, Lakhani S, Segal D, Au M, Graham JM, Verma S, Waggoner D, Shinawi M, B?nnemann CG, Chung WK, Chinnadurai G. A pathogenic CtBP1 missense mutation causes altered cofactor binding and transcriptional activity. Neurogenetics. 2019 08; 20(3):129-143. | 
																	
																		
																			
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