 Primaquine
"Primaquine" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An aminoquinoline that is given by mouth to produce a radical cure and prevent relapse of vivax and ovale malarias following treatment with a blood schizontocide. It has also been used to prevent transmission of falciparum malaria by those returning to areas where there is a potential for re-introduction of malaria. Adverse effects include anemias and GI disturbances. (From Martindale, The Extra Pharmacopeia, 30th ed, p404)
| Descriptor ID |
D011319
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| MeSH Number(s) |
D03.633.100.810.050.650
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Primaquine".
Below are MeSH descriptors whose meaning is more specific than "Primaquine".
This graph shows the total number of publications written about "Primaquine" by people in this website by year, and whether "Primaquine" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2004 | 0 | 1 | 1 |
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Below are the most recent publications written about "Primaquine" by people in Profiles.
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Flaherty S, Strauch P, Maktabi M, Pybus BS, Reichard G, Walker LA, Rochford R. Mechanisms of 8-aminoquinoline induced haemolytic toxicity in a G6PDd humanized mouse model. J Cell Mol Med. 2022 07; 26(13):3675-3686.
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Srinivasan S, Roy D, Chavas TEJ, Vlaskin V, Ho DK, Pottenger A, LeGuyader CLM, Maktabi M, Strauch P, Jackson C, Flaherty SM, Lin H, Zhang J, Pybus B, Li Q, Huber HE, Burke PA, Wesche D, Rochford R, Stayton PS. Liver-targeted polymeric prodrugs of 8-aminoquinolines for malaria radical cure. J Control Release. 2021 03 10; 331:213-227.
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Wickham KS, Baresel PC, Marcsisin SR, Sousa J, Vuong CT, Reichard GA, Campo B, Tekwani BL, Walker LA, Rochford R. Single-Dose Primaquine in a Preclinical Model of Glucose-6-Phosphate Dehydrogenase Deficiency: Implications for Use in Malaria Transmission-Blocking Programs. Antimicrob Agents Chemother. 2016 10; 60(10):5906-13.
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Nanayakkara NP, Tekwani BL, Herath HM, Sahu R, Gettayacamin M, Tungtaeng A, van Gessel Y, Baresel P, Wickham KS, Bartlett MS, Fronczek FR, Melendez V, Ohrt C, Reichard GA, McChesney JD, Rochford R, Walker LA. Scalable preparation and differential pharmacologic and toxicologic profiles of primaquine enantiomers. Antimicrob Agents Chemother. 2014 Aug; 58(8):4737-44.
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Rochford R, Ohrt C, Baresel PC, Campo B, Sampath A, Magill AJ, Tekwani BL, Walker LA. Humanized mouse model of glucose 6-phosphate dehydrogenase deficiency for in vivo assessment of hemolytic toxicity. Proc Natl Acad Sci U S A. 2013 Oct 22; 110(43):17486-91.
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Rifakis PM, Hernandez O, Fern?ndez CT, Rodriguez-Morales AJ, Von A, Franco-Paredes C. Atypical Plasmodium vivax malaria in a traveler: bilateral hydronephrosis, severe thrombocytopenia, and hypotension. J Travel Med. 2008 Mar-Apr; 15(2):119-21.
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Kwiek JJ, Haystead TA, Rudolph J. Kinetic mechanism of quinone oxidoreductase 2 and its inhibition by the antimalarial quinolines. Biochemistry. 2004 Apr 20; 43(15):4538-47.
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Strous GJ, van Kerkhof P, van Bokhoven A, Schwartz AL, de Pont JJ. Effect of primaquine on the topology of Na,K-ATPase and the receptor for asialoglycoproteins. Prog Clin Biol Res. 1988; 268B:437-42.
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