Evaluation of chemical degradation of a trivalent recombinant protein vaccine against botulinum neurotoxin by LysC peptide mapping and MALDI-TOF mass spectrometry.

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Evaluation of chemical degradation of a trivalent recombinant protein vaccine against botulinum neurotoxin by LysC peptide mapping and MALDI-TOF mass spectrometry.

Estey T, Vessely C, Randolph TW, Henderson I, Braun LJ, Nayar R, Carpenter JF. Evaluation of chemical degradation of a trivalent recombinant protein vaccine against botulinum neurotoxin by LysC peptide mapping and MALDI-TOF mass spectrometry. J Pharm Sci. 2009 Sep; 98(9):2994-3012.

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subject areas

Adjuvants, Immunologic
Amino Acid Sequence
Bacterial Vaccines
Botulinum Toxins
Molecular Sequence Data
Oxidation-Reduction
Protein Binding
Protein Stability
Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
Vaccines, Synthetic

authors with profiles

Theodore W Randolph

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