Colorado PROFILES, The Colorado Clinical and Translational Sciences Institute (CCTSI)
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Dawid S Zyla

TitleAssistant Professor
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM-BioChem&Molecular Genetics

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Acciani M, Zyla D, Niemeyer G, Harkins S, Parekh D, Pawlack E, Lacarbonara D, Kansara D, Ackerman ME, Niewiesk S, Porotto M, Hastie KM, Saphire EO. Human neutralizing antibodies targeting the measles virus hemagglutinin and fusion surface proteins. Cell Host Microbe. 2026 Jun 10; 34(6):1067-1081.e12. PMID: 42102820.
      View in: PubMed
    2. Zyla DS, Della Marca R, Lacarbonara D, Niemeyer G, Zipursky G, Di Clemente L, Verbruggen MHL, van Dijk LLA, Ceh OM, Jonathan-Trakht G, Kalantarov G, Acciani M, Laterza G, Vyshenska D, Leedale C, Pawlack E, Hastie KM, Horvat B, de Swart RL, de Vries RD, Greninger AL, Niewiesk S, Ollmann Saphire E, Porotto M. Structural and mechanistic basis for antibody neutralization of the measles fusion protein. Nat Commun. 2026 Apr 06; 17(1). PMID: 41942450.
      View in: PubMed
    3. Callaway HM, Zyla DS, Hastie KM, Harkins SS, Kothalawalage S, Samarasinghe N, Flynn A, Hariharan C, Yin J, Corti D, Bourhy H, Dessain SK, Saphire EO. Antigenic landscape of rabies and related lyssaviruses revealed by cryo-EM. bioRxiv. 2026 Jan 14. PMID: 41648591.
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    4. Zyla DS, Zipursky G, Marca RD, Lacarbonara D, Niemeyer G, Peng W, Predella C, Stearns K, Leedale C, Miller J, Tay D, Kao J, Acciani M, Di Clemente L, Das A, Parekh D, Avalos RD, McGill G, Dorrello NV, Hastie KM, Alabi CA, Snijder J, Moscona A, Greninger AL, Niewiesk S, Saphire EO, Porotto M. Stabilized Full-Length Measles Fusion Protein Elicits Potent Immunity and Protection In Vivo. bioRxiv. 2025 Oct 09. PMID: 41278811.
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    5. Zyla DS, Della Marca R, Lacarbonara D, Niemeyer G, Zipursky G, Di Clemente L, Jonathan-Trakht G, Kalantarov G, Acciani M, Laterza G, Vyshenska D, Hastie KM, Horvat B, Greninger AL, Niewiesk S, Saphire EO, Porotto M. Structural and Mechanistic Basis for Antibody Neutralization of the Measles Fusion Protein. bioRxiv. 2025 Sep 16. PMID: 41000703.
      View in: PubMed
    6. Acciani M, Zyla D, Niemeyer G, Harkins S, Parekh D, Pawlack E, LaCarbonara D, Niewiesk S, Porotto M, Hastie KM, Saphire EO. Uncovering the features of Measles-targeting human antibodies elicited by the MMR vaccine. bioRxiv. 2025 Sep 15. PMID: 41000712.
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    7. Shek J, Sun C, Wilson EM, Moadab F, Hastie KM, Rajamanickam RR, Penalosa PJ, Harkins SS, Parekh D, Hariharan C, Zyla DS, Yu C, Shaffer KCL, Lewis VI, Avalos RD, Mustelin T, Saphire EO. Human endogenous retrovirus K (HERV-K) envelope structures in pre- and postfusion by cryo-EM. Sci Adv. 2025 Aug 29; 11(35):eady8168. PMID: 40864726.
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    8. Olmedillas E, Rajamanickam RR, Avalos RD, Ana-Sosa-Batiz F, Zyla D, Zandonatti MA, Harkins SS, Shresta S, Hastie KM, Saphire EO. Structure of a SARS-CoV-2 spike S2 subunit in a pre-fusion, open conformation. Cell Rep. 2025 Aug 26; 44(8):116052. PMID: 40705599.
      View in: PubMed
    9. Zyla DS. How herpes is assembled. Elife. 2025 Mar 17; 14. PMID: 40094284.
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    10. Watanabe R, Zyla D, Parekh D, Hong C, Jones Y, Schendel SL, Wan W, Castillon G, Saphire EO. Intracellular Ebola virus nucleocapsid assembly revealed by in situ cryo-electron tomography. Cell. 2024 Oct 03; 187(20):5587-5603.e19. PMID: 39293445.
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    11. Zyla DS, Della Marca R, Niemeyer G, Zipursky G, Stearns K, Leedale C, Sobolik EB, Callaway HM, Hariharan C, Peng W, Parekh D, Marcink TC, Diaz Avalos R, Horvat B, Mathieu C, Snijder J, Greninger AL, Hastie KM, Niewiesk S, Moscona A, Porotto M, Saphire EO. A neutralizing antibody prevents postfusion transition of measles virus fusion protein. Science. 2024 06 28; 384(6703):eadm8693. PMID: 38935733.
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    12. Zyla DS, Wiegand T, Bachmann P, Zdanowicz R, Giese C, Meier BH, Waksman G, Hospenthal MK, Glockshuber R. The assembly platform FimD is required to obtain the most stable quaternary structure of type 1 pili. Nat Commun. 2024 Apr 08; 15(1):3032. PMID: 38589417.
      View in: PubMed
    13. Hastie KM, Yu X, Ana-Sosa-Batiz F, Zyla DS, Harkins SS, Hariharan C, Wasserman H, Zandonatti MA, Miller R, Maule E, Kim K, Valentine KM, Shresta S, Saphire EO. Potent Omicron-neutralizing antibodies isolated from a patient vaccinated 6 months before Omicron emergence. Cell Rep. 2023 05 30; 42(5):112421. PMID: 37083327.
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    14. Moon-Walker A, Zhang Z, Zyla DS, Buck TK, Li H, Diaz Avalos R, Schendel SL, Hastie KM, Crotty S, Saphire EO. Structural basis for antibody-mediated neutralization of lymphocytic choriomeningitis virus. Cell Chem Biol. 2023 04 20; 30(4):403-411.e4. PMID: 36990092.
      View in: PubMed
    15. Li H, Buck T, Zandonatti M, Yin J, Moon-Walker A, Fang J, Koval A, Heinrich ML, Rowland MM, Diaz Avalos R, Schendel SL, Parekh D, Zyla D, Enriquez A, Harkins S, Sullivan B, Smith V, Chukwudozie O, Watanabe R, Robinson JE, Garry RF, Branco LM, Hastie KM, Saphire EO. A cocktail of protective antibodies subverts the dense glycan shield of Lassa virus. Sci Transl Med. 2022 10 26; 14(668):eabq0991. PMID: 36288283.
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    16. Callaway HM, Zyla D, Larrous F, de Melo GD, Hastie KM, Avalos RD, Agarwal A, Corti D, Bourhy H, Saphire EO. Structure of the rabies virus glycoprotein trimer bound to a prefusion-specific neutralizing antibody. Sci Adv. 2022 Jun 17; 8(24):eabp9151. PMID: 35714192.
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    17. Hastie KM, Li H, Bedinger D, Schendel SL, Dennison SM, Li K, Rayaprolu V, Yu X, Mann C, Zandonatti M, Diaz Avalos R, Zyla D, Buck T, Hui S, Shaffer K, Hariharan C, Yin J, Olmedillas E, Enriquez A, Parekh D, Abraha M, Feeney E, Horn GQ, Aldon Y, Ali H, Aracic S, Cobb RR, Federman RS, Fernandez JM, Glanville J, Green R, Grigoryan G, Lujan Hernandez AG, Ho DD, Huang KA, Ingraham J, Jiang W, Kellam P, Kim C, Kim M, Kim HM, Kong C, Krebs SJ, Lan F, Lang G, Lee S, Leung CL, Liu J, Lu Y, MacCamy A, McGuire AT, Palser AL, Rabbitts TH, Rikhtegaran Tehrani Z, Sajadi MM, Sanders RW, Sato AK, Schweizer L, Seo J, Shen B, Snitselaar JL, Stamatatos L, Tan Y, Tomic MT, van Gils MJ, Youssef S, Yu J, Yuan TZ, Zhang Q, Peters B, Tomaras GD, Germann T, Saphire EO. Defining variant-resistant epitopes targeted by SARS-CoV-2 antibodies: A global consortium study. Science. 2021 Oct 22; 374(6566):472-478. PMID: 34554826.
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    18. Callon M, Malär AA, Pfister S, Rímal V, Weber ME, Wiegand T, Zehnder J, Chávez M, Cadalbert R, Deb R, Däpp A, Fogeron ML, Hunkeler A, Lecoq L, Torosyan A, Zyla D, Glockshuber R, Jonas S, Nassal M, Ernst M, Böckmann A, Meier BH. Biomolecular solid-state NMR spectroscopy at 1200 MHz: the gain in resolution. J Biomol NMR. 2021 Jul; 75(6-7):255-272. PMID: 34170475.
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    19. Kuster A, Mozaffari NL, Wilkinson OJ, Wojtaszek JL, Zurfluh C, Przetocka S, Zyla D, von Aesch C, Dillingham MS, Williams RS, Sartori AA. A stapled peptide mimetic of the CtIP tetramerization motif interferes with double-strand break repair and replication fork protection. Sci Adv. 2021 02; 7(8). PMID: 33608267.
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    20. Lee C, Betschinger P, Wu K, Zyla DS, Glockshuber R, Bardwell JC. A metabolite binding protein moonlights as a bile-responsive chaperone. EMBO J. 2020 10 15; 39(20):e104231. PMID: 32882062.
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    21. Stanisich JJ, Zyla DS, Afanasyev P, Xu J, Kipp A, Olinger E, Devuyst O, Pilhofer M, Boehringer D, Glockshuber R. The cryo-EM structure of the human uromodulin filament core reveals a unique assembly mechanism. Elife. 2020 08 20; 9. PMID: 32815518.
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    22. Zyla D, Echeverria B, Glockshuber R. Donor strand sequence, rather than donor strand orientation, determines the stability and non-equilibrium folding of the type 1 pilus subunit FimA. J Biol Chem. 2020 08 28; 295(35):12437-12448. PMID: 32651228.
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    23. Weiss GL, Stanisich JJ, Sauer MM, Lin CW, Eras J, Zyla DS, Trück J, Devuyst O, Aebi M, Pilhofer M, Glockshuber R. Architecture and function of human uromodulin filaments in urinary tract infections. Science. 2020 08 21; 369(6506):1005-1010. PMID: 32616672.
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    24. Zyla DS, Prota AE, Capitani G, Glockshuber R. Alternative folding to a monomer or homopolymer is a common feature of the type 1 pilus subunit FimA from enteroinvasive bacteria. J Biol Chem. 2019 07 05; 294(27):10553-10563. PMID: 31126987.
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    25. Hospenthal MK, Zyla D, Costa TRD, Redzej A, Giese C, Lillington J, Glockshuber R, Waksman G. The Cryoelectron Microscopy Structure of the Type 1 Chaperone-Usher Pilus Rod. Structure. 2017 12 05; 25(12):1829-1838.e4. PMID: 29129382.
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