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SPP1hi macrophages in fibrin niches promote hyperplastic tissue remodeling in rheumatoid arthritis synovium.

Mantel I, Zhang H, Vargas J, Ce G, Townsend H, Bell R, Lakhanpal A, Fein MR, Norman TM, Orange DE, Ramirez DC, DiCarlo EF, Goodman SM, Smith MH, Zhang F, Wei K, Dey KK, Rudensky AY, Leslie CS, Donlin LT. SPP1hi macrophages in fibrin niches promote hyperplastic tissue remodeling in rheumatoid arthritis synovium. Sci Transl Med. 2026 Jun 24; 18(855):eaed3087.

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