Colorado PROFILES, The Colorado Clinical and Translational Sciences Institute (CCTSI)
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Heather Fairfield

TitleInstructor
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM-PEDS

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Murphy CS, Fairfield H, DeMambro VE, Fadel S, Gartner CA, Karam M, Potts C, Rodriguez P, Qiang YW, Hamidi H, Guan X, Vary CPH, Reagan MR. Inhibition of acyl-CoA synthetase long-chain isozymes decreases multiple myeloma cell proliferation and causes mitochondrial dysfunction. Mol Oncol. 2025 Jun; 19(6):1687-1706. PMID: 39853696.
      View in: PubMed
    2. Fairfield H, Karam M, Schimelman A, Qiang YW, Reagan MR. Adipocytes and metabolism: Contributions to multiple myeloma. J Bone Oncol. 2024 Jun; 46:100609. PMID: 38872708.
      View in: PubMed
    3. Murphy CS, DeMambro VE, Fadel S, Fairfield H, Garter CA, Rodriguez P, Qiang YW, Vary CPH, Reagan MR. Inhibition of Acyl-CoA Synthetase Long Chain Isozymes Decreases Multiple Myeloma Cell Proliferation and Causes Mitochondrial Dysfunction. bioRxiv. 2024 Mar 14. PMID: 38559245.
      View in: PubMed
    4. Fairfield H, Reagan MR. The hope for targeting fatty acid binding proteins in multiple myeloma. Oncotarget. 2023 06 19; 14:612-613. PMID: 37335289.
      View in: PubMed
    5. Farrell M, Fairfield H, Karam M, D'Amico A, Murphy CS, Falank C, Pistofidi RS, Cao A, Marinac CR, Dragon JA, McGuinness L, Gartner CG, Iorio RD, Jachimowicz E, DeMambro V, Vary C, Reagan MR. Targeting the fatty acid binding proteins disrupts multiple myeloma cell cycle progression and MYC signaling. Elife. 2023 03 07; 12. PMID: 36880649.
      View in: PubMed
    6. Marques-Mourlet C, Di Iorio R, Fairfield H, Reagan MR. Obesity and myeloma: Clinical and mechanistic contributions to disease progression. Front Endocrinol (Lausanne). 2023; 14:1118691. PMID: 36909335.
      View in: PubMed
    7. Fairfield H, Condruti R, Farrell M, Di Iorio R, Gartner CA, Vary C, Reagan MR. Development and characterization of three cell culture systems to investigate the relationship between primary bone marrow adipocytes and myeloma cells. Front Oncol. 2022; 12:912834. PMID: 36713534.
      View in: PubMed
    8. Sundberg JP, Galantino-Homer H, Fairfield H, Ward-Bailey PF, Harris BS, Berry M, Pratt CH, Gott NE, Bechtold LS, Kaplan PR, Durbin-Johnson BP, Rocke DM, Rice RH. Witch Nails (Krt90whnl): A spontaneous mouse mutation affecting nail growth and development. PLoS One. 2022; 17(11):e0277284. PMID: 36374931.
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    9. Jafari A, Fairfield H, Andersen TL, Reagan MR. Myeloma-bone marrow adipocyte axis in tumour survival and treatment response. Br J Cancer. 2021 09; 125(6):775-777. PMID: 33859343.
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    10. Costa S, Fairfield H, Farrell M, Murphy CS, Soucy A, Vary C, Holdsworth G, Reagan MR. Sclerostin antibody increases trabecular bone and bone mechanical properties by increasing osteoblast activity damaged by whole-body irradiation in mice. Bone. 2021 06; 147:115918. PMID: 33737193.
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    11. Fairfield H, Costa S, Falank C, Farrell M, Murphy CS, D'Amico A, Driscoll H, Reagan MR. Multiple Myeloma Cells Alter Adipogenesis, Increase Senescence-Related and Inflammatory Gene Transcript Expression, and Alter Metabolism in Preadipocytes. Front Oncol. 2020; 10:584683. PMID: 33680918.
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    12. Reagan MR, Fairfield H, Rosen CJ. Bone Marrow Adipocytes: A Link between Obesity and Bone Cancer. Cancers (Basel). 2021 Jan 20; 13(3). PMID: 33498240.
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    13. Fairfield H, Dudakovic A, Khatib CM, Farrell M, Costa S, Falank C, Hinge M, Murphy CS, DeMambro V, Pettitt JA, Lary CW, Driscoll HE, McDonald MM, Kassem M, Rosen C, Andersen TL, van Wijnen AJ, Jafari A, Reagan MR. Myeloma-Modified Adipocytes Exhibit Metabolic Dysfunction and a Senescence-Associated Secretory Phenotype. Cancer Res. 2021 02 01; 81(3):634-647. PMID: 33218968.
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    14. Fairfield H, Costa S, DeMambro V, Schott C, Martins JDS, Ferron M, Vary C, Reagan MR. Targeting Bone Cells During Sexual Maturation Reveals Sexually Dimorphic Regulation of Endochondral Ossification. JBMR Plus. 2020 Nov; 4(11):e10413. PMID: 33210065.
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    15. Farrell M, Fairfield H, Costa S, D'Amico A, Falank C, Brooks DJ, Reagan MR. Sclerostin-Neutralizing Antibody Treatment Rescues Negative Effects of Rosiglitazone on Mouse Bone Parameters. J Bone Miner Res. 2021 01; 36(1):158-169. PMID: 32845528.
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    16. Sarkar S, Chauhan SKS, Daly J, Natoni A, Fairfield H, Henderson R, Nolan E, Swan D, Hu J, Reagan MR, O'Dwyer M. The CD38low natural killer cell line KHYG1 transiently expressing CD16F158V in combination with daratumumab targets multiple myeloma cells with minimal effector NK cell fratricide. Cancer Immunol Immunother. 2020 Mar; 69(3):421-434. PMID: 31919623.
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    17. Sharma M, Srivastava A, Fairfield HE, Bergstrom D, Flynn WF, Braun RE. Identification of EOMES-expressing spermatogonial stem cells and their regulation by PLZF. Elife. 2019 05 31; 8. PMID: 31149899.
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    18. Costa S, Fairfield H, Reagan MR. Inverse correlation between trabecular bone volume and bone marrow adipose tissue in rats treated with osteoanabolic agents. Bone. 2019 06; 123:211-223. PMID: 30954729.
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    19. Fairfield H, Falank C, Farrell M, Vary C, Boucher JM, Driscoll H, Liaw L, Rosen CJ, Reagan MR. Development of a 3D bone marrow adipose tissue model. Bone. 2019 01; 118:77-88. PMID: 29366838.
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    20. Falank C, Fairfield H, Reagan MR. Reflections on Cancer in the Bone Marrow: Adverse Roles of Adipocytes. Curr Mol Biol Rep. 2017 Dec; 3(4):254-262. PMID: 29399440.
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    21. Bornstein S, Moschetta M, Kawano Y, Sacco A, Huynh D, Brooks D, Manier S, Fairfield H, Falank C, Roccaro AM, Nagano K, Baron R, Bouxein M, Vary C, Ghobrial IM, Rosen CJ, Reagan MR. Metformin Affects Cortical Bone Mass and Marrow Adiposity in Diet-Induced Obesity in Male Mice. Endocrinology. 2017 10 01; 158(10):3369-3385. PMID: 28977604.
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    22. Jenks MZ, Fairfield HE, Johnson EC, Morrison RF, Muday GK. Sex Steroid Hormones Regulate Leptin Transcript Accumulation and Protein Secretion in 3T3-L1 Cells. Sci Rep. 2017 08 15; 7(1):8232. PMID: 28811502.
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    23. Sitarski AM, Fairfield H, Falank C, Reagan MR. 3d Tissue Engineered In Vitro Models Of Cancer In Bone. ACS Biomater Sci Eng. 2018 Feb 12; 4(2):324-336. PMID: 29756030.
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    24. Fairfield H, Falank C, Harris E, Demambro V, McDonald M, Pettitt JA, Mohanty ST, Croucher P, Kramer I, Kneissel M, Rosen CJ, Reagan MR. The skeletal cell-derived molecule sclerostin drives bone marrow adipogenesis. J Cell Physiol. 2018 Feb; 233(2):1156-1167. PMID: 28460416.
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    25. McDonald MM, Reagan MR, Youlten SE, Mohanty ST, Seckinger A, Terry RL, Pettitt JA, Simic MK, Cheng TL, Morse A, Le LMT, Abi-Hanna D, Kramer I, Falank C, Fairfield H, Ghobrial IM, Baldock PA, Little DG, Kneissel M, Vanderkerken K, Bassett JHD, Williams GR, Oyajobi BO, Hose D, Phan TG, Croucher PI. Inhibiting the osteocyte-specific protein sclerostin increases bone mass and fracture resistance in multiple myeloma. Blood. 2017 06 29; 129(26):3452-3464. PMID: 28515094.
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    26. Fairfield H, Rosen CJ, Reagan MR. Connecting Bone and Fat: The Potential Role for Sclerostin. Curr Mol Biol Rep. 2017 Jun; 3(2):114-121. PMID: 28580233.
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    27. Dadwal U, Falank C, Fairfield H, Linehan S, Rosen CJ, Kaplan DL, Sterling J, Reagan MR. Tissue-engineered 3D cancer-in-bone modeling: silk and PUR protocols. Bonekey Rep. 2016; 5:842. PMID: 27790370.
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    28. McDonald MM, Fairfield H, Falank C, Reagan MR. Adipose, Bone, and Myeloma: Contributions from the Microenvironment. Calcif Tissue Int. 2017 05; 100(5):433-448. PMID: 27343063.
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    29. Falank C, Fairfield H, Reagan MR. Signaling Interplay between Bone Marrow Adipose Tissue and Multiple Myeloma cells. Front Endocrinol (Lausanne). 2016; 7:67. PMID: 27379019.
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    30. Tomberg K, Khoriaty R, Westrick RJ, Fairfield HE, Reinholdt LG, Brodsky GL, Davizon-Castillo P, Ginsburg D, Di Paola J. Spontaneous 8bp Deletion in Nbeal2 Recapitulates the Gray Platelet Syndrome in Mice. PLoS One. 2016; 11(3):e0150852. PMID: 26950939.
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    31. Pratt CH, Dionne LA, Fairfield H, Dadras SS, Potter CS, Sundberg JP. Gnaq(M1J): An ENU-Induced Mutant Allele Affecting Pigmentation in the Mouse. J Invest Dermatol. 2016 Jan; 136(1):334-336. PMID: 26763459.
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    32. Fairfield H, Falank C, Avery L, Reagan MR. Multiple myeloma in the marrow: pathogenesis and treatments. Ann N Y Acad Sci. 2016 Jan; 1364:32-51. PMID: 27002787.
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    33. Palmer K, Fairfield H, Borgeia S, Curtain M, Hassan MG, Dionne L, Yong Karst S, Coombs H, Bronson RT, Reinholdt LG, Bergstrom DE, Donahue LR, Cox TC, Murray SA. Discovery and characterization of spontaneous mouse models of craniofacial dysmorphology. Dev Biol. 2016 07 15; 415(2):216-227. PMID: 26234751.
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    34. Fairfield H, Srivastava A, Ananda G, Liu R, Kircher M, Lakshminarayana A, Harris BS, Karst SY, Dionne LA, Kane CC, Curtain M, Berry ML, Ward-Bailey PF, Greenstein I, Byers C, Czechanski A, Sharp J, Palmer K, Gudis P, Martin W, Tadenev A, Bogdanik L, Pratt CH, Chang B, Schroeder DG, Cox GA, Cliften P, Milbrandt J, Murray S, Burgess R, Bergstrom DE, Donahue LR, Hamamy H, Masri A, Santoni FA, Makrythanasis P, Antonarakis SE, Shendure J, Reinholdt LG. Exome sequencing reveals pathogenic mutations in 91 strains of mice with Mendelian disorders. Genome Res. 2015 Jul; 25(7):948-57. PMID: 25917818.
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    35. Davisson MT, Cook SA, Akeson EC, Liu D, Heffner C, Gudis P, Fairfield H, Murray SA. Kidney adysplasia and variable hydronephrosis, a new mutation affecting the odd-skipped related 1 gene in the mouse, causes variable defects in kidney development and hydronephrosis. Am J Physiol Renal Physiol. 2015 Jun 15; 308(12):F1335-42. PMID: 25834070.
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    36. Herbert Pratt C, Potter CS, Fairfield H, Reinholdt LG, Bergstrom DE, Harris BS, Greenstein I, Dadras SS, Liang BT, Schofield PN, Sundberg JP. Dsp rul: a spontaneous mouse mutation in desmoplakin as a model of Carvajal-Huerta syndrome. Exp Mol Pathol. 2015 Apr; 98(2):164-72. PMID: 25659760.
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    37. Li Q, Pratt CH, Dionne LA, Fairfield H, Karst SY, Sundberg JP, Uitto J. Spontaneous asj-2J mutant mouse as a model for generalized arterial calcification of infancy: a large deletion/insertion mutation in the Enpp1 gene. PLoS One. 2014; 9(12):e113542. PMID: 25479107.
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    38. Akiyama K, Noguchi J, Hirose M, Kajita S, Katayama K, Khalaj M, Tsuji T, Fairfield H, Byers C, Reinholdt L, Ogura A, Kunieda T. A mutation in the nuclear pore complex gene Tmem48 causes gametogenesis defects in skeletal fusions with sterility (sks) mice. J Biol Chem. 2013 Nov 01; 288(44):31830-41. PMID: 24045954.
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    39. Fairfield H, Gilbert GJ, Barter M, Corrigan RR, Curtain M, Ding Y, D'Ascenzo M, Gerhardt DJ, He C, Huang W, Richmond T, Rowe L, Probst FJ, Bergstrom DE, Murray SA, Bult C, Richardson J, Kile BT, Gut I, Hager J, Sigurdsson S, Mauceli E, Di Palma F, Lindblad-Toh K, Cunningham ML, Cox TC, Justice MJ, Spector MS, Lowe SW, Albert T, Donahue LR, Jeddeloh J, Shendure J, Reinholdt LG. Mutation discovery in mice by whole exome sequencing. Genome Biol. 2011 Sep 14; 12(9):R86. PMID: 21917142.
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    40. Flaherty JP, Fairfield HE, Spruce CA, McCarty CM, Bergstrom DE. Molecular characterization of an allelic series of mutations in the mouse Nox3 gene. Mamm Genome. 2011 Apr; 22(3-4):156-69. PMID: 21161235.
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    41. Flaherty JP, Spruce CA, Fairfield HE, Bergstrom DE. Generation of a conditional null allele of NADPH oxidase activator 1 (NOXA1). Genesis. 2010 Sep; 48(9):568-75. PMID: 20645308.
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    42. Morabito JE, Trott JF, Korz DM, Fairfield HE, Buck SH, Hovey RC. A 5' distal palindrome within the mouse mammary tumor virus-long terminal repeat recruits a mammary gland-specific complex and is required for a synergistic response to progesterone plus prolactin. J Mol Endocrinol. 2008 Aug; 41(2):75-90. PMID: 18524869.
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