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Patricia Ernst

InstitutionUniversity of Colorado Denver - Anschutz Medical Campus

    Collapse Biography 
    Collapse awards and honors
    2017 - 2019Editorial Board, Journal of Experimental Medicine
    2017 - 2020Editorial Board, Blood
    2016 - 2018Review Panel, Leukemia & Lymphoma Society
    2013 - 2016Elected Board of Directors, ISEH
    2012 - 2018MCH Study Section Member, NIH
    2010 - 2010Research Award, Lauri Strauss Leukemia Foundation
    2009 - 2012Cancer Research Award, Gabrielle's Angel Foundation
    2005 - 2007Scholar Award, V Foundation
    2005 - 2007Scholar Award, Sydney Kimmel Foundation
    2001 - 2004Special Fellow, Leukemia & Lymphoma Society
    1997 - 2000Fellow for Cancer Research, Damon Runyon-Walter Winchell Foundation

    Collapse Overview 
    Collapse overview
    See the lab web site at Dr. Ernst obtained a B.S. in Biochemistry at University of Washington in Seattle, then a Ph.D. in Microbiology and Immunology at the University of California, Los Angeles. This was followed by post-doctoral studies with Dr. Korsmeyer first in St. Louis then moving with the lab to complete her studies at the Dana Farber Cancer Institute. She then took a faculty position at Dartmouth Medical School in 2004 where she became a Co-Director of the Cancer Mechanisms Program in the Norris Cotton Cancer Center. In 2014, she was recruited by the University of Colorado, Denver Pediatrics Department together with the Pharmacology Department. Her lab focuses on epigenetic mechanisms regulating normal hematopoiesis and leukemia focusing on the MLL1 histone methyltransferase.

    Collapse Research 
    Collapse research activities and funding
    K01DK067119     (ERNST, PATRICIA A)Apr 10, 2004 - Mar 31, 2010
    MII Regulation of Hematopoiesis
    Role: Principal Investigator

    R01HL090036     (ERNST, PATRICIA A)Jul 18, 2007 - Jun 30, 2016
    MLL Function in the Maintenance of the Blood Forming System
    Role: Principal Investigator

    28506     (ERNST, PATRICIA)Jul 1, 2014 - Jun 30, 2017
    Alex's Lemonade Stand Foundation
    Exploiting epigenetic dependencies of Notch1 for clinical benefit
    Role: Principal Investigator

    R21OD019716     (ERNST, PATRICIA A)Jul 15, 2014 - May 31, 2016
    Modeling hematologic malignancy and self-renewal with gain-of-function MLL1
    Role: Principal Investigator

    1R21AI129426-01     (ERNST, PATRICIA)Aug 1, 2017 - Jul 31, 2019
    Connecting Epigenetic Regulator MLL1 to ERK and Survival Signaling in B cells
    Role: Principal Investigator

    R21AI129426     (ERNST, PATRICIA A)Aug 1, 2017 - Jul 31, 2019
    Connecting Epigenetic Regulator MLL1 to ERK and Survival Signaling in B cells
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. Yang W, Ernst P. Distinct functions of histone H3, lysine 4 methyltransferases in normal and malignant hematopoiesis. Curr Opin Hematol. 2017 Jul; 24(4):322-328. PMID: 28375985.
      View in: PubMed
    2. Chen Y, Anastassiadis K, Kranz A, Stewart A.F., Arndt K, Waskow C, Yokoyama A, Jones K, Neff T, Lee Y and P Ernst. MLL2, not MLL1, plays a major role in sustaining MLL-rearranged Acute Myeloid Leukemia. Cancer Cell. 2017; 6(31):1-16.
    3. Xu H, Valerio DG, Eisold ME, Sinha A, Koche RP, Hu W, Chen CW, Chu SH, Brien GL, Park CY, Hsieh JJ, Ernst P, Armstrong SA. NUP98 Fusion Proteins Interact with the NSL and MLL1 Complexes to Drive Leukemogenesis. Cancer Cell. 2016 Dec 12; 30(6):863-878. PMID: 27889185.
      View in: PubMed
    4. Lin W, Francis JM, Li H, Gao X, Pedamallu CS, Ernst P, Meyerson M. Kmt2a cooperates with menin to suppress tumorigenesis in mouse pancreatic islets. Cancer Biol Ther. 2016 Dec; 17(12):1274-1281. PMID: 27801610.
      View in: PubMed
    5. Yang W, Ernst P. SET/MLL family proteins in hematopoiesis and leukemia. Int J Hematol. 2017 Jan; 105(1):7-16. PMID: 27796741.
      View in: PubMed
    6. Shen EY, Jiang Y, Javidfar B, Kassim B, Loh YE, Ma Q, Mitchell AC, Pothula V, Stewart AF, Ernst P, Yao WD, Martin G, Shen L, Jakovcevski M, Akbarian S. Neuronal Deletion of Kmt2a/Mll1 Histone Methyltransferase in Ventral Striatum is Associated with Defective Spike-Timing-Dependent Striatal Synaptic Plasticity, Altered Response to Dopaminergic Drugs, and Increased Anxiety. Neuropsychopharmacology. 2016 Dec; 41(13):3103-3113. PMID: 27485686.
      View in: PubMed
    7. Watanabe T, Ernst P. Context, Context, Context: New Gene Programs Linked to Bad Behavior in MLL-AF9-Initiated Leukemia. Cancer Cell. 2016 07 11; 30(1):3-5. PMID: 27411579.
      View in: PubMed
    8. Riedel SS, Haladyna JN, Bezzant M, Stevens B, Pollyea DA, Sinha AU, Armstrong SA, Wei Q, Pollock RM, Daigle SR, Jordan CT, Ernst P, Neff T, Bernt KM. MLL1 and DOT1L cooperate with meningioma-1 to induce acute myeloid leukemia. J Clin Invest. 2016 Apr 01; 126(4):1438-50. PMID: 26927674; PMCID: PMC4811120.
    9. Jakovcevski M, Ruan H, Shen EY, Dincer A, Javidfar B, Ma Q, Peter CJ, Cheung I, Mitchell AC, Jiang Y, Lin CL, Pothula V, Stewart AF, Ernst P, Yao WD, Akbarian S. Neuronal Kmt2a/Mll1 histone methyltransferase is essential for prefrontal synaptic plasticity and working memory. J Neurosci. 2015 Apr 01; 35(13):5097-108. PMID: 25834037; PMCID: PMC4380991.
    10. Harte PJ, Ernst P. Harnessing gene repression to inhibit leukemia. Nat Med. 2015 Apr; 21(4):308-10. PMID: 25849269.
      View in: PubMed
    11. Bharadwaj R, Peter CJ, Jiang Y, Roussos P, Vogel-Ciernia A, Shen EY, Mitchell AC, Mao W, Whittle C, Dincer A, Jakovcevski M, Pothula V, Rasmussen TP, Giakoumaki SG, Bitsios P, Sherif A, Gardner PD, Ernst P, Ghose S, Sklar P, Haroutunian V, Tamminga C, Myers RH, Futai K, Wood MA, Akbarian S. Conserved higher-order chromatin regulates NMDA receptor gene expression and cognition. Neuron. 2014 Dec 03; 84(5):997-1008. PMID: 25467983; PMCID: PMC4258154.
    12. Li BE, Ernst P. Two decades of leukemia oncoprotein epistasis: the MLL1 paradigm for epigenetic deregulation in leukemia. Exp Hematol. 2014 Dec; 42(12):995-1012. PMID: 25264566; PMCID: PMC4307938.
    13. Mishra BP, Zaffuto KM, Artinger EL, Org T, Mikkola HK, Cheng C, Djabali M, Ernst P. The histone methyltransferase activity of MLL1 is dispensable for hematopoiesis and leukemogenesis. Cell Rep. 2014 May 22; 7(4):1239-47. PMID: 24813891; PMCID: PMC4120120.
    14. Artinger EL, Ernst P. Cell context in the control of self-renewal and proliferation regulated by MLL1. Cell Cycle. 2013 Sep 15; 12(18):2969-72. PMID: 23974107; PMCID: PMC3875671.
    15. Li BE, Gan T, Meyerson M, Rabbitts TH, Ernst P. Distinct pathways regulated by menin and by MLL1 in hematopoietic stem cells and developing B cells. Blood. 2013 Sep 19; 122(12):2039-46. PMID: 23908472; PMCID: PMC3778547.
    16. Huang LH, Gui J, Artinger E, Craig R, Berwin BL, Ernst PA, Chang CC, Chang TY. Acat1 gene ablation in mice increases hematopoietic progenitor cell proliferation in bone marrow and causes leukocytosis. Arterioscler Thromb Vasc Biol. 2013 Sep; 33(9):2081-7. PMID: 23846496; PMCID: PMC3882116.
    17. Artinger EL, Mishra BP, Zaffuto KM, Li BE, Chung EK, Moore AW, Chen Y, Cheng C, Ernst P. An MLL-dependent network sustains hematopoiesis. Proc Natl Acad Sci U S A. 2013 Jul 16; 110(29):12000-5. PMID: 23744037; PMCID: PMC3718146.
    18. Stan RV, Tse D, Deharvengt SJ, Smits NC, Xu Y, Luciano MR, McGarry CL, Buitendijk M, Nemani KV, Elgueta R, Kobayashi T, Shipman SL, Moodie KL, Daghlian CP, Ernst PA, Lee HK, Suriawinata AA, Schned AR, Longnecker DS, Fiering SN, Noelle RJ, Gimi B, Shworak NW, Carrière C. The diaphragms of fenestrated endothelia: gatekeepers of vascular permeability and blood composition. Dev Cell. 2012 Dec 11; 23(6):1203-18. PMID: 23237953; PMCID: PMC3525343.
    19. Ernst P, Vakoc CR. WRAD: enabler of the SET1-family of H3K4 methyltransferases. Brief Funct Genomics. 2012 May; 11(3):217-26. PMID: 22652693; PMCID: PMC3388306.
    20. Cai X, Gaudet JJ, Mangan JK, Chen MJ, De Obaldia ME, Oo Z, Ernst P, Speck NA. Runx1 loss minimally impacts long-term hematopoietic stem cells. PLoS One. 2011; 6(12):e28430. PMID: 22145044; PMCID: PMC3228772.
    21. Thiel AT, Blessington P, Zou T, Feather D, Wu X, Yan J, Zhang H, Liu Z, Ernst P, Koretzky GA, Hua X. MLL-AF9-induced leukemogenesis requires coexpression of the wild-type Mll allele. Cancer Cell. 2010 Feb 17; 17(2):148-59. PMID: 20159607; PMCID: PMC2830208.
    22. Passegué E, Ernst P. IFN-alpha wakes up sleeping hematopoietic stem cells. Nat Med. 2009 Jun; 15(6):612-3. PMID: 19498372; PMCID: PMC2892628.
    23. Lim DA, Huang YC, Swigut T, Mirick AL, Garcia-Verdugo JM, Wysocka J, Ernst P, Alvarez-Buylla A. Chromatin remodelling factor Mll1 is essential for neurogenesis from postnatal neural stem cells. Nature. 2009 Mar 26; 458(7237):529-33. PMID: 19212323; PMCID: PMC3800116.
    24. Jude CD, Gaudet JJ, Speck NA, Ernst P. Leukemia and hematopoietic stem cells: balancing proliferation and quiescence. Cell Cycle. 2008 Mar 01; 7(5):586-91. PMID: 18239455; PMCID: PMC2892629.
    25. Jude CD, Climer L, Xu D, Artinger E, Fisher JK, Ernst P. Unique and independent roles for MLL in adult hematopoietic stem cells and progenitors. Cell Stem Cell. 2007 Sep 13; 1(3):324-37. PMID: 18371366; PMCID: PMC2234224.
    26. Bansal D, Scholl C, Fröhling S, McDowell E, Lee BH, Döhner K, Ernst P, Davidson AJ, Daley GQ, Zon LI, Gilliland DG, Huntly BJ. Cdx4 dysregulates Hox gene expression and generates acute myeloid leukemia alone and in cooperation with Meis1a in a murine model. Proc Natl Acad Sci U S A. 2006 Nov 07; 103(45):16924-9. PMID: 17068127; PMCID: PMC1636555.
    27. Wang Y, Yates F, Naveiras O, Ernst P, Daley GQ. Embryonic stem cell-derived hematopoietic stem cells. Proc Natl Acad Sci U S A. 2005 Dec 27; 102(52):19081-6. PMID: 16357205; PMCID: PMC1323159.
    28. Wang J, Iwasaki H, Krivtsov A, Febbo PG, Thorner AR, Ernst P, Anastasiadou E, Kutok JL, Kogan SC, Zinkel SS, Fisher JK, Hess JL, Golub TR, Armstrong SA, Akashi K, Korsmeyer SJ. Conditional MLL-CBP targets GMP and models therapy-related myeloproliferative disease. EMBO J. 2005 Jan 26; 24(2):368-81. PMID: 15635450; PMCID: PMC545811.
    29. Ernst P, Mabon M, Davidson AJ, Zon LI, Korsmeyer SJ. An Mll-dependent Hox program drives hematopoietic progenitor expansion. Curr Biol. 2004 Nov 23; 14(22):2063-9. PMID: 15556871.
      View in: PubMed
    30. Ernst P, Fisher JK, Avery W, Wade S, Foy D, Korsmeyer SJ. Definitive hematopoiesis requires the mixed-lineage leukemia gene. Dev Cell. 2004 Mar; 6(3):437-43. PMID: 15030765.
      View in: PubMed
    31. Davidson AJ, Ernst P, Wang Y, Dekens MP, Kingsley PD, Palis J, Korsmeyer SJ, Daley GQ, Zon LI. cdx4 mutants fail to specify blood progenitors and can be rescued by multiple hox genes. Nature. 2003 Sep 18; 425(6955):300-6. PMID: 13679919.
      View in: PubMed
    32. Hsieh JJ, Ernst P, Erdjument-Bromage H, Tempst P, Korsmeyer SJ. Proteolytic cleavage of MLL generates a complex of N- and C-terminal fragments that confers protein stability and subnuclear localization. Mol Cell Biol. 2003 Jan; 23(1):186-94. PMID: 12482972; PMCID: PMC140678.
    33. Ernst P, Wang J, Korsmeyer SJ. The role of MLL in hematopoiesis and leukemia. Curr Opin Hematol. 2002 Jul; 9(4):282-7. PMID: 12042701.
      View in: PubMed
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