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Patricia Ernst

TitleProfessor
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM-PEDS
Phone303/724-8804
ORCID ORCID Icon0000-0001-7638-2939 Additional info

    Collapse Biography 
    Collapse education and training
    University of Washington, SeattleBS1990Biochemistry
    University of California, Los AngelesPhD 1996Micro and Immunology
    Washington University, St. LouisPostdoc1999Molecular Oncology
    Harvard Medical School, BostonPostdoc2004Molecular Oncology
    Collapse awards and honors
    2022 - presScientific Advisory Board, Kate Amato Foundation
    2022 - 2025External Advisory Board Member, University of Tokyo, Institute of Medical Science
    2021 - 2025Editorial Board, Frontiers in Immunology
    2021 - 2022Immediate Past President, International Society of Experimental Hematology
    2020 - 2021President, International Society of Experimental Hematology
    2019 - 2020President Elect, International Society of Experimental Hematology
    2020 - 2021Research Award, Morgan Adams Foundation
    2020Program Co-Leader, Molecular and Cellular Oncology, University of Colorado Cancer Center
    2019Postle Family Chair in Pediatric Cancer and Blood Disorders, Children's Hospital Colorado Foundation
    2018 - 2019Vice President , International Society of Experimental Hematology
    2018 - 2019Research Award, Kate Amato Foundation
    2017 - 2019Editorial Board, Journal of Experimental Medicine
    2017 - 2020Editorial Board, Blood
    2016 - 2022Review Panel-CDP grants, Leukemia & Lymphoma Society
    2013 - 2016Elected Board of Directors, International Society of Experimental Hematology
    2012 - 2018MCH Study Section Member, National Institutes of Health
    2010 - 2010Research Award, Lauri Strauss Leukemia Foundation
    2009 - 2012Cancer Research Award, Gabrielle's Angel Foundation
    2005 - 2007Scholar Award, V Foundation
    2005 - 2007Scholar Award, Sydney Kimmel Foundation
    2001 - 2004Special Fellow, Leukemia & Lymphoma Society
    1997 - 2000Fellow for Cancer Research, Damon Runyon-Walter Winchell Foundation

    Collapse Overview 
    Collapse overview
    See the lab web site at http://pharmacology.ucdenver.edu/ernst/ Dr. Ernst obtained a B.S. in Biochemistry at University of Washington in Seattle, then a Ph.D. in Microbiology and Immunology at the University of California, Los Angeles. This was followed by post-doctoral studies with Dr. Korsmeyer first in St. Louis then moving with the lab to complete her studies at the Dana Farber Cancer Institute. She then took a faculty position at Dartmouth Medical School in 2004 where she became a Co-Director of the Cancer Mechanisms Program in the NCI-designated Norris Cotton Cancer Center. In 2014, she was recruited by the University of Colorado, Denver Pediatrics Department together with the Pharmacology Department. Her lab focuses on epigenetic mechanisms regulating normal hematopoiesis and leukemia focusing on MLL-family histone methyltransferases.

    Collapse Research 
    Collapse research activities and funding
    n/a     (ERNST, FAULK)Oct 1, 2023 - Sep 30, 2024
    Golfers Against Cancer
    Bedside to Bench Discovery of Menin Inhibitor Mechanisms in Trial AALL2121
    Role: co-Investigator
    7319     (ERNST, FAULK)Jan 2, 2023 - Dec 31, 2024
    Morgan Adams Foundation
    Targeting an Oncogenic Driver in Infant Acute Lymphoblastic Leukemia: Bedside to Bench Correlative Studies
    Role: co-Investigator
    R01CA269269     (ERNST, FRY, KOHLER)Apr 1, 2022 - Mar 31, 2026
    NIH/NCI
    Escape from CAR T surveillance through lineage plasticity
    Role: PI
    5627-21     (VU, THERESE)Jan 1, 2021 - Dec 31, 2023
    The Leukemia and Lymphoma Society/ The Mark Foundation
    Evaluating a novel collaboration between NOTCH1 and MLL1 for improved targeted treatments in T-ALL
    Role: Mentor
    2200009     (ERNST, PATRICIA/ALLEN, MARY ANN)Dec 1, 2020 - Nov 30, 2021
    NEXUS AB
    Identification of an embryonic cell-intrinsic cancer checkpoint: studying differential transcriptional effects of the proto-oncogene MLL1 versus MLL-ENL in an embryonic system
    Role: Co-Investigator
    6433     (ERNST, LIAO)Jan 1, 2020 - Dec 31, 2021
    Morgan Adams Foundation
    Developing Pediatric B-ALL Models to Identify Mechanisms of Relapse upon CAR-T Failure
    Role: Principal Investigator
    R01DK120369     (ERNST, PATRICIA)Sep 15, 2019 - Jun 30, 2022
    NIH
    Enhancing hematopoiesis through modulation of a histone methyltransferase: evaluating a new MLL1 gain-of-function animal model
    Role: Principal Investigator
    2407     (LIAO, WENJUAN)Jul 1, 2018 - Jul 31, 2019
    Lady Tata Memorial Trust Fellowship
    MLL2 as an Epigenetic Target in Acute Myelogenous Leukemia
    Role: Mentor
    R01CA224436     (ERNST, PATRICIA)Jun 1, 2018 - May 31, 2024
    NIH
    MLL Family Histone Methyltransferases in Myeloid Leukemia
    Role: Principal Investigator
    Pilot Intramural Funding     (ERNST, PATRICIA)Jan 1, 2018 - Dec 31, 2018
    University of Colorado RNA Biosciences Initiative
    Enhancing Hematopoietic Stem Cell Emergence from Pluripotent Embryonic Stem Cells Using MLL1 Induction
    Role Description: Seed funding for single cell sequencing
    Role: Principal Investigator
    1R21AI129426-01     (ERNST, PATRICIA)Aug 1, 2017 - Jul 31, 2019
    NIH/NIAID
    Connecting Epigenetic Regulator MLL1 to ERK and Survival Signaling in B cells
    Role: Principal Investigator
    R21OD019716     (ERNST, PATRICIA A)Jul 15, 2014 - May 31, 2016
    NIH
    Modeling hematologic malignancy and self-renewal with gain-of-function MLL1
    Role: Principal Investigator
    28506     (ERNST, PATRICIA)Jul 1, 2014 - Jun 30, 2017
    Alex's Lemonade Stand Foundation
    Exploiting epigenetic dependencies of Notch1 for clinical benefit
    Role: Principal Investigator
    RSG-10-242-LIB     Jan 1, 2011 - Dec 31, 2014
    ACS
    Molecular Pathways Regulated by the MLL Proto-Oncogene During Lymphopoiesis
    Role: Principal Investigator
    R01HL090036     (ERNST, PATRICIA A)Jul 18, 2007 - Jun 30, 2018
    NIH
    MLL Function in the Maintenance of the Blood Forming System
    Role: Principal Investigator
    K01DK067119     (ERNST, PATRICIA A)Apr 10, 2004 - Mar 31, 2010
    NIH
    MII Regulation of Hematopoiesis
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. Sparbier CE, Gillespie A, Gomez J, Kumari N, Motazedian A, Chan KL, Bell CC, Gilan O, Chan YC, Popp S, Gough DJ, Eckersley-Maslin MA, Dawson SJ, Lehner PJ, Sutherland KD, Ernst P, McGeehan GM, Lam EYN, Burr ML, Dawson MA. Targeting Menin disrupts the KMT2A/B and polycomb balance to paradoxically activate bivalent genes. Nat Cell Biol. 2023 02; 25(2):258-272. PMID: 36635503.
      View in: PubMed
    2. Nguyen N, Gudmundsson KO, Soltis AR, Oakley K, Roy KR, Han Y, Gurnari C, Maciejewski JP, Crouch G, Ernst P, Dalgard CL, Du Y. Recruitment of MLL1 complex is essential for SETBP1 to induce myeloid transformation. iScience. 2022 Jan 21; 25(1):103679. PMID: 35036869.
      View in: PubMed
    3. Liao W, Kohler ME, Fry T, Ernst P. Corrigendum to : <[Experimental Hematology 2021; 100: 1-11]>. Exp Hematol. 2021 Nov; 103:73-74. PMID: 34555335.
      View in: PubMed
    4. Liao W, Kohler ME, Fry T, Ernst P. Does lineage plasticity enable escape from CAR-T cell therapy? Lessons from MLL-r leukemia. Exp Hematol. 2021 08; 100:1-11. PMID: 34298117.
      View in: PubMed
    5. Rogawski DS, Deng J, Li H, Miao H, Borkin D, Purohit T, Song J, Chase J, Li S, Ndoj J, Klossowski S, Kim E, Mao F, Zhou B, Ropa J, Krotoska MZ, Jin Z, Ernst P, Feng X, Huang G, Nishioka K, Kelly S, He M, Wen B, Sun D, Muntean A, Dou Y, Maillard I, Cierpicki T, Grembecka J. Discovery of first-in-class inhibitors of ASH1L histone methyltransferase with anti-leukemic activity. Nat Commun. 2021 05 14; 12(1):2792. PMID: 33990599.
      View in: PubMed
    6. Libbrecht C, Xie HM, Kingsley MC, Haladyna JN, Riedel SS, Alikarami F, Lenard A, McGeehan GM, Ernst P, Bernt KM. Menin is necessary for long term maintenance of meningioma-1 driven leukemia. Leukemia. 2021 05; 35(5):1405-1417. PMID: 33542482.
      View in: PubMed
    7. Yang W, Trahan GD, Howell ED, Speck NA, Jones KL, Gillen AE, Riemondy K, Hesselberth J Bryder D and P Ernst. . Enhancing hematopoiesis from murine embryonic stem cells through MLL1-induced activation of a Rac/Rho/integrin signaling axis. Stem Cell Reports. 2020; 2(14):285-299.
    8. Addicks GC, Brun CE, Sincennes MC, Saber J, Porter CJ, Francis Stewart A, Ernst P, Rudnicki MA. MLL1 is required for PAX7 expression and satellite cell self-renewal in mice. Nat Commun. 2019 09 18; 10(1):4256. PMID: 31534153.
      View in: PubMed
    9. Hurtz C, Chan LN, Geng H, Ballabio E, Xiao G, Deb G, Khoury H, Chen CW, Armstrong SA, Chen J, Ernst P, Melnick A, Milne T, M?schen M. Rationale for targeting BCL6 in MLL-rearranged acute lymphoblastic leukemia. Genes Dev. 2019 09 01; 33(17-18):1265-1279. PMID: 31395741.
      View in: PubMed
    10. Chen Y, Ernst P. Hematopoietic transformation in the absence of MLL1/KMT2A: distinctions in target gene reactivation. Cell Cycle. 2019 07; 18(14):1525-1531. PMID: 31161857.
      View in: PubMed
    11. Chen Y, Jones KL, Anastassiadis K, Kranz A, Stewart AF, Grembecka J, Meyerson M, Ernst P. Distinct pathways affected by menin versus MLL1/MLL2 in MLL-rearranged acute myeloid leukemia. Exp Hematol. 2019 01; 69:37-42. PMID: 30315824.
      View in: PubMed
    12. Gan T, Li BE, Mishra BP, Jones KL, Ernst P. MLL1 Promotes IL-7 Responsiveness and Survival during B Cell Differentiation. J Immunol. 2018 03 01; 200(5):1682-1691. PMID: 29351999.
      View in: PubMed
    13. Yang W, Ernst P. Distinct functions of histone H3, lysine 4 methyltransferases in normal and malignant hematopoiesis. Curr Opin Hematol. 2017 Jul; 24(4):322-328. PMID: 28375985.
      View in: PubMed
    14. Chen Y, Anastassiadis K, Kranz A, Stewart AF, Arndt K, Waskow C, Yokoyama A, Jones K, Neff T, Lee Y, Ernst P. MLL2, Not MLL1, Plays a Major Role in Sustaining MLL-Rearranged Acute Myeloid Leukemia. Cancer Cell. 2017 06 12; 31(6):755-770.e6. PMID: 28609655.
      View in: PubMed
    15. Xu H, Valerio DG, Eisold ME, Sinha A, Koche RP, Hu W, Chen CW, Chu SH, Brien GL, Park CY, Hsieh JJ, Ernst P, Armstrong SA. NUP98 Fusion Proteins Interact with the NSL and MLL1 Complexes to Drive Leukemogenesis. Cancer Cell. 2016 Dec 12; 30(6):863-878. PMID: 27889185.
      View in: PubMed
    16. Lin W, Francis JM, Li H, Gao X, Pedamallu CS, Ernst P, Meyerson M. Kmt2a cooperates with menin to suppress tumorigenesis in mouse pancreatic islets. Cancer Biol Ther. 2016 12; 17(12):1274-1281. PMID: 27801610.
      View in: PubMed
    17. Yang W, Ernst P. SET/MLL family proteins in hematopoiesis and leukemia. Int J Hematol. 2017 Jan; 105(1):7-16. PMID: 27796741.
      View in: PubMed
    18. Shen EY, Jiang Y, Javidfar B, Kassim B, Loh YE, Ma Q, Mitchell AC, Pothula V, Stewart AF, Ernst P, Yao WD, Martin G, Shen L, Jakovcevski M, Akbarian S. Neuronal Deletion of Kmt2a/Mll1 Histone Methyltransferase in Ventral Striatum is Associated with Defective Spike-Timing-Dependent Striatal Synaptic Plasticity, Altered Response to Dopaminergic Drugs, and Increased Anxiety. Neuropsychopharmacology. 2016 12; 41(13):3103-3113. PMID: 27485686.
      View in: PubMed
    19. Watanabe T, Ernst P. Context, Context, Context: New Gene Programs Linked to Bad Behavior in MLL-AF9-Initiated Leukemia. Cancer Cell. 2016 07 11; 30(1):3-5. PMID: 27411579.
      View in: PubMed
    20. Riedel SS, Haladyna JN, Bezzant M, Stevens B, Pollyea DA, Sinha AU, Armstrong SA, Wei Q, Pollock RM, Daigle SR, Jordan CT, Ernst P, Neff T, Bernt KM. MLL1 and DOT1L cooperate with meningioma-1 to induce acute myeloid leukemia. J Clin Invest. 2016 Apr 01; 126(4):1438-50. PMID: 26927674.
      View in: PubMed
    21. Jakovcevski M, Ruan H, Shen EY, Dincer A, Javidfar B, Ma Q, Peter CJ, Cheung I, Mitchell AC, Jiang Y, Lin CL, Pothula V, Stewart AF, Ernst P, Yao WD, Akbarian S. Neuronal Kmt2a/Mll1 histone methyltransferase is essential for prefrontal synaptic plasticity and working memory. J Neurosci. 2015 Apr 01; 35(13):5097-108. PMID: 25834037.
      View in: PubMed
    22. Harte PJ, Ernst P. Harnessing gene repression to inhibit leukemia. Nat Med. 2015 Apr; 21(4):308-10. PMID: 25849269.
      View in: PubMed
    23. Bharadwaj R, Peter CJ, Jiang Y, Roussos P, Vogel-Ciernia A, Shen EY, Mitchell AC, Mao W, Whittle C, Dincer A, Jakovcevski M, Pothula V, Rasmussen TP, Giakoumaki SG, Bitsios P, Sherif A, Gardner PD, Ernst P, Ghose S, Sklar P, Haroutunian V, Tamminga C, Myers RH, Futai K, Wood MA, Akbarian S. Conserved higher-order chromatin regulates NMDA receptor gene expression and cognition. Neuron. 2014 Dec 03; 84(5):997-1008. PMID: 25467983.
      View in: PubMed
    24. Li BE, Ernst P. Two decades of leukemia oncoprotein epistasis: the MLL1 paradigm for epigenetic deregulation in leukemia. Exp Hematol. 2014 Dec; 42(12):995-1012. PMID: 25264566.
      View in: PubMed
    25. Mishra BP, Zaffuto KM, Artinger EL, Org T, Mikkola HK, Cheng C, Djabali M, Ernst P. The histone methyltransferase activity of MLL1 is dispensable for hematopoiesis and leukemogenesis. Cell Rep. 2014 May 22; 7(4):1239-47. PMID: 24813891.
      View in: PubMed
    26. Artinger EL, Ernst P. Cell context in the control of self-renewal and proliferation regulated by MLL1. Cell Cycle. 2013 Sep 15; 12(18):2969-72. PMID: 23974107.
      View in: PubMed
    27. Li BE, Gan T, Meyerson M, Rabbitts TH, Ernst P. Distinct pathways regulated by menin and by MLL1 in hematopoietic stem cells and developing B cells. Blood. 2013 Sep 19; 122(12):2039-46. PMID: 23908472.
      View in: PubMed
    28. Huang LH, Gui J, Artinger E, Craig R, Berwin BL, Ernst PA, Chang CC, Chang TY. Acat1 gene ablation in mice increases hematopoietic progenitor cell proliferation in bone marrow and causes leukocytosis. Arterioscler Thromb Vasc Biol. 2013 Sep; 33(9):2081-7. PMID: 23846496.
      View in: PubMed
    29. Artinger EL, Mishra BP, Zaffuto KM, Li BE, Chung EK, Moore AW, Chen Y, Cheng C, Ernst P. An MLL-dependent network sustains hematopoiesis. Proc Natl Acad Sci U S A. 2013 Jul 16; 110(29):12000-5. PMID: 23744037.
      View in: PubMed
    30. Stan RV, Tse D, Deharvengt SJ, Smits NC, Xu Y, Luciano MR, McGarry CL, Buitendijk M, Nemani KV, Elgueta R, Kobayashi T, Shipman SL, Moodie KL, Daghlian CP, Ernst PA, Lee HK, Suriawinata AA, Schned AR, Longnecker DS, Fiering SN, Noelle RJ, Gimi B, Shworak NW, Carri?re C. The diaphragms of fenestrated endothelia: gatekeepers of vascular permeability and blood composition. Dev Cell. 2012 Dec 11; 23(6):1203-18. PMID: 23237953.
      View in: PubMed
    31. Ernst P, Vakoc CR. WRAD: enabler of the SET1-family of H3K4 methyltransferases. Brief Funct Genomics. 2012 May; 11(3):217-26. PMID: 22652693.
      View in: PubMed
    32. Cai X, Gaudet JJ, Mangan JK, Chen MJ, De Obaldia ME, Oo Z, Ernst P, Speck NA. Runx1 loss minimally impacts long-term hematopoietic stem cells. PLoS One. 2011; 6(12):e28430. PMID: 22145044.
      View in: PubMed
    33. Thiel AT, Blessington P, Zou T, Feather D, Wu X, Yan J, Zhang H, Liu Z, Ernst P, Koretzky GA, Hua X. MLL-AF9-induced leukemogenesis requires coexpression of the wild-type Mll allele. Cancer Cell. 2010 Feb 17; 17(2):148-59. PMID: 20159607.
      View in: PubMed
    34. Passegu? E, Ernst P. IFN-alpha wakes up sleeping hematopoietic stem cells. Nat Med. 2009 Jun; 15(6):612-3. PMID: 19498372.
      View in: PubMed
    35. Lim DA, Huang YC, Swigut T, Mirick AL, Garcia-Verdugo JM, Wysocka J, Ernst P, Alvarez-Buylla A. Chromatin remodelling factor Mll1 is essential for neurogenesis from postnatal neural stem cells. Nature. 2009 Mar 26; 458(7237):529-33. PMID: 19212323.
      View in: PubMed
    36. Jude CD, Gaudet JJ, Speck NA, Ernst P. Leukemia and hematopoietic stem cells: balancing proliferation and quiescence. Cell Cycle. 2008 Mar 01; 7(5):586-91. PMID: 18239455.
      View in: PubMed
    37. Jude CD, Climer L, Xu D, Artinger E, Fisher JK, Ernst P. Unique and independent roles for MLL in adult hematopoietic stem cells and progenitors. Cell Stem Cell. 2007 Sep 13; 1(3):324-37. PMID: 18371366.
      View in: PubMed
    38. Bansal D, Scholl C, Fr?hling S, McDowell E, Lee BH, D?hner K, Ernst P, Davidson AJ, Daley GQ, Zon LI, Gilliland DG, Huntly BJ. Cdx4 dysregulates Hox gene expression and generates acute myeloid leukemia alone and in cooperation with Meis1a in a murine model. Proc Natl Acad Sci U S A. 2006 Nov 07; 103(45):16924-9. PMID: 17068127.
      View in: PubMed
    39. Wang Y, Yates F, Naveiras O, Ernst P, Daley GQ. Embryonic stem cell-derived hematopoietic stem cells. Proc Natl Acad Sci U S A. 2005 Dec 27; 102(52):19081-6. PMID: 16357205.
      View in: PubMed
    40. Wang J, Iwasaki H, Krivtsov A, Febbo PG, Thorner AR, Ernst P, Anastasiadou E, Kutok JL, Kogan SC, Zinkel SS, Fisher JK, Hess JL, Golub TR, Armstrong SA, Akashi K, Korsmeyer SJ. Conditional MLL-CBP targets GMP and models therapy-related myeloproliferative disease. EMBO J. 2005 Jan 26; 24(2):368-81. PMID: 15635450.
      View in: PubMed
    41. Ernst P, Mabon M, Davidson AJ, Zon LI, Korsmeyer SJ. An Mll-dependent Hox program drives hematopoietic progenitor expansion. Curr Biol. 2004 Nov 23; 14(22):2063-9. PMID: 15556871.
      View in: PubMed
    42. Ernst P, Fisher JK, Avery W, Wade S, Foy D, Korsmeyer SJ. Definitive hematopoiesis requires the mixed-lineage leukemia gene. Dev Cell. 2004 Mar; 6(3):437-43. PMID: 15030765.
      View in: PubMed
    43. Davidson AJ, Ernst P, Wang Y, Dekens MP, Kingsley PD, Palis J, Korsmeyer SJ, Daley GQ, Zon LI. cdx4 mutants fail to specify blood progenitors and can be rescued by multiple hox genes. Nature. 2003 Sep 18; 425(6955):300-6. PMID: 13679919.
      View in: PubMed
    44. Hsieh JJ, Ernst P, Erdjument-Bromage H, Tempst P, Korsmeyer SJ. Proteolytic cleavage of MLL generates a complex of N- and C-terminal fragments that confers protein stability and subnuclear localization. Mol Cell Biol. 2003 Jan; 23(1):186-94. PMID: 12482972.
      View in: PubMed
    45. Ernst P, Wang J, Korsmeyer SJ. The role of MLL in hematopoiesis and leukemia. Curr Opin Hematol. 2002 Jul; 9(4):282-7. PMID: 12042701.
      View in: PubMed
    46. Ito K, Takaishi H, Jin Y, Song F, Denning TL, Ernst PB. Staphylococcal enterotoxin B stimulates expansion of autoreactive T cells that induce apoptosis in intestinal epithelial cells: regulation of autoreactive responses by IL-10. J Immunol. 2000 Mar 15; 164(6):2994-3001. PMID: 10706687.
      View in: PubMed
    47. Carman PS, Ernst PB, Rosenthal KL, Clark DA, Befus AD, Bienenstock J. Intraepithelial leukocytes contain a unique subpopulation of NK-like cytotoxic cells active in the defense of gut epithelium to enteric murine coronavirus. J Immunol. 1986 Mar 01; 136(5):1548-53. PMID: 3005395.
      View in: PubMed
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