Colorado PROFILES, The Colorado Clinical and Translational Sciences Institute (CCTSI)
Keywords
Last Name
Institution

Ram H Nagaraj

TitleProfessor
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM-OP General Operations

    Collapse Research 
    Collapse research activities and funding
    R01EY033915     (NAGARAJ, RAM H)Sep 30, 2022 - Jul 31, 2026
    NIH
    Lens capsule and secondary cataract
    Role: Principal Investigator
    R01EY028836     (NAGARAJ, RAM H)Sep 1, 2018 - Jun 30, 2022
    NIH
    Acylation of Lens Proteins
    Role: Principal Investigator
    R01EY023286     (NAGARAJ, RAM H)Sep 1, 2013 - Dec 31, 2023
    NIH
    Molecular mechanisms of protein crosslinking in the lens
    Role: Principal Investigator
    R01EY022061     (NAGARAJ, RAM H)Feb 1, 2013 - Feb 28, 2019
    NIH
    LENS CAPSULE AND SECONDARY CATARACT
    Role: Principal Investigator
    R01EY016219     (NAGARAJ, RAM H)Sep 9, 2005 - Aug 31, 2011
    NIH
    Modifications of Small Heat Shock Proteins in the Lens
    Role: Principal Investigator
    R21DK068045     (NAGARAJ, RAM H)Jul 1, 2004 - Jun 30, 2007
    NIH
    Novel Pathways of AGE Formation in Diabetes
    Role: Principal Investigator
    R01EY009912     (NAGARAJ, RAM H)Sep 1, 1994 - Mar 31, 2013
    NIH
    Maillard Reactions and Oxidation in Cataractogenesis
    Role: Principal Investigator
    R29EY009912     (NAGARAJ, RAM H)Sep 1, 1994 - Nov 30, 1997
    NIH
    MAILLARD REACTION OF ASCORBATE WITH LENS PROTEINS
    Role: Principal Investigator

    Collapse Bibliographic 
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Panja S, Rankenberg J, Michel C, Cooksley G, Glomb MA, Nagaraj RH. Proximal cysteine residues in proteins promote Ne-carboxyalkylation of lysine residues by a-dicarbonyl compounds. J Biol Chem. 2025 Apr; 301(4):108377. PMID: 40049410.
      View in: PubMed
    2. Johnson GA, Krishnamoorthy RR, Nagaraj RH, Stankowska DL. A Neuroprotective Peptide Modulates Retinal cAMP Response Element-Binding Protein (CREB), Synapsin I (SYN1), and Growth-Associated Protein 43 (GAP43) in Rats with Silicone Oil-Induced Ocular Hypertension. Biomolecules. 2025 Feb 03; 15(2). PMID: 40001522.
      View in: PubMed
    3. Nam MH, Dhillon A, Nahomi RB, Carrillo NL, Hougen CS, Nagaraj RH. Peptain-1 blocks ischemia/reperfusion-induced retinal capillary degeneration in mice. Front Cell Neurosci. 2024; 18:1441924. PMID: 39149168.
      View in: PubMed
    4. Johnson GA, Kodati B, Nahomi RB, Pham JH, Krishnamoorthy VR, Phillips NR, Krishnamoorthy RR, Nagaraj RH, Stankowska DL. Mechanisms contributing to inhibition of retinal ganglion cell death by cell permeable peptain-1 under glaucomatous stress. Cell Death Discov. 2024 Jun 28; 10(1):305. PMID: 38942762.
      View in: PubMed
    5. Schwab SK, Harris PS, Michel C, McGinnis CD, Nahomi RB, Assiri MA, Reisdorph R, Henriksen K, Orlicky DJ, Levi M, Rosenberg A, Nagaraj RH, Fritz KS. Quantifying Protein Acetylation in Diabetic Nephropathy from Formalin-Fixed Paraffin-Embedded Tissue. Proteomics Clin Appl. 2024 Nov; 18(6):e202400018. PMID: 38923810.
      View in: PubMed
    6. Panja S, Nahomi RB, Rankenberg J, Michel CR, Nagaraj RH. Thiol-Mediated Enhancement of Ne-Acetyllysine Formation in Lens Proteins. ACS Chem Biol. 2024 07 19; 19(7):1495-1505. PMID: 38904252.
      View in: PubMed
    7. Cooksley G, Nam MH, Nahomi RB, Rankenberg J, Smith AJO, Wormstone YM, Wormstone IM, Nagaraj RH. Lens capsule advanced glycation end products induce senescence in epithelial cells: Implications for secondary cataracts. Aging Cell. 2024 Oct; 23(10):e14249. PMID: 39384405.
      View in: PubMed
    8. Panja S, Nam MH, Gaikwad H, Rankenberg J, Nagaraj RH. Topical ocular application of aggrelyte-2A reduces lens stiffness in mice. Front Ophthalmol (Lausanne). 2023; 3:1274825. PMID: 38983035.
      View in: PubMed
    9. Panja S, Nahomi RB, Rankenberg J, Michel CR, Gaikwad H, Nam MH, Nagaraj RH. Aggrelyte-2 promotes protein solubility and decreases lens stiffness through lysine acetylation and disulfide reduction: Implications for treating presbyopia. Aging Cell. 2023 04; 22(4):e13797. PMID: 36823285.
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    10. Panja S, Gaikwad H, Rankenberg J, Nam MH, Nagaraj RH. Promotion of Protein Solubility and Reduction in Stiffness in Human Lenses by Aggrelyte-1: Implications for Reversing Presbyopia. Int J Mol Sci. 2023 Jan 22; 24(3). PMID: 36768517.
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    11. Nam MH, Stankowska DL, Johnson GA, Nahomi RB, Pantcheva MB, Nagaraj RH. Peptains block retinal ganglion cell death in animal models of ocular hypertension: implications for neuroprotection in glaucoma. Cell Death Dis. 2022 11 15; 13(11):958. PMID: 36379926.
      View in: PubMed
    12. Nam MH, Nahomi RB, Pantcheva MB, Dhillon A, Chiodo VA, Smith WC, Nagaraj RH. AAV2-Mediated Expression of HspB1 in RGCs Prevents Somal Damage and Axonal Transport Deficits in a Mouse Model of Ocular Hypertension. Transl Vis Sci Technol. 2022 11 01; 11(11):8. PMID: 36355386.
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    13. Rajeswaren V, Wong JO, Yabroudi D, Nahomi RB, Rankenberg J, Nam MH, Nagaraj RH. Small Heat Shock Proteins in Retinal Diseases. Front Mol Biosci. 2022; 9:860375. PMID: 35480891.
      View in: PubMed
    14. Rankenberg J, Rakete S, Wagner BD, Patnaik JL, Henning C, Lynch A, Glomb MA, Nagaraj RH. Advanced glycation end products in human diabetic lens capsules. Exp Eye Res. 2021 09; 210:108704. PMID: 34302851.
      View in: PubMed
    15. Nam MH, Pantcheva MB, Rankenberg J, Nagaraj RH. Transforming growth factor-?2-mediated mesenchymal transition in lens epithelial cells is repressed in the absence of RAGE. Biochem J. 2021 06 25; 478(12):2285-2296. PMID: 34143864.
      View in: PubMed
    16. Jagannadham MV, Gayatri P, Binny TM, Raman B, Kameshwari DB, Nagaraj R. Mass Spectral Analysis of Synthetic Peptides: Implications in Proteomics. J Biomol Tech. 2021 04; 32(1):30-35. PMID: 33953644.
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    17. Nandi SK, Rankenberg J, Rakete S, Nahomi RB, Glomb MA, Linetsky MD, Nagaraj RH. Glycation-mediated protein crosslinking and stiffening in mouse lenses are inhibited by carboxitin in vitro. Glycoconj J. 2021 06; 38(3):347-359. PMID: 33245448.
      View in: PubMed
    18. Nandi SK, Rankenberg J, Glomb MA, Nagaraj RH. Transient elevation of temperature promotes cross-linking of a-crystallin-client proteins through formation of advanced glycation endproducts: A potential role in presbyopia and cataracts. Biochem Biophys Res Commun. 2020 12 17; 533(4):1352-1358. PMID: 33081971.
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    19. Nandi SK, Nahomi RB, Rankenberg J, Glomb MA, Nagaraj RH. Glycation-mediated inter-protein cross-linking is promoted by chaperone-client complexes of a-crystallin: Implications for lens aging and presbyopia. J Biol Chem. 2020 04 24; 295(17):5701-5716. PMID: 32184356.
      View in: PubMed
    20. Nahomi RB, Nam MH, Rankenberg J, Rakete S, Houck JA, Johnson GC, Stankowska DL, Pantcheva MB, MacLean PS, Nagaraj RH. Kynurenic Acid Protects Against Ischemia/Reperfusion-Induced Retinal Ganglion Cell Death in Mice. Int J Mol Sci. 2020 Mar 05; 21(5). PMID: 32151061.
      View in: PubMed
    21. Nam MH, Smith AJO, Pantcheva MB, Park KU, Brzezinski JA, Galligan JJ, Fritz K, Wormstone IM, Nagaraj RH. Aspirin inhibits TGF?2-induced epithelial to mesenchymal transition of lens epithelial cells: selective acetylation of K56 and K122 in histone H3. Biochem J. 2020 01 17; 477(1):75-97. PMID: 31815277.
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    22. Nahomi RB, Nandi SK, Rakete S, Michel C, Fritz KS, Nagaraj RH. Lysine malonylation and propionylation are prevalent in human lens proteins. Exp Eye Res. 2020 01; 190:107864. PMID: 31678036.
      View in: PubMed
    23. Stankowska DL, Nam MH, Nahomi RB, Chaphalkar RM, Nandi SK, Fudala R, Krishnamoorthy RR, Nagaraj RH. Correction: Systemically administered peptain-1 inhibits retinal ganglion cell death in animal models: implications for neuroprotection in glaucoma. Cell Death Discov. 2019; 5:122. PMID: 31372242.
      View in: PubMed
    24. Stankowska DL, Nam MH, Nahomi RB, Chaphalkar RM, Nandi SK, Fudala R, Krishnamoorthy RR, Nagaraj RH. Systemically administered peptain-1 inhibits retinal ganglion cell death in animal models: implications for neuroprotection in glaucoma. Cell Death Discov. 2019; 5:112. PMID: 31285855.
      View in: PubMed
    25. Nandi SK, Nahomi RB, Harris PS, Michel CR, Fritz KS, Nagaraj RH. The absence of SIRT3 and SIRT5 promotes the acetylation of lens proteins and improves the chaperone activity of a-crystallin in mouse lenses. Exp Eye Res. 2019 05; 182:1-9. PMID: 30849386.
      View in: PubMed
    26. Nandi SK, Rakete S, Nahomi RB, Michel C, Dunbar A, Fritz KS, Nagaraj RH. Succinylation Is a Gain-of-Function Modification in Human Lens aB-Crystallin. Biochemistry. 2019 03 05; 58(9):1260-1274. PMID: 30758948.
      View in: PubMed
    27. Nahomi RB, Nandi SK, Nagaraj RH. A monoclonal antibody targeted to the functional peptide of aB-crystallin inhibits the chaperone and anti-apoptotic activities. J Immunol Methods. 2019 04; 467:37-47. PMID: 30738041.
      View in: PubMed
    28. Nahomi RB, Nagaraj RH. The role of HIF-1a in the TGF-?2-mediated epithelial-to-mesenchymal transition of human lens epithelial cells. J Cell Biochem. 2018 08; 119(8):6814-6827. PMID: 29693273.
      View in: PubMed
    29. Nam MH, Nagaraj RH. Matrix-bound AGEs enhance TGF?2-mediated mesenchymal transition of lens epithelial cells via the noncanonical pathway: implications for secondary cataract formation. Biochem J. 2018 04 23; 475(8):1427-1440. PMID: 29588342.
      View in: PubMed
    30. Nahomi RB, Sampathkumar S, Myers AM, Elghazi L, Smith DG, Tang J, Lee CA, Kern TS, Nagaraj RH, Fort PE. The Absence of Indoleamine 2,3-Dioxygenase Inhibits Retinal Capillary Degeneration in Diabetic Mice. Invest Ophthalmol Vis Sci. 2018 04 01; 59(5):2042-2053. PMID: 29677366.
      View in: PubMed
    31. Fl?ckiger R, Cocuzzi E, Nagaraj RH, Shoham M, Kern TS, Medof ME. DAF in diabetic patients is subject to glycation/inactivation at its active site residues. Mol Immunol. 2018 01; 93:246-252. PMID: 28886871.
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    32. Rakete S, Nagaraj RH. UVA Light-mediated Ascorbate Oxidation in Human Lenses. Photochem Photobiol. 2017 07; 93(4):1091-1095. PMID: 28084012.
      View in: PubMed
    33. Raghavan CT, Nagaraj RH. Erratum to: AGE-RAGE interaction in the TGF?2-mediated epithelial to mesenchymal transition of human lens epithelial cells. Glycoconj J. 2016 Oct; 33(5):837-838. PMID: 27485830.
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    34. Raghavan CT, Nagaraj RH. AGE-RAGE interaction in the TGF?2-mediated epithelial to mesenchymal transition of human lens epithelial cells. Glycoconj J. 2016 08; 33(4):631-43. PMID: 27263094.
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    35. Nahomi RB, Pantcheva MB, Nagaraj RH. aB-crystallin is essential for the TGF-?2-mediated epithelial to mesenchymal transition of lens epithelial cells. Biochem J. 2016 05 15; 473(10):1455-69. PMID: 26987815.
      View in: PubMed
    36. Rakete S, Nagaraj RH. Identification of Kynoxazine, a Novel Fluorescent Product of the Reaction between 3-Hydroxykynurenine and Erythrulose in the Human Lens, and Its Role in Protein Modification. J Biol Chem. 2016 Apr 29; 291(18):9596-609. PMID: 26941078.
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    37. Raghavan CT, Smuda M, Smith AJ, Howell S, Smith DG, Singh A, Gupta P, Glomb MA, Wormstone IM, Nagaraj RH. AGEs in human lens capsule promote the TGF?2-mediated EMT of lens epithelial cells: implications for age-associated fibrosis. Aging Cell. 2016 06; 15(3):465-76. PMID: 26853893.
      View in: PubMed
    38. Panda AK, Nandi SK, Chakraborty A, Nagaraj RH, Biswas A. Differential role of arginine mutations on the structure and functions of a-crystallin. Biochim Biophys Acta. 2016 Jan; 1860(1 Pt B):199-210. PMID: 26080000.
      View in: PubMed
    39. Smuda M, Henning C, Raghavan CT, Johar K, Vasavada AR, Nagaraj RH, Glomb MA. Comprehensive analysis of maillard protein modifications in human lenses: effect of age and cataract. Biochemistry. 2015 Apr 21; 54(15):2500-7. PMID: 25849437.
      View in: PubMed
    40. Nagaraj RH, Nahomi RB, Mueller NH, Raghavan CT, Ammar DA, Petrash JM. Therapeutic potential of a-crystallin. Biochim Biophys Acta. 2016 Jan; 1860(1 Pt B):252-7. PMID: 25840354.
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    41. Holm T, Raghavan CT, Nahomi R, Nagaraj RH, Kessel L. Effects of photobleaching on selected advanced glycation end products in the human lens. BMC Res Notes. 2015 Jan 16; 8:5. PMID: 25592966.
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    42. Nahomi RB, DiMauro MA, Wang B, Nagaraj RH. Identification of peptides in human Hsp20 and Hsp27 that possess molecular chaperone and anti-apoptotic activities. Biochem J. 2015 Jan 01; 465(1):115-25. PMID: 25332102.
      View in: PubMed
    43. DiMauro MA, Nandi SK, Raghavan CT, Kar RK, Wang B, Bhunia A, Nagaraj RH, Biswas A. Acetylation of Gly1 and Lys2 promotes aggregation of human ?D-crystallin. Biochemistry. 2014 Nov 25; 53(46):7269-82. PMID: 25393041.
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    44. Linetsky M, Raghavan CT, Johar K, Fan X, Monnier VM, Vasavada AR, Nagaraj RH. UVA light-excited kynurenines oxidize ascorbate and modify lens proteins through the formation of advanced glycation end products: implications for human lens aging and cataract formation. J Biol Chem. 2014 Jun 13; 289(24):17111-23. PMID: 24798334.
      View in: PubMed
    45. Nahomi RB, Palmer A, Green KM, Fort PE, Nagaraj RH. Pro-inflammatory cytokines downregulate Hsp27 and cause apoptosis of human retinal capillary endothelial cells. Biochim Biophys Acta. 2014 Feb; 1842(2):164-74. PMID: 24252613.
      View in: PubMed
    46. Nahomi RB, Huang R, Nandi SK, Wang B, Padmanabha S, Santhoshkumar P, Filipek S, Biswas A, Nagaraj RH. Acetylation of lysine 92 improves the chaperone and anti-apoptotic activities of human aB-crystallin. Biochemistry. 2013 Nov 12; 52(45):8126-38. PMID: 24128140.
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    47. Nahomi RB, Wang B, Raghavan CT, Voss O, Doseff AI, Santhoshkumar P, Nagaraj RH. Chaperone peptides of a-crystallin inhibit epithelial cell apoptosis, protein insolubilization, and opacification in experimental cataracts. J Biol Chem. 2013 May 03; 288(18):13022-35. PMID: 23508955.
      View in: PubMed
    48. Nahomi RB, Oya-Ito T, Nagaraj RH. The combined effect of acetylation and glycation on the chaperone and anti-apoptotic functions of human a-crystallin. Biochim Biophys Acta. 2013 Jan; 1832(1):195-203. PMID: 22982407.
      View in: PubMed
    49. Nagaraj RH, Panda AK, Shanthakumar S, Santhoshkumar P, Pasupuleti N, Wang B, Biswas A. Hydroimidazolone modification of the conserved Arg12 in small heat shock proteins: studies on the structure and chaperone function using mutant mimics. PLoS One. 2012; 7(1):e30257. PMID: 22272318; PMCID: PMC3260246.
      View in: PubMed, PubMed Central
    50. Nagaraj RH, Nahomi RB, Shanthakumar S, Linetsky M, Padmanabha S, Pasupuleti N, Wang B, Santhoshkumar P, Panda AK, Biswas A. Acetylation of aA-crystallin in the human lens: effects on structure and chaperone function. Biochim Biophys Acta. 2012 Feb; 1822(2):120-9. PMID: 22120592.
      View in: PubMed
    51. Linetsky M, Kaid Johar SR, Meltretter J, Padmanabha S, Parmar T, Vasavada AR, Pischetsrieder M, Nagaraj RH. Determination of dideoxyosone precursors of AGEs in human lens proteins. Arch Biochem Biophys. 2011 Oct; 514(1-2):16-26. PMID: 21820400.
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    52. Nagaraj RH, Linetsky M, Stitt AW. The pathogenic role of Maillard reaction in the aging eye. Amino Acids. 2012 Apr; 42(4):1205-20. PMID: 20963455.
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    53. Hegde KR, Kowluru RA, Mohr S, Nagaraj RH, Petrash JM. New horizons in research on diabetic complications of the eye: special emphasis on diabetic cataracts and retinopathy. J Ophthalmol. 2010; 2010:979040. PMID: 21049002.
      View in: PubMed
    54. Gangadhariah MH, Mailankot M, Reneker L, Nagaraj RH. Inhibition of methylglyoxal-mediated protein modification in glyoxalase I overexpressing mouse lenses. J Ophthalmol. 2010; 2010:274317. PMID: 20671953; PMCID: PMC2910474.
      View in: PubMed, PubMed Central
    55. Rawat A, Nagaraj R. Determinants of membrane association in the SH4 domain of Fyn: roles of N-terminus myristoylation and side-chain thioacylation. Biochim Biophys Acta. 2010 Oct; 1798(10):1854-63. PMID: 20599685.
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    56. Mailankot M, Howell S, Nagaraj RH. Kynurenine inhibits fibroblast growth factor 2-mediated expression of crystallins and MIP26 in lens epithelial cells. Biochim Biophys Acta. 2010 Jul-Aug; 1802(7-8):609-20. PMID: 20478381.
      View in: PubMed
    57. Pasupuleti N, Gangadhariah M, Padmanabha S, Santhoshkumar P, Nagaraj RH. The role of the cysteine residue in the chaperone and anti-apoptotic functions of human Hsp27. J Cell Biochem. 2010 May 15; 110(2):408-19. PMID: 20225272.
      View in: PubMed
    58. Mailankot M, Nagaraj RH. Induction of indoleamine 2,3-dioxygenase by interferon-gamma in human lens epithelial cells: apoptosis through the formation of 3-hydroxykynurenine. Int J Biochem Cell Biol. 2010 Sep; 42(9):1446-54. PMID: 20435158.
      View in: PubMed
    59. Gangadhariah MH, Wang B, Linetsky M, Henning C, Spanneberg R, Glomb MA, Nagaraj RH. Hydroimidazolone modification of human alphaA-crystallin: Effect on the chaperone function and protein refolding ability. Biochim Biophys Acta. 2010 Apr; 1802(4):432-41. PMID: 20085807.
      View in: PubMed
    60. Bonda DJ, Mailankot M, Stone JG, Garrett MR, Staniszewska M, Castellani RJ, Siedlak SL, Zhu X, Lee HG, Perry G, Nagaraj RH, Smith MA. Indoleamine 2,3-dioxygenase and 3-hydroxykynurenine modifications are found in the neuropathology of Alzheimer's disease. Redox Rep. 2010; 15(4):161-8. PMID: 20663292.
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    61. Pasupuleti N, Matsuyama S, Voss O, Doseff AI, Song K, Danielpour D, Nagaraj RH. The anti-apoptotic function of human aA-crystallin is directly related to its chaperone activity. Cell Death Dis. 2010; 1:e31. PMID: 21364639.
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    62. Nagaraj RH, Padmanabha S, Mailankot M, Staniszewska M, Mun LJ, Glomb MA, Linetsky MD. Modulation of advanced glycation endproduct synthesis by kynurenines in human lens proteins. Biochim Biophys Acta. 2010 Apr; 1804(4):829-38. PMID: 20026434.
      View in: PubMed
    63. Mailankot M, Padmanabha S, Pasupuleti N, Major D, Howell S, Nagaraj RH. Glyoxalase I activity and immunoreactivity in the aging human lens. Biogerontology. 2009 Dec; 10(6):711-20. PMID: 19238574.
      View in: PubMed
    64. Ni J, Yuan X, Gu J, Yue X, Gu X, Nagaraj RH, Crabb JW. Plasma protein pentosidine and carboxymethyllysine, biomarkers for age-related macular degeneration. Mol Cell Proteomics. 2009 Aug; 8(8):1921-33. PMID: 19435712; PMCID: PMC2722770.
      View in: PubMed, PubMed Central
    65. Mailankot M, Staniszewska MM, Butler H, Caprara MH, Howell S, Wang B, Doller C, Reneker LW, Nagaraj RH. Indoleamine 2,3-dioxygenase overexpression causes kynurenine-modification of proteins, fiber cell apoptosis and cataract formation in the mouse lens. Lab Invest. 2009 May; 89(5):498-512. PMID: 19308046.
      View in: PubMed
    66. Kanade SR, Pasupuleti N, Nagaraj RH. Role of cysteine residues in the enhancement of chaperone function in methylglyoxal-modified human alpha A-crystallin. Mol Cell Biochem. 2009 Feb; 322(1-2):185-91. PMID: 19020808.
      View in: PubMed
    67. Guo ZJ, Niu HX, Hou FF, Zhang L, Fu N, Nagai R, Lu X, Chen BH, Shan YX, Tian JW, Nagaraj RH, Xie D, Zhang X. Advanced oxidation protein products activate vascular endothelial cells via a RAGE-mediated signaling pathway. Antioxid Redox Signal. 2008 Oct; 10(10):1699-712. PMID: 18576917.
      View in: PubMed
    68. Mailankot M, Smith D, Howell S, Wang B, Jacobberger JW, Stefan T, Nagaraj RH. Cell cycle arrest by kynurenine in lens epithelial cells. Invest Ophthalmol Vis Sci. 2008 Dec; 49(12):5466-75. PMID: 18676626.
      View in: PubMed
    69. Nagaraj RH, Biswas A, Miller A, Oya-Ito T, Bhat M. The other side of the Maillard reaction. Ann N Y Acad Sci. 2008 Apr; 1126:107-12. PMID: 18448802.
      View in: PubMed
    70. Biswas A, Lewis S, Wang B, Miyagi M, Santoshkumar P, Gangadhariah MH, Nagaraj RH. Chemical modulation of the chaperone function of human alphaA-crystallin. J Biochem. 2008 Jul; 144(1):21-32. PMID: 18344542.
      View in: PubMed
    71. Biswas A, Wang B, Miyagi M, Nagaraj RH. Effect of methylglyoxal modification on stress-induced aggregation of client proteins and their chaperoning by human alphaA-crystallin. Biochem J. 2008 Feb 01; 409(3):771-7. PMID: 17941823.
      View in: PubMed
    72. Staniszewska M, Nagaraj RH. Detection of kynurenine modifications in proteins using a monoclonal antibody. J Immunol Methods. 2007 Jul 31; 324(1-2):63-73. PMID: 17574268.
      View in: PubMed
    73. Biswas A, Goshe J, Miller A, Santhoshkumar P, Luckey C, Bhat MB, Nagaraj RH. Paradoxical effects of substitution and deletion mutation of Arg56 on the structure and chaperone function of human alphaB-crystallin. Biochemistry. 2007 Feb 06; 46(5):1117-27. PMID: 17260942.
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    74. Puttaiah S, Biswas A, Staniszewska M, Nagaraj RH. Methylglyoxal inhibits glycation-mediated loss in chaperone function and synthesis of pentosidine in alpha-crystallin. Exp Eye Res. 2007 May; 84(5):914-21. PMID: 17368444.
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    75. Padival S, Nagaraj RH. Pyridoxamine inhibits maillard reactions in diabetic rat lenses. Ophthalmic Res. 2006; 38(5):294-302. PMID: 16974131.
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    76. Oya-Ito T, Liu BF, Nagaraj RH. Effect of methylglyoxal modification and phosphorylation on the chaperone and anti-apoptotic properties of heat shock protein 27. J Cell Biochem. 2006 Sep 01; 99(1):279-91. PMID: 16615138.
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    77. Biswas A, Miller A, Oya-Ito T, Santhoshkumar P, Bhat M, Nagaraj RH. Effect of site-directed mutagenesis of methylglyoxal-modifiable arginine residues on the structure and chaperone function of human alphaA-crystallin. Biochemistry. 2006 Apr 11; 45(14):4569-77. PMID: 16584192.
      View in: PubMed
    78. Staniszewska MM, Nagaraj RH. Upregulation of glyoxalase I fails to normalize methylglyoxal levels: a possible mechanism for biochemical changes in diabetic mouse lenses. Mol Cell Biochem. 2006 Aug; 288(1-2):29-36. PMID: 16583141.
      View in: PubMed
    79. Puttaiah S, Zhang Y, Pilch HA, Pfahler C, Oya-Ito T, Sayre LM, Nagaraj RH. Detection of dideoxyosone intermediates of glycation using a monoclonal antibody: characterization of major epitope structures. Arch Biochem Biophys. 2006 Feb 15; 446(2):186-96. PMID: 16406213.
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    80. Harishchandran A, Nagaraj R. Interaction of a pseudosubstrate peptide of protein kinase C and its myristoylated form with lipid vesicles: only the myristoylated form translocates into the lipid bilayer. Biochim Biophys Acta. 2005 Jul 30; 1713(2):73-82. PMID: 15990084.
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    81. Nagaraj RH, Oya-Ito T, Bhat M, Liu B. Dicarbonyl stress and apoptosis of vascular cells: prevention by alphaB-crystallin. Ann N Y Acad Sci. 2005 Jun; 1043:158-65. PMID: 16037235.
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    82. Staniszewska MM, Nagaraj RH. 3-hydroxykynurenine-mediated modification of human lens proteins: structure determination of a major modification using a monoclonal antibody. J Biol Chem. 2005 Jun 10; 280(23):22154-64. PMID: 15817458.
      View in: PubMed
    83. Liu B, Bhat M, Nagaraj RH. AlphaB-crystallin inhibits glucose-induced apoptosis in vascular endothelial cells. Biochem Biophys Res Commun. 2004 Aug 13; 321(1):254-8. PMID: 15358243.
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    84. Liu B, Bhat M, Padival AK, Smith DG, Nagaraj RH. Effect of dicarbonyl modification of fibronectin on retinal capillary pericytes. Invest Ophthalmol Vis Sci. 2004 Jun; 45(6):1983-95. PMID: 15161867.
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    85. Sitaram N, Subbalakshmi C, Nagaraj R. Indolicidin, a 13-residue basic antimicrobial peptide rich in tryptophan and proline, interacts with Ca(2+)-calmodulin. Biochem Biophys Res Commun. 2003 Oct 03; 309(4):879-84. PMID: 13679055.
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    86. Nagaraj RH, Oya-Ito T, Padayatti PS, Kumar R, Mehta S, West K, Levison B, Sun J, Crabb JW, Padival AK. Enhancement of chaperone function of alpha-crystallin by methylglyoxal modification. Biochemistry. 2003 Sep 16; 42(36):10746-55. PMID: 12962499.
      View in: PubMed
    87. Dahm R, Bramke S, Dawczynski J, Nagaraj RH, Kasper M. Developmental aspects of galectin-3 expression in the lens. Histochem Cell Biol. 2003 Mar; 119(3):219-26. PMID: 12649736.
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    88. Kessel L, Kalinin S, Nagaraj RH, Larsen M, Johansson LB. Time-resolved and steady-state fluorescence spectroscopic studies of the human lens with comparison to argpyrimidine, pentosidine and 3-OH-kynurenine. Photochem Photobiol. 2002 Nov; 76(5):549-54. PMID: 12462652.
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    89. Mathys KC, Ponnampalam SN, Padival S, Nagaraj RH. Semicarbazide-sensitive amine oxidase in aortic smooth muscle cells mediates synthesis of a methylglyoxal-AGE: implications for vascular complications in diabetes. Biochem Biophys Res Commun. 2002 Oct 04; 297(4):863-9. PMID: 12359232.
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    90. Swamy-Mruthinti S, Miriam KC, Kumar SK, Biswas J, Ramakrishnan S, Nagaraj RH, Sulochana KN. Immunolocalization and quantification of advanced glycation end products in retinal neovascular membranes and serum: a possible role in ocular neovascularization. Curr Eye Res. 2002 Sep; 25(3):139-45. PMID: 12607183.
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    91. Nagaraj RH, Sarkar P, Mally A, Biemel KM, Lederer MO, Padayatti PS. Effect of pyridoxamine on chemical modification of proteins by carbonyls in diabetic rats: characterization of a major product from the reaction of pyridoxamine and methylglyoxal. Arch Biochem Biophys. 2002 Jun 01; 402(1):110-9. PMID: 12051689.
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    92. Padayatti PS, Jiang C, Glomb MA, Uchida K, Nagaraj RH. High concentrations of glucose induce synthesis of argpyrimidine in retinal endothelial cells. Curr Eye Res. 2001 Aug; 23(2):106-15. PMID: 11840348.
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    93. Padayatti PS, Ng AS, Uchida K, Glomb MA, Nagaraj RH. Argpyrimidine, a blue fluorophore in human lens proteins: high levels in brunescent cataractous lenses. Invest Ophthalmol Vis Sci. 2001 May; 42(6):1299-304. PMID: 11328743.
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    94. Wilker SC, Chellan P, Arnold BM, Nagaraj RH. Chromatographic quantification of argpyrimidine, a methylglyoxal-derived product in tissue proteins: comparison with pentosidine. Anal Biochem. 2001 Mar; 290(2):353-8. PMID: 11237339.
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    95. Glomb MA, Rösch D, Nagaraj RH. N(delta)-(5-hydroxy-4,6-dimethylpyrimidine-2-yl)-l-ornithine, a novel methylglyoxal-arginine modification in beer. J Agric Food Chem. 2001 Jan; 49(1):366-72. PMID: 11170600.
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    96. Chellan P, Nagaraj RH. Early glycation products produce pentosidine cross-links on native proteins. novel mechanism of pentosidine formation and propagation of glycation. J Biol Chem. 2001 Feb 09; 276(6):3895-903. PMID: 11076948.
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    97. Sady C, Jiang CL, Chellan P, Madhun Z, Duve Y, Glomb MA, Nagaraj RH. Maillard reactions by alpha-oxoaldehydes: detection of glyoxal-modified proteins. Biochim Biophys Acta. 2000 Sep 29; 1481(2):255-64. PMID: 11018716.
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    98. Shamsi FA, Sharkey E, Creighton D, Nagaraj RH. Maillard reactions in lens proteins: methylglyoxal-mediated modifications in the rat lens. Exp Eye Res. 2000 Mar; 70(3):369-80. PMID: 10712823.
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    99. Shamsi FA, Nagaraj RH. Immunochemical detection of dicarbonyl-derived imidazolium protein crosslinks in human lenses. Curr Eye Res. 1999 Sep; 19(3):276-84. PMID: 10487968.
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    100. Chellan P, Nagaraj RH. Protein crosslinking by the Maillard reaction: dicarbonyl-derived imidazolium crosslinks in aging and diabetes. Arch Biochem Biophys. 1999 Aug 01; 368(1):98-104. PMID: 10415116.
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    101. Nagaraj RH, Shamsi FA, Huber B, Pischetsrieder M. Immunochemical detection of oxalate monoalkylamide, an ascorbate-derived Maillard reaction product in the human lens. FEBS Lett. 1999 Jun 25; 453(3):327-30. PMID: 10405169.
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    102. Shamsi FA, Lin K, Sady C, Nagaraj RH. Methylglyoxal-derived modifications in lens aging and cataract formation. Invest Ophthalmol Vis Sci. 1998 Nov; 39(12):2355-64. PMID: 9804144.
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    103. Shamsi FA, Partal A, Sady C, Glomb MA, Nagaraj RH. Immunological evidence for methylglyoxal-derived modifications in vivo. Determination of antigenic epitopes. J Biol Chem. 1998 Mar 20; 273(12):6928-36. PMID: 9506998.
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    104. Shipanova IN, Glomb MA, Nagaraj RH. Protein modification by methylglyoxal: chemical nature and synthetic mechanism of a major fluorescent adduct. Arch Biochem Biophys. 1997 Aug 01; 344(1):29-36. PMID: 9244378.
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    105. Zhao HR, Nagaraj RH, Abraham EC. The role of alpha- and epsilon-amino groups in the glycation-mediated cross-linking of gammaB-crystallin. Study of three site-directed mutants. J Biol Chem. 1997 May 30; 272(22):14465-9. PMID: 9162088.
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    106. Ortwerth BJ, Prabhakaram M, Nagaraj RH, Linetsky M. The relative UV sensitizer activity of purified advanced glycation endproducts. Photochem Photobiol. 1997 Apr; 65(4):666-72. PMID: 9114742.
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    107. Nagaraj RH, Shipanova IN, Faust FM. Protein cross-linking by the Maillard reaction. Isolation, characterization, and in vivo detection of a lysine-lysine cross-link derived from methylglyoxal. J Biol Chem. 1996 Aug 09; 271(32):19338-45. PMID: 8702619.
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    108. Nagaraj RH, Kern TS, Sell DR, Fogarty J, Engerman RL, Monnier VM. Evidence of a glycemic threshold for the formation of pentosidine in diabetic dog lens but not in collagen. Diabetes. 1996 May; 45(5):587-94. PMID: 8621008.
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    109. Smith MA, Siedlak SL, Richey PL, Nagaraj RH, Elhammer A, Perry G. Quantitative solubilization and analysis of insoluble paired helical filaments from Alzheimer disease. Brain Res. 1996 Apr 22; 717(1-2):99-108. PMID: 8738259.
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    110. Nagaraj RH, Sady C. The presence of a glucose-derived Maillard reaction product in the human lens. FEBS Lett. 1996 Mar 18; 382(3):234-8. PMID: 8605976.
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    111. Monnier VM, Nagaraj RH, Portero-Otin M, Glomb M, Elgawish AH, Sell DR, Friedlander MA. Structure of advanced Maillard reaction products and their pathological role. Nephrol Dial Transplant. 1996; 11 Suppl 5:20-6. PMID: 9044302.
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    112. Nagaraj RH, Monnier VM. Protein modification by the degradation products of ascorbate: formation of a novel pyrrole from the Maillard reaction of L-threose with proteins. Biochim Biophys Acta. 1995 Nov 15; 1253(1):75-84. PMID: 7492603.
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    113. Portero-Otin M, Nagaraj RH, Monnier VM. Chromatographic evidence for pyrraline formation during protein glycation in vitro and in vivo. Biochim Biophys Acta. 1995 Feb 22; 1247(1):74-80. PMID: 7873594.
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    114. Nagaraj RH, Prabhakaram M, Ortwerth BJ, Monnier VM. Suppression of pentosidine formation in galactosemic rat lens by an inhibitor of aldose reductase. Diabetes. 1994 Apr; 43(4):580-6. PMID: 8138064.
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    115. Monnier VM, Miyata S, Nagaraj RH, Sell DR. Relevance of the early and advanced Maillard reaction in diabetic neuropathy. Diabet Med. 1993; 10 Suppl 2:103S-106S. PMID: 7687529.
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    116. Nagaraj RH, Monnier VM. Isolation and characterization of a blue fluorophore from human eye lens crystallins: in vitro formation from Maillard reaction with ascorbate and ribose. Biochim Biophys Acta. 1992 Mar 05; 1116(1):34-42. PMID: 1540622.
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    117. Sell DR, Nagaraj RH, Grandhee SK, Odetti P, Lapolla A, Fogarty J, Monnier VM. Pentosidine: a molecular marker for the cumulative damage to proteins in diabetes, aging, and uremia. Diabetes Metab Rev. 1991 Dec; 7(4):239-51. PMID: 1813279.
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    118. Nagaraj RH, Sell DR, Prabhakaram M, Ortwerth BJ, Monnier VM. High correlation between pentosidine protein crosslinks and pigmentation implicates ascorbate oxidation in human lens senescence and cataractogenesis. Proc Natl Acad Sci U S A. 1991 Nov 15; 88(22):10257-61. PMID: 1946446.
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    119. Nagaraj RH, Monnier VM. Non-tryptophan fluorescence and high molecular weight protein formation in lens crystallins of rats with chronic galactosemia: prevention by the aldose reductase inhibitor sorbinil. Exp Eye Res. 1990 Oct; 51(4):411-8. PMID: 2120080.
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