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Ram H Nagaraj

TitleProfessor
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM-Ophthalmology

    Collapse Research 
    Collapse research activities and funding
    R29EY009912     (NAGARAJ, RAM H)Sep 1, 1994 - Nov 30, 1997
    NIH/NEI
    MAILLARD REACTION OF ASCORBATE WITH LENS PROTEINS
    Role: Principal Investigator

    R01EY009912     (NAGARAJ, RAM H)Sep 1, 1994 - Mar 31, 2013
    NIH/NEI
    Maillard Reactions and Oxidation in Cataractogenesis
    Role: Principal Investigator

    R21DK068045     (NAGARAJ, RAM H)Jul 1, 2004 - Jun 30, 2007
    NIH/NIDDK
    Novel Pathways of AGE Formation in Diabetes
    Role: Principal Investigator

    R01EY016219     (NAGARAJ, RAM H)Sep 9, 2005 - Aug 31, 2011
    NIH/NEI
    Modifications of Small Heat Shock Proteins in the Lens
    Role: Principal Investigator

    R01EY022061     (NAGARAJ, RAM H)Feb 1, 2013 - Feb 28, 2018
    NIH/NEI
    LENS CAPSULE AND SECONDARY CATARACT
    Role: Principal Investigator

    R01EY023286     (NAGARAJ, RAM H)Sep 1, 2013 - Jul 31, 2017
    NIH/NEI
    Molecular mechanisms of protein crosslinking in the lens
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Rakete S, Nagaraj RH. UVA Light-mediated Ascorbate Oxidation in Human Lenses. Photochem Photobiol. 2017 Jan 13. PMID: 28084012.
      View in: PubMed
    2. Raghavan CT, Nagaraj RH. Erratum to: AGE-RAGE interaction in the TGFß2-mediated epithelial to mesenchymal transition of human lens epithelial cells. Glycoconj J. 2016 Oct; 33(5):837-838. PMID: 27485830.
      View in: PubMed
    3. Raghavan CT, Nagaraj RH. AGE-RAGE interaction in the TGFß2-mediated epithelial to mesenchymal transition of human lens epithelial cells. Glycoconj J. 2016 Aug; 33(4):631-43. PMID: 27263094; PMCID: PMC4975983 [Available on 08/01/17].
    4. Nahomi RB, Pantcheva MB, Nagaraj RH. aB-crystallin is essential for the TGF-ß2-mediated epithelial to mesenchymal transition of lens epithelial cells. Biochem J. 2016 May 15; 473(10):1455-69. PMID: 26987815; PMCID: PMC4928857.
    5. Rakete S, Nagaraj RH. Identification of Kynoxazine, a Novel Fluorescent Product of the Reaction between 3-Hydroxykynurenine and Erythrulose in the Human Lens, and Its Role in Protein Modification. J Biol Chem. 2016 Apr 29; 291(18):9596-609. PMID: 26941078; PMCID: PMC4850297 [Available on 04/29/17].
    6. Raghavan CT, Smuda M, Smith AJ, Howell S, Smith DG, Singh A, Gupta P, Glomb MA, Wormstone IM, Nagaraj RH. AGEs in human lens capsule promote the TGFß2-mediated EMT of lens epithelial cells: implications for age-associated fibrosis. Aging Cell. 2016 Jun; 15(3):465-76. PMID: 26853893; PMCID: PMC4854921.
    7. Mathew B, Nagaraj R. Antimicrobial activity of human a-defensin 6 analogs: insights into the physico-chemical reasons behind weak bactericidal activity of HD6 in vitro. J Pept Sci. 2015 Nov; 21(11):811-8. PMID: 26400692.
      View in: PubMed
    8. Panda AK, Nandi SK, Chakraborty A, Nagaraj RH, Biswas A. Differential role of arginine mutations on the structure and functions of a-crystallin. Biochim Biophys Acta. 2016 Jan; 1860(1 Pt B):199-210. PMID: 26080000; PMCID: PMC4914040.
    9. Smuda M, Henning C, Raghavan CT, Johar K, Vasavada AR, Nagaraj RH, Glomb MA. Comprehensive analysis of maillard protein modifications in human lenses: effect of age and cataract. Biochemistry. 2015 Apr 21; 54(15):2500-7. PMID: 25849437; PMCID: PMC4467907.
    10. Nagaraj RH, Nahomi RB, Mueller NH, Raghavan CT, Ammar DA, Petrash JM. Therapeutic potential of a-crystallin. Biochim Biophys Acta. 2016 Jan; 1860(1 Pt B):252-7. PMID: 25840354; PMCID: PMC4591086 [Available on 01/01/17].
    11. Sharma H, Nagaraj R. Human ß-defensin 4 with non-native disulfide bridges exhibit antimicrobial activity. PLoS One. 2015; 10(3):e0119525. PMID: 25785690; PMCID: PMC4364940.
    12. Krishnakumari V, Nagaraj R. N-Terminal fatty acylation of peptides spanning the cationic C-terminal segment of bovine ß-defensin-2 results in salt-resistant antibacterial activity. Biophys Chem. 2015 Apr; 199:25-33. PMID: 25791057.
      View in: PubMed
    13. Holm T, Raghavan CT, Nahomi R, Nagaraj RH, Kessel L. Effects of photobleaching on selected advanced glycation end products in the human lens. BMC Res Notes. 2015 Jan 16; 8:5. PMID: 25592966; PMCID: PMC4302587.
    14. Nahomi RB, DiMauro MA, Wang B, Nagaraj RH. Identification of peptides in human Hsp20 and Hsp27 that possess molecular chaperone and anti-apoptotic activities. Biochem J. 2015 Jan 01; 465(1):115-25. PMID: 25332102; PMCID: PMC4425413.
    15. DiMauro MA, Nandi SK, Raghavan CT, Kar RK, Wang B, Bhunia A, Nagaraj RH, Biswas A. Acetylation of Gly1 and Lys2 promotes aggregation of human ?D-crystallin. Biochemistry. 2014 Nov 25; 53(46):7269-82. PMID: 25393041; PMCID: PMC4245984.
    16. Linetsky M, Raghavan CT, Johar K, Fan X, Monnier VM, Vasavada AR, Nagaraj RH. UVA light-excited kynurenines oxidize ascorbate and modify lens proteins through the formation of advanced glycation end products: implications for human lens aging and cataract formation. J Biol Chem. 2014 Jun 13; 289(24):17111-23. PMID: 24798334; PMCID: PMC4059152.
    17. Nahomi RB, Palmer A, Green KM, Fort PE, Nagaraj RH. Pro-inflammatory cytokines downregulate Hsp27 and cause apoptosis of human retinal capillary endothelial cells. Biochim Biophys Acta. 2014 Feb; 1842(2):164-74. PMID: 24252613; PMCID: PMC3905326.
    18. Rawat A, Nagaraj R. Covalently attached fatty acyl chains alter the aggregation behavior of an amyloidogenic peptide derived from human ß(2)-microglobulin. J Pept Sci. 2013 Dec; 19(12):770-83. PMID: 24243599.
      View in: PubMed
    19. Nahomi RB, Huang R, Nandi SK, Wang B, Padmanabha S, Santhoshkumar P, Filipek S, Biswas A, Nagaraj RH. Acetylation of lysine 92 improves the chaperone and anti-apoptotic activities of human aB-crystallin. Biochemistry. 2013 Nov 12; 52(45):8126-38. PMID: 24128140; PMCID: PMC3889837.
    20. Olli S, Rangaraj N, Nagaraj R. Effect of selectively introducing arginine and D-amino acids on the antimicrobial activity and salt sensitivity in analogs of human beta-defensins. PLoS One. 2013; 8(9):e77031. PMID: 24086767; PMCID: PMC3785448.
    21. Nahomi RB, Wang B, Raghavan CT, Voss O, Doseff AI, Santhoshkumar P, Nagaraj RH. Chaperone peptides of a-crystallin inhibit epithelial cell apoptosis, protein insolubilization, and opacification in experimental cataracts. J Biol Chem. 2013 May 03; 288(18):13022-35. PMID: 23508955; PMCID: PMC3642345.
    22. Rawat A, Harishchandran A, Nagaraj R. Fatty acyl chain-dependent but charge-independent association of the SH4 domain of Lck with lipid membranes. J Biosci. 2013 Mar; 38(1):63-71. PMID: 23385814.
      View in: PubMed
    23. Lokappa SB, Nagaraj R. Interaction of peptides spanning the transmembrane domain of caveolin-1 with model membranes. J Pept Sci. 2012 Nov; 18(11):696-703. PMID: 23027578.
      View in: PubMed
    24. Nahomi RB, Oya-Ito T, Nagaraj RH. The combined effect of acetylation and glycation on the chaperone and anti-apoptotic functions of human a-crystallin. Biochim Biophys Acta. 2013 Jan; 1832(1):195-203. PMID: 22982407; PMCID: PMC3518661.
    25. Li Y, Smith D, Li Q, Sheibani N, Huang S, Kern T, Nagaraj RH, Lin F. Antibody-mediated retinal pericyte injury: implications for diabetic retinopathy. Invest Ophthalmol Vis Sci. 2012 Aug 13; 53(9):5520-6. PMID: 22786897; PMCID: PMC3419006.
    26. Nagaraj RH, Panda AK, Shanthakumar S, Santhoshkumar P, Pasupuleti N, Wang B, Biswas A. Hydroimidazolone modification of the conserved Arg12 in small heat shock proteins: studies on the structure and chaperone function using mutant mimics. PLoS One. 2012; 7(1):e30257. PMID: 22272318; PMCID: PMC3260246.
    27. Chaudhary N, Nagaraj R. Tau fibrillogenesis. Subcell Biochem. 2012; 65:75-90. PMID: 23225000.
      View in: PubMed
    28. Nagaraj RH, Nahomi RB, Shanthakumar S, Linetsky M, Padmanabha S, Pasupuleti N, Wang B, Santhoshkumar P, Panda AK, Biswas A. Acetylation of aA-crystallin in the human lens: effects on structure and chaperone function. Biochim Biophys Acta. 2012 Feb; 1822(2):120-9. PMID: 22120592; PMCID: PMC3249504.
    29. SivakamaSundari C, Rukmani S, Nagaraj R. Effect of introducing a short amyloidogenic sequence from the Aß peptide at the N-terminus of 18-residue amphipathic helical peptides. J Pept Sci. 2012 Feb; 18(2):122-8. PMID: 22052825.
      View in: PubMed
    30. Chaudhary N, Singh S, Nagaraj R. Aggregation properties of a short peptide that mediates amyloid fibril formation in model proteins unrelated to disease. J Biosci. 2011 Sep; 36(4):679-89. PMID: 21857114.
      View in: PubMed
    31. Linetsky M, Kaid Johar SR, Meltretter J, Padmanabha S, Parmar T, Vasavada AR, Pischetsrieder M, Nagaraj RH. Determination of dideoxyosone precursors of AGEs in human lens proteins. Arch Biochem Biophys. 2011 Oct; 514(1-2):16-26. PMID: 21820400; PMCID: PMC3172345.
    32. Chaudhary N, Nagaraj R. Impact on the replacement of Phe by Trp in a short fragment of Aß amyloid peptide on the formation of fibrils. J Pept Sci. 2011 Feb; 17(2):115-23. PMID: 21234983.
      View in: PubMed
    33. Nagaraj RH, Linetsky M, Stitt AW. The pathogenic role of Maillard reaction in the aging eye. Amino Acids. 2012 Apr; 42(4):1205-20. PMID: 20963455.
      View in: PubMed
    34. Hegde KR, Kowluru RA, Mohr S, Nagaraj RH, Petrash JM. New horizons in research on diabetic complications of the eye: special emphasis on diabetic cataracts and retinopathy. J Ophthalmol. 2010; 2010:979040. PMID: 21049002; PMCID: PMC2964913.
    35. Miller AG, Tan G, Binger KJ, Pickering RJ, Thomas MC, Nagaraj RH, Cooper ME, Wilkinson-Berka JL. Candesartan attenuates diabetic retinal vascular pathology by restoring glyoxalase-I function. Diabetes. 2010 Dec; 59(12):3208-15. PMID: 20852029; PMCID: PMC2992784.
    36. Gangadhariah MH, Mailankot M, Reneker L, Nagaraj RH. Inhibition of methylglyoxal-mediated protein modification in glyoxalase I overexpressing mouse lenses. J Ophthalmol. 2010; 2010:274317. PMID: 20671953; PMCID: PMC2910474.
    37. Rawat A, Nagaraj R. Determinants of membrane association in the SH4 domain of Fyn: roles of N-terminus myristoylation and side-chain thioacylation. Biochim Biophys Acta. 2010 Oct; 1798(10):1854-63. PMID: 20599685.
      View in: PubMed
    38. Mailankot M, Howell S, Nagaraj RH. Kynurenine inhibits fibroblast growth factor 2-mediated expression of crystallins and MIP26 in lens epithelial cells. Biochim Biophys Acta. 2010 Jul-Aug; 1802(7-8):609-20. PMID: 20478381; PMCID: PMC2893274.
    39. Pasupuleti N, Gangadhariah M, Padmanabha S, Santhoshkumar P, Nagaraj RH. The role of the cysteine residue in the chaperone and anti-apoptotic functions of human Hsp27. J Cell Biochem. 2010 May 15; 110(2):408-19. PMID: 20225272; PMCID: PMC4562675.
    40. Mailankot M, Nagaraj RH. Induction of indoleamine 2,3-dioxygenase by interferon-gamma in human lens epithelial cells: apoptosis through the formation of 3-hydroxykynurenine. Int J Biochem Cell Biol. 2010 Sep; 42(9):1446-54. PMID: 20435158; PMCID: PMC2910246.
    41. Gangadhariah MH, Wang B, Linetsky M, Henning C, Spanneberg R, Glomb MA, Nagaraj RH. Hydroimidazolone modification of human alphaA-crystallin: Effect on the chaperone function and protein refolding ability. Biochim Biophys Acta. 2010 Apr; 1802(4):432-41. PMID: 20085807; PMCID: PMC2826572.
    42. Bonda DJ, Mailankot M, Stone JG, Garrett MR, Staniszewska M, Castellani RJ, Siedlak SL, Zhu X, Lee HG, Perry G, Nagaraj RH, Smith MA. Indoleamine 2,3-dioxygenase and 3-hydroxykynurenine modifications are found in the neuropathology of Alzheimer's disease. Redox Rep. 2010; 15(4):161-8. PMID: 20663292; PMCID: PMC2956440.
    43. Pasupuleti N, Matsuyama S, Voss O, Doseff AI, Song K, Danielpour D, Nagaraj RH. The anti-apoptotic function of human aA-crystallin is directly related to its chaperone activity. Cell Death Dis. 2010; 1:e31. PMID: 21364639; PMCID: PMC3032290.
    44. Nagaraj RH, Padmanabha S, Mailankot M, Staniszewska M, Mun LJ, Glomb MA, Linetsky MD. Modulation of advanced glycation endproduct synthesis by kynurenines in human lens proteins. Biochim Biophys Acta. 2010 Apr; 1804(4):829-38. PMID: 20026434; PMCID: PMC2829369.
    45. Mailankot M, Padmanabha S, Pasupuleti N, Major D, Howell S, Nagaraj RH. Glyoxalase I activity and immunoreactivity in the aging human lens. Biogerontology. 2009 Dec; 10(6):711-20. PMID: 19238574; PMCID: PMC3560407.
    46. Sivakamasundari C, Nagaraj R. Interaction of 18-residue peptides derived from amphipathic helical segments of globular proteins with model membranes. J Biosci. 2009 Jun; 34(2):239-50. PMID: 19550040.
      View in: PubMed
    47. Ni J, Yuan X, Gu J, Yue X, Gu X, Nagaraj RH, Crabb JW. Plasma protein pentosidine and carboxymethyllysine, biomarkers for age-related macular degeneration. Mol Cell Proteomics. 2009 Aug; 8(8):1921-33. PMID: 19435712; PMCID: PMC2722770.
    48. Chaudhary N, Nagaraj R. Hen lysozyme amyloid fibrils induce aggregation of erythrocytes and lipid vesicles. Mol Cell Biochem. 2009 Aug; 328(1-2):209-15. PMID: 19322639.
      View in: PubMed
    49. Mailankot M, Staniszewska MM, Butler H, Caprara MH, Howell S, Wang B, Doller C, Reneker LW, Nagaraj RH. Indoleamine 2,3-dioxygenase overexpression causes kynurenine-modification of proteins, fiber cell apoptosis and cataract formation in the mouse lens. Lab Invest. 2009 May; 89(5):498-512. PMID: 19308046; PMCID: PMC2722445.
    50. Kanade SR, Pasupuleti N, Nagaraj RH. Role of cysteine residues in the enhancement of chaperone function in methylglyoxal-modified human alpha A-crystallin. Mol Cell Biochem. 2009 Feb; 322(1-2):185-91. PMID: 19020808; PMCID: PMC3552637.
    51. Chakraborty TK, Koley D, Ravi R, Krishnakumari V, Nagaraj R, Kunwar AC. Synthesis, conformational analysis and biological studies of cyclic cationic antimicrobial peptides containing sugar amino acids. J Org Chem. 2008 Nov 21; 73(22):8731-44. PMID: 18937406.
      View in: PubMed
    52. Guo ZJ, Niu HX, Hou FF, Zhang L, Fu N, Nagai R, Lu X, Chen BH, Shan YX, Tian JW, Nagaraj RH, Xie D, Zhang X. Advanced oxidation protein products activate vascular endothelial cells via a RAGE-mediated signaling pathway. Antioxid Redox Signal. 2008 Oct; 10(10):1699-712. PMID: 18576917.
      View in: PubMed
    53. Mailankot M, Smith D, Howell S, Wang B, Jacobberger JW, Stefan T, Nagaraj RH. Cell cycle arrest by kynurenine in lens epithelial cells. Invest Ophthalmol Vis Sci. 2008 Dec; 49(12):5466-75. PMID: 18676626; PMCID: PMC2610264.
    54. Nagaraj RH, Biswas A, Miller A, Oya-Ito T, Bhat M. The other side of the Maillard reaction. Ann N Y Acad Sci. 2008 Apr; 1126:107-12. PMID: 18448802.
      View in: PubMed
    55. Biswas A, Lewis S, Wang B, Miyagi M, Santoshkumar P, Gangadhariah MH, Nagaraj RH. Chemical modulation of the chaperone function of human alphaA-crystallin. J Biochem. 2008 Jul; 144(1):21-32. PMID: 18344542; PMCID: PMC3564238.
    56. Biswas A, Wang B, Miyagi M, Nagaraj RH. Effect of methylglyoxal modification on stress-induced aggregation of client proteins and their chaperoning by human alphaA-crystallin. Biochem J. 2008 Feb 01; 409(3):771-7. PMID: 17941823.
      View in: PubMed
    57. Staniszewska M, Nagaraj RH. Detection of kynurenine modifications in proteins using a monoclonal antibody. J Immunol Methods. 2007 Jul 31; 324(1-2):63-73. PMID: 17574268.
      View in: PubMed
    58. Biswas A, Goshe J, Miller A, Santhoshkumar P, Luckey C, Bhat MB, Nagaraj RH. Paradoxical effects of substitution and deletion mutation of Arg56 on the structure and chaperone function of human alphaB-crystallin. Biochemistry. 2007 Feb 06; 46(5):1117-27. PMID: 17260942.
      View in: PubMed
    59. Puttaiah S, Biswas A, Staniszewska M, Nagaraj RH. Methylglyoxal inhibits glycation-mediated loss in chaperone function and synthesis of pentosidine in alpha-crystallin. Exp Eye Res. 2007 May; 84(5):914-21. PMID: 17368444.
      View in: PubMed
    60. Padival S, Nagaraj RH. Pyridoxamine inhibits maillard reactions in diabetic rat lenses. Ophthalmic Res. 2006; 38(5):294-302. PMID: 16974131.
      View in: PubMed
    61. Oya-Ito T, Liu BF, Nagaraj RH. Effect of methylglyoxal modification and phosphorylation on the chaperone and anti-apoptotic properties of heat shock protein 27. J Cell Biochem. 2006 Sep 01; 99(1):279-91. PMID: 16615138.
      View in: PubMed
    62. Varkey J, Singh S, Nagaraj R. Antibacterial activity of linear peptides spanning the carboxy-terminal beta-sheet domain of arthropod defensins. Peptides. 2006 Nov; 27(11):2614-23. PMID: 16914230.
      View in: PubMed
    63. Biswas A, Miller A, Oya-Ito T, Santhoshkumar P, Bhat M, Nagaraj RH. Effect of site-directed mutagenesis of methylglyoxal-modifiable arginine residues on the structure and chaperone function of human alphaA-crystallin. Biochemistry. 2006 Apr 11; 45(14):4569-77. PMID: 16584192; PMCID: PMC2597574.
    64. Staniszewska MM, Nagaraj RH. Upregulation of glyoxalase I fails to normalize methylglyoxal levels: a possible mechanism for biochemical changes in diabetic mouse lenses. Mol Cell Biochem. 2006 Aug; 288(1-2):29-36. PMID: 16583141.
      View in: PubMed
    65. Miller AG, Smith DG, Bhat M, Nagaraj RH. Glyoxalase I is critical for human retinal capillary pericyte survival under hyperglycemic conditions. J Biol Chem. 2006 Apr 28; 281(17):11864-71. PMID: 16505483.
      View in: PubMed
    66. Sowmya BL, Jagannadham MV, Nagaraj R. Interaction of synthetic peptides corresponding to the scaffolding domain of Caveolin-3 with model membranes. Biopolymers. 2006; 84(6):615-24. PMID: 16948121.
      View in: PubMed
    67. Puttaiah S, Zhang Y, Pilch HA, Pfahler C, Oya-Ito T, Sayre LM, Nagaraj RH. Detection of dideoxyosone intermediates of glycation using a monoclonal antibody: characterization of major epitope structures. Arch Biochem Biophys. 2006 Feb 15; 446(2):186-96. PMID: 16406213.
      View in: PubMed
    68. Harishchandran A, Nagaraj R. Interaction of a pseudosubstrate peptide of protein kinase C and its myristoylated form with lipid vesicles: only the myristoylated form translocates into the lipid bilayer. Biochim Biophys Acta. 2005 Jul 30; 1713(2):73-82. PMID: 15990084.
      View in: PubMed
    69. Nagaraj RH, Oya-Ito T, Bhat M, Liu B. Dicarbonyl stress and apoptosis of vascular cells: prevention by alphaB-crystallin. Ann N Y Acad Sci. 2005 Jun; 1043:158-65. PMID: 16037235.
      View in: PubMed
    70. Staniszewska MM, Nagaraj RH. 3-hydroxykynurenine-mediated modification of human lens proteins: structure determination of a major modification using a monoclonal antibody. J Biol Chem. 2005 Jun 10; 280(23):22154-64. PMID: 15817458.
      View in: PubMed
    71. Dhople VM, Nagaraj R. Conformation and activity of delta-lysin and its analogs. Peptides. 2005 Feb; 26(2):217-25. PMID: 15629533.
      View in: PubMed
    72. Liu B, Bhat M, Nagaraj RH. AlphaB-crystallin inhibits glucose-induced apoptosis in vascular endothelial cells. Biochem Biophys Res Commun. 2004 Aug 13; 321(1):254-8. PMID: 15358243.
      View in: PubMed
    73. Liu B, Bhat M, Padival AK, Smith DG, Nagaraj RH. Effect of dicarbonyl modification of fibronectin on retinal capillary pericytes. Invest Ophthalmol Vis Sci. 2004 Jun; 45(6):1983-95. PMID: 15161867.
      View in: PubMed
    74. Sitaram N, Subbalakshmi C, Nagaraj R. Indolicidin, a 13-residue basic antimicrobial peptide rich in tryptophan and proline, interacts with Ca(2+)-calmodulin. Biochem Biophys Res Commun. 2003 Oct 03; 309(4):879-84. PMID: 13679055.
      View in: PubMed
    75. Nagaraj RH, Oya-Ito T, Padayatti PS, Kumar R, Mehta S, West K, Levison B, Sun J, Crabb JW, Padival AK. Enhancement of chaperone function of alpha-crystallin by methylglyoxal modification. Biochemistry. 2003 Sep 16; 42(36):10746-55. PMID: 12962499.
      View in: PubMed
    76. Padival AK, Crabb JW, Nagaraj RH. Methylglyoxal modifies heat shock protein 27 in glomerular mesangial cells. FEBS Lett. 2003 Sep 11; 551(1-3):113-8. PMID: 12965214.
      View in: PubMed
    77. Krishnakumari V, Sharadadevi A, Singh S, Nagaraj R. Single disulfide and linear analogues corresponding to the carboxy-terminal segment of bovine beta-defensin-2: effects of introducing the beta-hairpin nucleating sequence d-pro-gly on antibacterial activity and Biophysical properties. Biochemistry. 2003 Aug 12; 42(31):9307-15. PMID: 12899617.
      View in: PubMed
    78. Dahm R, Bramke S, Dawczynski J, Nagaraj RH, Kasper M. Developmental aspects of galectin-3 expression in the lens. Histochem Cell Biol. 2003 Mar; 119(3):219-26. PMID: 12649736.
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    79. Pallavi B, Nagaraj R. Palmitoylated peptides from the cysteine-rich domain of SNAP-23 cause membrane fusion depending on peptide length, position of cysteines, and extent of palmitoylation. J Biol Chem. 2003 Apr 11; 278(15):12737-44. PMID: 12551899.
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    80. Kessel L, Kalinin S, Nagaraj RH, Larsen M, Johansson LB. Time-resolved and steady-state fluorescence spectroscopic studies of the human lens with comparison to argpyrimidine, pentosidine and 3-OH-kynurenine. Photochem Photobiol. 2002 Nov; 76(5):549-54. PMID: 12462652.
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    81. Mathys KC, Ponnampalam SN, Padival S, Nagaraj RH. Semicarbazide-sensitive amine oxidase in aortic smooth muscle cells mediates synthesis of a methylglyoxal-AGE: implications for vascular complications in diabetes. Biochem Biophys Res Commun. 2002 Oct 04; 297(4):863-9. PMID: 12359232.
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    82. Harishchandran A, Pallavi B, Nagaraj R. A synthetic strategy for ON-resin amino acid specific multiple fatty acid acylation of peptides. Protein Pept Lett. 2002 Oct; 9(5):411-7. PMID: 12370029.
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    83. Swamy-Mruthinti S, Miriam KC, Kumar SK, Biswas J, Ramakrishnan S, Nagaraj RH, Sulochana KN. Immunolocalization and quantification of advanced glycation end products in retinal neovascular membranes and serum: a possible role in ocular neovascularization. Curr Eye Res. 2002 Sep; 25(3):139-45. PMID: 12607183.
      View in: PubMed
    84. John GB, Anjum R, Khar A, Nagaraj R. Subcellular localization and physiological consequences of introducing a mitochondrial matrix targeting signal sequence in bax and its mutants. Exp Cell Res. 2002 Aug 15; 278(2):198-208. PMID: 12169275.
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    85. Sitaram N, Sai KP, Singh S, Sankaran K, Nagaraj R. Structure-function relationship studies on the frog skin antimicrobial peptide tigerinin 1: design of analogs with improved activity and their action on clinical bacterial isolates. Antimicrob Agents Chemother. 2002 Jul; 46(7):2279-83. PMID: 12069990; PMCID: PMC127301.
    86. Nagaraj RH, Sarkar P, Mally A, Biemel KM, Lederer MO, Padayatti PS. Effect of pyridoxamine on chemical modification of proteins by carbonyls in diabetic rats: characterization of a major product from the reaction of pyridoxamine and methylglyoxal. Arch Biochem Biophys. 2002 Jun 01; 402(1):110-9. PMID: 12051689.
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    87. Padayatti PS, Jiang C, Glomb MA, Uchida K, Nagaraj RH. High concentrations of glucose induce synthesis of argpyrimidine in retinal endothelial cells. Curr Eye Res. 2001 Aug; 23(2):106-15. PMID: 11840348.
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    88. Padayatti PS, Ng AS, Uchida K, Glomb MA, Nagaraj RH. Argpyrimidine, a blue fluorophore in human lens proteins: high levels in brunescent cataractous lenses. Invest Ophthalmol Vis Sci. 2001 May; 42(6):1299-304. PMID: 11328743.
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    89. Wilker SC, Chellan P, Arnold BM, Nagaraj RH. Chromatographic quantification of argpyrimidine, a methylglyoxal-derived product in tissue proteins: comparison with pentosidine. Anal Biochem. 2001 Mar; 290(2):353-8. PMID: 11237339.
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    90. Glomb MA, Rösch D, Nagaraj RH. N(delta)-(5-hydroxy-4,6-dimethylpyrimidine-2-yl)-l-ornithine, a novel methylglyoxal-arginine modification in beer. J Agric Food Chem. 2001 Jan; 49(1):366-72. PMID: 11170600.
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    91. Chellan P, Nagaraj RH. Early glycation products produce pentosidine cross-links on native proteins. novel mechanism of pentosidine formation and propagation of glycation. J Biol Chem. 2001 Feb 09; 276(6):3895-903. PMID: 11076948.
      View in: PubMed
    92. Kern TS, Tang J, Mizutani M, Kowluru RA, Nagaraj RH, Romeo G, Podesta F, Lorenzi M. Response of capillary cell death to aminoguanidine predicts the development of retinopathy: comparison of diabetes and galactosemia. Invest Ophthalmol Vis Sci. 2000 Nov; 41(12):3972-8. PMID: 11053301.
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    93. Sady C, Jiang CL, Chellan P, Madhun Z, Duve Y, Glomb MA, Nagaraj RH. Maillard reactions by alpha-oxoaldehydes: detection of glyoxal-modified proteins. Biochim Biophys Acta. 2000 Sep 29; 1481(2):255-64. PMID: 11018716.
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    94. Shamsi FA, Sharkey E, Creighton D, Nagaraj RH. Maillard reactions in lens proteins: methylglyoxal-mediated modifications in the rat lens. Exp Eye Res. 2000 Mar; 70(3):369-80. PMID: 10712823.
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    95. Shamsi FA, Nagaraj RH. Immunochemical detection of dicarbonyl-derived imidazolium protein crosslinks in human lenses. Curr Eye Res. 1999 Sep; 19(3):276-84. PMID: 10487968.
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    96. Chellan P, Nagaraj RH. Protein crosslinking by the Maillard reaction: dicarbonyl-derived imidazolium crosslinks in aging and diabetes. Arch Biochem Biophys. 1999 Aug 01; 368(1):98-104. PMID: 10415116.
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    97. Nagaraj RH, Shamsi FA, Huber B, Pischetsrieder M. Immunochemical detection of oxalate monoalkylamide, an ascorbate-derived Maillard reaction product in the human lens. FEBS Lett. 1999 Jun 25; 453(3):327-30. PMID: 10405169.
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    98. Shamsi FA, Lin K, Sady C, Nagaraj RH. Methylglyoxal-derived modifications in lens aging and cataract formation. Invest Ophthalmol Vis Sci. 1998 Nov; 39(12):2355-64. PMID: 9804144.
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    99. Shamsi FA, Partal A, Sady C, Glomb MA, Nagaraj RH. Immunological evidence for methylglyoxal-derived modifications in vivo. Determination of antigenic epitopes. J Biol Chem. 1998 Mar 20; 273(12):6928-36. PMID: 9506998.
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    100. Shipanova IN, Glomb MA, Nagaraj RH. Protein modification by methylglyoxal: chemical nature and synthetic mechanism of a major fluorescent adduct. Arch Biochem Biophys. 1997 Aug 01; 344(1):29-36. PMID: 9244378.
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    101. Smith MA, Nagaraj RH, Perry G. Protocol for quantitative analysis of paired helical filament solubilization: a method applicable to insoluble amyloids and inclusion bodies. Brain Res Brain Res Protoc. 1997 Aug; 1(3):247-52. PMID: 9385061.
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    102. Zhao HR, Nagaraj RH, Abraham EC. The role of alpha- and epsilon-amino groups in the glycation-mediated cross-linking of gammaB-crystallin. Study of three site-directed mutants. J Biol Chem. 1997 May 30; 272(22):14465-9. PMID: 9162088.
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    103. Ortwerth BJ, Prabhakaram M, Nagaraj RH, Linetsky M. The relative UV sensitizer activity of purified advanced glycation endproducts. Photochem Photobiol. 1997 Apr; 65(4):666-72. PMID: 9114742.
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    104. Portero-Otín M, Pamplona R, Bellmunt MJ, Bergua M, Nagaraj RH, Prat J. Urinary pyrraline as a biochemical marker of non-oxidative Maillard reactions in vivo. Life Sci. 1997; 60(4-5):279-87. PMID: 9010483.
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    105. Nagaraj RH, Shipanova IN, Faust FM. Protein cross-linking by the Maillard reaction. Isolation, characterization, and in vivo detection of a lysine-lysine cross-link derived from methylglyoxal. J Biol Chem. 1996 Aug 09; 271(32):19338-45. PMID: 8702619.
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    106. Nagaraj RH, Kern TS, Sell DR, Fogarty J, Engerman RL, Monnier VM. Evidence of a glycemic threshold for the formation of pentosidine in diabetic dog lens but not in collagen. Diabetes. 1996 May; 45(5):587-94. PMID: 8621008.
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    107. Smith MA, Siedlak SL, Richey PL, Nagaraj RH, Elhammer A, Perry G. Quantitative solubilization and analysis of insoluble paired helical filaments from Alzheimer disease. Brain Res. 1996 Apr 22; 717(1-2):99-108. PMID: 8738259.
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    108. Nagaraj RH, Sady C. The presence of a glucose-derived Maillard reaction product in the human lens. FEBS Lett. 1996 Mar 18; 382(3):234-8. PMID: 8605976.
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    109. Nagaraj RH, Portero-Otin M, Monnier VM. Pyrraline ether crosslinks as a basis for protein crosslinking by the advanced Maillard reaction in aging and diabetes. Arch Biochem Biophys. 1996 Jan 15; 325(2):152-8. PMID: 8561492.
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    110. Monnier VM, Nagaraj RH, Portero-Otin M, Glomb M, Elgawish AH, Sell DR, Friedlander MA. Structure of advanced Maillard reaction products and their pathological role. Nephrol Dial Transplant. 1996; 11 Suppl 5:20-6. PMID: 9044302.
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    111. Nagaraj RH, Monnier VM. Protein modification by the degradation products of ascorbate: formation of a novel pyrrole from the Maillard reaction of L-threose with proteins. Biochim Biophys Acta. 1995 Nov 15; 1253(1):75-84. PMID: 7492603.
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    112. Portero-Otin M, Nagaraj RH, Monnier VM. Chromatographic evidence for pyrraline formation during protein glycation in vitro and in vivo. Biochim Biophys Acta. 1995 Feb 22; 1247(1):74-80. PMID: 7873594.
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    113. Nagaraj RH, Prabhakaram M, Ortwerth BJ, Monnier VM. Suppression of pentosidine formation in galactosemic rat lens by an inhibitor of aldose reductase. Diabetes. 1994 Apr; 43(4):580-6. PMID: 8138064.
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    114. Monnier VM, Sell DR, Nagaraj RH. [The role of glucose in the pathogenesis of diabetes complications]. Journ Annu Diabetol Hotel Dieu. 1994; 61-70. PMID: 8051832.
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    115. Monnier VM, Miyata S, Nagaraj RH, Sell DR. Relevance of the early and advanced Maillard reaction in diabetic neuropathy. Diabet Med. 1993; 10 Suppl 2:103S-106S. PMID: 7687529.
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    116. Monnier VM, Sell DR, Nagaraj RH, Miyata S, Grandhee S, Odetti P, Ibrahim SA. Maillard reaction-mediated molecular damage to extracellular matrix and other tissue proteins in diabetes, aging, and uremia. Diabetes. 1992 Oct; 41 Suppl 2:36-41. PMID: 1526333.
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    117. Nagaraj RH, Monnier VM. Isolation and characterization of a blue fluorophore from human eye lens crystallins: in vitro formation from Maillard reaction with ascorbate and ribose. Biochim Biophys Acta. 1992 Mar 05; 1116(1):34-42. PMID: 1540622.
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    118. Sell DR, Nagaraj RH, Grandhee SK, Odetti P, Lapolla A, Fogarty J, Monnier VM. Pentosidine: a molecular marker for the cumulative damage to proteins in diabetes, aging, and uremia. Diabetes Metab Rev. 1991 Dec; 7(4):239-51. PMID: 1813279.
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    119. Nagaraj RH, Sell DR, Prabhakaram M, Ortwerth BJ, Monnier VM. High correlation between pentosidine protein crosslinks and pigmentation implicates ascorbate oxidation in human lens senescence and cataractogenesis. Proc Natl Acad Sci U S A. 1991 Nov 15; 88(22):10257-61. PMID: 1946446; PMCID: PMC52907.
    120. Monnier VM, Sell DR, Nagaraj RH, Miyata S. Mechanisms of protection against damage mediated by the Maillard reaction in aging. Gerontology. 1991; 37(1-3):152-65. PMID: 2055496.
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    121. Nagaraj RH, Monnier VM. Non-tryptophan fluorescence and high molecular weight protein formation in lens crystallins of rats with chronic galactosemia: prevention by the aldose reductase inhibitor sorbinil. Exp Eye Res. 1990 Oct; 51(4):411-8. PMID: 2120080.
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    122. Hayase F, Nagaraj RH, Miyata S, Njoroge FG, Monnier VM. Aging of proteins: immunological detection of a glucose-derived pyrrole formed during maillard reaction in vivo. J Biol Chem. 1989 Mar 05; 264(7):3758-64. PMID: 2917974.
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