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Eric M Poeschla

TitleProfessor
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM-MED

    Collapse Overview 
    Collapse overview
    Mailing Address: University of Colorado? Division of Infectious Diseases, Mail Code B168,?12700 E. 19th Avenue,?Aurora, CO 80045

    Medical School:
    Yale Medical School

    Residency:
    Internal Medicine, University of California at San Francisco

    Fellowship:
    Infectious Diseases, University of California at San Diego

    Prior Faculty Appointments:
    University of University of California at San Diego
    Mayo Clinic College of Medicine (1999-2014)

    Present Appointment (September 2014 to Present):

    Tim Gill Professor of Medicine and
    Chief, Division of Infectious Diseases
    University of Colorado School of Medicine



    Mailing Address:
    Division of Infectious Diseases, Mail Code B168, 12700 E. 19th Avenue, Aurora, CO 80045

    Medical School:
    Yale Medical School

    Residency:
    Internal Medicine, University of California at San Francisco

    Fellowship:
    Infectious Diseases, University of California at San Diego

    Prior Faculty Appointments:
    University of University of California at San Diego
    Mayo Clinic College of Medicine (1999-2014)

    Present Appointment (September 2014 to Present):

    Tim Gill Professor of Medicine and
    Chief, Division of Infectious Diseases
    University of Colorado School of Medicine


    Collapse Research 
    Collapse research activities and funding
    R21AI047536     (POESCHLA, ERIC M.)Sep 1, 1999 - Aug 31, 2005
    NIH/NIAID
    Lentiviral Genome Processing
    Role: Principal Investigator

    R01AI047536     (POESCHLA, ERIC M.)Sep 1, 1999 - Jul 31, 2009
    NIH/NIAID
    Lentiviral Genome Processing
    Role: Principal Investigator

    R01EY014411     (POESCHLA, ERIC M.)Apr 1, 2003 - Feb 28, 2013
    NIH/NEI
    Eicosanoid Gene Therapy
    Role: Principal Investigator

    R01AI077344     (POESCHLA, ERIC M.)May 1, 2008 - Feb 28, 2019
    NIH/NIAID
    Dependency Factors in HIV-1 Cytoplasmic-Nuclear Transit and Intgeration
    Role: Principal Investigator

    R01AI100797     (POESCHLA, ERIC M.)May 1, 2012 - Apr 30, 2017
    NIH/NIAID
    Introducing restriction factors into the genome of an AIDS virus host species
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Sowd GA, Serrao E, Wang H, Wang W, Fadel HJ, Poeschla EM, Engelman AN. A critical role for alternative polyadenylation factor CPSF6 in targeting HIV-1 integration to transcriptionally active chromatin. Proc Natl Acad Sci U S A. 2016 Feb 23; 113(8):E1054-63. PMID: 26858452; PMCID: PMC4776470.
    2. Painter MM, Morrison JH, Zoecklein LJ, Rinkoski TA, Watzlawik JO, Papke LM, Warrington AE, Bieber AJ, Matchett WE, Turkowski KL, Poeschla EM, Rodriguez M. Antiviral Protection via RdRP-Mediated Stable Activation of Innate Immunity. PLoS Pathog. 2015 Dec; 11(12):e1005311. PMID: 26633895; PMCID: PMC4669089.
    3. Singh PK, Plumb MR, Ferris AL, Iben JR, Wu X, Fadel HJ, Luke BT, Esnault C, Poeschla EM, Hughes SH, Kvaratskhelia M, Levin HL. LEDGF/p75 interacts with mRNA splicing factors and targets HIV-1 integration to highly spliced genes. Genes Dev. 2015 Nov 01; 29(21):2287-97. PMID: 26545813; PMCID: PMC4647561.
    4. Thierry S, Munir S, Thierry E, Subra F, Leh H, Zamborlini A, Saenz D, Levy DN, Lesbats P, Saïb A, Parissi V, Poeschla E, Deprez E, Delelis O. Integrase inhibitor reversal dynamics indicate unintegrated HIV-1 dna initiate de novo integration. Retrovirology. 2015 Mar 12; 12:24. PMID: 25808736; PMCID: PMC4372172.
    5. Pattabiraman PP, Rinkoski T, Poeschla E, Proia A, Challa P, Rao PV. RhoA GTPase-induced ocular hypertension in a rodent model is associated with increased fibrogenic activity in the trabecular meshwork. Am J Pathol. 2015 Feb; 185(2):496-512. PMID: 25499974; PMCID: PMC4305183.
    6. Slaughter A, Jurado KA, Deng N, Feng L, Kessl JJ, Shkriabai N, Larue RC, Fadel HJ, Patel PA, Jena N, Fuchs JR, Poeschla E, Levy RM, Engelman A, Kvaratskhelia M. The mechanism of H171T resistance reveals the importance of Nd-protonated His171 for the binding of allosteric inhibitor BI-D to HIV-1 integrase. Retrovirology. 2014 Nov 25; 11:100. PMID: 25421939; PMCID: PMC4251946.
    7. Abidi MZ, Sohail MR, Cummins N, Wilhelm M, Wengenack N, Brumble L, Shah H, Jane Hata D, McCullough A, Wendel A, Vikram HR, Kusne S, Litzow M, Letendre L, Lahr BD, Poeschla E, Walker RC. Stability in the cumulative incidence, severity and mortality of 101 cases of invasive mucormycosis in high-risk patients from 1995 to 2011: a comparison of eras immediately before and after the availability of voriconazole and echinocandin-amphotericin combination therapies. Mycoses. 2014 Nov; 57(11):687-98. PMID: 25040241; PMCID: PMC4192082.
    8. Fadel HJ, Morrison JH, Saenz DT, Fuchs JR, Kvaratskhelia M, Ekker SC, Poeschla EM. TALEN knockout of the PSIP1 gene in human cells: analyses of HIV-1 replication and allosteric integrase inhibitor mechanism. J Virol. 2014 Sep 01; 88(17):9704-17. PMID: 24942577; PMCID: PMC4136317.
    9. Sharma A, Slaughter A, Jena N, Feng L, Kessl JJ, Fadel HJ, Malani N, Male F, Wu L, Poeschla E, Bushman FD, Fuchs JR, Kvaratskhelia M. A new class of multimerization selective inhibitors of HIV-1 integrase. PLoS Pathog. 2014 May; 10(5):e1004171. PMID: 24874515; PMCID: PMC4038613.
    10. Meehan AM, Saenz DT, Guevera R, Morrison JH, Peretz M, Fadel HJ, Hamada M, van Deursen J, Poeschla EM. A cyclophilin homology domain-independent role for Nup358 in HIV-1 infection. PLoS Pathog. 2014 Feb; 10(2):e1003969. PMID: 24586169; PMCID: PMC3930637.
    11. Morrison JH, Guevara RB, Marcano AC, Saenz DT, Fadel HJ, Rogstad DK, Poeschla EM. Feline immunodeficiency virus envelope glycoproteins antagonize tetherin through a distinctive mechanism that requires virion incorporation. J Virol. 2014 Mar; 88(6):3255-72. PMID: 24390322; PMCID: PMC3957917.
    12. Boisgerault N, Kottke T, Pulido J, Thompson J, Diaz RM, Rommelfanger-Konkol D, Embry A, Saenz D, Poeschla E, Pandha H, Harrington K, Melcher A, Selby P, Vile R. Functional cloning of recurrence-specific antigens identifies molecular targets to treat tumor relapse. Mol Ther. 2013 Aug; 21(8):1507-16. PMID: 23752316; PMCID: PMC3734666.
    13. Poeschla E. The importance of becoming double-stranded: Innate immunity and the kinetic model of HIV-1 central plus strand synthesis. Virology. 2013 Jun 20; 441(1):1-11. PMID: 23561461; PMCID: PMC3891808.
    14. Bancos I, Bida JP, Tian D, Bundrick M, John K, Holte MN, Her YF, Evans D, Saenz DT, Poeschla EM, Hook D, Georg G, Maher LJ. High-throughput screening for growth inhibitors using a yeast model of familial paraganglioma. PLoS One. 2013; 8(2):e56827. PMID: 23451094; PMCID: PMC3579935.
    15. Xu X, Powell DW, Lambring CJ, Puckett AH, Deschenes L, Prough RA, Poeschla EM, Samuelson DJ. Human MCS5A1 candidate breast cancer susceptibility gene FBXO10 is induced by cellular stress and correlated with lens epithelium-derived growth factor (LEDGF). Mol Carcinog. 2014 Apr; 53(4):300-13. PMID: 23138933.
      View in: PubMed
    16. Elinav H, Wu Y, Coskun A, Hryckiewicz K, Kemler I, Hu Y, Rogers H, Hao B, Ben Mamoun C, Poeschla E, Sutton R. Human CRM1 augments production of infectious human and feline immunodeficiency viruses from murine cells. J Virol. 2012 Nov; 86(22):12053-68. PMID: 22933280; PMCID: PMC3486471.
    17. Kemler I, Saenz D, Poeschla E. Feline immunodeficiency virus Gag is a nuclear shuttling protein. J Virol. 2012 Aug; 86(16):8402-11. PMID: 22623802; PMCID: PMC3421727.
    18. Fadel HJ, Saenz DT, Poeschla EM. Construction and testing of orfA +/- FIV reporter viruses. Viruses. 2012 01; 4(1):184-99. PMID: 22355458; PMCID: PMC3280524.
    19. Saenz DT, Barraza R, Loewen N, Teo W, Poeschla EM. Production and harvest of feline immunodeficiency virus-based lentiviral vector from cells grown in T75 tissue-culture flasks. Cold Spring Harb Protoc. 2012 Jan 01; 2012(1):124-5. PMID: 22194266.
      View in: PubMed
    20. Saenz DT, Barraza R, Loewen N, Teo W, Poeschla EM. Feline immunodeficiency virus-based lentiviral vectors. Cold Spring Harb Protoc. 2012 Jan 01; 2012(1):71-6. PMID: 22194268.
      View in: PubMed
    21. Saenz DT, Barraza R, Loewen N, Teo W, Poeschla EM. Production, harvest, and concentration of feline immunodeficiency virus-based lentiviral vector from cells grown in CF10 or CF2 devices. Cold Spring Harb Protoc. 2012 Jan 01; 2012(1):118-23. PMID: 22194265.
      View in: PubMed
    22. Saenz DT, Barraza R, Loewen N, Teo W, Poeschla EM. Titration of feline immunodeficiency virus-based lentiviral vector preparations. Cold Spring Harb Protoc. 2012 Jan 01; 2012(1):126-8. PMID: 22194267.
      View in: PubMed
    23. Fadel HJ, Saenz DT, Guevara R, von Messling V, Peretz M, Poeschla EM. Productive replication and evolution of HIV-1 in ferret cells. J Virol. 2012 Feb; 86(4):2312-22. PMID: 22171279; PMCID: PMC3302389.
    24. Wongsrikeao P, Saenz D, Rinkoski T, Otoi T, Poeschla E. Antiviral restriction factor transgenesis in the domestic cat. Nat Methods. 2011 Sep 11; 8(10):853-9. PMID: 21909101; PMCID: PMC4006694.
    25. Fadel HJ, Poeschla EM. Retroviral restriction and dependency factors in primates and carnivores. Vet Immunol Immunopathol. 2011 Oct 15; 143(3-4):179-89. PMID: 21715018; PMCID: PMC3902784.
    26. Poeschla EM. Primate and feline lentiviruses in current intrinsic immunity research: the cat is back. Vet Immunol Immunopathol. 2011 Oct 15; 143(3-4):215-20. PMID: 21715025; PMCID: PMC3167931.
    27. Sainski AM, Natesampillai S, Cummins NW, Bren GD, Taylor J, Saenz DT, Poeschla EM, Badley AD. The HIV-1-specific protein Casp8p41 induces death of infected cells through Bax/Bak. J Virol. 2011 Aug; 85(16):7965-75. PMID: 21653671; PMCID: PMC3147983.
    28. Meehan AM, Saenz DT, Morrison J, Hu C, Peretz M, Poeschla EM. LEDGF dominant interference proteins demonstrate prenuclear exposure of HIV-1 integrase and synergize with LEDGF depletion to destroy viral infectivity. J Virol. 2011 Apr; 85(7):3570-83. PMID: 21270171; PMCID: PMC3067863.
    29. Hu C, Saenz DT, Fadel HJ, Walker W, Peretz M, Poeschla EM. The HIV-1 central polypurine tract functions as a second line of defense against APOBEC3G/F. J Virol. 2010 Nov; 84(22):11981-93. PMID: 20844042; PMCID: PMC2977901.
    30. Stern MA, Hu C, Saenz DT, Fadel HJ, Sims O, Peretz M, Poeschla EM. Productive replication of Vif-chimeric HIV-1 in feline cells. J Virol. 2010 Jul; 84(14):7378-95. PMID: 20463079; PMCID: PMC2898257.
    31. Kemler I, Meehan A, Poeschla EM. Live-cell coimaging of the genomic RNAs and Gag proteins of two lentiviruses. J Virol. 2010 Jul; 84(13):6352-66. PMID: 20392841; PMCID: PMC2903278.
    32. Barraza RA, McLaren JW, Poeschla EM. Prostaglandin pathway gene therapy for sustained reduction of intraocular pressure. Mol Ther. 2010 Mar; 18(3):491-501. PMID: 19953083; PMCID: PMC2839422.
    33. Lachance DH, Lennon VA, Pittock SJ, Tracy JA, Krecke KN, Amrami KK, Poeschla EM, Orenstein R, Scheithauer BW, Sejvar JJ, Holzbauer S, Devries AS, Dyck PJ. An outbreak of neurological autoimmunity with polyradiculoneuropathy in workers exposed to aerosolised porcine neural tissue: a descriptive study. Lancet Neurol. 2010 Jan; 9(1):55-66. PMID: 19945916.
      View in: PubMed
    34. Meehan AM, Poeschla EM. Chromatin tethering and retroviral integration: recent discoveries and parallels with DNA viruses. Biochim Biophys Acta. 2010 Mar-Apr; 1799(3-4):182-91. PMID: 19836475.
      View in: PubMed
    35. Meehan AM, Saenz DT, Morrison JH, Garcia-Rivera JA, Peretz M, Llano M, Poeschla EM. LEDGF/p75 proteins with alternative chromatin tethers are functional HIV-1 cofactors. PLoS Pathog. 2009 Jul; 5(7):e1000522. PMID: 19609362; PMCID: PMC2706977.
    36. Barraza RA, Rasmussen CA, Loewen N, Cameron JD, Gabelt BT, Teo WL, Kaufman PL, Poeschla EM. Prolonged transgene expression with lentiviral vectors in the aqueous humor outflow pathway of nonhuman primates. Hum Gene Ther. 2009 Mar; 20(3):191-200. PMID: 19301472; PMCID: PMC2855254.
    37. Llano M, Gaznick N, Poeschla EM. Rapid, controlled and intensive lentiviral vector-based RNAi. Methods Mol Biol. 2009; 485:257-70. PMID: 19020831; PMCID: PMC3095943.
    38. Llano M, Morrison J, Poeschla EM. Virological and cellular roles of the transcriptional coactivator LEDGF/p75. Curr Top Microbiol Immunol. 2009; 339:125-46. PMID: 20012527; PMCID: PMC3093762.
    39. Miest T, Saenz D, Meehan A, Llano M, Poeschla EM. Intensive RNAi with lentiviral vectors in mammalian cells. Methods. 2009 Apr; 47(4):298-303. PMID: 19041944; PMCID: PMC2879882.
    40. Ezzat MK, Howell KG, Bahler CK, Beito TG, Loewen N, Poeschla EM, Fautsch MP. Characterization of monoclonal antibodies against the glaucoma-associated protein myocilin. Exp Eye Res. 2008 Oct; 87(4):376-84. PMID: 18674535; PMCID: PMC2866087.
    41. Poeschla EM. Integrase, LEDGF/p75 and HIV replication. Cell Mol Life Sci. 2008 May; 65(9):1403-24. PMID: 18264802; PMCID: PMC3902792.
    42. Barraza RA, Poeschla EM. Human gene therapy vectors derived from feline lentiviruses. Vet Immunol Immunopathol. 2008 May 15; 123(1-2):23-31. PMID: 18289699; PMCID: PMC2443640.
    43. Marshall HM, Ronen K, Berry C, Llano M, Sutherland H, Saenz D, Bickmore W, Poeschla E, Bushman FD. Role of PSIP1/LEDGF/p75 in lentiviral infectivity and integration targeting. PLoS One. 2007 Dec 19; 2(12):e1340. PMID: 18092005; PMCID: PMC2129110.
    44. Diaz-Griffero F, Kar A, Lee M, Stremlau M, Poeschla E, Sodroski J. Comparative requirements for the restriction of retrovirus infection by TRIM5alpha and TRIMCyp. Virology. 2007 Dec 20; 369(2):400-10. PMID: 17920096; PMCID: PMC2153441.
    45. Khare PD, Loewen N, Teo W, Barraza RA, Saenz DT, Johnson DH, Poeschla EM. Durable, safe, multi-gene lentiviral vector expression in feline trabecular meshwork. Mol Ther. 2008 Jan; 16(1):97-106. PMID: 17912236.
      View in: PubMed
    46. Llano M, Saenz DT, Meehan A, Wongthida P, Peretz M, Walker WH, Teo W, Poeschla EM. An essential role for LEDGF/p75 in HIV integration. Science. 2006 Oct 20; 314(5798):461-4. PMID: 16959972.
      View in: PubMed
    47. Temesgen Z, Cainelli F, Poeschla EM, Vlahakis SA, Vento S. Approach to salvage antiretroviral therapy in heavily antiretroviral-experienced HIV-positive adults. Lancet Infect Dis. 2006 Aug; 6(8):496-507. PMID: 16870528.
      View in: PubMed
    48. Llano M, Vanegas M, Hutchins N, Thompson D, Delgado S, Poeschla EM. Identification and characterization of the chromatin-binding domains of the HIV-1 integrase interactor LEDGF/p75. J Mol Biol. 2006 Jul 21; 360(4):760-73. PMID: 16793062.
      View in: PubMed
    49. Fautsch MP, Bahler CK, Vrabel AM, Howell KG, Loewen N, Teo WL, Poeschla EM, Johnson DH. Perfusion of his-tagged eukaryotic myocilin increases outflow resistance in human anterior segments in the presence of aqueous humor. Invest Ophthalmol Vis Sci. 2006 Jan; 47(1):213-21. PMID: 16384965.
      View in: PubMed
    50. Saenz DT, Teo W, Olsen JC, Poeschla EM. Restriction of feline immunodeficiency virus by Ref1, Lv1, and primate TRIM5alpha proteins. J Virol. 2005 Dec; 79(24):15175-88. PMID: 16306589; PMCID: PMC1316021.
    51. Ciuffi A, Llano M, Poeschla E, Hoffmann C, Leipzig J, Shinn P, Ecker JR, Bushman F. A role for LEDGF/p75 in targeting HIV DNA integration. Nat Med. 2005 Dec; 11(12):1287-9. PMID: 16311605.
      View in: PubMed
    52. Vanegas M, Llano M, Delgado S, Thompson D, Peretz M, Poeschla E. Identification of the LEDGF/p75 HIV-1 integrase-interaction domain and NLS reveals NLS-independent chromatin tethering. J Cell Sci. 2005 Apr 15; 118(Pt 8):1733-43. PMID: 15797927.
      View in: PubMed
    53. Merten CA, Stitz J, Braun G, Poeschla EM, Cichutek K, Buchholz CJ. Directed evolution of retrovirus envelope protein cytoplasmic tails guided by functional incorporation into lentivirus particles. J Virol. 2005 Jan; 79(2):834-40. PMID: 15613311; PMCID: PMC538528.
    54. Loewen N, Poeschla EM. Lentiviral vectors. Adv Biochem Eng Biotechnol. 2005; 99:169-91. PMID: 16568892.
      View in: PubMed
    55. Llano M, Delgado S, Vanegas M, Poeschla EM. Lens epithelium-derived growth factor/p75 prevents proteasomal degradation of HIV-1 integrase. J Biol Chem. 2004 Dec 31; 279(53):55570-7. PMID: 15475359.
      View in: PubMed
    56. Kemler I, Azmi I, Poeschla EM. The critical role of proximal gag sequences in feline immunodeficiency virus genome encapsidation. Virology. 2004 Sep 15; 327(1):111-20. PMID: 15327902.
      View in: PubMed
    57. Llano M, Vanegas M, Fregoso O, Saenz D, Chung S, Peretz M, Poeschla EM. LEDGF/p75 determines cellular trafficking of diverse lentiviral but not murine oncoretroviral integrase proteins and is a component of functional lentiviral preintegration complexes. J Virol. 2004 Sep; 78(17):9524-37. PMID: 15308744; PMCID: PMC506940.
    58. Loewen N, Fautsch MP, Teo WL, Bahler CK, Johnson DH, Poeschla EM. Long-term, targeted genetic modification of the aqueous humor outflow tract coupled with noninvasive imaging of gene expression in vivo. Invest Ophthalmol Vis Sci. 2004 Sep; 45(9):3091-8. PMID: 15326125.
      View in: PubMed
    59. Loewen N, Leske DA, Cameron JD, Chen Y, Whitwam T, Simari RD, Teo WL, Fautsch MP, Poeschla EM, Holmes JM. Long-term retinal transgene expression with FIV versus adenoviral vectors. Mol Vis. 2004 Apr 13; 10:272-80. PMID: 15094709.
      View in: PubMed
    60. Saenz DT, Loewen N, Peretz M, Whitwam T, Barraza R, Howell KG, Holmes JM, Good M, Poeschla EM. Unintegrated lentivirus DNA persistence and accessibility to expression in nondividing cells: analysis with class I integrase mutants. J Virol. 2004 Mar; 78(6):2906-20. PMID: 14990709; PMCID: PMC353756.
    61. Nguyen KL, llano M, Akari H, Miyagi E, Poeschla EM, Strebel K, Bour S. Codon optimization of the HIV-1 vpu and vif genes stabilizes their mRNA and allows for highly efficient Rev-independent expression. Virology. 2004 Feb 20; 319(2):163-75. PMID: 15015498.
      View in: PubMed
    62. Saenz DT, Poeschla EM. FIV: from lentivirus to lentivector. J Gene Med. 2004 Feb; 6 Suppl 1:S95-104. PMID: 14978754.
      View in: PubMed
    63. Loewen N, Leske DA, Chen Y, Teo WL, Saenz DT, Peretz M, Holmes JM, Poeschla EM. Comparison of wild-type and class I integrase mutant-FIV vectors in retina demonstrates sustained expression of integrated transgenes in retinal pigment epithelium. J Gene Med. 2003 Dec; 5(12):1009-17. PMID: 14661176.
      View in: PubMed
    64. Poeschla EM. Non-primate lentiviral vectors. Curr Opin Mol Ther. 2003 Oct; 5(5):529-40. PMID: 14601523.
      View in: PubMed
    65. Loewen N, Barraza R, Whitwam T, Saenz DT, Kemler I, Poeschla EM. FIV Vectors. Methods Mol Biol. 2003; 229:251-71. PMID: 12824636.
      View in: PubMed
    66. Kemler I, Barraza R, Poeschla EM. Mapping the encapsidation determinants of feline immunodeficiency virus. J Virol. 2002 Dec; 76(23):11889-903. PMID: 12414931; PMCID: PMC136900.
    67. Loewen N, Bahler C, Teo WL, Whitwam T, Peretz M, Xu R, Fautsch MP, Johnson DH, Poeschla EM. Preservation of aqueous outflow facility after second-generation FIV vector-mediated expression of marker genes in anterior segments of human eyes. Invest Ophthalmol Vis Sci. 2002 Dec; 43(12):3686-90. PMID: 12454037.
      View in: PubMed
    68. Llano M, Kelly T, Vanegas M, Peretz M, Peterson TE, Simari RD, Poeschla EM. Blockade of human immunodeficiency virus type 1 expression by caveolin-1. J Virol. 2002 Sep; 76(18):9152-64. PMID: 12186899; PMCID: PMC136432.
    69. Meehan AM, Virk A, Swanson K, Poeschla EM. Severe pleuropulmonary paragonimiasis 8 years after emigration from a region of endemicity. Clin Infect Dis. 2002 Jul 01; 35(1):87-90. PMID: 12060881.
      View in: PubMed
    70. Cheng L, Chaidhawangul S, Wong-Staal F, Gilbert J, Poeschla E, Toyoguchi M, El-Bradey M, Bergeron-Lynn G, Soules KA, Freeman WR. Human immunodeficiency virus type 2 (HIV-2) vector-mediated in vivo gene transfer into adult rabbit retina. Curr Eye Res. 2002 Mar; 24(3):196-201. PMID: 12221527.
      View in: PubMed
    71. Thompson DL, Sabbagh Y, Tenenhouse HS, Roche PC, Drezner MK, Salisbury JL, Grande JP, Poeschla EM, Kumar R. Ontogeny of Phex/PHEX protein expression in mouse embryo and subcellular localization in osteoblasts. J Bone Miner Res. 2002 Feb; 17(2):311-20. PMID: 11811562.
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    72. Loewen N, Fautsch MP, Peretz M, Bahler CK, Cameron JD, Johnson DH, Poeschla EM. Genetic modification of human trabecular meshwork with lentiviral vectors. Hum Gene Ther. 2001 Nov 20; 12(17):2109-19. PMID: 11747600.
      View in: PubMed
    73. Whitwam T, Peretz M, Poeschla E. Identification of a central DNA flap in feline immunodeficiency virus. J Virol. 2001 Oct; 75(19):9407-14. PMID: 11533203; PMCID: PMC114508.
    74. Wong-Staal F, Poeschla EM, Looney DJ. A controlled, Phase 1 clinical trial to evaluate the safety and effects in HIV-1 infected humans of autologous lymphocytes transduced with a ribozyme that cleaves HIV-1 RNA. Hum Gene Ther. 1998 Nov 01; 9(16):2407-25. PMID: 9829540.
      View in: PubMed
    75. Poeschla E, Gilbert J, Li X, Huang S, Ho A, Wong-Staal F. Identification of a human immunodeficiency virus type 2 (HIV-2) encapsidation determinant and transduction of nondividing human cells by HIV-2-based lentivirus vectors. J Virol. 1998 Aug; 72(8):6527-36. PMID: 9658096; PMCID: PMC109822.
    76. Poeschla EM, Looney DJ. CXCR4 is required by a nonprimate lentivirus: heterologous expression of feline immunodeficiency virus in human, rodent, and feline cells. J Virol. 1998 Aug; 72(8):6858-66. PMID: 9658135; PMCID: PMC109895.
    77. Poeschla EM, Wong-Staal F, Looney DJ. Efficient transduction of nondividing human cells by feline immunodeficiency virus lentiviral vectors. Nat Med. 1998 Mar; 4(3):354-7. PMID: 9500613.
      View in: PubMed
    78. Poeschla E, Corbeau P, Wong-Staal F. Development of HIV vectors for anti-HIV gene therapy. Proc Natl Acad Sci U S A. 1996 Oct 15; 93(21):11395-9. PMID: 8876146; PMCID: PMC38068.
    79. Yu M, Poeschla E, Yamada O, Degrandis P, Leavitt MC, Heusch M, Yees JK, Wong-Staal F, Hampel A. In vitro and in vivo characterization of a second functional hairpin ribozyme against HIV-1. Virology. 1995 Jan 10; 206(1):381-6. PMID: 7831794.
      View in: PubMed
    80. Poeschla EM, Wong-Staal F. Gene therapy and HIV disease. AIDS Clin Rev. 1995-1996; 1-45. PMID: 7488553.
      View in: PubMed
    81. Poeschla E, Wong-Staal F. Antiviral and anticancer ribozymes. Curr Opin Oncol. 1994 Nov; 6(6):601-6. PMID: 7827172.
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    82. Leavitt MC, Yu M, Yamada O, Kraus G, Looney D, Poeschla E, Wong-Staal F. Transfer of an anti-HIV-1 ribozyme gene into primary human lymphocytes. Hum Gene Ther. 1994 Sep; 5(9):1115-20. PMID: 7833371.
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    83. Poeschla E, Wong-Staal F. Molecular biology of HIV: challenges for the second decade. AIDS Res Hum Retroviruses. 1994 Feb; 10(2):111-2. PMID: 8198866.
      View in: PubMed
    84. Yu M, Poeschla E, Wong-Staal F. Progress towards gene therapy for HIV infection. Gene Ther. 1994 Jan; 1(1):13-26. PMID: 7584055.
      View in: PubMed
    85. Kelley GG, Poeschla EM, Barron HV, Forrest JN. A1 adenosine receptors inhibit chloride transport in the shark rectal gland. Dissociation of inhibition and cyclic AMP. J Clin Invest. 1990 May; 85(5):1629-36. PMID: 1970583; PMCID: PMC296615.
    86. Ukena D, Poeschla E, Hüttemann E, Schwabe U. Effects of N-ethylmaleimide on adenosine receptors of rat fat cells and human platelets. Naunyn Schmiedebergs Arch Pharmacol. 1984 Sep; 327(3):247-53. PMID: 6092976.
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    87. Ukena D, Poeschla E, Schwabe U. Guanine nucleotide and cation regulation of radioligand binding to Ri adenosine receptors of rat fat cells. Naunyn Schmiedebergs Arch Pharmacol. 1984 Jun; 326(3):241-7. PMID: 6089005.
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    Poeschla's Networks
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