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Eric M Poeschla

TitleProfessor
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM-MED
    Other Positions
    TitleDivision Head
    InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
    DepartmentSOM-MED
    DivisionInfectious Disease


    Collapse Overview 
    Collapse overview
    Mailing Address: University of Colorado? Division of Infectious Diseases, Mail Code B168,?12700 E. 19th Avenue,?Aurora, CO 80045

    Medical School:
    Yale Medical School

    Residency:
    Internal Medicine, University of California at San Francisco

    Fellowship:
    Infectious Diseases, University of California at San Diego

    Prior Faculty Appointments:
    University of University of California at San Diego
    Mayo Clinic College of Medicine (1999-2014)

    Present Appointment (September 2014 to Present):

    Tim Gill Professor of Medicine and
    Chief, Division of Infectious Diseases
    University of Colorado School of Medicine



    Mailing Address:
    Division of Infectious Diseases, Mail Code B168, 12700 E. 19th Avenue, Aurora, CO 80045

    Medical School:
    Yale Medical School

    Residency:
    Internal Medicine, University of California at San Francisco

    Fellowship:
    Infectious Diseases, University of California at San Diego

    Prior Faculty Appointments:
    University of University of California at San Diego
    Mayo Clinic College of Medicine (1999-2014)

    Present Appointment (September 2014 to Present):

    Tim Gill Professor of Medicine and
    Chief, Division of Infectious Diseases
    University of Colorado School of Medicine

    Collapse Research 
    Collapse research activities and funding
    R01AI047536     (POESCHLA, ERIC M.)Sep 1, 1999 - Aug 31, 2003
    NIH
    Lentiviral Genome Processing
    Role: Principal Investigator

    R21AI047536     (POESCHLA, ERIC M.)Sep 1, 1999 - Aug 31, 2005
    NIH
    Lentiviral Genome Processing
    Role: Principal Investigator

    R01EY014411     (POESCHLA, ERIC M.)Apr 1, 2003 - Feb 29, 2008
    NIH
    Eicosanoid Gene Therapy
    Role: Principal Investigator

    R01AI077344     (POESCHLA, ERIC M.)May 1, 2008 - Apr 30, 2013
    NIH
    Dependency Factors in HIV-1 Cytoplasmic-Nuclear Transit and Intgeration
    Role: Principal Investigator

    R01AI100797     (POESCHLA, ERIC M.)Mar 2, 2015 - Jun 30, 2014
    NIH
    Introducing restriction factors into the genome of an AIDS virus host species
    Role: Principal Investigator

    DP1DA043915     (POESCHLA, ERIC M.)Apr 1, 2017 - Feb 28, 2022
    NIH
    Novel Approaches to Innate Immunity Against HIV-1 and Other Co-infection Viruses
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Rebensburg SV, Wei G, Larue RC, Lindenberger J, Francis AC, Annamalai AS, Morrison J, Shkriabai N, Huang SW, KewalRamani V, Poeschla EM, Melikyan GB, Kvaratskhelia M. Sec24C is an HIV-1 host dependency factor crucial for virus replication. Nat Microbiol. 2021 Mar 01. PMID: 33649557.
      View in: PubMed
    2. Miller MA, Molina KC, Gutman JA, Scherger S, Lum JM, Mossad SB, Burgess M, Cheng MP, Chuang ST, Jacobs SE, Melendez DP, Shah DP, Zimmer A, Sohail MR, Syed S, Walker RC, Poeschla EM, Abidi MZ. Mucormycosis in Hematopoietic Cell Transplant Recipients and in Patients With Hematological Malignancies in the Era of New Antifungal Agents. Open Forum Infect Dis. 2021 Feb; 8(2):ofaa646. PMID: 33575424.
      View in: PubMed
    3. Poeschla E. Neutralizing SARS-CoV-2. Elife. 2020 12 15; 9. PMID: 33320086.
      View in: PubMed
    4. Bonfiglio G, Rosal K, Henao-Martínez A, Franco-Paredes C, Poeschla EM, Moo-Young J, Seefeldt T, Dunlevy H, Haas M, Young J. The long journey inside immigration detention centres in the USA. J Travel Med. 2020 11 09; 27(7). PMID: 32463091.
      View in: PubMed
    5. Bester SM, Wei G, Zhao H, Adu-Ampratwum D, Iqbal N, Courouble VV, Francis AC, Annamalai AS, Singh PK, Shkriabai N, Van Blerkom P, Morrison J, Poeschla EM, Engelman AN, Melikyan GB, Griffin PR, Fuchs JR, Asturias FJ, Kvaratskhelia M. Structural and mechanistic bases for a potent HIV-1 capsid inhibitor. Science. 2020 10 16; 370(6514):360-364. PMID: 33060363.
      View in: PubMed
    6. Li W, Singh PK, Sowd GA, Bedwell GJ, Jang S, Achuthan V, Oleru AV, Wong D, Fadel HJ, Lee K, KewalRamani VN, Poeschla EM, Herschhorn A, Engelman AN. CPSF6-Dependent Targeting of Speckle-Associated Domains Distinguishes Primate from Nonprimate Lentiviral Integration. mBio. 2020 09 29; 11(5). PMID: 32994325.
      View in: PubMed
    7. Franco-Paredes C, Ghandnoosh N, Latif H, Krsak M, Henao-Martinez AF, Robins M, Vargas Barahona L, Poeschla EM. Decarceration and community re-entry in the COVID-19 era. Lancet Infect Dis. 2021 01; 21(1):e11-e16. PMID: 33007225.
      View in: PubMed
    8. Morrison JH, Miller C, Bankers L, Crameri G, Wang LF, Poeschla EM. A Potent Postentry Restriction to Primate Lentiviruses in a Yinpterochiropteran Bat. mBio. 2020 09 15; 11(5). PMID: 32934084.
      View in: PubMed
    9. Krsak M, Johnson SC, Poeschla EM. COVID-19 Serosurveillance May Facilitate Return-to-Work Decisions. Am J Trop Med Hyg. 2020 06; 102(6):1189-1190. PMID: 32329432.
      View in: PubMed
    10. Krsak M, Morrisette T, Miller M, Molina K, Huang M, Damioli L, Pisney L, Wong M, Poeschla E. Advantages of Outpatient Treatment with Long-Acting Lipoglycopeptides for Serious Gram-Positive Infections: A Review. Pharmacotherapy. 2020 05; 40(5):469-478. PMID: 32239771.
      View in: PubMed
    11. Miller CM, Barrett BS, Chen J, Morrison JH, Radomile C, Santiago ML, Poeschla EM. Systemic Expression of a Viral RdRP Protects against Retrovirus Infection and Disease. J Virol. 2020 04 16; 94(9). PMID: 32051266.
      View in: PubMed
    12. Bankers L, Miller C, Liu G, Thongkittidilok C, Morrison J, Poeschla EM. Development of IFN-Stimulated Gene Expression from Embryogenesis through Adulthood, with and without Constitutive MDA5 Pathway Activation. J Immunol. 2020 05 15; 204(10):2791-2807. PMID: 32277054.
      View in: PubMed
    13. Chand S, Thapa S, Kon S, Johnson SC, Poeschla EM, Franco-Paredes C, Rodríguez-Morales AJ, Mattar S, Henao-Martínez AF. Hantavirus Infection with Renal Failure and Proteinuria, Colorado, USA, 2019. Emerg Infect Dis. 2020 02; 26(2):383-385. PMID: 31961310.
      View in: PubMed
    14. Godavarthy A, Kelly R, Jimah J, Beckford M, Caza T, Fernandez D, Huang N, Duarte M, Lewis J, Fadel HJ, Poeschla EM, Banki K, Perl A. Lupus-associated endogenous retroviral LTR polymorphism and epigenetic imprinting promote HRES-1/RAB4 expression and mTOR activation. JCI Insight. 2020 01 16; 5(1). PMID: 31805010.
      View in: PubMed
    15. Decker CJ, Steiner HR, Hoon-Hanks LL, Morrison JH, Haist KC, Stabell AC, Poeschla EM, Morrison TE, Stenglein MD, Sawyer SL, Parker R. dsRNA-Seq: Identification of Viral Infection by Purifying and Sequencing dsRNA. Viruses. 2019 10 14; 11(10). PMID: 31615058.
      View in: PubMed
    16. Krsak M, Patel NU, Poeschla EM. Case Report: Hepatic Fascioliasis in a Young Afghani Woman with Severe Wheezing, High-Grade Peripheral Eosinophilia, and Liver Lesions: A Brief Literature Review. Am J Trop Med Hyg. 2019 03; 100(3):588-590. PMID: 30628571.
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    17. Achuthan V, Perreira JM, Sowd GA, Puray-Chavez M, McDougall WM, Paulucci-Holthauzen A, Wu X, Fadel HJ, Poeschla EM, Multani AS, Hughes SH, Sarafianos SG, Brass AL, Engelman AN. Capsid-CPSF6 Interaction Licenses Nuclear HIV-1 Trafficking to Sites of Viral DNA Integration. . 2018 09 12; 24(3):392-404.e8. PMID: 30173955.
      View in: PubMed
    18. Kumar S, Morrison JH, Dingli D, Poeschla E. HIV-1 Activation of Innate Immunity Depends Strongly on the Intracellular Level of TREX1 and Sensing of Incomplete Reverse Transcription Products. J Virol. 2018 08 15; 92(16). PMID: 29769349.
      View in: PubMed
    19. Sowd GA, Serrao E, Wang H, Wang W, Fadel HJ, Poeschla EM, Engelman AN. A critical role for alternative polyadenylation factor CPSF6 in targeting HIV-1 integration to transcriptionally active chromatin. Proc Natl Acad Sci U S A. 2016 Feb 23; 113(8):E1054-63. PMID: 26858452.
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    20. Painter MM, Morrison JH, Zoecklein LJ, Rinkoski TA, Watzlawik JO, Papke LM, Warrington AE, Bieber AJ, Matchett WE, Turkowski KL, Poeschla EM, Rodriguez M. Antiviral Protection via RdRP-Mediated Stable Activation of Innate Immunity. PLoS Pathog. 2015 Dec; 11(12):e1005311. PMID: 26633895.
      View in: PubMed
    21. Singh PK, Plumb MR, Ferris AL, Iben JR, Wu X, Fadel HJ, Luke BT, Esnault C, Poeschla EM, Hughes SH, Kvaratskhelia M, Levin HL. LEDGF/p75 interacts with mRNA splicing factors and targets HIV-1 integration to highly spliced genes. Genes Dev. 2015 Nov 01; 29(21):2287-97. PMID: 26545813.
      View in: PubMed
    22. Thierry S, Munir S, Thierry E, Subra F, Leh H, Zamborlini A, Saenz D, Levy DN, Lesbats P, Saïb A, Parissi V, Poeschla E, Deprez E, Delelis O. Integrase inhibitor reversal dynamics indicate unintegrated HIV-1 dna initiate de novo integration. Retrovirology. 2015 Mar 12; 12:24. PMID: 25808736.
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    23. Pattabiraman PP, Rinkoski T, Poeschla E, Proia A, Challa P, Rao PV. RhoA GTPase-induced ocular hypertension in a rodent model is associated with increased fibrogenic activity in the trabecular meshwork. Am J Pathol. 2015 Feb; 185(2):496-512. PMID: 25499974.
      View in: PubMed
    24. Slaughter A, Jurado KA, Deng N, Feng L, Kessl JJ, Shkriabai N, Larue RC, Fadel HJ, Patel PA, Jena N, Fuchs JR, Poeschla E, Levy RM, Engelman A, Kvaratskhelia M. The mechanism of H171T resistance reveals the importance of Nd-protonated His171 for the binding of allosteric inhibitor BI-D to HIV-1 integrase. Retrovirology. 2014 Nov 25; 11:100. PMID: 25421939.
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    25. Abidi MZ, Sohail MR, Cummins N, Wilhelm M, Wengenack N, Brumble L, Shah H, Jane Hata D, McCullough A, Wendel A, Vikram HR, Kusne S, Litzow M, Letendre L, Lahr BD, Poeschla E, Walker RC. Stability in the cumulative incidence, severity and mortality of 101 cases of invasive mucormycosis in high-risk patients from 1995 to 2011: a comparison of eras immediately before and after the availability of voriconazole and echinocandin-amphotericin combination therapies. Mycoses. 2014 Nov; 57(11):687-98. PMID: 25040241.
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    26. Fadel HJ, Morrison JH, Saenz DT, Fuchs JR, Kvaratskhelia M, Ekker SC, Poeschla EM. TALEN knockout of the PSIP1 gene in human cells: analyses of HIV-1 replication and allosteric integrase inhibitor mechanism. J Virol. 2014 Sep 01; 88(17):9704-17. PMID: 24942577.
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    27. Sharma A, Slaughter A, Jena N, Feng L, Kessl JJ, Fadel HJ, Malani N, Male F, Wu L, Poeschla E, Bushman FD, Fuchs JR, Kvaratskhelia M. A new class of multimerization selective inhibitors of HIV-1 integrase. PLoS Pathog. 2014 May; 10(5):e1004171. PMID: 24874515.
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    28. Meehan AM, Saenz DT, Guevera R, Morrison JH, Peretz M, Fadel HJ, Hamada M, van Deursen J, Poeschla EM. A cyclophilin homology domain-independent role for Nup358 in HIV-1 infection. PLoS Pathog. 2014 Feb; 10(2):e1003969. PMID: 24586169.
      View in: PubMed
    29. Morrison JH, Guevara RB, Marcano AC, Saenz DT, Fadel HJ, Rogstad DK, Poeschla EM. Feline immunodeficiency virus envelope glycoproteins antagonize tetherin through a distinctive mechanism that requires virion incorporation. J Virol. 2014 Mar; 88(6):3255-72. PMID: 24390322.
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    30. Boisgerault N, Kottke T, Pulido J, Thompson J, Diaz RM, Rommelfanger-Konkol D, Embry A, Saenz D, Poeschla E, Pandha H, Harrington K, Melcher A, Selby P, Vile R. Functional cloning of recurrence-specific antigens identifies molecular targets to treat tumor relapse. Mol Ther. 2013 Aug; 21(8):1507-16. PMID: 23752316.
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    31. Poeschla E. The importance of becoming double-stranded: Innate immunity and the kinetic model of HIV-1 central plus strand synthesis. Virology. 2013 Jun 20; 441(1):1-11. PMID: 23561461.
      View in: PubMed
    32. Bancos I, Bida JP, Tian D, Bundrick M, John K, Holte MN, Her YF, Evans D, Saenz DT, Poeschla EM, Hook D, Georg G, Maher LJ. High-throughput screening for growth inhibitors using a yeast model of familial paraganglioma. PLoS One. 2013; 8(2):e56827. PMID: 23451094.
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    33. Xu X, Powell DW, Lambring CJ, Puckett AH, Deschenes L, Prough RA, Poeschla EM, Samuelson DJ. Human MCS5A1 candidate breast cancer susceptibility gene FBXO10 is induced by cellular stress and correlated with lens epithelium-derived growth factor (LEDGF). Mol Carcinog. 2014 Apr; 53(4):300-13. PMID: 23138933.
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    34. Elinav H, Wu Y, Coskun A, Hryckiewicz K, Kemler I, Hu Y, Rogers H, Hao B, Ben Mamoun C, Poeschla E, Sutton R. Human CRM1 augments production of infectious human and feline immunodeficiency viruses from murine cells. J Virol. 2012 Nov; 86(22):12053-68. PMID: 22933280.
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    35. Kemler I, Saenz D, Poeschla E. Feline immunodeficiency virus Gag is a nuclear shuttling protein. J Virol. 2012 Aug; 86(16):8402-11. PMID: 22623802.
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    36. Fadel HJ, Saenz DT, Poeschla EM. Construction and testing of orfA +/- FIV reporter viruses. Viruses. 2012 01; 4(1):184-99. PMID: 22355458.
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    37. Saenz DT, Barraza R, Loewen N, Teo W, Poeschla EM. Production and harvest of feline immunodeficiency virus-based lentiviral vector from cells grown in T75 tissue-culture flasks. Cold Spring Harb Protoc. 2012 Jan 01; 2012(1):124-5. PMID: 22194266.
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    38. Saenz DT, Barraza R, Loewen N, Teo W, Poeschla EM. Feline immunodeficiency virus-based lentiviral vectors. Cold Spring Harb Protoc. 2012 Jan 01; 2012(1):71-6. PMID: 22194268.
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    39. Saenz DT, Barraza R, Loewen N, Teo W, Poeschla EM. Production, harvest, and concentration of feline immunodeficiency virus-based lentiviral vector from cells grown in CF10 or CF2 devices. Cold Spring Harb Protoc. 2012 Jan 01; 2012(1):118-23. PMID: 22194265.
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    40. Saenz DT, Barraza R, Loewen N, Teo W, Poeschla EM. Titration of feline immunodeficiency virus-based lentiviral vector preparations. Cold Spring Harb Protoc. 2012 Jan 01; 2012(1):126-8. PMID: 22194267.
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    41. Fadel HJ, Saenz DT, Guevara R, von Messling V, Peretz M, Poeschla EM. Productive replication and evolution of HIV-1 in ferret cells. J Virol. 2012 Feb; 86(4):2312-22. PMID: 22171279.
      View in: PubMed
    42. Wongsrikeao P, Saenz D, Rinkoski T, Otoi T, Poeschla E. Antiviral restriction factor transgenesis in the domestic cat. Nat Methods. 2011 Sep 11; 8(10):853-9. PMID: 21909101.
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    43. Fadel HJ, Poeschla EM. Retroviral restriction and dependency factors in primates and carnivores. Vet Immunol Immunopathol. 2011 Oct 15; 143(3-4):179-89. PMID: 21715018.
      View in: PubMed
    44. Poeschla EM. Primate and feline lentiviruses in current intrinsic immunity research: the cat is back. Vet Immunol Immunopathol. 2011 Oct 15; 143(3-4):215-20. PMID: 21715025.
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    45. Sainski AM, Natesampillai S, Cummins NW, Bren GD, Taylor J, Saenz DT, Poeschla EM, Badley AD. The HIV-1-specific protein Casp8p41 induces death of infected cells through Bax/Bak. J Virol. 2011 Aug; 85(16):7965-75. PMID: 21653671.
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    46. Meehan AM, Saenz DT, Morrison J, Hu C, Peretz M, Poeschla EM. LEDGF dominant interference proteins demonstrate prenuclear exposure of HIV-1 integrase and synergize with LEDGF depletion to destroy viral infectivity. J Virol. 2011 Apr; 85(7):3570-83. PMID: 21270171.
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    47. Hu C, Saenz DT, Fadel HJ, Walker W, Peretz M, Poeschla EM. The HIV-1 central polypurine tract functions as a second line of defense against APOBEC3G/F. J Virol. 2010 Nov; 84(22):11981-93. PMID: 20844042.
      View in: PubMed
    48. Stern MA, Hu C, Saenz DT, Fadel HJ, Sims O, Peretz M, Poeschla EM. Productive replication of Vif-chimeric HIV-1 in feline cells. J Virol. 2010 Jul; 84(14):7378-95. PMID: 20463079.
      View in: PubMed
    49. Kemler I, Meehan A, Poeschla EM. Live-cell coimaging of the genomic RNAs and Gag proteins of two lentiviruses. J Virol. 2010 Jul; 84(13):6352-66. PMID: 20392841.
      View in: PubMed
    50. Barraza RA, McLaren JW, Poeschla EM. Prostaglandin pathway gene therapy for sustained reduction of intraocular pressure. Mol Ther. 2010 Mar; 18(3):491-501. PMID: 19953083.
      View in: PubMed
    51. Lachance DH, Lennon VA, Pittock SJ, Tracy JA, Krecke KN, Amrami KK, Poeschla EM, Orenstein R, Scheithauer BW, Sejvar JJ, Holzbauer S, Devries AS, Dyck PJ. An outbreak of neurological autoimmunity with polyradiculoneuropathy in workers exposed to aerosolised porcine neural tissue: a descriptive study. Lancet Neurol. 2010 Jan; 9(1):55-66. PMID: 19945916.
      View in: PubMed
    52. Meehan AM, Poeschla EM. Chromatin tethering and retroviral integration: recent discoveries and parallels with DNA viruses. Biochim Biophys Acta. 2010 Mar-Apr; 1799(3-4):182-91. PMID: 19836475.
      View in: PubMed
    53. Meehan AM, Saenz DT, Morrison JH, Garcia-Rivera JA, Peretz M, Llano M, Poeschla EM. LEDGF/p75 proteins with alternative chromatin tethers are functional HIV-1 cofactors. PLoS Pathog. 2009 Jul; 5(7):e1000522. PMID: 19609362.
      View in: PubMed
    54. Barraza RA, Rasmussen CA, Loewen N, Cameron JD, Gabelt BT, Teo WL, Kaufman PL, Poeschla EM. Prolonged transgene expression with lentiviral vectors in the aqueous humor outflow pathway of nonhuman primates. Hum Gene Ther. 2009 Mar; 20(3):191-200. PMID: 19301472.
      View in: PubMed
    55. Llano M, Gaznick N, Poeschla EM. Rapid, controlled and intensive lentiviral vector-based RNAi. Methods Mol Biol. 2009; 485:257-70. PMID: 19020831.
      View in: PubMed
    56. Llano M, Morrison J, Poeschla EM. Virological and cellular roles of the transcriptional coactivator LEDGF/p75. Curr Top Microbiol Immunol. 2009; 339:125-46. PMID: 20012527.
      View in: PubMed
    57. Miest T, Saenz D, Meehan A, Llano M, Poeschla EM. Intensive RNAi with lentiviral vectors in mammalian cells. Methods. 2009 Apr; 47(4):298-303. PMID: 19041944.
      View in: PubMed
    58. Ezzat MK, Howell KG, Bahler CK, Beito TG, Loewen N, Poeschla EM, Fautsch MP. Characterization of monoclonal antibodies against the glaucoma-associated protein myocilin. Exp Eye Res. 2008 Oct; 87(4):376-84. PMID: 18674535.
      View in: PubMed
    59. Poeschla EM. Integrase, LEDGF/p75 and HIV replication. Cell Mol Life Sci. 2008 May; 65(9):1403-24. PMID: 18264802.
      View in: PubMed
    60. Barraza RA, Poeschla EM. Human gene therapy vectors derived from feline lentiviruses. Vet Immunol Immunopathol. 2008 May 15; 123(1-2):23-31. PMID: 18289699.
      View in: PubMed
    61. Marshall HM, Ronen K, Berry C, Llano M, Sutherland H, Saenz D, Bickmore W, Poeschla E, Bushman FD. Role of PSIP1/LEDGF/p75 in lentiviral infectivity and integration targeting. PLoS One. 2007 Dec 19; 2(12):e1340. PMID: 18092005.
      View in: PubMed
    62. Diaz-Griffero F, Kar A, Lee M, Stremlau M, Poeschla E, Sodroski J. Comparative requirements for the restriction of retrovirus infection by TRIM5alpha and TRIMCyp. Virology. 2007 Dec 20; 369(2):400-10. PMID: 17920096.
      View in: PubMed
    63. Khare PD, Loewen N, Teo W, Barraza RA, Saenz DT, Johnson DH, Poeschla EM. Durable, safe, multi-gene lentiviral vector expression in feline trabecular meshwork. Mol Ther. 2008 Jan; 16(1):97-106. PMID: 17912236.
      View in: PubMed
    64. Llano M, Saenz DT, Meehan A, Wongthida P, Peretz M, Walker WH, Teo W, Poeschla EM. An essential role for LEDGF/p75 in HIV integration. Science. 2006 Oct 20; 314(5798):461-4. PMID: 16959972.
      View in: PubMed
    65. Temesgen Z, Cainelli F, Poeschla EM, Vlahakis SA, Vento S. Approach to salvage antiretroviral therapy in heavily antiretroviral-experienced HIV-positive adults. Lancet Infect Dis. 2006 Aug; 6(8):496-507. PMID: 16870528.
      View in: PubMed
    66. Llano M, Vanegas M, Hutchins N, Thompson D, Delgado S, Poeschla EM. Identification and characterization of the chromatin-binding domains of the HIV-1 integrase interactor LEDGF/p75. J Mol Biol. 2006 Jul 21; 360(4):760-73. PMID: 16793062.
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    67. Fautsch MP, Bahler CK, Vrabel AM, Howell KG, Loewen N, Teo WL, Poeschla EM, Johnson DH. Perfusion of his-tagged eukaryotic myocilin increases outflow resistance in human anterior segments in the presence of aqueous humor. Invest Ophthalmol Vis Sci. 2006 Jan; 47(1):213-21. PMID: 16384965.
      View in: PubMed
    68. Saenz DT, Teo W, Olsen JC, Poeschla EM. Restriction of feline immunodeficiency virus by Ref1, Lv1, and primate TRIM5alpha proteins. J Virol. 2005 Dec; 79(24):15175-88. PMID: 16306589.
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    69. Ciuffi A, Llano M, Poeschla E, Hoffmann C, Leipzig J, Shinn P, Ecker JR, Bushman F. A role for LEDGF/p75 in targeting HIV DNA integration. Nat Med. 2005 Dec; 11(12):1287-9. PMID: 16311605.
      View in: PubMed
    70. Vanegas M, Llano M, Delgado S, Thompson D, Peretz M, Poeschla E. Identification of the LEDGF/p75 HIV-1 integrase-interaction domain and NLS reveals NLS-independent chromatin tethering. J Cell Sci. 2005 Apr 15; 118(Pt 8):1733-43. PMID: 15797927.
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    71. Merten CA, Stitz J, Braun G, Poeschla EM, Cichutek K, Buchholz CJ. Directed evolution of retrovirus envelope protein cytoplasmic tails guided by functional incorporation into lentivirus particles. J Virol. 2005 Jan; 79(2):834-40. PMID: 15613311.
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    72. Loewen N, Poeschla EM. Lentiviral vectors. Adv Biochem Eng Biotechnol. 2005; 99:169-91. PMID: 16568892.
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    73. Llano M, Delgado S, Vanegas M, Poeschla EM. Lens epithelium-derived growth factor/p75 prevents proteasomal degradation of HIV-1 integrase. J Biol Chem. 2004 Dec 31; 279(53):55570-7. PMID: 15475359.
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    74. Kemler I, Azmi I, Poeschla EM. The critical role of proximal gag sequences in feline immunodeficiency virus genome encapsidation. Virology. 2004 Sep 15; 327(1):111-20. PMID: 15327902.
      View in: PubMed
    75. Llano M, Vanegas M, Fregoso O, Saenz D, Chung S, Peretz M, Poeschla EM. LEDGF/p75 determines cellular trafficking of diverse lentiviral but not murine oncoretroviral integrase proteins and is a component of functional lentiviral preintegration complexes. J Virol. 2004 Sep; 78(17):9524-37. PMID: 15308744.
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    76. Loewen N, Fautsch MP, Teo WL, Bahler CK, Johnson DH, Poeschla EM. Long-term, targeted genetic modification of the aqueous humor outflow tract coupled with noninvasive imaging of gene expression in vivo. Invest Ophthalmol Vis Sci. 2004 Sep; 45(9):3091-8. PMID: 15326125.
      View in: PubMed
    77. Loewen N, Leske DA, Cameron JD, Chen Y, Whitwam T, Simari RD, Teo WL, Fautsch MP, Poeschla EM, Holmes JM. Long-term retinal transgene expression with FIV versus adenoviral vectors. Mol Vis. 2004 Apr 13; 10:272-80. PMID: 15094709.
      View in: PubMed
    78. Saenz DT, Loewen N, Peretz M, Whitwam T, Barraza R, Howell KG, Holmes JM, Good M, Poeschla EM. Unintegrated lentivirus DNA persistence and accessibility to expression in nondividing cells: analysis with class I integrase mutants. J Virol. 2004 Mar; 78(6):2906-20. PMID: 14990709.
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    79. Nguyen KL, llano M, Akari H, Miyagi E, Poeschla EM, Strebel K, Bour S. Codon optimization of the HIV-1 vpu and vif genes stabilizes their mRNA and allows for highly efficient Rev-independent expression. Virology. 2004 Feb 20; 319(2):163-75. PMID: 15015498.
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    80. Saenz DT, Poeschla EM. FIV: from lentivirus to lentivector. J Gene Med. 2004 Feb; 6 Suppl 1:S95-104. PMID: 14978754.
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    81. Loewen N, Leske DA, Chen Y, Teo WL, Saenz DT, Peretz M, Holmes JM, Poeschla EM. Comparison of wild-type and class I integrase mutant-FIV vectors in retina demonstrates sustained expression of integrated transgenes in retinal pigment epithelium. J Gene Med. 2003 Dec; 5(12):1009-17. PMID: 14661176.
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    82. Poeschla EM. Non-primate lentiviral vectors. Curr Opin Mol Ther. 2003 Oct; 5(5):529-40. PMID: 14601523.
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    83. Loewen N, Barraza R, Whitwam T, Saenz DT, Kemler I, Poeschla EM. FIV Vectors. Methods Mol Biol. 2003; 229:251-71. PMID: 12824636.
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    84. Kemler I, Barraza R, Poeschla EM. Mapping the encapsidation determinants of feline immunodeficiency virus. J Virol. 2002 Dec; 76(23):11889-903. PMID: 12414931.
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    85. Loewen N, Bahler C, Teo WL, Whitwam T, Peretz M, Xu R, Fautsch MP, Johnson DH, Poeschla EM. Preservation of aqueous outflow facility after second-generation FIV vector-mediated expression of marker genes in anterior segments of human eyes. Invest Ophthalmol Vis Sci. 2002 Dec; 43(12):3686-90. PMID: 12454037.
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    86. Llano M, Kelly T, Vanegas M, Peretz M, Peterson TE, Simari RD, Poeschla EM. Blockade of human immunodeficiency virus type 1 expression by caveolin-1. J Virol. 2002 Sep; 76(18):9152-64. PMID: 12186899.
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    87. Meehan AM, Virk A, Swanson K, Poeschla EM. Severe pleuropulmonary paragonimiasis 8 years after emigration from a region of endemicity. Clin Infect Dis. 2002 Jul 01; 35(1):87-90. PMID: 12060881.
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    88. Cheng L, Chaidhawangul S, Wong-Staal F, Gilbert J, Poeschla E, Toyoguchi M, El-Bradey M, Bergeron-Lynn G, Soules KA, Freeman WR. Human immunodeficiency virus type 2 (HIV-2) vector-mediated in vivo gene transfer into adult rabbit retina. Curr Eye Res. 2002 Mar; 24(3):196-201. PMID: 12221527.
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    89. Thompson DL, Sabbagh Y, Tenenhouse HS, Roche PC, Drezner MK, Salisbury JL, Grande JP, Poeschla EM, Kumar R. Ontogeny of Phex/PHEX protein expression in mouse embryo and subcellular localization in osteoblasts. J Bone Miner Res. 2002 Feb; 17(2):311-20. PMID: 11811562.
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    90. Loewen N, Fautsch MP, Peretz M, Bahler CK, Cameron JD, Johnson DH, Poeschla EM. Genetic modification of human trabecular meshwork with lentiviral vectors. Hum Gene Ther. 2001 Nov 20; 12(17):2109-19. PMID: 11747600.
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    91. Whitwam T, Peretz M, Poeschla E. Identification of a central DNA flap in feline immunodeficiency virus. J Virol. 2001 Oct; 75(19):9407-14. PMID: 11533203.
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    92. Wong-Staal F, Poeschla EM, Looney DJ. A controlled, Phase 1 clinical trial to evaluate the safety and effects in HIV-1 infected humans of autologous lymphocytes transduced with a ribozyme that cleaves HIV-1 RNA. Hum Gene Ther. 1998 Nov 01; 9(16):2407-25. PMID: 9829540.
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    93. Poeschla E, Gilbert J, Li X, Huang S, Ho A, Wong-Staal F. Identification of a human immunodeficiency virus type 2 (HIV-2) encapsidation determinant and transduction of nondividing human cells by HIV-2-based lentivirus vectors. J Virol. 1998 Aug; 72(8):6527-36. PMID: 9658096.
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    94. Poeschla EM, Looney DJ. CXCR4 is required by a nonprimate lentivirus: heterologous expression of feline immunodeficiency virus in human, rodent, and feline cells. J Virol. 1998 Aug; 72(8):6858-66. PMID: 9658135.
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    95. Poeschla EM, Wong-Staal F, Looney DJ. Efficient transduction of nondividing human cells by feline immunodeficiency virus lentiviral vectors. Nat Med. 1998 Mar; 4(3):354-7. PMID: 9500613.
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    96. Poeschla E, Corbeau P, Wong-Staal F. Development of HIV vectors for anti-HIV gene therapy. Proc Natl Acad Sci U S A. 1996 Oct 15; 93(21):11395-9. PMID: 8876146.
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    97. Yu M, Poeschla E, Yamada O, Degrandis P, Leavitt MC, Heusch M, Yees JK, Wong-Staal F, Hampel A. In vitro and in vivo characterization of a second functional hairpin ribozyme against HIV-1. Virology. 1995 Jan 10; 206(1):381-6. PMID: 7831794.
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    98. Poeschla EM, Wong-Staal F. Gene therapy and HIV disease. AIDS Clin Rev. 1995-1996; 1-45. PMID: 7488553.
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    99. Poeschla E, Wong-Staal F. Antiviral and anticancer ribozymes. Curr Opin Oncol. 1994 Nov; 6(6):601-6. PMID: 7827172.
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    100. Leavitt MC, Yu M, Yamada O, Kraus G, Looney D, Poeschla E, Wong-Staal F. Transfer of an anti-HIV-1 ribozyme gene into primary human lymphocytes. Hum Gene Ther. 1994 Sep; 5(9):1115-20. PMID: 7833371.
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    101. Poeschla E, Wong-Staal F. Molecular biology of HIV: challenges for the second decade. AIDS Res Hum Retroviruses. 1994 Feb; 10(2):111-2. PMID: 8198866.
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    102. Yu M, Poeschla E, Wong-Staal F. Progress towards gene therapy for HIV infection. Gene Ther. 1994 Jan; 1(1):13-26. PMID: 7584055.
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    103. Kelley GG, Poeschla EM, Barron HV, Forrest JN. A1 adenosine receptors inhibit chloride transport in the shark rectal gland. Dissociation of inhibition and cyclic AMP. J Clin Invest. 1990 May; 85(5):1629-36. PMID: 1970583.
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    104. Ukena D, Poeschla E, Hüttemann E, Schwabe U. Effects of N-ethylmaleimide on adenosine receptors of rat fat cells and human platelets. Naunyn Schmiedebergs Arch Pharmacol. 1984 Sep; 327(3):247-53. PMID: 6092976.
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    105. Ukena D, Poeschla E, Schwabe U. Guanine nucleotide and cation regulation of radioligand binding to Ri adenosine receptors of rat fat cells. Naunyn Schmiedebergs Arch Pharmacol. 1984 Jun; 326(3):241-7. PMID: 6089005.
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