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Anna Malykhina

TitleAssociate Professor
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM-SRG

    Collapse Research 
    Collapse research activities and funding
    R01DK077699     (MALYKHINA, ANNA P.)Jul 1, 2008 - Apr 30, 2014
    NIH/NIDDK
    Cross-sensitization in the pelvis and neurogenic bladder
    Role: Principal Investigator

    P20DK097819     (MALYKHINA, ANNA P.)Sep 29, 2012 - Jul 31, 2015
    NIH/NIDDK
    Neurogenic bladder dysfunctions in neurological disorders
    Role: Principal Investigator

    R01DK095817     (MALYKHINA, ANNA P.)Sep 8, 2014 - May 31, 2018
    NIH/NIDDK
    Role of Mechanotransduction in detrusor over activity
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Pineda RH, Nedumaran B, Hypolite JA, Pan XQ, Wilson S, Meacham RB, Malykhina AP. Altered expression and modulation of the two-pore domain (K2p) mechano-gated potassium channel TREK-1 in overactive human detrusor. Am J Physiol Renal Physiol. 2017 May 24; ajprenal.00638.2016. PMID: 28539337.
      View in: PubMed
    2. Richter HE, Moalli P, Amundsen CL, Malykhina AP, Wallace D, Rogers R, Myers D, Paraiso M, Albo M, Shi H, Nolen T, Meikle S, Word RA. Urinary Biomarkers in Women with Refractory Urgency Urinary Incontinence Randomized to Sacral Neuromodulation versus OnabotulinumtoxinA Compared to Controls. J Urol. 2017 Jun; 197(6):1487-1495. PMID: 28089729.
      View in: PubMed
    3. Malykhina AP, Brodie KE, Wilcox DT. Genitourinary and gastrointestinal co-morbidities in children: The role of neural circuits in regulation of visceral function. J Pediatr Urol. 2017 Apr; 13(2):177-182. PMID: 28392009.
      View in: PubMed
    4. Smith AL, Hantsoo L, Malykhina AP, File DW, Valentino R, Wein AJ, Sammel MD, Epperson CN. Basal and stress-activated hypothalamic pituitary adrenal axis function in postmenopausal women with overactive bladder. Int Urogynecol J. 2016 Sep; 27(9):1383-91. PMID: 26942596; PMCID: PMC4988874.
    5. Iguchi N, Malykhina AP, Wilcox DT. Inhibition of HIF Reduces Bladder Hypertrophy and Improves Bladder Function in Murine Model of Partial Bladder Outlet Obstruction. J Urol. 2016 Apr; 195(4 Pt 2):1250-6. PMID: 26926557.
      View in: PubMed
    6. Weissbart SJ, Pechersky D, Malykhina A, Bavaria T, Parrillo L, Arya LA, Bilello M, Wein AJ, Smith AL. The impact of pontine disease on lower urinary tract symptoms in patients with multiple sclerosis. Neurourol Urodyn. 2017 Feb; 36(2):453-456. PMID: 26741487.
      View in: PubMed
    7. Hypolite JA, Malykhina AP. Regulation of urinary bladder function by protein kinase C in physiology and pathophysiology. BMC Urol. 2015 Nov 04; 15:110. PMID: 26538012; PMCID: PMC4634593.
    8. Hypolite JA, Chang S, Wein AJ, Chacko S, Malykhina AP. Protein kinase C modulates frequency of micturition and non-voiding contractions in the urinary bladder via neuronal and myogenic mechanisms. BMC Urol. 2015 Apr 21; 15:34. PMID: 25896919; PMCID: PMC4407874.
    9. Lamarre NS, Braverman AS, Malykhina AP, Barbe MF, Ruggieri MR. Alterations in nerve-evoked bladder contractions in a coronavirus-induced mouse model of multiple sclerosis. PLoS One. 2014; 9(10):e109314. PMID: 25310403; PMCID: PMC4195612.
    10. McMillan MT, Pan XQ, Smith AL, Newman DK, Weiss SR, Ruggieri MR, Malykhina AP. Coronavirus-induced demyelination of neural pathways triggers neurogenic bladder overactivity in a mouse model of multiple sclerosis. Am J Physiol Renal Physiol. 2014 Sep 01; 307(5):F612-22. PMID: 25007876; PMCID: PMC4154110.
    11. Lei Q, Pan XQ, Chang S, Malkowicz SB, Guzzo TJ, Malykhina AP. Response of the human detrusor to stretch is regulated by TREK-1, a two-pore-domain (K2P) mechano-gated potassium channel. J Physiol. 2014 Jul 15; 592(14):3013-30. PMID: 24801307; PMCID: PMC4214657.
    12. Pan XQ, Malykhina AP. Estrous cycle dependent fluctuations of regulatory neuropeptides in the lower urinary tract of female rats upon colon-bladder cross-sensitization. PLoS One. 2014; 9(5):e94872. PMID: 24788240; PMCID: PMC4006778.
    13. Malykhina A, Hanno P. How are we going to make progress treating bladder pain syndrome? ICI-RS 2013. Neurourol Urodyn. 2014 Jun; 33(5):625-9. PMID: 24615847.
      View in: PubMed
    14. Malykhina AP, Lei Q, Chang S, Pan XQ, Villamor AN, Smith AL, Seftel AD. Bladder outlet obstruction triggers neural plasticity in sensory pathways and contributes to impaired sensitivity in erectile dysfunction. Am J Physiol Regul Integr Comp Physiol. 2013 May 15; 304(10):R837-45. PMID: 23535456.
      View in: PubMed
    15. Lei Q, Pan XQ, Villamor AN, Asfaw TS, Chang S, Zderic SA, Malykhina AP. Lack of transient receptor potential vanilloid 1 channel modulates the development of neurogenic bladder dysfunction induced by cross-sensitization in afferent pathways. J Neuroinflammation. 2013 Jan 11; 10:3. PMID: 23305398; PMCID: PMC3556132.
    16. Hypolite JA, Lei Q, Chang S, Zderic SA, Butler S, Wein AJ, Malykhina AP, Chacko S. Spontaneous and evoked contractions are regulated by PKC-mediated signaling in detrusor smooth muscle: involvement of BK channels. Am J Physiol Renal Physiol. 2013 Mar 01; 304(5):F451-62. PMID: 23269650; PMCID: PMC3602715.
    17. Malykhina AP, Lei Q, Erickson CS, Epstein ML, Saban MR, Davis CA, Saban R. VEGF induces sensory and motor peripheral plasticity, alters bladder function, and promotes visceral sensitivity. BMC Physiol. 2012 Dec 19; 12:15. PMID: 23249422; PMCID: PMC3543727.
    18. Malykhina AP, Qin C, Lei Q, Pan XQ, Greenwood-Van Meerveld B, Foreman RD. Differential effects of intravesical resiniferatoxin on excitability of bladder spinal neurons upon colon-bladder cross-sensitization. Brain Res. 2013 Jan 23; 1491:213-24. PMID: 23146715; PMCID: PMC3607291.
    19. Malykhina AP, Wyndaele JJ, Andersson KE, De Wachter S, Dmochowski RR. Do the urinary bladder and large bowel interact, in sickness or in health? ICI-RS 2011. Neurourol Urodyn. 2012 Mar; 31(3):352-8. PMID: 22378593; PMCID: PMC3309116.
    20. Cory L, Harvie HS, Northington G, Malykhina A, Whitmore K, Arya L. Association of neuropathic pain with bladder, bowel and catastrophizing symptoms in women with bladder pain syndrome. J Urol. 2012 Feb; 187(2):503-7. PMID: 22177143; PMCID: PMC4465103.
    21. Asfaw TS, Hypolite J, Northington GM, Arya LA, Wein AJ, Malykhina AP. Acute colonic inflammation triggers detrusor instability via activation of TRPV1 receptors in a rat model of pelvic organ cross-sensitization. Am J Physiol Regul Integr Comp Physiol. 2011 Jun; 300(6):R1392-400. PMID: 21474425; PMCID: PMC3119151.
    22. Pan XQ, Gonzalez JA, Chang S, Chacko S, Wein AJ, Malykhina AP. Experimental colitis triggers the release of substance P and calcitonin gene-related peptide in the urinary bladder via TRPV1 signaling pathways. Exp Neurol. 2010 Oct; 225(2):262-73. PMID: 20501335; PMCID: PMC2939259.
    23. Matveev AV, Fitzgerald JB, Xu J, Malykhina AP, Rodgers KK, Ding XQ. The disease-causing mutations in the carboxyl terminus of the cone cyclic nucleotide-gated channel CNGA3 subunit alter the local secondary structure and interfere with the channel active conformational change. Biochemistry. 2010 Mar 02; 49(8):1628-39. PMID: 20088482; PMCID: PMC2829136.
    24. Fitzgerald JB, Malykhina AP, Al-Ubaidi MR, Ding XQ. Functional expression of cone cyclic nucleotide-gated channel in cone photoreceptor-derived 661W cells. Adv Exp Med Biol. 2008; 613:327-34. PMID: 18188961.
      View in: PubMed
    25. Noronha R, Akbarali H, Malykhina A, Foreman RD, Greenwood-Van Meerveld B. Changes in urinary bladder smooth muscle function in response to colonic inflammation. Am J Physiol Renal Physiol. 2007 Nov; 293(5):F1461-7. PMID: 17715261.
      View in: PubMed
    26. Ross GR, Kang M, Shirwany N, Malykhina AP, Drozd M, Akbarali HI. Nitrotyrosylation of Ca2+ channels prevents c-Src kinase regulation of colonic smooth muscle contractility in experimental colitis. J Pharmacol Exp Ther. 2007 Sep; 322(3):948-56. PMID: 17551092.
      View in: PubMed
    27. Malykhina AP, Qin C, Greenwood-van Meerveld B, Foreman RD, Lupu F, Akbarali HI. Hyperexcitability of convergent colon and bladder dorsal root ganglion neurons after colonic inflammation: mechanism for pelvic organ cross-talk. Neurogastroenterol Motil. 2006 Oct; 18(10):936-48. PMID: 16961697.
      View in: PubMed
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