Colorado PROFILES, The Colorado Clinical and Translational Sciences Institute (CCTSI)
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Melanie Cree-Green

TitleAsst Professor
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM-PEDS
Email

    Collapse Biography 
    Collapse education and training
    Bryn Mawr College, Bryn Mawr, PABA1999Biology & Chemistry
    University of Texas Medical Branch, Galveston, TXPhD5/2007Clinical Investigations
    University of Texas Medical Branch, Galveston, TXMD6/2007
    University of Colorado, Anschutz, Aurora, CO6/2011Pediatric Residency
    University of Colorado, Anschutz, Aurora, CO6/2014Pediatric Endocrinology
    Collapse awards and honors
    2017Highest Patient Satisfaction Award, Children's Hospital Colorado
    2017Best of 2017 Journal of the Endocrine Society Article, Endocrine Society
    20161st annual Carmel Prize for Academic Excellence, Western Section American Federation for Medical Research
    2016Early Investigators Award, Endocrine Society
    2015Junior Faculty Outstanding Abstract Award, Endocrine Society

    Collapse Overview 
    Collapse overview
    I am interested in how insulin resistance affects the reproductive axis, risk for diabetes and liver health. As an MD, PhD with clinical training in pediatric endocrinology and research training in human physiology, I perform translational work in youth with endocrine disorders using stable isotope tracers, magnetic resonance spectroscopy and mathematical modeling. In particular, I am challenged by the extent of insulin resistance-related co-morbidities in girls with polycystic ovary syndrome, including a 21 fold increased risk of type 2 diabetes, common pre-diabetes and >50% with elevated liver fat. My overall goal is to improve the long term health for adolescents with polycystic ovary syndrome or type 2 diabetes and to perform work to inform clinical trials for new therapeutic strategies.

    Collapse Research 
    Collapse research activities and funding
    Mentored Pilot Award     (CREE-GREEN, MELANIE)Jan 1, 2011 - Dec 31, 2012
    Thrasher Pediatric Foundation
    Mechanism of insulin resistance in girls with polycystic ovary disease
    Role: Principal Investigator

    Mentored Pilot, TL1 RR025778     (CREE-GREEN, MELANIE)Jun 1, 2011 - Mar 1, 2013
    University of Colorado CTSI
    Role of androgens and obesity in insulin resistance and cardiovascular disease in PCOS
    Role: Principal Investigator

    T32 DK063687     (KLINGENSMITH, G)Jul 1, 2011 - Aug 31, 2012
    NIH NIDDK
    Fellowship Training Grant in Pediatric Diabetes
    Role: Trainee

    Pilot Award     (CREE-GREEN, MELANIE)Oct 1, 2012 - Dec 1, 2013
    Center for Women's Health Research
    Impact of obesity and androgens on CV function and organ specific IR in youth with PCOS
    Role: Principal Investogator

    13CRP14120015     (CREE-GREEN, MELANIE)Jan 1, 2013 - Dec 31, 2014
    American Heart Association
    Impact of obesity and androgens on CV function and organ specific IR in youth with PCOS
    Role: Principal Investigator

    Clinical Research Fellowship in Women’s Health     (CREE-GREEN, MELANIE)Jun 1, 2013 - Mar 31, 2014
    Endocrine Society
    Impact of obesity and androgens on serum lipoproteins in youth with PCOS
    Role: Principal Investigator

    Research Fellowship Award     (CREE-GREEN, MELANIE)Jun 1, 2013 - May 31, 2014
    Pediatric Endocrine Society
    Impact of obesity and androgens on CV function and organ specific IR in youth with PCOS
    Role: Principal Investigator

    K12HD057022     (REGENSTEINER, JUDY)Apr 1, 2014
    NIH
    Building Interdisciplinary Careers in Women's Health
    Role: Trainee Scholar

    Collaborative Pilot Award     (CREE-GREEN, MELANIE)Jun 1, 2014 - May 31, 2015
    Children's Hospital Colorado/Colorado School of the Mines
    Modeling Hepatic and Adipose IR with stable isotopes during an oral glucose tolerance test
    Role: Principal Investigator

    Pilot Grant, P30 DK048520     (CREE-GREEN, MELANIE)Sep 1, 2014 - Sep 30, 2016
    University of Colorado Nutrition and Obesity Research Core
    Modeling hepatic and adipose insulin sensitivity with stable isotope tracers during an oral glucose load
    Role: Principal Investigator

    Pilot Award     (CREE-GREEN, MELANIE)Jan 1, 2015 - Dec 31, 2015
    Children’s Hospital Colorado Research Institute
    Role of hepatic de novo lipogenesis in development of hepatic steatosis in obese girls with PCOS
    Role: Principal Investigator

    Biomedical Research Award     (CREE-GREEN, MELANIE)Jul 1, 2015 - Jun 30, 2018
    Boettcher Webb-Waring Foundation
    Non-invasive assessment of liver glucose metabolism in obese girls
    Role: Principal Investigator

    K23DK107871     (CREE GREEN, MELANIE C)Sep 21, 2015 - Aug 31, 2019
    NIH
    Influence of peripheral insulin resistance and hepatic lipogenesis on liver fat in obese PCOS girls
    Role: Principal Investigator

    Caregivers Fellowship 2015212     (REGENSTEINER, JUDY)May 1, 2016 - Apr 30, 2018
    Doris Duke Foundation
    Role: Recipient

    Pilot/Feasibility Grant     (BURANT, C)Jul 1, 2016 - Jun 30, 2017
    University of Michigan MRC2
    The role of branched chain amino acid metabolism in muscle insulin resistance in youth with obesity and Polycystic ovarian syndrome
    Role: Pilot Principal Investigator

    R01DK111559     (BERGMAN, BRYAN C)Feb 1, 2017 - Jan 31, 2021
    NIH/NIDDK
    Skeletal muscle diacylglycerol and sphingolipids: Impact of localization and species on insulin resistance in humans
    Role: Co-Investigator

    Pilot     (CREE-GREEN, MELANIE)Oct 2, 2017 - Oct 31, 2019
    GI & Liver Innate Immune Program
    Do alterations in testosterone concentrations mediate improvements in insulin sensitivity and hepatic health via microbiota taxa abundance changes?
    Role: Principal Investigator

    Multi-Center Pilot     (CREE-GREEN, MELANIE)Mar 1, 2018 - Feb 28, 2020
    Nutrition and Obesity Research Center
    Comparison of in-vivo and ex-vivo measures of mitochondrial flux in non-alcoholic fatty liver disease across the lifespan
    Role: Principal Investigator

    Pilot, UL1 TR002535     (CREE-GREEN, MELANIE)Apr 1, 2018 - Mar 31, 2019
    Colorado CTSI, NIH/NCATS
    Do alterations in serum testosterone mediate systemic insulin sensitivity and hepatic health via the gut microbiota
    Role: Pilot Principal Investigator

    CDSA     (CREE-GREEN, MELANIE)Jul 1, 2018 - Jun 20, 2021
    Doris Duke Foundation
    Use of essential amino acid supplementation to decrease metabolic disease in high risk obese girls with PCOS
    Role: Principal Investigator

    R01DK118149     (BERGMAN, BRYAN C)Aug 1, 2018 - Jul 31, 2023
    NIH/NIDDK
    Intermuscular adipose tissue (IMAT): protagonist in sarcopenia and insulin resistance in humans
    Role: Co-Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. Effects of Treatment of Impaired Glucose Tolerance or Recently Diagnosed Type 2 Diabetes With Metformin Alone or in Combination With Insulin Glargine on ß-Cell Function: Comparison of Responses In Youth And Adults. Diabetes. 2019 Jun 09. PMID: 31178433.
      View in: PubMed
    2. Lack of Durable Improvements in ß-Cell Function Following Withdrawal of Pharmacological Interventions in Adults With Impaired Glucose Tolerance or Recently Diagnosed Type 2 Diabetes. Diabetes Care. 2019 Jun 09. PMID: 31178434.
      View in: PubMed
    3. Scalzo RL, Rafferty D, Schauer I, Huebschmann AG, Cree-Green M, Reusch JEB, Regensteiner JG. Sitagliptin improves diastolic cardiac function but not cardiorespiratory fitness in adults with type 2 diabetes. J Diabetes Complications. 2019 May 10. PMID: 31182338.
      View in: PubMed
    4. Carreau AM, Jin ES, Garcia-Reyes Y, Rahat H, Nadeau KJ, Malloy CR, Cree-Green M. A Simple Method to Monitor Hepatic Gluconeogenesis and Triglyceride Synthesis Following Oral Sugar Tolerance Test in Obese Adolescents. Am J Physiol Regul Integr Comp Physiol. 2019 May 01. PMID: 31042400.
      View in: PubMed
    5. Cree-Green M, Bergman BC, Cengiz E, Fox LA, Hannon TS, Miller K, Nathan B, Pyle L, Kahn D, Tansey M, Tichy E, Tsalikian E, Libman I, Nadeau KJ. Metformin Improves Peripheral Insulin Sensitivity in Youth with Type 1 Diabetes. J Clin Endocrinol Metab. 2019 Apr 02. PMID: 30938764.
      View in: PubMed
    6. Wiromrat P, Bjornstad P, Roncal C, Cree-Green M, Baumgartner A, Coe G, Reyes YG, Schäfer M, Truong U, Pyle L, Johnson RJ, Nadeau KJ. Serum uromodulin inversely associates with aortic stiffness in youth with type 1 diabetes: A brief report from EMERALD study. J Diabetes Complications. 2019 Jun; 33(6):434-436. PMID: 31003921.
      View in: PubMed
    7. Simon SL, McWhirter L, Behn CD, Bubar KM, Kaar JL, Pyle L, Rahat H, Garcia-Reyes Y, Carreau AM, Wright KP, Nadeau KJ, Cree-Green M. Morning circadian misalignment is associated with insulin resistance in girls with obesity & Polycystic Ovarian Syndrome. J Clin Endocrinol Metab. 2019 Mar 19. PMID: 30888398.
      View in: PubMed
    8. Cree-Green M, Carreau AM, Rahat H, Garcia-Reyes Y, Bergman BC, Pyle L, Nadeau KJ. Amino acid and fatty acid metabolomic profile during fasting and hyperinsulinemia in girls with polycystic ovarian syndrome. Am J Physiol Endocrinol Metab. 2019 May 01; 316(5):E707-E718. PMID: 30753112.
      View in: PubMed
    9. Cree-Green M. Postglucose Hyperinsulinemia in Black Women Is Not What We Thought. J Clin Endocrinol Metab. 2019 Feb 01; 104(2):266-268. PMID: 30371868.
      View in: PubMed
    10. Ravi SJ, Cree-Green M. Use of Successive Pharmacologic Hormone Suppression Testing for a Severe Presentation of Adolescent Polycystic Ovarian Syndrome: A Case Report. J Investig Med High Impact Case Rep. 2019 Jan-Dec; 7:2324709619850215. PMID: 31113263.
      View in: PubMed
    11. Cree-Green M, Wiromrat P, Stuppy JJ, Thurston J, Bergman BC, Baumgartner AD, Bacon S, Scherzinger A, Pyle L, Nadeau KJ. Youth with type 2 diabetes have hepatic, peripheral, and adipose insulin resistance. Am J Physiol Endocrinol Metab. 2019 Feb 01; 316(2):E186-E195. PMID: 30562061.
      View in: PubMed
    12. Bjornstad P, Schäfer M, Truong U, Cree-Green M, Pyle L, Baumgartner A, Garcia Reyes Y, Maniatis A, Nayak S, Wadwa RP, Browne LP, Reusch JEB, Nadeau KJ. Metformin Improves Insulin Sensitivity and Vascular Health in Youth With Type 1 Diabetes Mellitus. Circulation. 2018 Dec 18; 138(25):2895-2907. PMID: 30566007.
      View in: PubMed
    13. Jensen T, Wieland A, Cree-Green M, Nadeau K, Sullivan S. Clinical workup of fatty liver for the primary care provider. Postgrad Med. 2019 Jan; 131(1):19-30. PMID: 30496690.
      View in: PubMed
    14. Simon SL, Behn CD, Cree-Green M, Kaar JL, Pyle L, Hawkins SMM, Rahat H, Garcia-Reyes Y, Wright KP, Nadeau KJ. Too Late and Not Enough: School Year Sleep Duration, Timing, and Circadian Misalignment Are Associated with Reduced Insulin Sensitivity in Adolescents with Overweight/Obesity. J Pediatr. 2019 Feb; 205:257-264.e1. PMID: 30497764.
      View in: PubMed
    15. Cree-Green M, Cai N, Thurston JE, Coe GV, Newnes L, Garcia-Reyes Y, Baumgartner AD, Pyle L, Nadeau KJ. Using simple clinical measures to predict insulin resistance or hyperglycemia in girls with polycystic ovarian syndrome. Pediatr Diabetes. 2018 12; 19(8):1370-1378. PMID: 30246333.
      View in: PubMed
    16. Cree-Green M, Stuppy JJ, Thurston J, Bergman BC, Coe GV, Baumgartner AD, Bacon S, Scherzinger A, Pyle L, Nadeau KJ. Youth With Type 1 Diabetes Have Adipose, Hepatic, and Peripheral Insulin Resistance. J Clin Endocrinol Metab. 2018 10 01; 103(10):3647-3657. PMID: 30020457.
      View in: PubMed
    17. Impact of Insulin and Metformin Versus Metformin Alone on ß-Cell Function in Youth With Impaired Glucose Tolerance or Recently Diagnosed Type 2 Diabetes. Diabetes Care. 2018 08; 41(8):1717-1725. PMID: 29941500.
      View in: PubMed
    18. Metabolic Contrasts Between Youth and Adults With Impaired Glucose Tolerance or Recently Diagnosed Type 2 Diabetes: I. Observations Using the Hyperglycemic Clamp. Diabetes Care. 2018 08; 41(8):1696-1706. PMID: 29941497.
      View in: PubMed
    19. Metabolic Contrasts Between Youth and Adults With Impaired Glucose Tolerance or Recently Diagnosed Type 2 Diabetes: II. Observations Using the Oral Glucose Tolerance Test. Diabetes Care. 2018 08; 41(8):1707-1716. PMID: 29941498.
      View in: PubMed
    20. Cree-Green M, Xie D, Rahat H, Garcia-Reyes Y, Bergman BC, Scherzinger A, Diniz Behn C, Chan CL, Kelsey MM, Pyle L, Nadeau KJ. Oral Glucose Tolerance Test Glucose Peak Time Is Most Predictive of Prediabetes and Hepatic Steatosis in Obese Girls. J Endocr Soc. 2018 Jun 01; 2(6):547-562. PMID: 29942919.
      View in: PubMed
    21. Cree-Green M, Scalzo RL, Harrall K, Newcomer BR, Schauer IE, Huebschmann AG, McMillin S, Brown MS, Orlicky D, Knaub L, Nadeau KJ, McClatchey PM, Bauer TA, Regensteiner JG, Reusch JEB. Supplemental Oxygen Improves In Vivo Mitochondrial Oxidative Phosphorylation Flux in Sedentary Obese Adults With Type 2 Diabetes. Diabetes. 2018 07; 67(7):1369-1379. PMID: 29643061.
      View in: PubMed
    22. Bjornstad P, Cree-Green M, Baumgartner A, Coe G, Reyes YG, Schäfer M, Pyle L, Regensteiner JG, Reusch JE, Nadeau KJ. Achieving ADA/ISPAD clinical guideline goals is associated with higher insulin sensitivity and cardiopulmonary fitness in adolescents with type 1 diabetes: Results from RESistance to InSulin in Type 1 ANd Type 2 diabetes (RESISTANT) and Effects of MEtformin on CardiovasculaR Function in AdoLescents with Type 1 Diabetes (EMERALD) Studies. Pediatr Diabetes. 2018 05; 19(3):436-442. PMID: 29082640.
      View in: PubMed
    23. Rozance PJ, Zastoupil L, Wesolowski SR, Goldstrohm DA, Strahan B, Cree-Green M, Sheffield-Moore M, Meschia G, Hay WW, Wilkening RB, Brown LD. Skeletal muscle protein accretion rates and hindlimb growth are reduced in late gestation intrauterine growth-restricted fetal sheep. J Physiol. 2018 01 01; 596(1):67-82. PMID: 28940557.
      View in: PubMed
    24. Cree-Green M, Rahat H, Newcomer BR, Bergman BC, Brown MS, Coe GV, Newnes L, Garcia-Reyes Y, Bacon S, Thurston JE, Pyle L, Scherzinger A, Nadeau KJ. Insulin Resistance, Hyperinsulinemia, and Mitochondria Dysfunction in Nonobese Girls With Polycystic Ovarian Syndrome. J Endocr Soc. 2017 Jul 01; 1(7):931-944. PMID: 29264544.
      View in: PubMed
    25. Cree-Green M, Cai N, Pyle L, Ringham B, Brown MS, Newcomer BR, Nadeau KJ, Dabelea D. Insulin Resistance in Youth Without Diabetes Is Not Related to Muscle Mitochondrial Dysfunction. J Clin Endocrinol Metab. 2017 05 01; 102(5):1652-1660. PMID: 28204552.
      View in: PubMed
    26. Bjornstad P, Cree-Green M, Baumgartner A, Coe G, Reyes YG, Schafer M, Pyle L, Regensteiner JG, Reusch JEB, Nadeau KJ. Leptin is associated with cardiopulmonary fitness independent of body-mass index and insulin sensitivity in adolescents with type 1 diabetes: a brief report from the EMERALD study. J Diabetes Complications. 2017 May; 31(5):850-853. PMID: 28336216.
      View in: PubMed
    27. Cree-Green M. Worldwide Dissatisfaction With the Diagnostic Process and Initial Treatment of PCOS. J Clin Endocrinol Metab. 2017 02 01; 102(2):375-378. PMID: 28359108.
      View in: PubMed
    28. Patel SS, Truong U, King M, Ferland A, Moreau KL, Dorosz J, Hokanson JE, Wang H, Kinney GL, Maahs DM, Eckel RH, Nadeau KJ, Cree-Green M. Obese adolescents with polycystic ovarian syndrome have elevated cardiovascular disease risk markers. Vasc Med. 2017 04; 22(2):85-95. PMID: 28095749.
      View in: PubMed
    29. Cree-Green M, Bergman BC, Coe GV, Newnes L, Baumgartner AD, Bacon S, Sherzinger A, Pyle L, Nadeau KJ. Hepatic Steatosis is Common in Adolescents with Obesity and PCOS and Relates to De Novo Lipogenesis but not Insulin Resistance. Obesity (Silver Spring). 2016 11; 24(11):2399-2406. PMID: 27804265.
      View in: PubMed
    30. Cree-Green M, Gupta A, Coe GV, Baumgartner AD, Pyle L, Reusch JE, Brown MS, Newcomer BR, Nadeau KJ. Insulin resistance in type 2 diabetes youth relates to serum free fatty acids and muscle mitochondrial dysfunction. J Diabetes Complications. 2017 01; 31(1):141-148. PMID: 27839922.
      View in: PubMed
    31. Ohman-Hanson RA, Cree-Green M, Kelsey MM, Bessesen DH, Sharp TA, Pyle L, Pereira RI, Nadeau KJ. Ethnic and Sex Differences in Adiponectin: From Childhood to Adulthood. J Clin Endocrinol Metab. 2016 12; 101(12):4808-4815. PMID: 27603898.
      View in: PubMed
    32. Chan CL, Pyle L, Morehead R, Baumgartner A, Cree-Green M, Nadeau KJ. The role of glycemia in insulin resistance in youth with type 1 and type 2 diabetes. Pediatr Diabetes. 2017 Sep; 18(6):470-477. PMID: 27503277.
      View in: PubMed
    33. Poppy A, Retamal-Munoz C, Cree-Green M, Wood C, Davis S, Clements SA, Majidi S, Steck AK, Alonso GT, Chambers C, Rewers A. Reduction of Insulin Related Preventable Severe Hypoglycemic Events in Hospitalized Children. Pediatrics. 2016 07; 138(1). PMID: 27317577.
      View in: PubMed
    34. Bjornstad P, Truong U, Pyle L, Dorosz JL, Cree-Green M, Baumgartner A, Coe G, Regensteiner JG, Reusch JE, Nadeau KJ. Youth with type 1 diabetes have worse strain and less pronounced sex differences in early echocardiographic markers of diabetic cardiomyopathy compared to their normoglycemic peers: A RESistance to InSulin in Type 1 ANd Type 2 diabetes (RESISTANT) Study. J Diabetes Complications. 2016 08; 30(6):1103-10. PMID: 27133451.
      View in: PubMed
    35. Bjornstad P, Truong U, Dorosz JL, Cree-Green M, Baumgartner A, Coe G, Pyle L, Regensteiner JG, Reusch JE, Nadeau KJ. Cardiopulmonary Dysfunction and Adiponectin in Adolescents With Type 2 Diabetes. J Am Heart Assoc. 2016 Mar 18; 5(3):e002804. PMID: 26994128.
      View in: PubMed
    36. Pyle L, Bergman BC, Nadeau KJ, Cree-Green M. Modeling changes in glucose and glycerol rates of appearance when true basal rates of appearance cannot be readily determined. Am J Physiol Endocrinol Metab. 2016 Mar 01; 310(5):E323-31. PMID: 26714848.
      View in: PubMed
    37. Cree-Green M, Maahs DM, Ferland A, Hokanson JE, Wang H, Pyle L, Kinney GL, King M, Eckel RH, Nadeau KJ. Lipoprotein subfraction cholesterol distribution is more atherogenic in insulin resistant adolescents with type 1 diabetes. Pediatr Diabetes. 2016 06; 17(4):257-65. PMID: 26080650.
      View in: PubMed
    38. Cree-Green M, Newcomer BR, Coe G, Newnes L, Baumgartner A, Brown MS, Pyle L, Reusch JE, Nadeau KJ. Peripheral insulin resistance in obese girls with hyperandrogenism is related to oxidative phosphorylation and elevated serum free fatty acids. Am J Physiol Endocrinol Metab. 2015 May 01; 308(9):E726-33. PMID: 25714677.
      View in: PubMed
    39. Bjornstad P, Cree-Green M, Baumgartner A, Maahs DM, Cherney DZ, Pyle L, Regensteiner JG, Reusch JE, Nadeau KJ. Renal function is associated with peak exercise capacity in adolescents with type 1 diabetes. Diabetes Care. 2015 Jan; 38(1):126-31. PMID: 25414156.
      View in: PubMed
    40. Cree-Green M, Newcomer BR, Brown M, Hull A, West AD, Singel D, Reusch JE, McFann K, Regensteiner JG, Nadeau KJ. Method for controlled mitochondrial perturbation during phosphorus MRS in children. Med Sci Sports Exerc. 2014 Oct; 46(10):2030-6. PMID: 24576856.
      View in: PubMed
    41. Cree-Green M, Newcomer BR, Brown MS, Baumgartner AD, Bergman B, Drew B, Regensteiner JG, Pyle L, Reusch JE, Nadeau KJ. Delayed skeletal muscle mitochondrial ADP recovery in youth with type 1 diabetes relates to muscle insulin resistance. Diabetes. 2015 Feb; 64(2):383-92. PMID: 25157095.
      View in: PubMed
    42. Bjornstad P, Maahs DM, Cherney DZ, Cree-Green M, West A, Pyle L, Nadeau KJ. Insulin sensitivity is an important determinant of renal health in adolescents with type 2 diabetes. Diabetes Care. 2014 Nov; 37(11):3033-9. PMID: 25071077.
      View in: PubMed
    43. Geary K, Knaub LA, Schauer IE, Keller AC, Watson PA, Miller MW, Garat CV, Nadeau KJ, Cree-Green M, Pugazhenthi S, Regensteiner JG, Klemm DJ, Reusch JE. Targeting mitochondria to restore failed adaptation to exercise in diabetes. Biochem Soc Trans. 2014 Apr; 42(2):231-8. PMID: 24646223.
      View in: PubMed
    44. Lindquist KA, Chow K, West A, Pyle L, Isbell TS, Cree-Green M, Nadeau KJ. The StatStrip glucose monitor is suitable for use during hyperinsulinemic euglycemic clamps in a pediatric population. Diabetes Technol Ther. 2014 May; 16(5):298-302. PMID: 24471560.
      View in: PubMed
    45. Messacar K, Cree-Green M, Lovell M, Anderson MS, Dominguez SR. Severe Neuroinvasive West Nile Virus Infection in a Child with Undiagnosed Addison's Disease. IDCases. 2014; 1(3):29-31. PMID: 25133095.
      View in: PubMed
    46. Cree-Green M, Triolo TM, Nadeau KJ. Etiology of insulin resistance in youth with type 2 diabetes. Curr Diab Rep. 2013 Feb; 13(1):81-8. PMID: 23135953.
      View in: PubMed
    47. Brumbaugh DE, Tearse P, Cree-Green M, Fenton LZ, Brown M, Scherzinger A, Reynolds R, Alston M, Hoffman C, Pan Z, Friedman JE, Barbour LA. Intrahepatic fat is increased in the neonatal offspring of obese women with gestational diabetes. J Pediatr. 2013 May; 162(5):930-6.e1. PMID: 23260099.
      View in: PubMed
    48. Mizokami-Stout K, Cree-Green M, Nadeau KJ. Insulin resistance in type 2 diabetic youth. Curr Opin Endocrinol Diabetes Obes. 2012 Aug; 19(4):255-62. PMID: 22732484.
      View in: PubMed
    49. Nokoff NJ, Rewers M, Cree Green M. The interplay of autoimmunity and insulin resistance in type 1 diabetes. Discov Med. 2012 Feb; 13(69):115-22. PMID: 22369970.
      View in: PubMed
    50. Fram RY, Cree MG, Wolfe RR, Barr D, Herndon DN. Impaired glucose tolerance in pediatric burn patients at discharge from the acute hospital stay. J Burn Care Res. 2010 Sep-Oct; 31(5):728-33. PMID: 20634704.
      View in: PubMed
    51. Fram RY, Cree MG, Wolfe RR, Mlcak RP, Qian T, Chinkes DL, Herndon DN. Intensive insulin therapy improves insulin sensitivity and mitochondrial function in severely burned children. Crit Care Med. 2010 Jun; 38(6):1475-83. PMID: 20400899.
      View in: PubMed
    52. Thyfault JP, Cree MG, Tapscott EB, Bell JA, Koves TR, Ilkayeva O, Wolfe RR, Dohm GL, Muoio DM. Metabolic profiling of muscle contraction in lean compared with obese rodents. Am J Physiol Regul Integr Comp Physiol. 2010 Sep; 299(3):R926-34. PMID: 20504904.
      View in: PubMed
    53. Cree MG, Paddon-Jones D, Newcomer BR, Ronsen O, Aarsland A, Wolfe RR, Ferrando A. Twenty-eight-day bed rest with hypercortisolemia induces peripheral insulin resistance and increases intramuscular triglycerides. Metabolism. 2010 May; 59(5):703-10. PMID: 19919871.
      View in: PubMed
    54. Katsanos CS, Aarsland A, Cree MG, Wolfe RR. Muscle protein synthesis and balance responsiveness to essential amino acids ingestion in the presence of elevated plasma free fatty acid concentrations. J Clin Endocrinol Metab. 2009 Aug; 94(8):2984-90. PMID: 19454587.
      View in: PubMed
    55. Børsheim E, Bui QU, Tissier S, Cree MG, Rønsen O, Morio B, Ferrando AA, Kobayashi H, Newcomer BR, Wolfe RR. Amino acid supplementation decreases plasma and liver triacylglycerols in elderly. Nutrition. 2009 Mar; 25(3):281-8. PMID: 19041223.
      View in: PubMed
    56. Cree MG, Fram RY, Herndon DN, Qian T, Angel C, Green JM, Mlcak R, Aarsland A, Wolfe RR. Human mitochondrial oxidative capacity is acutely impaired after burn trauma. Am J Surg. 2008 Aug; 196(2):234-9. PMID: 18639661.
      View in: PubMed
    57. Cree MG, Fram RY, Barr D, Chinkes D, Wolfe RR, Herndon DN. Insulin resistance, secretion and breakdown are increased 9 months following severe burn injury. Burns. 2009 Feb; 35(1):63-9. PMID: 18672331.
      View in: PubMed
    58. Cree MG, Zwetsloot JJ, Herndon DN, Newcomer BR, Fram RY, Angel C, Green JM, Dohm GL, Sun D, Aarsland A, Wolfe RR. Insulin sensitivity is related to fat oxidation and protein kinase C activity in children with acute burn injury. J Burn Care Res. 2008 Jul-Aug; 29(4):585-94. PMID: 18535477.
      View in: PubMed
    59. Cree MG, Wolfe RR. Postburn trauma insulin resistance and fat metabolism. Am J Physiol Endocrinol Metab. 2008 Jan; 294(1):E1-9. PMID: 17957035.
      View in: PubMed
    60. Fram RY, Cree MG, Chinkes DL, Herndon DN, Wolfe RR. Recovery of labeled CO2 from acetate in severely burned children. Am J Physiol Endocrinol Metab. 2007 Dec; 293(6):E1726-9. PMID: 17895286.
      View in: PubMed
    61. Cree MG, Aarsland A, Herndon DN, Wolfe RR. Role of fat metabolism in burn trauma-induced skeletal muscle insulin resistance. Crit Care Med. 2007 Sep; 35(9 Suppl):S476-83. PMID: 17713396.
      View in: PubMed
    62. Cree MG, Newcomer BR, Read LK, Sheffield-Moore M, Paddon-Jones D, Chinkes D, Aarsland A, Wolfe RR. Plasma triglycerides are not related to tissue lipids and insulin sensitivity in elderly following PPAR-alpha agonist treatment. Mech Ageing Dev. 2007 Oct; 128(10):558-65. PMID: 17904198.
      View in: PubMed
    63. Cree MG, Newcomer BR, Herndon DN, Qian T, Sun D, Morio B, Zwetsloot JJ, Dohm GL, Fram RY, Mlcak RP, Aarsland A, Wolfe RR. PPAR-alpha agonism improves whole body and muscle mitochondrial fat oxidation, but does not alter intracellular fat concentrations in burn trauma children in a randomized controlled trial. Nutr Metab (Lond). 2007 Apr 23; 4:9. PMID: 17451602.
      View in: PubMed
    64. Cree MG, Zwetsloot JJ, Herndon DN, Qian T, Morio B, Fram R, Sanford AP, Aarsland A, Wolfe RR. Insulin sensitivity and mitochondrial function are improved in children with burn injury during a randomized controlled trial of fenofibrate. Ann Surg. 2007 Feb; 245(2):214-21. PMID: 17245174.
      View in: PubMed
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