Colorado PROFILES, The Colorado Clinical and Translational Sciences Institute (CCTSI)
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Last Name
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Amy Amara

TitleProfessor
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM-NEUR General Operations

    Collapse Research 
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    R01HD100670     (AMARA, AMY WILLIS)Apr 1, 2021 - Mar 31, 2026
    NIH
    Slow wave sleep as a biomarker of rehabilitation-induced cognitive improvement in Parkinson's disease
    Role: Principal Investigator
    K23NS080912     (AMARA, AMY WILLIS)Sep 26, 2012 - Oct 31, 2017
    NIH
    The Effect of Low Frequency STN DBS on Sleep and Vigilance in PD Patients
    Role: Principal Investigator

    Collapse Bibliographic 
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Baumgartner AJ, Hirt L, Amara AW, Kern DS, Thompson JA. Diurnal fluctuations of subthalamic nucleus local field potentials follow naturalistic sleep-wake behavior in Parkinson's disease. Sleep. 2025 Jun 13; 48(6). PMID: 39798074.
      View in: PubMed
    2. Johansson E, Freuchet A, Williams GP, Michealis T, Frazier A, Litvan I, Goldman JG, Alcalay RN, Standaert DG, Amara AW, Stover N, Fon EA, Postuma RB, Sidney J, Sulzer D, Lindestam Arlehamn CS, Sette A. T cell responses towards PINK1 and a-synuclein are elevated in prodromal Parkinson's disease. NPJ Parkinsons Dis. 2025 May 26; 11(1):137. PMID: 40419563.
      View in: PubMed
    3. Forbes E, Lattanzio L, Hardin K, Quiller L, Amara AW, Seeberger LC, Buard I. Neurologic Music Therapy for Fine Motor Recovery in Huntington's disease: A Proof-Of-Concept Magnetoencephalography Evaluation. NeuroRehabilitation. 2025 May 11; 10538135251330979. PMID: 40350667.
      View in: PubMed
    4. Nenert R, Mueller C, Catiul C, Pilkington J, LeVan P, Sharma A, Szaflarski JP, Amara AW. Brain physiological pulsations are linked to sleep architecture and cognitive performance in older adults. Neuroimage. 2025 May 01; 311:121187. PMID: 40187437.
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    5. Anderson KE, Marras C, Amara A, Chahine LM, Eberly S, Hosamath A, Kinel D, Mantri S, Mathur S, Oakes D, Purks JL, Standaert DG, Weintraub D, Shoulson I, Arbatti L. What Parkinson's disease patients say in their own words about their mood and anxiety symptoms. Parkinsonism Relat Disord. 2025 Jan; 130:107190. PMID: 39579746.
      View in: PubMed
    6. Amara AW, Catiul C, Videnovic A. Let there be light for Parkinson's disease... but only at the right time. Sleep. 2024 08 14; 47(8). PMID: 38880971.
      View in: PubMed
    7. Mueller C, Nenert R, Catiul C, Pilkington J, Szaflarski JP, Amara AW. Brain metabolites are associated with sleep architecture and cognitive functioning in older adults. Brain Commun. 2024; 6(4):fcae245. PMID: 39104903.
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    8. Wood KH, Nenert R, Miften AM, Kent GW, Sleyster M, Memon RA, Joop A, Pilkington J, Memon AA, Wilson RN, Catiul C, Szaflarski J, Amara AW. Diffusion Tensor Imaging-Along the Perivascular-Space Index Is Associated with Disease Progression in Parkinson's Disease. Mov Disord. 2024 Sep; 39(9):1504-1513. PMID: 38988232.
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    9. Purks JL, Arbatti L, Hosamath A, Amara AW, Anderson KE, Chahine L, Eberly SW, Kinel D, Mantri S, Mathur S, Oakes D, Standaert DG, Weintraub D, Shoulson I, Marras C. Cognitive Symptoms in Cross-Sectional Parkinson Disease Cohort Evaluated by Human-in-the-Loop Machine Learning and Natural Language Processing. Neurol Clin Pract. 2024 Oct; 14(5):e200334. PMID: 38962394.
      View in: PubMed
    10. Mueller C, Nenert R, Catiul C, Pilkington J, Szaflarski JP, Amara AW. Relationship between sleep, physical fitness, brain microstructure, and cognition in healthy older adults: A pilot study. Brain Res. 2024 Sep 15; 1839:149016. PMID: 38768934.
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    11. Mueller C, Thomas A, Amara AW, DeWolfe J, Thomas SJ. Effects of exercise on sleep in patients with epilepsy: A systematic review. Epilepsy Behav Rep. 2024; 26:100675. PMID: 38779424.
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    12. Weintraub D, Marras C, Amara A, Anderson KE, Chahine LM, Eberly S, Hosamath A, Kinel D, Mantri S, Mathur S, Oakes D, Purks JL, Standaert DG, Shoulson I, Arbatti L. Association between Subjective Cognitive Complaints and Incident Functional Impairment in Parkinson's Disease. Mov Disord. 2024 Apr; 39(4):706-714. PMID: 38318953.
      View in: PubMed
    13. Memon AA, George EB, Nazir T, Sunkara Y, Catiul C, Amara AW. Heart rate variability during sleep in synucleinopathies: a review. Front Neurol. 2023; 14:1323454. PMID: 38239321.
      View in: PubMed
    14. Mantri S, Purks JL, Kinel D, Arbatti L, Hosamath A, Allen A, Amara A, Anderson K, Chahine LM, Eberly S, Mathur S, Standaert D, Oakes D, Weintraub D, Shoulson I, Marras C. In Their Own Words: Fears Expressed by People with Parkinson's Disease in an Online Symptom Database. J Parkinsons Dis. 2024; 14(4):865-872. PMID: 38669556.
      View in: PubMed
    15. Chahine LM, Arbatti L, Hosamath A, Amara A, Anderson KE, Purks J, Eberly S, Kinel D, Mantri S, Mathur S, Oakes D, Standaert DG, Weintraub D, Shoulson I, Marras C. Internal tremor in people with Parkinson's Disease: Demographic characteristics and comorbid symptoms. Clin Park Relat Disord. 2023; 9:100229. PMID: 38045566.
      View in: PubMed
    16. Memon AA, Gelman K, Melott J, Billings R, Fullard M, Catiul C, Miocinovic S, Amara AW. A systematic review of health disparities research in deep brain stimulation surgery for Parkinson's disease. Front Hum Neurosci. 2023; 17:1269401. PMID: 37964803.
      View in: PubMed
    17. Feuerstein JS, Amara A. REM Behavior Disorder: Implications for PD Therapeutics. Curr Neurol Neurosci Rep. 2023 11; 23(11):727-734. PMID: 37831394.
      View in: PubMed
    18. Memon AA, Edney BS, Baumgartner AJ, Gardner AJ, Catiul C, Irwin ZT, Joop A, Miocinovic S, Amara AW. Effects of deep brain stimulation on quantitative sleep electroencephalogram during non-rapid eye movement in Parkinson's disease. Front Hum Neurosci. 2023; 17:1269864. PMID: 37810765.
      View in: PubMed
    19. Memon AA, Catiul C, Irwin Z, Pilkington J, Memon RA, Joop A, Wood KH, Cutter G, Miocinovic S, Amara AW. Quantitative sleep electroencephalogram and cognitive performance in Parkinson's disease with and without rapid eye movement sleep behavior disorder. Front Neurol. 2023; 14:1223974. PMID: 37745647.
      View in: PubMed
    20. Parajuli M, Amara AW, Shaban M. Deep-learning detection of mild cognitive impairment from sleep electroencephalography for patients with Parkinson's disease. PLoS One. 2023; 18(8):e0286506. PMID: 37535549.
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    21. Yacoubian TA, Fang YD, Gerstenecker A, Amara A, Stover N, Ruffrage L, Collette C, Kennedy R, Zhang Y, Hong H, Qin H, McConathy J, Benveniste EN, Standaert DG. Brain and Systemic Inflammation in De Novo Parkinson's Disease. Mov Disord. 2023 05; 38(5):743-754. PMID: 36853618.
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    22. Tan C, Nawaz H, Lageman SK, Cloud LJ, Amara AW, Newman BT, Druzgal TJ, Berman BD, Mukhopadhyay N, Barrett MJ. Cholinergic Nucleus 4 Degeneration and Cognitive Impairment in Isolated Rapid Eye Movement Sleep Behavior Disorder. Mov Disord. 2023 03; 38(3):474-479. PMID: 36598142.
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    23. Memon AA, Catiul C, Irwin Z, Pilkington J, Memon RA, Joop A, Wood KH, Cutter G, Miocinovic S, Amara AW. Quantitative Sleep Electroencephalogram in Parkinson's Disease: A Case-Control Study. J Parkinsons Dis. 2023; 13(3):351-365. PMID: 37066921.
      View in: PubMed
    24. Marras C, Arbatti L, Hosamath A, Amara A, Anderson KE, Chahine LM, Eberly S, Kinel D, Mantri S, Mathur S, Oakes D, Purks JL, Standaert DG, Tanner CM, Weintraub D, Shoulson I. What Patients Say: Large-Scale Analyses of Replies to the Parkinson's Disease Patient Report of Problems (PD-PROP). J Parkinsons Dis. 2023; 13(5):757-767. PMID: 37334615.
      View in: PubMed
    25. Williams GP, Muskat K, Frazier A, Xu Y, Mateus J, Grifoni A, da Silva Antunes R, Weiskopf D, Amara AW, Standaert DG, Goldman JG, Litvan I, Alcalay RN, Sulzer D, Lindestam Arlehamn CS, Sette A. Unaltered T cell responses to common antigens in individuals with Parkinson's disease. J Neurol Sci. 2023 01 15; 444:120510. PMID: 36495691.
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    26. Memon AA, Catiul C, Irwin Z, Pilkington J, Memon RA, Joop A, Wood KH, Cutter G, Bamman M, Miocinovic S, Amara AW. Effects of exercise on sleep spindles in Parkinson's disease. Front Rehabil Sci. 2022; 3:952289. PMID: 36188974.
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    27. Dhanwani R, Lima-Junior JR, Sethi A, Pham J, Williams G, Frazier A, Xu Y, Amara AW, Standaert DG, Goldman JG, Litvan I, Alcalay RN, Peters B, Sulzer D, Arlehamn CSL, Sette A. Transcriptional analysis of peripheral memory T cells reveals Parkinson's disease-specific gene signatures. NPJ Parkinsons Dis. 2022 Mar 21; 8(1):30. PMID: 35314697.
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    28. Mansuri Z, Reddy A, Vadukapuram R, Trivedi C, Amara A. Pimavanserin in the Treatment of Parkinson's Disease Psychosis: Meta-analysis and Meta-regression of Randomized Clinical Trials. Innov Clin Neurosci. 2022 Jan-Mar; 19(1-3):46-51. PMID: 35382074.
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    29. Srivastava H, Joop A, Memon RA, Pilkington J, Wood KH, Natelson Love M, Amara AW. Taking the Time to Assess Cognition in Parkinson's Disease: The Clock Drawing Test. J Parkinsons Dis. 2022; 12(2):713-722. PMID: 34864688.
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    30. Memon AA, Bagley ME, Creed RB, Amara AW, Goldberg MS, McMahon LL. Basal Synaptic Transmission and Long-Term Plasticity at CA3-CA1 Synapses Are Unaffected in Young Adult PINK1-Deficient Rats. Front Neurosci. 2021; 15:655901. PMID: 34483814.
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    31. Videnovic A, Amara AW, Comella C, Schweitzer PK, Emsellem H, Liu K, Sterkel AL, Gottwald MD, Steinerman JR, Jochelson P, Zomorodi K, Hauser RA. Solriamfetol for Excessive Daytime Sleepiness in Parkinson's Disease: Phase 2 Proof-of-Concept Trial. Mov Disord. 2021 10; 36(10):2408-2412. PMID: 34191352.
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    32. Szaflarski JP, Nenert R, Allendorfer JB, Martin AN, Amara AW, Griffis JC, Dietz A, Mark VW, Sung VW, Walker HC, Zhou X, Lindsell CJ. Intermittent Theta Burst Stimulation (iTBS) for Treatment of Chronic Post-Stroke Aphasia: Results of a Pilot Randomized, Double-Blind, Sham-Controlled Trial. Med Sci Monit. 2021 Jun 29; 27:e931468. PMID: 34183640.
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    33. Lee I, Kazamel M, McPherson T, McAdam J, Bamman M, Amara A, Smith DL, King PH. Fat mass loss correlates with faster disease progression in amyotrophic lateral sclerosis patients: Exploring the utility of dual-energy x-ray absorptiometry in a prospective study. PLoS One. 2021; 16(5):e0251087. PMID: 33956876.
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    34. Singhania A, Pham J, Dhanwani R, Frazier A, Rezende Dutra J, Marder KS, Phillips E, Mallal S, Amara AW, Standaert DG, Sulzer D, Peters B, Sette A, Lindestam Arlehamn CS. The TCR repertoire of a-synuclein-specific T cells in Parkinson's disease is surprisingly diverse. Sci Rep. 2021 01 11; 11(1):302. PMID: 33432042.
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    35. Wood KH, Memon AA, Memon RA, Joop A, Pilkington J, Catiul C, Gerstenecker A, Triebel K, Cutter G, Bamman MM, Miocinovic S, Amara AW. Slow Wave Sleep and EEG Delta Spectral Power are Associated with Cognitive Function in Parkinson's Disease. J Parkinsons Dis. 2021; 11(2):703-714. PMID: 33361608.
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    36. Chahine LM, Brumm MC, Caspell-Garcia C, Oertel W, Mollenhauer B, Amara A, Fernandez-Arcos A, Tolosa E, Simonet C, Hogl B, Videnovic A, Hutten SJ, Tanner C, Weintraub D, Burghardt E, Coffey C, Cho HR, Kieburtz K, Poston KL, Merchant K, Galasko D, Foroud T, Siderowf A, Marek K, Simuni T, Iranzo A. Dopamine transporter imaging predicts clinically-defined a-synucleinopathy in REM sleep behavior disorder. Ann Clin Transl Neurol. 2021 01; 8(1):201-212. PMID: 33321002.
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    37. Cristini J, Weiss M, De Las Heras B, Medina-Rinc?n A, Dagher A, Postuma RB, Huber R, Doyon J, Rosa-Neto P, Carrier J, Amara AW, Roig M. The effects of exercise on sleep quality in persons with Parkinson's disease: A systematic review with meta-analysis. Sleep Med Rev. 2021 02; 55:101384. PMID: 32987321.
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    38. Amara AW. Sleep and cognition in Parkinson's disease. Sleep Med. 2020 09; 73:179-180. PMID: 32841925.
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    39. Amara AW, Wood KH, Joop A, Memon RA, Pilkington J, Tuggle SC, Reams J, Barrett MJ, Edwards DA, Weltman AL, Hurt CP, Cutter G, Bamman MM. Reply to: Exercise for "Sleep Rehabilitation" in Parkinson's Disease. Mov Disord. 2020 07; 35(7):1286. PMID: 32691908.
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    40. Lindestam Arlehamn CS, Dhanwani R, Pham J, Kuan R, Frazier A, Rezende Dutra J, Phillips E, Mallal S, Roederer M, Marder KS, Amara AW, Standaert DG, Goldman JG, Litvan I, Peters B, Sulzer D, Sette A. a-Synuclein-specific T cell reactivity is associated with preclinical and early Parkinson's disease. Nat Commun. 2020 04 20; 11(1):1875. PMID: 32313102.
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    41. Memon AA, Coleman JJ, Amara AW. Effects of exercise on sleep in neurodegenerative disease. Neurobiol Dis. 2020 07; 140:104859. PMID: 32243913.
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    42. Amara AW, Wood KH, Joop A, Memon RA, Pilkington J, Tuggle SC, Reams J, Barrett MJ, Edwards DA, Weltman AL, Hurt CP, Cutter G, Bamman MM. Randomized, Controlled Trial of Exercise on Objective and Subjective Sleep in Parkinson's Disease. Mov Disord. 2020 06; 35(6):947-958. PMID: 32092190.
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    43. Cederberg KL, Brinkley EB, Belotserkovkaya N, Memon RA, Motl RW, Amara AW. Does restless legs syndrome impact cognitive function via sleep quality in adults with Parkinson's disease? Int J Neurosci. 2020 Apr; 130(4):322-329. PMID: 31625438.
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    44. Lindestam Arlehamn CS, Pham J, Alcalay RN, Frazier A, Shorr E, Carpenter C, Sidney J, Dhanwani R, Agin-Liebes J, Garretti F, Amara AW, Standaert DG, Phillips EJ, Mallal SA, Peters B, Sulzer D, Sette A. Widespread Tau-Specific CD4 T Cell Reactivity in the General Population. J Immunol. 2019 07 01; 203(1):84-92. PMID: 31085590.
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    45. Chahine LM, Iranzo A, Fern?ndez-Arcos A, Simuni T, Seedorff N, Caspell-Garcia C, Amara AW, Comella C, H?gl B, Hamilton J, Marek K, Mayer G, Mollenhauer B, Postuma R, Tolosa E, Trenkwalder C, Videnovic A, Oertel W. Basic clinical features do not predict dopamine transporter binding in idiopathic REM behavior disorder. NPJ Parkinsons Dis. 2019; 5:2. PMID: 30701189.
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    46. Amara AW, Chahine L, Seedorff N, Caspell-Garcia CJ, Coffey C, Simuni T. Self-reported physical activity levels and clinical progression in early Parkinson's disease. Parkinsonism Relat Disord. 2019 04; 61:118-125. PMID: 30554993.
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    47. Sharma VD, Sengupta S, Chitnis S, Amara AW. Deep Brain Stimulation and Sleep-Wake Disturbances in Parkinson Disease: A Review. Front Neurol. 2018; 9:697. PMID: 30210429.
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    48. Szaflarski JP, Griffis J, Vannest J, Allendorfer JB, Nenert R, Amara AW, Sung V, Walker HC, Martin AN, Mark VW, Zhou X. A feasibility study of combined intermittent theta burst stimulation and modified constraint-induced aphasia therapy in chronic post-stroke aphasia. Restor Neurol Neurosci. 2018; 36(4):503-518. PMID: 29889086.
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    49. Kelly NA, Wood KH, Allendorfer JB, Ford MP, Bickel CS, Marstrander J, Amara AW, Anthony T, Bamman MM, Skidmore FM. High-Intensity Exercise Acutely Increases Substantia Nigra and Prefrontal Brain Activity in Parkinson's Disease. Med Sci Monit. 2017 Dec 23; 23:6064-6071. PMID: 29273705.
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    50. Amara AW, Memon AA. Effects of Exercise on Non-motor Symptoms in Parkinson's Disease. Clin Ther. 2018 01; 40(1):8-15. PMID: 29198450.
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    51. Ford KJ, Joop A, Memon RA, Wood KH, Ball K, Cutter GR, Schwebel DC, Amara AW. Pedestrian safety in patients with Parkinson's disease: A case-control study. Mov Disord. 2017 Dec; 32(12):1748-1755. PMID: 28976016.
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    52. Amara AW, Chahine LM, Videnovic A. Treatment of Sleep Dysfunction in Parkinson's Disease. Curr Treat Options Neurol. 2017 Jul; 19(7):26. PMID: 28567500.
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    53. Amara AW, Chahine LM, Caspell-Garcia C, Long JD, Coffey C, H?gl B, Videnovic A, Iranzo A, Mayer G, Foldvary-Schaefer N, Postuma R, Oertel W, Lasch S, Marek K, Simuni T. Longitudinal assessment of excessive daytime sleepiness in early Parkinson's disease. J Neurol Neurosurg Psychiatry. 2017 08; 88(8):653-662. PMID: 28554959.
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    54. Birchall EL, Walker HC, Cutter G, Guthrie S, Joop A, Memon RA, Watts RL, Standaert DG, Amara AW. The effect of unilateral subthalamic nucleus deep brain stimulation on depression in Parkinson's disease. Brain Stimul. 2017 May - Jun; 10(3):651-656. PMID: 28065487.
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    55. Chahine LM, Amara AW, Videnovic A. A systematic review of the literature on disorders of sleep and wakefulness in Parkinson's disease from 2005 to 2015. Sleep Med Rev. 2017 10; 35:33-50. PMID: 27863901.
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    56. Amara AW, Walker HC, Joop A, Cutter G, DeWolfe JL, Harding SM, Standaert DG. Effects of subthalamic nucleus deep brain stimulation on objective sleep outcomes in Parkinson's disease. Mov Disord Clin Pract. 2017 Mar-Apr; 4(2):183-190. PMID: 28924578.
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    57. Chahine LM, Xie SX, Simuni T, Tran B, Postuma R, Amara A, Oertel WH, Iranzo A, Scordia C, Fullard M, Linder C, Purri R, Darin A, Rennert L, Videnovic A, Del Riva P, Weintraub D. Longitudinal changes in cognition in early Parkinson's disease patients with REM sleep behavior disorder. Parkinsonism Relat Disord. 2016 06; 27:102-6. PMID: 27010070.
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    58. Simuni T, Caspell-Garcia C, Coffey C, Chahine LM, Lasch S, Oertel WH, Mayer G, H?gl B, Postuma R, Videnovic A, Amara AW, Marek K. Correlates of excessive daytime sleepiness in de novo Parkinson's disease: A case control study. Mov Disord. 2015 Sep; 30(10):1371-81. PMID: 26095202.
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    59. Rinker JR, Salter AR, Walker H, Amara A, Meador W, Cutter GR. Prevalence and characteristics of tremor in the NARCOMS multiple sclerosis registry: a cross-sectional survey. BMJ Open. 2015 Jan 08; 5(1):e006714. PMID: 25573524.
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    60. Amara AW, Standaert DG. Metabolomics and the search for biomarkers in Parkinson's disease. Mov Disord. 2013 Oct; 28(12):1620-1. PMID: 24105981.
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    61. Amara AW, Standaert DG, Guthrie S, Cutter G, Watts RL, Walker HC. Unilateral subthalamic nucleus deep brain stimulation improves sleep quality in Parkinson's disease. Parkinsonism Relat Disord. 2012 Jan; 18(1):63-8. PMID: 21924664.
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    62. Amara AW, Watts RL, Walker HC. The effects of deep brain stimulation on sleep in Parkinson's disease. Ther Adv Neurol Disord. 2011 Jan; 4(1):15-24. PMID: 21339905.
      View in: PubMed
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