Colorado PROFILES, The Colorado Clinical and Translational Sciences Institute (CCTSI)
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Andrew David Grotzinger

TitleAssistant Professor
InstitutionUniversity of Colorado Boulder
DepartmentInstitute for Behav Genetics
    Other Positions
    TitleAssistant Professor
    InstitutionUniversity of Colorado Boulder
    DepartmentPsych-Psychology


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    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Clapp Sullivan ML, Schwaba T, Harden KP, Grotzinger AD, Nivard MG, Tucker-Drob EM. Beyond the factor indeterminacy problem using genome-wide association data. Nat Hum Behav. 2024 Feb; 8(2):205-218. PMID: 38225407.
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    2. Lawrence JM, Breunig S, Foote IF, Tallis CB, Grotzinger AD. Genomic SEM applied to explore etiological divergences in bipolar subtypes. Psychol Med. 2024 Apr; 54(6):1152-1159. PMID: 37885278.
      View in: PubMed
    3. Malanchini M, Allegrini AG, Nivard MG, Biroli P, Rimfeld K, Cheesman R, von Stumm S, Demange PA, van Bergen E, Grotzinger AD, Raffington L, De la Fuente J, Pingault JB, Harden KP, Tucker-Drob EM, Plomin R. Genetic contributions of noncognitive skills to academic development. bioRxiv. 2023 Oct 26. PMID: 37066409.
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    4. Smeland OB, Kutrolli G, Bahrami S, Fominykh V, Parker N, Hindley GFL, R?devand L, Jaholkowski P, Tesfaye M, Parekh P, Elvs?shagen T, Grotzinger AD, Steen NE, van der Meer D, O'Connell KS, Djurovic S, Dale AM, Shadrin AA, Frei O, Andreassen OA. The shared genetic risk architecture of neurological and psychiatric disorders: a genome-wide analysis. medRxiv. 2023 Sep 26. PMID: 37503175.
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    5. Bountress KE, Cusack SE, Hawn SE, Grotzinger A, Bustamante D, Kirkpatrick RM, Edenberg HJ, Amstadter AB. Genetic associations between alcohol phenotypes and life satisfaction: a genomic structural equation modelling approach. Sci Rep. 2023 08 18; 13(1):13443. PMID: 37596344.
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    6. Warrier V, Stauffer EM, Huang QQ, Wigdor EM, Slob EAW, Seidlitz J, Ronan L, Valk SL, Mallard TT, Grotzinger AD, Romero-Garcia R, Baron-Cohen S, Geschwind DH, Lancaster MA, Murray GK, Gandal MJ, Alexander-Bloch A, Won H, Martin HC, Bullmore ET, Bethlehem RAI. Genetic insights into human cortical organization and development through genome-wide analyses of 2,347 neuroimaging phenotypes. Nat Genet. 2023 09; 55(9):1483-1493. PMID: 37592024.
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    7. Grotzinger AD, Singh K, Miller-Fleming TW, Lam M, Mallard TT, Chen Y, Liu Z, Ge T, Smoller JW. Transcriptome-Wide Structural Equation Modeling of 13 Major Psychiatric Disorders for Cross-Disorder Risk and Drug Repurposing. JAMA Psychiatry. 2023 08 01; 80(8):811-821. PMID: 37314780.
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    8. Adams MJ, Thorp JG, Jermy BS, Kwong ASF, K?iv K, Grotzinger AD, Nivard MG, Marshall S, Milaneschi Y, Baune BT, M?ller-Myhsok B, Penninx BW, Boomsma DI, Levinson DF, Breen G, Pistis G, Grabe HJ, Tiemeier H, Berger K, Rietschel M, Magnusson PK, Uher R, Hamilton SP, Lucae S, Lehto K, Li QS, Byrne EM, Hickie IB, Martin NG, Medland SE, Wray NR, Tucker-Drob EM, Lewis CM, McIntosh AM, Derks EM. Genetic structure of major depression symptoms across clinical and community cohorts. medRxiv. 2023 Jul 07. PMID: 37461564.
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    9. Zorina-Lichtenwalter K, Bango CI, Van Oudenhove L, Ceko M, Lindquist MA, Grotzinger AD, Keller MC, Friedman NP, Wager TD. Genetic risk shared across 24 chronic pain conditions: identification and characterization with genomic structural equation modeling. Pain. 2023 10 01; 164(10):2239-2252. PMID: 37219871.
      View in: PubMed
    10. Evans LM, Arehart CH, Grotzinger AD, Mize TJ, Brasher MS, Stitzel JA, Ehringer MA, Hoeffer CA. Transcriptome-wide gene-gene interaction associations elucidate pathways and functional enrichment of complex traits. PLoS Genet. 2023 05; 19(5):e1010693. PMID: 37216417.
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    11. Lawrence JM, Breunig S, Foote IF, Tallis CB, Grotzinger AD. Genomic SEM Applied to Explore Etiological Divergences in Bipolar Subtypes. medRxiv. 2023 May 09. PMID: 37215038.
      View in: PubMed
    12. Malanchini M, Allegrini AG, Nivard MG, Biroli P, Rimfeld K, Cheesman R, von Stumm S, Demange PA, van Bergen E, Grotzinger AD, Raffington L, De la Fuente J, Pingault JB, Harden KP, Tucker-Drob EM, Plomin R. Genetic contributions of noncognitive skills to academic development. Res Sq. 2023 Apr 07. PMID: 37066329.
      View in: PubMed
    13. Hatoum AS, Colbert SMC, Johnson EC, Huggett SB, Deak JD, Pathak G, Jennings MV, Paul SE, Karcher NR, Hansen I, Baranger DAA, Edwards A, Grotzinger A, Tucker-Drob EM, Kranzler HR, Davis LK, Sanchez-Roige S, Polimanti R, Gelernter J, Edenberg HJ, Bogdan R, Agrawal A. Multivariate genome-wide association meta-analysis of over 1 million subjects identifies loci underlying multiple substance use disorders. Nat Ment Health. 2023 Mar; 1(3):210-223. PMID: 37250466.
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    14. Grotzinger AD, Mallard TT, Liu Z, Seidlitz J, Ge T, Smoller JW. Multivariate genomic architecture of cortical thickness and surface area at multiple levels of analysis. Nat Commun. 2023 02 20; 14(1):946. PMID: 36806290.
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    15. Mallard TT, Grotzinger AD, Smoller JW. Examining the shared etiology of psychopathology with genome-wide association studies. Physiol Rev. 2023 04 01; 103(2):1645-1665. PMID: 36634217.
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    16. Grotzinger AD, Keller MC. Potential bias in genetic correlations. Science. 2022 11 18; 378(6621):709-710. PMID: 36395208.
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    17. Patterson MW, Pivnick L, Mann FD, Grotzinger AD, Monahan KC, Steinberg LD, Oosterhoff B, Tackett JL, Tucker-Drob EM, Harden KP. A Mixed-Methods Approach to Refining and Measuring the Construct of Positive Risk-Taking in Adolescence. J Res Adolesc. 2023 06; 33(2):680-700. PMID: 36358015.
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    18. Grotzinger AD, de la Fuente J, Davies G, Nivard MG, Tucker-Drob EM. Transcriptome-wide and stratified genomic structural equation modeling identify neurobiological pathways shared across diverse cognitive traits. Nat Commun. 2022 10 21; 13(1):6280. PMID: 36271044.
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    19. Raffington L, Malanchini M, Grotzinger AD, Madole JW, Engelhardt LE, Sabhlok A, Youn C, Patterson MW, Harden KP, Tucker-Drob EM. An in-laboratory stressor reveals unique genetic variation in child cortisol output. Dev Psychol. 2022 Oct; 58(10):1832-1848. PMID: 35771497.
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    20. Mallard TT, Linn?r RK, Grotzinger AD, Sanchez-Roige S, Seidlitz J, Okbay A, de Vlaming R, Meddens SFW, Palmer AA, Davis LK, Tucker-Drob EM, Kendler KS, Keller MC, Koellinger PD, Harden KP. Multivariate GWAS of psychiatric disorders and their cardinal symptoms reveal two dimensions of cross-cutting genetic liabilities. Cell Genom. 2022 06 08; 2(6). PMID: 35812988.
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    21. Grotzinger AD, Fuente J, Priv? F, Nivard MG, Tucker-Drob EM. Pervasive Downward Bias in Estimates of Liability-Scale Heritability in Genome-wide Association Study Meta-analysis: A Simple Solution. Biol Psychiatry. 2023 01 01; 93(1):29-36. PMID: 35973856.
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    22. de la Fuente J, Grotzinger AD, Marioni RE, Nivard MG, Tucker-Drob EM. Integrated analysis of direct and proxy genome wide association studies highlights polygenicity of Alzheimer's disease outside of the APOE region. PLoS Genet. 2022 06; 18(6):e1010208. PMID: 35658006.
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    23. Grotzinger AD, Mallard TT, Akingbuwa WA, Ip HF, Adams MJ, Lewis CM, McIntosh AM, Grove J, Dalsgaard S, Lesch KP, Strom N, Meier SM, Mattheisen M, B?rglum AD, Mors O, Breen G, Lee PH, Kendler KS, Smoller JW, Tucker-Drob EM, Nivard MG. Genetic architecture of 11 major psychiatric disorders at biobehavioral, functional genomic and molecular genetic levels of analysis. Nat Genet. 2022 05; 54(5):548-559. PMID: 35513722.
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    24. Youn C, Grotzinger AD, Lill CM, Bertram L, Schmiedek F, L?vd?n M, Lindenberger U, Nivard M, Harden KP, Tucker-Drob EM. Genetic associations with learning over 100 days of practice. NPJ Sci Learn. 2022 May 04; 7(1):7. PMID: 35508486.
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    25. Bountress KE, Brick LA, Sheerin C, Grotzinger A, Bustamante D, Hawn SE, Gillespie N, Kirkpatrick RM, Kranzler H, Morey R, Edenberg HJ, Maihofer AX, Disner S, Ashley-Koch A, Peterson R, Lori A, Stein DJ, Kimbrel N, Nievergelt C, Andreassen OA, Luykx J, Javanbakht A, Youssef NA, Amstadter AB. Alcohol use and alcohol use disorder differ in their genetic relationships with PTSD: A genomic structural equation modelling approach. Drug Alcohol Depend. 2022 05 01; 234:109430. PMID: 35367939.
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    26. Karlsson Linn?r R, Mallard TT, Barr PB, Sanchez-Roige S, Madole JW, Driver MN, Poore HE, de Vlaming R, Grotzinger AD, Tielbeek JJ, Johnson EC, Liu M, Rosenthal SB, Ideker T, Zhou H, Kember RL, Pasman JA, Verweij KJH, Liu DJ, Vrieze S, Kranzler HR, Gelernter J, Harris KM, Tucker-Drob EM, Waldman ID, Palmer AA, Harden KP, Koellinger PD, Dick DM. Multivariate analysis of 1.5 million people identifies genetic associations with traits related to self-regulation and addiction. Nat Neurosci. 2021 10; 24(10):1367-1376. PMID: 34446935.
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    27. Mallard TT, Savage JE, Johnson EC, Huang Y, Edwards AC, Hottenga JJ, Grotzinger AD, Gustavson DE, Jennings MV, Anokhin A, Dick DM, Edenberg HJ, Kramer JR, Lai D, Meyers JL, Pandey AK, Harden KP, Nivard MG, de Geus EJC, Boomsma DI, Agrawal A, Davis LK, Clarke TK, Palmer AA, Sanchez-Roige S. Item-Level Genome-Wide Association Study of the Alcohol Use Disorders Identification Test in Three Population-Based Cohorts. Am J Psychiatry. 2022 Jan; 179(1):58-70. PMID: 33985350.
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    28. Thorp JG, Campos AI, Grotzinger AD, Gerring ZF, An J, Ong JS, Wang W, Shringarpure S, Byrne EM, MacGregor S, Martin NG, Medland SE, Middeldorp CM, Derks EM. Symptom-level modelling unravels the shared genetic architecture of anxiety and depression. Nat Hum Behav. 2021 10; 5(10):1432-1442. PMID: 33859377.
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    29. Grotzinger AD. Shared genetic architecture across psychiatric disorders. Psychol Med. 2021 10; 51(13):2210-2216. PMID: 33729112.
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    30. Demange PA, Malanchini M, Mallard TT, Biroli P, Cox SR, Grotzinger AD, Tucker-Drob EM, Abdellaoui A, Arseneault L, van Bergen E, Boomsma DI, Caspi A, Corcoran DL, Domingue BW, Harris KM, Ip HF, Mitchell C, Moffitt TE, Poulton R, Prinz JA, Sugden K, Wertz J, Williams BS, de Zeeuw EL, Belsky DW, Harden KP, Nivard MG. Investigating the genetic architecture of noncognitive skills using GWAS-by-subtraction. Nat Genet. 2021 01; 53(1):35-44. PMID: 33414549.
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    31. Van den Akker AL, Briley DA, Grotzinger AD, Tackett JL, Tucker-Drob EM, Harden KP. Adolescent Big Five personality and pubertal development: Pubertal hormone concentrations and self-reported pubertal status. Dev Psychol. 2021 Jan; 57(1):60-72. PMID: 33382326.
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    32. de la Fuente J, Davies G, Grotzinger AD, Tucker-Drob EM, Deary IJ. A general dimension of genetic sharing across diverse cognitive traits inferred from molecular data. Nat Hum Behav. 2021 01; 5(1):49-58. PMID: 32895543.
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    33. Brumpton B, Sanderson E, Heilbron K, Hartwig FP, Harrison S, Vie G?, Cho Y, Howe LD, Hughes A, Boomsma DI, Havdahl A, Hopper J, Neale M, Nivard MG, Pedersen NL, Reynolds CA, Tucker-Drob EM, Grotzinger A, Howe L, Morris T, Li S, Auton A, Windmeijer F, Chen WM, Bj?rngaard JH, Hveem K, Willer C, Evans DM, Kaprio J, Davey Smith G, ?svold BO, Hemani G, Davies NM. Avoiding dynastic, assortative mating, and population stratification biases in Mendelian randomization through within-family analyses. Nat Commun. 2020 07 14; 11(1):3519. PMID: 32665587.
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    34. Malanchini M, Engelhardt LE, Raffington LA, Sabhlok A, Grotzinger AD, Briley DA, Madole JW, Freis SM, Patterson MW, Harden KP, Tucker-Drob EM. Weak and uneven associations of home, neighborhood, and school environments with stress hormone output across multiple timescales. Mol Psychiatry. 2021 09; 26(9):4823-4838. PMID: 32366955.
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    35. Wood AC, Vainik U, Engelhardt LE, Briley DA, Grotzinger AD, Church JA, Harden KP, Tucker-Drob EM. Genetic overlap between executive functions and BMI in childhood. Am J Clin Nutr. 2019 10 01; 110(4):814-822. PMID: 31216571.
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    36. Harden KP, Engelhardt LE, Mann FD, Patterson MW, Grotzinger AD, Savicki SL, Thibodeaux ML, Freis SM, Tackett JL, Church JA, Tucker-Drob EM. Genetic Associations Between Executive Functions and a General Factor of Psychopathology. J Am Acad Child Adolesc Psychiatry. 2020 06; 59(6):749-758. PMID: 31102652.
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    37. Madole JW, Rhemtulla M, Grotzinger AD, Tucker-Drob EM, Harden PK. Testing Cold and Hot Cognitive Control as Moderators of a Network of Comorbid Psychopathology Symptoms in Adolescence. Clin Psychol Sci. 2019 Jul; 7(4):701-718. PMID: 32309042.
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    38. Grotzinger AD, Rhemtulla M, de Vlaming R, Ritchie SJ, Mallard TT, Hill WD, Ip HF, Marioni RE, McIntosh AM, Deary IJ, Koellinger PD, Harden KP, Nivard MG, Tucker-Drob EM. Genomic structural equation modelling provides insights into the multivariate genetic architecture of complex traits. Nat Hum Behav. 2019 05; 3(5):513-525. PMID: 30962613.
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    39. Grotzinger AD, Cheung AK, Patterson MW, Harden KP, Tucker-Drob EM. Genetic and Environmental Links between : General Factors of Psychopathology and Cognitive Ability in Early Childhood. Clin Psychol Sci. 2019 May; 7(3):430-444. PMID: 31440427.
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    40. Malanchini M, Engelhardt LE, Grotzinger AD, Harden KP, Tucker-Drob EM. "Same but different": Associations between multiple aspects of self-regulation, cognition, and academic abilities. J Pers Soc Psychol. 2019 Dec; 117(6):1164-1188. PMID: 30550329.
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    41. Patterson MW, Mann FD, Grotzinger AD, Tackett JL, Tucker-Drob EM, Harden KP. Genetic and environmental influences on internalizing psychopathology across age and pubertal development. Dev Psychol. 2018 Oct; 54(10):1928-1939. PMID: 30234342.
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    42. Grotzinger AD, Briley DA, Engelhardt LE, Mann FD, Patterson MW, Tackett JL, Tucker-Drob EM, Paige Harden K. Corrigendum to "Genetic and environmental influences on pubertal hormones in human hair across development" [Psychoneuroendocrinology 90 (2018) 76-84]. Psychoneuroendocrinology. 2018 12; 98:253. PMID: 30119917.
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    43. Ayoub M, Briley DA, Grotzinger A, Patterson MW, Engelhardt LE, Tackett JL, Harden KP, Tucker-Drob EM. Genetic and Environmental Associations Between Child Personality and Parenting. Soc Psychol Personal Sci. 2019 Aug; 10(6):711-721. PMID: 31807233.
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    44. Grotzinger AD, Mann FD, Patterson MW, Tackett JL, Tucker-Drob EM, Harden KP. Hair and Salivary Testosterone, Hair Cortisol, and Externalizing Behaviors in Adolescents. Psychol Sci. 2018 05; 29(5):688-699. PMID: 29443645.
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    45. Grotzinger AD, Briley DA, Engelhardt LE, Mann FD, Patterson MW, Tackett JL, Tucker-Drob EM, Harden KP. Genetic and environmental influences on pubertal hormones in human hair across development. Psychoneuroendocrinology. 2018 04; 90:76-84. PMID: 29454168.
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    46. Grotzinger AD, Mann FD, Patterson MW, Herzhoff K, Tackett JL, Tucker-Drob EM, Paige Harden K. Twin models of environmental and genetic influences on pubertal development, salivary testosterone, and estradiol in adolescence. Clin Endocrinol (Oxf). 2018 02; 88(2):243-250. PMID: 29161770.
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    47. Harden KP, Mann FD, Grotzinger AD, Patterson MW, Steinberg L, Tackett JL, Tucker-Drob EM. Developmental differences in reward sensitivity and sensation seeking in adolescence: Testing sex-specific associations with gonadal hormones and pubertal development. J Pers Soc Psychol. 2018 Jul; 115(1):161-178. PMID: 29094961.
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    48. Tucker-Drob EM, Grotzinger AD, Briley DA, Engelhardt LE, Mann FD, Patterson M, Kirschbaum C, Adam EK, Church JA, Tackett JL, Harden KP. Genetic influences on hormonal markers of chronic hypothalamic-pituitary-adrenal function in human hair. Psychol Med. 2017 Jun; 47(8):1389-1401. PMID: 28100283.
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    49. Mann FD, Engelhardt L, Briley DA, Grotzinger AD, Patterson MW, Tackett JL, Strathan DB, Heath A, Lynskey M, Slutske W, Martin NG, Tucker-Drob EM, Harden KP. Sensation seeking and impulsive traits as personality endophenotypes for antisocial behavior: Evidence from two independent samples. Pers Individ Dif. 2017 Jan 15; 105:30-39. PMID: 28824215.
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    50. Harden KP, Wrzus C, Luong G, Grotzinger A, Bajbouj M, Rauers A, Wagner GG, Riediger M. Diurnal coupling between testosterone and cortisol from adolescence to older adulthood. Psychoneuroendocrinology. 2016 11; 73:79-90. PMID: 27474909.
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    51. Mann FD, Patterson MW, Grotzinger AD, Kretsch N, Tackett JL, Tucker-Drob EM, Harden KP. Sensation seeking, peer deviance, and genetic influences on adolescent delinquency: Evidence for person-environment correlation and interaction. J Abnorm Psychol. 2016 07; 125(5):679-91. PMID: 27124714.
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    52. Hildebrandt T, Grotzinger A, Schulz K. Anorexia nervosa, emotional go/no-go, and the distinct effect of testosterone. Int J Eat Disord. 2016 Jan; 49(1):69-76. PMID: 26332596.
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    53. Hildebrandt T, Grotzinger A, Reddan M, Greif R, Levy I, Goodman W, Schiller D. Testing the disgust conditioning theory of food-avoidance in adolescents with recent onset anorexia nervosa. Behav Res Ther. 2015 Aug; 71:131-8. PMID: 26131915.
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    54. Grotzinger A, Hildebrandt T, Yu J. The benefits of using semi-continuous and continuous models to analyze binge eating data: A Monte Carlo investigation. Int J Eat Disord. 2015 Sep; 48(6):746-58. PMID: 25195793.
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