Colorado PROFILES, The Colorado Clinical and Translational Sciences Institute (CCTSI)
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Jason M Christie

TitleProfessor
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM-PHYS General Operations

    Collapse Research 
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    RF1MH126706     (WILLIAMS, MICHAEL ROLAND)Sep 13, 2021 - Sep 12, 2024
    NIH
    AnteroTag, a Novel Method for Trans-Synaptic Delivery of Active Agents to Map and Modify Anterograde Populations
    Role: Co-Principal Investigator
    R01NS123933     (PUGH, JASON RICHARD)Jul 1, 2021 - Apr 30, 2026
    NIH
    Cerebellar pathology in the absence of plasticity gating
    Role: Co-Principal Investigator
    R01NS118401     (CHRISTIE, JASON M)Aug 1, 2020 - Jun 30, 2025
    NIH
    Organization of inhibition in the cerebellar cortex
    Role: Principal Investigator
    R01NS112289     (CHRISTIE, JASON M)Apr 15, 2020 - Mar 31, 2025
    NIH
    Motor Memory Storage in the Cerebellum
    Role: Principal Investigator
    R01NS114430     (PERSON, ABIGAIL L)Sep 18, 2019 - Jun 30, 2029
    NIH
    Circuit mechanisms of cerebellar control of reaching movements
    Role: Co-Principal Investigator
    R01NS105958     (CHRISTIE, JASON M)Sep 1, 2018 - Aug 31, 2023
    NIH
    Regulation of instructive signaling in the cerebellum
    Role: Principal Investigator
    R01NS083894     (CHRISTIE, JASON M)May 15, 2013 - Oct 31, 2018
    NIH
    Action Potential Signaling in Axons of CNS Interneurons
    Role: Principal Investigator
    R01MH096847     (RUMBAUGH, GAVIN R)Sep 1, 2012 - Oct 31, 2027
    NIH
    Intersection of causal neurodevelopmental disorder risk genes, cortical circuit function, and cognitive processing required for behavioral adaptions
    Role: Co-Principal Investigator
    F31DC005124     (CHRISTIE, JASON M)Aug 1, 2001 - Sep 30, 2004
    NIH
    Dendritic Processing in the Olfactory Bulb
    Role: Principal Investigator

    Collapse Bibliographic 
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Ogunbeku TH, Allmond JM, Gray TJ, Ong WJ, Brown BA, Gargano A, Grzywacz R, Holt JD, Macchiavelli AO, Miyagi T, Neupane S, Rasco BC, Schatz H, Sherrill BM, Tarasov OB, Arora H, Ayangeakaa AD, Berg HC, Berkman JM, Bleuel DL, Bosmpotinis K, Carpenter MP, Cerizza G, Chester A, Christie JM, Cox I, Crawford HL, Crider BP, Davis J, Doetsch AA, Duarte JG, Estrade A, Fijalkowska A, Frantzis C, Gaballah T, Good EC, Haak K, Hanai S, Harke JT, Hartley AC, Hermansen K, Hoff DEM, Hoskins D, Huffman J, Van Isacker P, Jain R, Karny M, King TT, Kitamura N, Kolos K, Laminack A, Liddick SN, Longfellow B, Lubna RS, Lyons S, Madurga M, Mogannam MJ, Owens-Fryar G, Palomino JR, Rajabali MM, Richard AL, Richardson IJ, Ronning EK, Rose GE, Ruland TJ, Rykaczewski KP, Scielzo ND, Scriven DP, Seweryniak D, Siegl K, Singh M, Spyrou A, Stepaniuk M, Stuchbery AE, Sweet A, Tripathi V, Tsantiri A, Uthayakumaar S, Walters WB, Watters S, Xu Z, Yokoyama R. Universal Effective Charges in the sd and fp Shells. Phys Rev Lett. 2025 Aug 15; 135(7):072501. PMID: 40929225.
      View in: PubMed
    2. Eom TY, Schmitt JE, Li Y, Davenport CM, Steinberg J, Bonnan A, Alam S, Ryu YS, Paul L, Hansen BS, Khairy K, Pelletier S, Pruett-Miller SM, Roalf DR, Gur RE, Emanuel BS, McDonald-McGinn DM, Smith JN, Li C, Christie JM, Northcott PA, Zakharenko SS. Tbx1 haploinsufficiency leads to local skull deformity, paraflocculus and flocculus dysplasia, and motor-learning deficit in 22q11.2 deletion syndrome. Nat Commun. 2024 12 05; 15(1):10510. PMID: 39638997.
      View in: PubMed
    3. Cantu E, Diamond J, Ganjoo N, Nottigham A, Ramon CV, McCurry M, Friskey J, Jin D, Anderson MR, Lisowski J, Le Mahajan A, Localio AR, Gallop R, Hsu J, Christie J, Schaubel DE. Scoring donor lungs for graft failure risk: The Lung Donor Risk Index (LDRI). Am J Transplant. 2024 May; 24(5):839-849. PMID: 38266712.
      View in: PubMed
    4. Chao OY, Pathak SS, Zhang H, Augustine GJ, Christie JM, Kikuchi C, Taniguchi H, Yang YM. Social memory deficit caused by dysregulation of the cerebellar vermis. Nat Commun. 2023 09 26; 14(1):6007. PMID: 37752149.
      View in: PubMed
    5. Zhang K, Yang Z, Gaffield MA, Gross GG, Arnold DB, Christie JM. Molecular layer disinhibition unlocks climbing-fiber-instructed motor learning in the cerebellum. bioRxiv. 2023 Aug 04. PMID: 38654827.
      View in: PubMed
    6. Bonnan A, Zhang K, Gaffield MA, Christie JM. Expression of a Form of Cerebellar Motor Memory Requires Learned Alterations to the Activity of Inhibitory Molecular Layer Interneurons. J Neurosci. 2023 01 25; 43(4):601-612. PMID: 36639897.
      View in: PubMed
    7. Gaffield MA, Sauerbrei BA, Christie JM. Cerebellum encodes and influences the initiation, performance, and termination of discontinuous movements in mice. Elife. 2022 04 22; 11. PMID: 35451957.
      View in: PubMed
    8. Wu WC, Bradley SP, Christie JM, Pugh JR. Mechanisms and Consequences of Cerebellar Purkinje Cell Disinhibition in a Mouse Model of Duchenne Muscular Dystrophy. J Neurosci. 2022 03 09; 42(10):2103-2115. PMID: 35064002.
      View in: PubMed
    9. Jerez D, Stuart E, Schmitt K, Guerrero-Given D, Christie JM, Hahn WE, Kamasawa N, Smirnov MS. Author Correction: A deep learning approach to identifying immunogold particles in electron microscopy images. Sci Rep. 2021 Oct 22; 11(1):21256. PMID: 34686743.
      View in: PubMed
    10. McQuiston A, Emtiazjoo A, Angel P, Machuca T, Christie J, Atkinson C. Set Up for Failure: Pre-Existing Autoantibodies in Lung Transplant. Front Immunol. 2021; 12:711102. PMID: 34456920.
      View in: PubMed
    11. Bonnan A, Rowan MMJ, Baker CA, Bolton MM, Christie JM. Autonomous Purkinje cell activation instructs bidirectional motor learning through evoked dendritic calcium signaling. Nat Commun. 2021 04 12; 12(1):2153. PMID: 33846328.
      View in: PubMed
    12. Jerez D, Stuart E, Schmitt K, Guerrero-Given D, Christie JM, Hahn WE, Kamasawa N, Smirnov MS. A deep learning approach to identifying immunogold particles in electron microscopy images. Sci Rep. 2021 04 08; 11(1):7771. PMID: 33833289.
      View in: PubMed
    13. Li C, Patel K, Tu Z, Yang X, Kulik L, Alawieh A, Allen P, Cheng Q, Wallace C, Kilkenny J, Kwon J, Gibney B, Cantu E, Sharma A, Pipkin M, Machuca T, Emtiazjoo A, Goddard M, Holers VM, Nadig S, Christie J, Tomlinson S, Atkinson C. A novel injury site-natural antibody targeted complement inhibitor protects against lung transplant injury. Am J Transplant. 2021 06; 21(6):2067-2078. PMID: 33210808.
      View in: PubMed
    14. Self WH, Semler MW, Leither LM, Casey JD, Angus DC, Brower RG, Chang SY, Collins SP, Eppensteiner JC, Filbin MR, Files DC, Gibbs KW, Ginde AA, Gong MN, Harrell FE, Hayden DL, Hough CL, Johnson NJ, Khan A, Lindsell CJ, Matthay MA, Moss M, Park PK, Rice TW, Robinson BRH, Schoenfeld DA, Shapiro NI, Steingrub JS, Ulysse CA, Weissman A, Yealy DM, Thompson BT, Brown SM, Steingrub J, Smithline H, Tiru B, Tidswell M, Kozikowski L, Thornton-Thompson S, De Souza L, Hou P, Baron R, Massaro A, Aisiku I, Fredenburgh L, Seethala R, Johnsky L, Riker R, Seder D, May T, Baumann M, Eldridge A, Lord C, Shapiro N, Talmor D, O?Mara T, Kirk C, Harrison K, Kurt L, Schermerhorn M, Banner-Goodspeed V, Boyle K, Dubosh N, Filbin M, Hibbert K, Parry B, Lavin-Parsons K, Pulido N, Lilley B, Lodenstein C, Margolin J, Brait K, Jones A, Galbraith J, Peacock R, Nandi U, Wachs T, Matthay M, Liu K, Kangelaris K, Wang R, Calfee C, Yee K, Hendey G, Chang S, Lim G, Qadir N, Tam A, Beutler R, Levitt J, Wilson J, Rogers A, Vojnik R, Roque J, Albertson T, Chenoweth J, Adams J, Pearson S, Juarez M, Almasri E, Fayed M, Hughes A, Hillard S, Huebinger R, Wang H, Vidales E, Patel B, Ginde A, Moss M, Baduashvili A, McKeehan J, Finck L, Higgins C, Howell M, Douglas I, Haukoos J, Hiller T, Lyle C, Cupelo A, Caruso E, Camacho C, Gravitz S, Finigan J, Griesmer C, Park P, Hyzy R, Nelson K, McDonough K, Olbrich N, Williams M, Kapoor R, Nash J, Willig M, Ford H, Gardner-Gray J, Ramesh M, Moses M, Ng Gong M, Aboodi M, Asghar A, Amosu O, Torres M, Kaur S, Chen JT, Hope A, Lopez B, Rosales K, Young You J, Mosier J, Hypes C, Natt B, Borg B, Salvagio Campbell E, Hite RD, Hudock K, Cresie A, Alhasan F, Gomez-Arroyo J, Duggal A, Mehkri O, Hastings A, Sahoo D, Abi Fadel F, Gole S, Shaner V, Wimer A, Meli Y, King A, Terndrup T, Exline M, Pannu S, Robart E, Karow S, Hough C, Robinson B, Johnson N, Henning D, Campo M, Gundel S, Seghal S, Katsandres S, Dean S, Khan A, Krol O, Jouzestani M, Huynh P, Weissman A, Yealy D, Scholl D, Adams P, McVerry B, Huang D, Angus D, Schooler J, Moore S, Files C, Miller C, Gibbs K, LaRose M, Flores L, Koehler L, Morse C, Sanders J, Langford C, Nanney K, MdalaGausi M, Yeboah P, Morris P, Sturgill J, Seif S, Cassity E, Dhar S, de Wit M, Mason J, Goodwin A, Hall G, Grady A, Chamberlain A, Brown S, Bledsoe J, Leither L, Peltan I, Starr N, Fergus M, Aston V, Montgomery Q, Smith R, Merrill M, Brown K, Armbruster B, Harris E, Middleton E, Paine R, Johnson S, Barrios M, Eppensteiner J, Limkakeng A, McGowan L, Porter T, Bouffler A, Leahy JC, deBoisblanc B, Lammi M, Happel K, Lauto P, Self W, Casey J, Semler M, Collins S, Harrell F, Lindsell C, Rice T, Stubblefield W, Gray C, Johnson J, Roth M, Hays M, Torr D, Zakaria A, Schoenfeld D, Thompson T, Hayden D, Ringwood N, Oldmixon C, Ulysse C, Morse R, Muzikansky A, Fitzgerald L, Whitaker S, Lagakos A, Brower R, Reineck L, Aggarwal N, Bienstock K, Freemer M, Maclawiw M, Weinmann G, Morrison L, Gillespie M, Kryscio R, Brodie D, Zareba W, Rompalo A, Boeckh M, Parsons P, Christie J, Hall J, Horton N, Zoloth L, Dickert N, Diercks D. Effect of Hydroxychloroquine on Clinical Status at 14 Days in Hospitalized Patients With COVID-19: A Randomized Clinical Trial. JAMA. 2020 12 01; 324(21):2165-2176. PMID: 33165621.
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    15. Gaffield MA, Bonnan A, Christie JM. Conversion of Graded Presynaptic Climbing Fiber Activity into Graded Postsynaptic Ca2+ Signals by Purkinje Cell Dendrites. Neuron. 2019 05 22; 102(4):762-769.e4. PMID: 30928170.
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    16. Michaelson SD, Ozkan ED, Aceti M, Maity S, Llamosas N, Weldon M, Mizrachi E, Vaissiere T, Gaffield MA, Christie JM, Holder JL, Miller CA, Rumbaugh G. SYNGAP1 heterozygosity disrupts sensory processing by reducing touch-related activity within somatosensory cortex circuits. Nat Neurosci. 2018 12; 21(12):1-13. PMID: 30455457.
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    17. Gaffield MA, Rowan MJM, Amat SB, Hirai H, Christie JM. Inhibition gates supralinear Ca2+ signaling in Purkinje cell dendrites during practiced movements. Elife. 2018 08 17; 7. PMID: 30117806.
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    18. Rowan MJM, Bonnan A, Zhang K, Amat SB, Kikuchi C, Taniguchi H, Augustine GJ, Christie JM. Graded Control of Climbing-Fiber-Mediated Plasticity and Learning by Inhibition in the Cerebellum. Neuron. 2018 09 05; 99(5):999-1015.e6. PMID: 30122378.
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    19. Amat SB, Rowan MJM, Gaffield MA, Bonnan A, Kikuchi C, Taniguchi H, Christie JM. Using c-kit to genetically target cerebellar molecular layer interneurons in adult mice. PLoS One. 2017; 12(6):e0179347. PMID: 28658323.
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    20. Gaffield MA, Christie JM. Movement Rate Is Encoded and Influenced by Widespread, Coherent Activity of Cerebellar Molecular Layer Interneurons. J Neurosci. 2017 05 03; 37(18):4751-4765. PMID: 28389475.
      View in: PubMed
    21. Rowan MJM, Christie JM. Rapid State-Dependent Alteration in Kv3 Channel Availability Drives Flexible Synaptic Signaling Dependent on Somatic Subthreshold Depolarization. Cell Rep. 2017 02 21; 18(8):2018-2029. PMID: 28228266.
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    22. Javaheri A, Molina M, Zamani P, Rodrigues A, Novak E, Chambers S, Stutman P, Maslanek W, Williams M, Lilly SM, Heeger P, Sayegh MH, Chandraker A, Briscoe DM, Daly KP, Starling R, Ikle D, Christie J, Rame JE, Goldberg LR, Billheimer J, Rader DJ. Cholesterol efflux capacity of high-density lipoprotein correlates with survival and allograft vasculopathy in cardiac transplant recipients. J Heart Lung Transplant. 2016 11; 35(11):1295-1302. PMID: 27498384.
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    23. Rowan MJ, DelCanto G, Yu JJ, Kamasawa N, Christie JM. Synapse-Level Determination of Action Potential Duration by K(+) Channel Clustering in Axons. Neuron. 2016 07 20; 91(2):370-83. PMID: 27346528.
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    24. Gaffield MA, Amat SB, Bito H, Christie JM. Chronic imaging of movement-related Purkinje cell calcium activity in awake behaving mice. J Neurophysiol. 2016 Jan 01; 115(1):413-22. PMID: 26561609.
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    25. Rowan MJ, Tranquil E, Christie JM. Distinct Kv channel subtypes contribute to differences in spike signaling properties in the axon initial segment and presynaptic boutons of cerebellar interneurons. J Neurosci. 2014 May 07; 34(19):6611-23. PMID: 24806686.
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    26. Christie JM, Chiu DN, Jahr CE. Ca(2+)-dependent enhancement of release by subthreshold somatic depolarization. Nat Neurosci. 2011 Jan; 14(1):62-8. PMID: 21170054.
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    27. Christie JM, Jahr CE. Selective expression of ligand-gated ion channels in L5 pyramidal cell axons. J Neurosci. 2009 Sep 16; 29(37):11441-50. PMID: 19759293.
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    28. Christie JM, Jahr CE. Dendritic NMDA receptors activate axonal calcium channels. Neuron. 2008 Oct 23; 60(2):298-307. PMID: 18957221.
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    29. Christie JM, Westbrook GL. Lateral excitation within the olfactory bulb. J Neurosci. 2006 Feb 22; 26(8):2269-77. PMID: 16495454.
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    30. Christie JM, Jahr CE. Multivesicular release at Schaffer collateral-CA1 hippocampal synapses. J Neurosci. 2006 Jan 04; 26(1):210-6. PMID: 16399689.
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    31. Christie JM, Bark C, Hormuzdi SG, Helbig I, Monyer H, Westbrook GL. Connexin36 mediates spike synchrony in olfactory bulb glomeruli. Neuron. 2005 Jun 02; 46(5):761-72. PMID: 15924862.
      View in: PubMed
    32. Christie JM, Westbrook GL. Regulation of backpropagating action potentials in mitral cell lateral dendrites by A-type potassium currents. J Neurophysiol. 2003 May; 89(5):2466-72. PMID: 12740404.
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    33. Christie JM, Schoppa NE, Westbrook GL. Tufted cell dendrodendritic inhibition in the olfactory bulb is dependent on NMDA receptor activity. J Neurophysiol. 2001 Jan; 85(1):169-73. PMID: 11152717.
      View in: PubMed
    34. Christie JM, Jane DE, Monaghan DT. Native N-methyl-D-aspartate receptors containing NR2A and NR2B subunits have pharmacologically distinct competitive antagonist binding sites. J Pharmacol Exp Ther. 2000 Mar; 292(3):1169-74. PMID: 10688637.
      View in: PubMed
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