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James P Bridges

TitleAffiliate - NJH
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM-MED

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    R01HL131634     (BRIDGES, JAMES PATRICK)Mar 18, 2016 - Feb 28, 2021
    NIH
    Role of GPR116 in Alveolar Homeostasis
    Role: Principal Investigator

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    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Lee E, Williams KJ, McCarthy C, Bridges JP, Redente EF, de Aguiar Vallim TQ, Barrington RA, Wang T, Tarling EJ. Alveolar macrophage lipid burden correlates with clinical improvement in patients with pulmonary alveolar proteinosis. J Lipid Res. 2024 02; 65(2):100496. PMID: 38185217.
      View in: PubMed
    2. Toth A, Kannan P, Snowball J, Kofron M, Wayman JA, Bridges JP, Miraldi ER, Swarr D, Zacharias WJ. Alveolar epithelial progenitor cells require Nkx2-1 to maintain progenitor-specific epigenomic state during lung homeostasis and regeneration. Nat Commun. 2023 Dec 19; 14(1):8452. PMID: 38114516.
      View in: PubMed
    3. O'Callaghan M, Duignan J, Tarling EJ, Waters DK, McStay M, O'Carroll O, Bridges JP, Redente EF, Franciosi AN, McGrath EE, Butler MW, Dodd JD, Fabre A, Murphy DJ, Keane MP, McCarthy C. Analysis of tissue lipidomics and computed tomography pulmonary fat attenuation volume (CTPFAV ) in idiopathic pulmonary fibrosis. Respirology. 2023 11; 28(11):1043-1052. PMID: 37642207.
      View in: PubMed
    4. Takahashi T, Fee EL, Takahashi Y, Usuda H, Carter SWD, Ikeda H, Saito M, Kumagai Y, Bridges JP, Jobe AH, Choolani MA, Kemp MW. LPCAT1 levels in the placenta, the maternal plasma and the fetal plasma do not predict fetal lung responses to glucocorticoids in a sheep model of pregnancy. Placenta. 2023 07; 138:1-9. PMID: 37146534.
      View in: PubMed
    5. Bridges JP, Safina C, Pirard B, Brown K, Filuta A, Panchanathan R, Bouhelal R, Reymann N, Patel S, Seuwen K, Miller WE, Ludwig MG. Regulation of pulmonary surfactant by the adhesion GPCR GPR116/ADGRF5 requires a tethered agonist-mediated activation mechanism. Elife. 2022 09 08; 11. PMID: 36073784.
      View in: PubMed
    6. Takahashi T, Takahashi Y, Fee EL, Saito M, Yaegashi N, Usuda H, Bridges JP, Milad MA, Furfaro L, Carter S, Schmidt AF, Newnham JP, Jobe AH, Kemp MW. Continuous but not pulsed low-dose fetal betamethasone exposures extend the durability of antenatal steroid therapy. Am J Physiol Lung Cell Mol Physiol. 2022 06 01; 322(6):L784-L793. PMID: 35380907.
      View in: PubMed
    7. Higano NS, Cao X, Guo J, Wang X, Kroenke CD, Filuta AL, Bridges JP, Woods JC. Fetal lung development via quantitative biomarkers from diffusion MRI and histological validation in rhesus macaques. J Perinatol. 2022 07; 42(7):866-872. PMID: 34686834.
      View in: PubMed
    8. Bridges JP, Vladar EK, Huang H, Mason RJ. Respiratory epithelial cell responses to SARS-CoV-2 in COVID-19. Thorax. 2022 02; 77(2):203-209. PMID: 34404754.
      View in: PubMed
    9. Sitaraman S, Martin EP, Na CL, Zhao S, Green J, Deshmukh H, Perl AT, Bridges JP, Xu Y, Weaver TE. Surfactant protein C mutation links postnatal type 2 cell dysfunction to adult disease. JCI Insight. 2021 07 22; 6(14). PMID: 34138759.
      View in: PubMed
    10. Schweitzer KS, Crue T, Nall JM, Foster D, Sajuthi S, Correll KA, Nakamura M, Everman JL, Downey GP, Seibold MA, Bridges JP, Serban KA, Chu HW, Petrache I. Influenza virus infection increases ACE2 expression and shedding in human small airway epithelial cells. Eur Respir J. 2021 07; 58(1). PMID: 33419885.
      View in: PubMed
    11. Rindler TN, Brown KM, Stockman CA, van Lieshout LP, Martin EP, Weaver TE, Zacharias WJ, Wootton SK, Whitsett JA, Bridges JP. Efficient Transduction of Alveolar Type 2 Cells with Adeno-associated Virus for the Study of Lung Regeneration. Am J Respir Cell Mol Biol. 2021 07; 65(1):118-121. PMID: 34241584.
      View in: PubMed
    12. Schmidt AF, Kannan PS, Bridges J, Presicce P, Jackson CM, Miller LA, Kallapur SG, Chougnet CA, Jobe AH. Prenatal inflammation enhances antenatal corticosteroid-induced fetal lung maturation. JCI Insight. 2020 12 17; 5(24). PMID: 33328385.
      View in: PubMed
    13. van Lieshout LP, Stegelmeier AA, Rindler TN, Lawder JJ, Sorensen DL, Frost KL, Booth SA, Bridges JP, Wootton SK. Engineered AAV8 capsid acquires heparin and AVB sepharose binding capacity but has altered in vivo transduction efficiency. Gene Ther. 2023 04; 30(3-4):236-244. PMID: 33028973.
      View in: PubMed
    14. Bridges JP, Sudha P, Lipps D, Wagner A, Guo M, Du Y, Brown K, Filuta A, Kitzmiller J, Stockman C, Chen X, Weirauch MT, Jobe AH, Whitsett JA, Xu Y. Glucocorticoid regulates mesenchymal cell differentiation required for perinatal lung morphogenesis and function. Am J Physiol Lung Cell Mol Physiol. 2020 08 01; 319(2):L239-L255. PMID: 32460513.
      View in: PubMed
    15. Oherle K, Acker E, Bonfield M, Wang T, Gray J, Lang I, Bridges J, Lewkowich I, Xu Y, Ahlfeld S, Zacharias W, Alenghat T, Deshmukh H. Insulin-like Growth Factor 1 Supports a Pulmonary Niche that Promotes Type 3 Innate Lymphoid Cell Development in Newborn Lungs. Immunity. 2020 Apr 14; 52(4):716-718. PMID: 32294410.
      View in: PubMed
    16. Oherle K, Acker E, Bonfield M, Wang T, Gray J, Lang I, Bridges J, Lewkowich I, Xu Y, Ahlfeld S, Zacharias W, Alenghat T, Deshmukh H. Insulin-like Growth Factor 1 Supports a Pulmonary Niche that Promotes Type 3 Innate Lymphoid Cell Development in Newborn Lungs. Immunity. 2020 02 18; 52(2):275-294.e9. PMID: 32075728.
      View in: PubMed
    17. Schmidt AF, Kemp MW, Milad M, Miller LA, Bridges JP, Clarke MW, Kannan PS, Jobe AH. Oral dosing for antenatal corticosteroids in the Rhesus macaque. PLoS One. 2019; 14(9):e0222817. PMID: 31536601.
      View in: PubMed
    18. Kemp MW, Saito M, Schmidt AF, Usuda H, Watanabe S, Sato S, Hanita T, Kumagai Y, Takahashi T, Musk GC, Furfaro L, Stinson L, Fee EL, Eddershaw PJ, Payne MS, Smallwood K, Bridges J, Newnham JP, Jobe AH. The duration of fetal antenatal steroid exposure determines the durability of preterm ovine lung maturation. Am J Obstet Gynecol. 2020 02; 222(2):183.e1-183.e9. PMID: 31494126.
      View in: PubMed
    19. Sitaraman S, Na CL, Yang L, Filuta A, Bridges JP, Weaver TE. Proteasome dysfunction in alveolar type 2 epithelial cells is associated with acute respiratory distress syndrome. Sci Rep. 2019 08 29; 9(1):12509. PMID: 31467330.
      View in: PubMed
    20. Schmidt AF, Jobe AH, Kannan PS, Bridges JP, Newnham JP, Saito M, Usuda H, Kumagai Y, Fee EL, Clarke M, Kemp MW. Oral antenatal corticosteroids evaluated in fetal sheep. Pediatr Res. 2019 11; 86(5):589-594. PMID: 31365919.
      View in: PubMed
    21. Schmidt AF, Kannan PS, Bridges JP, Filuta A, Lipps D, Kemp M, Miller LA, Kallapur SG, Xu Y, Whitsett JA, Jobe AH. Dosing and formulation of antenatal corticosteroids for fetal lung maturation and gene expression in rhesus macaques. Sci Rep. 2019 06 21; 9(1):9039. PMID: 31227752.
      View in: PubMed
    22. Balczon R, Pittet JF, Wagener BM, Moser SA, Voth S, Vorhees CV, Williams MT, Bridges JP, Alvarez DF, Koloteva A, Xu Y, Zha XM, Audia JP, Stevens T, Lin MT. Infection-induced endothelial amyloids impair memory. FASEB J. 2019 09; 33(9):10300-10314. PMID: 31211919.
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    23. Morgan RK, Anderson GR, Ara? D, Aust G, Balenga N, Boucard A, Bridges JP, Engel FB, Formstone CJ, Glitsch MD, Gray RS, Hall RA, Hsiao CC, Kim HY, Knierim AB, Kusuluri DK, Leon K, Liebscher I, Piao X, Pr?mel S, Scholz N, Srivastava S, Thor D, Tolias KF, Ushkaryov YA, Vallon M, Van Meir EG, Vanhollebeke B, Wolfrum U, Wright KM, Monk KR, Mogha A. The expanding functional roles and signaling mechanisms of adhesion G protein-coupled receptors. Ann N Y Acad Sci. 2019 11; 1456(1):5-25. PMID: 31168816.
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    24. Hayashi Y, Zhang Y, Yokota A, Yan X, Liu J, Choi K, Li B, Sashida G, Peng Y, Xu Z, Huang R, Zhang L, Freudiger GM, Wang J, Dong Y, Zhou Y, Wang J, Wu L, Bu J, Chen A, Zhao X, Sun X, Chetal K, Olsson A, Watanabe M, Romick-Rosendale LE, Harada H, Shih LY, Tse W, Bridges JP, Caligiuri MA, Huang T, Zheng Y, Witte DP, Wang QF, Qu CK, Salomonis N, Grimes HL, Nimer SD, Xiao Z, Huang G. Pathobiological Pseudohypoxia as a Putative Mechanism Underlying Myelodysplastic Syndromes. Cancer Discov. 2018 11; 8(11):1438-1457. PMID: 30139811.
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    25. McCarthy C, Lee E, Bridges JP, Sallese A, Suzuki T, Woods JC, Bartholmai BJ, Wang T, Chalk C, Carey BC, Arumugam P, Shima K, Tarling EJ, Trapnell BC. Statin as a novel pharmacotherapy of pulmonary alveolar proteinosis. Nat Commun. 2018 08 07; 9(1):3127. PMID: 30087322.
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    26. van Lieshout LP, Domm JM, Rindler TN, Frost KL, Sorensen DL, Medina SJ, Booth SA, Bridges JP, Wootton SK. A Novel Triple-Mutant AAV6 Capsid Induces Rapid and Potent Transgene Expression in the Muscle and Respiratory Tract of Mice. Mol Ther Methods Clin Dev. 2018 Jun 15; 9:323-329. PMID: 30038936.
      View in: PubMed
    27. Moreno-Fernandez ME, Giles DA, Stankiewicz TE, Sheridan R, Karns R, Cappelletti M, Lampe K, Mukherjee R, Sina C, Sallese A, Bridges JP, Hogan SP, Aronow BJ, Hoebe K, Divanovic S. Peroxisomal ?-oxidation regulates whole body metabolism, inflammatory vigor, and pathogenesis of nonalcoholic fatty liver disease. JCI Insight. 2018 03 22; 3(6). PMID: 29563328.
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    28. Rindler TN, Stockman CA, Filuta AL, Brown KM, Snowball JM, Zhou W, Veldhuizen R, Zink EM, Dautel SE, Clair G, Ansong C, Xu Y, Bridges JP, Whitsett JA. Alveolar injury and regeneration following deletion of ABCA3. JCI Insight. 2017 12 21; 2(24). PMID: 29263307.
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    29. Wang J, Hayashi Y, Yokota A, Xu Z, Zhang Y, Huang R, Yan X, Liu H, Ma L, Azam M, Bridges JP, Cancelas JA, Kalfa TA, An X, Xiao Z, Huang G. Expansion of EPOR-negative macrophages besides erythroblasts by elevated EPOR signaling in erythrocytosis mouse models. Haematologica. 2018 01; 103(1):40-50. PMID: 29051279.
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    30. Trapnell BC, Bridges J. Does Granulocyte-Macrophage Colony-Stimulating Factor Coordinate a Hepatopulmonary Axis of Lipid Metabolism? Am J Respir Cell Mol Biol. 2017 10; 57(4):383-385. PMID: 28960104.
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    31. Sallese A, Suzuki T, McCarthy C, Bridges J, Filuta A, Arumugam P, Shima K, Ma Y, Wessendarp M, Black D, Chalk C, Carey B, Trapnell BC. Targeting cholesterol homeostasis in lung diseases. Sci Rep. 2017 08 31; 7(1):10211. PMID: 28860566.
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    32. Huang R, Hayashi Y, Yan X, Bu J, Wang J, Zhang Y, Zhou Y, Tang Y, Wu L, Xu Z, Liu X, Wang Q, Zhou J, Xiao Z, Bridges JP, Marsh RA, Zhang K, Jordan MB, Li Y, Huang G. HIF1A is a critical downstream mediator for hemophagocytic lymphohistiocytosis. Haematologica. 2017 11; 102(11):1956-1968. PMID: 28860338.
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    33. Brown K, Filuta A, Ludwig MG, Seuwen K, Jaros J, Vidal S, Arora K, Naren AP, Kandasamy K, Parthasarathi K, Offermanns S, Mason RJ, Miller WE, Whitsett JA, Bridges JP. Epithelial Gpr116 regulates pulmonary alveolar homeostasis via Gq/11 signaling. JCI Insight. 2017 Jun 02; 2(11). PMID: 28570277.
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    34. Du Y, Kitzmiller JA, Sridharan A, Perl AK, Bridges JP, Misra RS, Pryhuber GS, Mariani TJ, Bhattacharya S, Guo M, Potter SS, Dexheimer P, Aronow B, Jobe AH, Whitsett JA, Xu Y. Lung Gene Expression Analysis (LGEA): an integrative web portal for comprehensive gene expression data analysis in lung development. Thorax. 2017 May; 72(5):481-484. PMID: 28070014.
      View in: PubMed
    35. Ludwig MG, Seuwen K, Bridges JP. Adhesion GPCR Function in Pulmonary Development and Disease. Handb Exp Pharmacol. 2016; 234:309-327. PMID: 27832494.
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    36. Saito A, Nikolaidis NM, Amlal H, Uehara Y, Gardner JC, LaSance K, Pitstick LB, Bridges JP, Wikenheiser-Brokamp KA, McGraw DW, Woods JC, Sabbagh Y, Schiavi SC, Altinisik G, Jakopovic M, Inoue Y, McCormack FX. Modeling pulmonary alveolar microlithiasis by epithelial deletion of the Npt2b sodium phosphate cotransporter reveals putative biomarkers and strategies for treatment. Sci Transl Med. 2015 Nov 11; 7(313):313ra181. PMID: 26560359.
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    37. Liebscher I, Ackley B, Ara? D, Ariestanti DM, Aust G, Bae BI, Bista BR, Bridges JP, Duman JG, Engel FB, Giera S, Goffinet AM, Hall RA, Hamann J, Hartmann N, Lin HH, Liu M, Luo R, Mogha A, Monk KR, Peeters MC, Pr?mel S, Ressl S, Schi?th HB, Sigoillot SM, Song H, Talbot WS, Tall GG, White JP, Wolfrum U, Xu L, Piao X. New functions and signaling mechanisms for the class of adhesion G protein-coupled receptors. Ann N Y Acad Sci. 2014 Dec; 1333:43-64. PMID: 25424900.
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    38. Bittencourt FM, Wu SE, Bridges JP, Miller WE. The M33 G protein-coupled receptor encoded by murine cytomegalovirus is dispensable for hematogenous dissemination but is required for growth within the salivary gland. J Virol. 2014 Oct; 88(20):11811-24. PMID: 25100846.
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    39. Bridges JP, Schehr A, Wang Y, Huo L, Besnard V, Ikegami M, Whitsett JA, Xu Y. Epithelial SCAP/INSIG/SREBP signaling regulates multiple biological processes during perinatal lung maturation. PLoS One. 2014; 9(5):e91376. PMID: 24806461.
      View in: PubMed
    40. Bridges JP, Ludwig MG, Mueller M, Kinzel B, Sato A, Xu Y, Whitsett JA, Ikegami M. Orphan G protein-coupled receptor GPR116 regulates pulmonary surfactant pool size. Am J Respir Cell Mol Biol. 2013 Sep; 49(3):348-57. PMID: 23590306.
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    41. Young LR, Gulleman PM, Bridges JP, Weaver TE, Deutsch GH, Blackwell TS, McCormack FX. The alveolar epithelium determines susceptibility to lung fibrosis in Hermansky-Pudlak syndrome. Am J Respir Crit Care Med. 2012 Nov 15; 186(10):1014-24. PMID: 23043085.
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    42. Starnes SL, Pathrose P, Wang J, Succop P, Morris JC, Bridges J, Kupert EY, Anderson M. Clinical and molecular predictors of recurrence in stage I non-small cell lung cancer. Ann Thorac Surg. 2012 May; 93(5):1606-12. PMID: 22440368.
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    43. Bridges JP, Lin S, Ikegami M, Shannon JM. Conditional hypoxia inducible factor-1a induction in embryonic pulmonary epithelium impairs maturation and augments lymphangiogenesis. Dev Biol. 2012 Feb 01; 362(1):24-41. PMID: 22094019.
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    44. Bridges JP, Ikegami M, Brilli LL, Chen X, Mason RJ, Shannon JM. LPCAT1 regulates surfactant phospholipid synthesis and is required for transitioning to air breathing in mice. J Clin Invest. 2010 May; 120(5):1736-48. PMID: 20407208.
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    45. Wang M, Bridges JP, Na CL, Xu Y, Weaver TE. Meckel-Gruber syndrome protein MKS3 is required for endoplasmic reticulum-associated degradation of surfactant protein C. J Biol Chem. 2009 Nov 27; 284(48):33377-83. PMID: 19815549.
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    46. Ahmad A, Ahmad S, Glover L, Miller SM, Shannon JM, Guo X, Franklin WA, Bridges JP, Schaack JB, Colgan SP, White CW. Adenosine A2A receptor is a unique angiogenic target of HIF-2alpha in pulmonary endothelial cells. Proc Natl Acad Sci U S A. 2009 Jun 30; 106(26):10684-9. PMID: 19541651.
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    47. Dong M, Bridges JP, Apsley K, Xu Y, Weaver TE. ERdj4 and ERdj5 are required for endoplasmic reticulum-associated protein degradation of misfolded surfactant protein C. Mol Biol Cell. 2008 Jun; 19(6):2620-30. PMID: 18400946.
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    48. Bridges J, Mulder J. End of life issues in oral cancer. Oral Maxillofac Surg Clin North Am. 2006 Nov; 18(4):643-5. PMID: 18088858.
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    49. Bridges JP, Xu Y, Na CL, Wong HR, Weaver TE. Adaptation and increased susceptibility to infection associated with constitutive expression of misfolded SP-C. J Cell Biol. 2006 Jan 30; 172(3):395-407. PMID: 16449190.
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    50. Bridges JP, Weaver TE. Use of transgenic mice to study lung morphogenesis and function. ILAR J. 2006; 47(1):22-31. PMID: 16391428.
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    51. Bridges JP, Wert SE, Nogee LM, Weaver TE. Expression of a human surfactant protein C mutation associated with interstitial lung disease disrupts lung development in transgenic mice. J Biol Chem. 2003 Dec 26; 278(52):52739-46. PMID: 14525980.
      View in: PubMed
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