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Joseph P Schacht

TitleAssociate Professor
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM-PSYCH
Phone303/724-3773
    Other Positions
    TitleDivision Head
    InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
    DepartmentSOM-PSYCH
    DivisionGeneral Operations


    Collapse Research 
    Collapse research activities and funding
    R21AA031146     (SCHACHT, JOSEPH P.)Sep 1, 2023 - Aug 31, 2025
    NIH
    An exploratory randomized controlled trial of the effects of oral semaglutide on alcohol craving and consumption
    Role: Principal Investigator
    R01AA027765     (SCHACHT, JOSEPH P.)Sep 20, 2019 - Aug 31, 2024
    NIH
    A pharmacogenetic human laboratory investigation of brexpiprazole in Alcohol Use Disorder
    Role: Principal Investigator
    R01AA026859     (SCHACHT, JOSEPH P.)Apr 20, 2019 - Mar 31, 2025
    NIH
    COMT inhibition as a potential therapeutic target among individuals with comorbid Alcohol Use Disorder and Attention-Deficit/Hyperactivity Disorder
    Role: Principal Investigator
    R00AA021419     (SCHACHT, JOSEPH P.)Sep 15, 2013 - Aug 31, 2019
    NIH
    Neural Connectivity and the Transition to Alcohol Dependence
    Role: Principal Investigator
    K99AA021419     (SCHACHT, JOSEPH P)Sep 15, 2013 - Aug 31, 2015
    NIH
    Neural Connectivity and the Transition to Alcohol Dependence
    Role: Principal Investigator
    F31DA021496     (SCHACHT, JOSEPH P)Sep 29, 2006 - Sep 28, 2009
    NIH
    A Transdisciplinary Approach to Cannabis Addiction
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. Schacht JP. Stress, Cues, and Craving: Does the Insula Hold the Key to Understanding Stress-Induced Drinking in Alcohol Use Disorder? Biol Psychiatry. 2024 Feb 01; 95(3):200-201. PMID: 38143097.
      View in: PubMed
    2. Leggio L, Hendershot CS, Farokhnia M, Fink-Jensen A, Klausen MK, Schacht JP, Simmons WK. GLP-1 receptor agonists are promising but unproven treatments for alcohol and substance use disorders. Nat Med. 2023 Dec; 29(12):2993-2995. PMID: 38001271.
      View in: PubMed
    3. Schacht JP, Kubicki M, Anton RF. A randomized trial of the effects of COMT inhibition on subjective response to alcohol: Moderation by baseline COMT activity and mediation of alcohol self-administration. Alcohol Clin Exp Res (Hoboken). 2024 Jan; 48(1):178-187. PMID: 38206282.
      View in: PubMed
    4. Schacht JP, Hoffman M, Voronin KE, Book SW, Anton RF. Effects of pharmacological and genetic regulation of COMT activity in alcohol use disorder: a randomized, placebo-controlled trial of tolcapone. Neuropsychopharmacology. 2022 10; 47(11):1953-1960. PMID: 35523943.
      View in: PubMed
    5. Ekhtiari H, Zare-Bidoky M, Sangchooli A, Janes AC, Kaufman MJ, Oliver JA, Prisciandaro JJ, W?stenberg T, Anton RF, Bach P, Baldacchino A, Beck A, Bjork JM, Brewer J, Childress AR, Claus ED, Courtney KE, Ebrahimi M, Filbey FM, Ghahremani DG, Azbari PG, Goldstein RZ, Goudriaan AE, Grodin EN, Hamilton JP, Hanlon CA, Hassani-Abharian P, Heinz A, Joseph JE, Kiefer F, Zonoozi AK, Kober H, Kuplicki R, Li Q, London ED, McClernon J, Noori HR, Owens MM, Paulus MP, Perini I, Potenza M, Potvin S, Ray L, Schacht JP, Seo D, Sinha R, Smolka MN, Spanagel R, Steele VR, Stein EA, Steins-Loeber S, Tapert SF, Verdejo-Garcia A, Vollst?dt-Klein S, Wetherill RR, Wilson SJ, Witkiewitz K, Yuan K, Zhang X, Zilverstand A. A methodological checklist for fMRI drug cue reactivity studies: development and expert consensus. Nat Protoc. 2022 03; 17(3):567-595. PMID: 35121856.
      View in: PubMed
    6. Ellingson JM, Hinckley JD, Ross JM, Schacht JP, Bidwell LC, Bryan AD, Hopfer CJ, Riggs P, Hutchison KE. The Neurocognitive Effects of Cannabis Across the Lifespan. Curr Behav Neurosci Rep. 2021 Dec; 8(4):124-133. PMID: 35979200.
      View in: PubMed
    7. Schacht JP, Hoffman M, Chen BH, Anton RF. Epigenetic moderators of naltrexone efficacy in reducing heavy drinking in Alcohol Use Disorder: a randomized trial. Pharmacogenomics J. 2022 02; 22(1):1-8. PMID: 34381173.
      View in: PubMed
    8. Bartels K, Schacht JP. Cocaine-Positive Patients Undergoing Elective Surgery: From Avoiding Case Cancellations to Treating Substance Use Disorders. Anesth Analg. 2021 02 01; 132(2):305-307. PMID: 33449554.
      View in: PubMed
    9. Burnette EM, Grodin EN, Schacht JP, Ray LA. Clinical and Neural Correlates of Reward and Relief Drinking. Alcohol Clin Exp Res. 2021 01; 45(1):194-203. PMID: 33119924.
      View in: PubMed
    10. Anton RF, Voronin KE, Book SW, Latham PK, Randall PK, Glen WB, Hoffman M, Schacht JP. Opioid and Dopamine Genes Interact to Predict Naltrexone Response in a Randomized Alcohol Use Disorder Clinical Trial. Alcohol Clin Exp Res. 2020 10; 44(10):2084-2096. PMID: 32772383.
      View in: PubMed
    11. Hartwell EE, Feinn R, Morris PE, Gelernter J, Krystal J, Arias AJ, Hoffman M, Petrakis I, Gueorguieva R, Schacht JP, Oslin D, Anton RF, Kranzler HR. Systematic review and meta-analysis of the moderating effect of rs1799971 in OPRM1, the mu-opioid receptor gene, on response to naltrexone treatment of alcohol use disorder. Addiction. 2020 08; 115(8):1426-1437. PMID: 31961981.
      View in: PubMed
    12. Prisciandaro JJ, Schacht JP, Prescot AP, Brenner HM, Renshaw PF, Brown TR, Anton RF. Intraindividual changes in brain GABA, glutamate, and glutamine during monitored abstinence from alcohol in treatment-naive individuals with alcohol use disorder. Addict Biol. 2020 11; 25(6):e12810. PMID: 31373138.
      View in: PubMed
    13. Prisciandaro JJ, Schacht JP, Prescot AP, Brenner HM, Renshaw PF, Brown TR, Anton RF. Evidence for a unique association between fronto-cortical glycine levels and recent heavy drinking in treatment na?ve individuals with alcohol use disorder. Neurosci Lett. 2019 07 27; 706:207-210. PMID: 31108129.
      View in: PubMed
    14. Karoly HC, Schacht JP, Jacobus J, Meredith LR, Taylor CT, Tapert SF, Gray KM, Squeglia LM. Preliminary evidence that computerized approach avoidance training is not associated with changes in fMRI cannabis cue reactivity in non-treatment-seeking adolescent cannabis users. Drug Alcohol Depend. 2019 07 01; 200:145-152. PMID: 31132681.
      View in: PubMed
    15. Prisciandaro JJ, Schacht JP, Prescot AP, Renshaw PF, Brown TR, Anton RF. Brain Glutamate, GABA, and Glutamine Levels and Associations with Recent Drinking in Treatment-Na?ve Individuals with Alcohol Use Disorder Versus Light Drinkers. Alcohol Clin Exp Res. 2019 02; 43(2):221-226. PMID: 30537347.
      View in: PubMed
    16. Schacht JP, Anton RF, McNamara PJ, Im Y, King AC. The dopamine transporter VNTR polymorphism moderates the relationship between acute response to alcohol and future alcohol use disorder symptoms. Addict Biol. 2019 09; 24(5):1109-1118. PMID: 30230123.
      View in: PubMed
    17. Karoly HC, Schacht JP, Meredith LR, Jacobus J, Tapert SF, Gray KM, Squeglia LM. Investigating a novel fMRI cannabis cue reactivity task in youth. Addict Behav. 2019 02; 89:20-28. PMID: 30243035.
      View in: PubMed
    18. Schacht JP. Parsing Cannabis Exposure and Predisposing Risk Effects: Does Adolescent Cannabis Use Cause Neurocognitive Impairment, or Result From It? Biol Psychiatry Cogn Neurosci Neuroimaging. 2018 08; 3(8):654-656. PMID: 30092915.
      View in: PubMed
    19. Anton RF, Latham PK, Voronin KE, Randall PK, Book SW, Hoffman M, Schacht JP. Nicotine-Use/Smoking Is Associated with the Efficacy of Naltrexone in the Treatment of Alcohol Dependence. Alcohol Clin Exp Res. 2018 Apr; 42(4):751-760. PMID: 29431852.
      View in: PubMed
    20. Nguyen-Louie TT, Simmons AN, Squeglia LM, Alejandra Infante M, Schacht JP, Tapert SF. Earlier alcohol use onset prospectively predicts changes in functional connectivity. Psychopharmacology (Berl). 2018 04; 235(4):1041-1054. PMID: 29306963.
      View in: PubMed
    21. Schacht JP, Voronin KE, Randall PK, Anton RF. Dopaminergic Genetic Variation Influences Aripiprazole Effects on Alcohol Self-Administration and the Neural Response to Alcohol Cues in a Randomized Trial. Neuropsychopharmacology. 2018 05; 43(6):1247-1256. PMID: 29362512.
      View in: PubMed
    22. Schacht JP, Randall PK, Latham PK, Voronin KE, Book SW, Myrick H, Anton RF. Predictors of Naltrexone Response in a Randomized Trial: Reward-Related Brain Activation, OPRM1 Genotype, and Smoking Status. Neuropsychopharmacology. 2017 12; 42(13):2654. PMID: 29123234.
      View in: PubMed
    23. Anton RF, Schacht JP, Voronin KE, Randall PK. Aripiprazole Suppression of Drinking in a Clinical Laboratory Paradigm: Influence of Impulsivity and Self-Control. Alcohol Clin Exp Res. 2017 Jul; 41(7):1370-1380. PMID: 28493623.
      View in: PubMed
    24. Schacht JP, Randall PK, Latham PK, Voronin KE, Book SW, Myrick H, Anton RF. Predictors of Naltrexone Response in a Randomized Trial: Reward-Related Brain Activation, OPRM1 Genotype, and Smoking Status. Neuropsychopharmacology. 2017 Dec; 42(13):2640-2653. PMID: 28409564.
      View in: PubMed
    25. Schacht JP. COMT val158met moderation of dopaminergic drug effects on cognitive function: a critical review. Pharmacogenomics J. 2016 10; 16(5):430-8. PMID: 27241058.
      View in: PubMed
    26. Boyd SJ, Schacht JP, Prisciandaro JJ, Voronin K, Anton RF. Alcohol-Induced Stimulation Mediates the Effect of a GABRA2 SNP on Alcohol Self-Administrated among Alcohol-Dependent Individuals. Alcohol Alcohol. 2016 Sep; 51(5):549-54. PMID: 27117237.
      View in: PubMed
    27. Adams ZW, Schacht JP, Randall P, Anton RF. The Reasons for Heavy Drinking Questionnaire: Factor Structure and Validity in Alcohol-Dependent Adults Involved in Clinical Trials. J Stud Alcohol Drugs. 2016 Mar; 77(2):354-61. PMID: 26997195.
      View in: PubMed
    28. Prisciandaro JJ, Schacht JP, Prescot AP, Renshaw PF, Brown TR, Anton RF. Associations Between Recent Heavy Drinking and Dorsal Anterior Cingulate N-Acetylaspartate and Glutamate Concentrations in Non-Treatment-Seeking Individuals with Alcohol Dependence. Alcohol Clin Exp Res. 2016 Mar; 40(3):491-6. PMID: 26853538.
      View in: PubMed
    29. Courtney KE, Schacht JP, Hutchison K, Roche DJ, Ray LA. Neural substrates of cue reactivity: association with treatment outcomes and relapse. Addict Biol. 2016 Jan; 21(1):3-22. PMID: 26435524.
      View in: PubMed
    30. Schacht JP, Anton RF, Randall PK, Li X, Henderson S, Myrick H. Varenicline effects on drinking, craving and neural reward processing among non-treatment-seeking alcohol-dependent individuals. Psychopharmacology (Berl). 2014 Sep; 231(18):3799-807. PMID: 24647921.
      View in: PubMed
    31. Anton RF, Schacht JP, Book SW. Pharmacologic treatment of alcoholism. Handb Clin Neurol. 2014; 125:527-42. PMID: 25307594.
      View in: PubMed
    32. Schacht JP, Anton RF, Randall PK, Li X, Henderson S, Myrick H. Effects of a GABA-ergic medication combination and initial alcohol withdrawal severity on cue-elicited brain activation among treatment-seeking alcoholics. Psychopharmacology (Berl). 2013 Jun; 227(4):627-37. PMID: 23389755.
      View in: PubMed
    33. Schacht JP, Anton RF, Voronin KE, Randall PK, Li X, Henderson S, Myrick H. Interacting effects of naltrexone and OPRM1 and DAT1 variation on the neural response to alcohol cues. Neuropsychopharmacology. 2013 Feb; 38(3):414-22. PMID: 23032071.
      View in: PubMed
    34. Schacht JP, Hutchison KE, Filbey FM. Associations between cannabinoid receptor-1 (CNR1) variation and hippocampus and amygdala volumes in heavy cannabis users. Neuropsychopharmacology. 2012 Oct; 37(11):2368-76. PMID: 22669173.
      View in: PubMed
    35. Schacht JP, Anton RF, Myrick H. Functional neuroimaging studies of alcohol cue reactivity: a quantitative meta-analysis and systematic review. Addict Biol. 2013 Jan; 18(1):121-33. PMID: 22574861.
      View in: PubMed
    36. Schacht JP, Randall PK, Waid LR, Baros AM, Latham PK, Wright TM, Myrick H, Anton RF. Neurocognitive performance, alcohol withdrawal, and effects of a combination of flumazenil and gabapentin in alcohol dependence. Alcohol Clin Exp Res. 2011 Nov; 35(11):2030-8. PMID: 21631542.
      View in: PubMed
    37. Schacht JP, Anton RF, Randall PK, Li X, Henderson S, Myrick H. Stability of fMRI striatal response to alcohol cues: a hierarchical linear modeling approach. Neuroimage. 2011 May 01; 56(1):61-8. PMID: 21316465.
      View in: PubMed
    38. Filbey FM, Schacht JP, Myers US, Chavez RS, Hutchison KE. Individual and additive effects of the CNR1 and FAAH genes on brain response to marijuana cues. Neuropsychopharmacology. 2010 Mar; 35(4):967-75. PMID: 20010552.
      View in: PubMed
    39. Filbey FM, Schacht JP, Myers US, Chavez RS, Hutchison KE. Marijuana craving in the brain. Proc Natl Acad Sci U S A. 2009 Aug 04; 106(31):13016-21. PMID: 19651613.
      View in: PubMed
    40. Schacht JP, Selling RE, Hutchison KE. Intermediate cannabis dependence phenotypes and the FAAH C385A variant: an exploratory analysis. Psychopharmacology (Berl). 2009 Apr; 203(3):511-7. PMID: 19002671.
      View in: PubMed
    41. Haughey HM, Marshall E, Schacht JP, Louis A, Hutchison KE. Marijuana withdrawal and craving: influence of the cannabinoid receptor 1 (CNR1) and fatty acid amide hydrolase (FAAH) genes. Addiction. 2008 Oct; 103(10):1678-86. PMID: 18705688.
      View in: PubMed
    42. Kharkheli E, Kevanishvili Z, Maglakelidze T, Davitashvili O, Schacht J. Does vitamin E prevent gentamicin-induced ototoxicity? Georgian Med News. 2007 May; (146):14-7. PMID: 17595452.
      View in: PubMed
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