Colorado PROFILES, The Colorado Clinical and Translational Sciences Institute (CCTSI)
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Margaret E Wierman

TitleProfessor
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM-MED
Phone303/393-8020

    Collapse Research 
    Collapse research activities and funding
    R29HD025275     (WIERMAN, MARGARET E.)Aug 1, 1989 - Jan 31, 1995
    NIH/NICHD
    PRETRANSLATIONAL REGULATION OF FSH AND LH
    Role: Principal Investigator

    K04HD001026     (WIERMAN, MARGARET E.)Jul 1, 1993 - Jun 30, 1998
    NIH/NICHD
    CONTROL OF GNRH GENE EXPRESSION
    Role: Principal Investigator

    R55HD031191     (WIERMAN, MARGARET E.)Sep 30, 1994 - Jun 30, 1995
    NIH/NICHD
    RAT GNRH GENE--TISSUE SPECIFIC AND HORMONAL CONTROLS
    Role: Principal Investigator

    R01HD031191     (WIERMAN, MARGARET E)Jul 1, 1995 - Jan 31, 2013
    NIH/NICHD
    Novel Factors that Regulate GnRH Neuronal Development
    Role: Principal Investigator

    R01DK053270     (WIERMAN, MARGARET E.)Jul 1, 1998 - Mar 31, 2003
    NIH/NIDDK
    DEVELOPMENTAL CONTROL OF GNRH EXPRESSION BY POU PROTEINS
    Role: Principal Investigator

    I01BX001876     (WIERMAN, MARGARET E)Oct 1, 2013 - Sep 30, 2017
    VA
    Role of the Sterile20 (Ste20)-like kinase MST4 in Pituitary Tumorigenesis
    Role: Principal Investigator

    Collapse Bibliographic 
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Kiseljak-Vassiliades K, Mills TS, Zhang Y, Xu M, Lillehei KO, Kleinschmidt-DeMasters BK, Wierman ME. Elucidating the Role of the Desmosome Protein p53 Apoptosis Effector Related to PMP-22 in Growth Hormone Tumors. Endocrinology. 2017 May 01; 158(5):1450-1460. PMID: 28323918.
      View in: PubMed
    2. Wierman ME, Chin WW, Clemmons DR, Gagel RF, Larsen JL. Changing of the Guard. Endocr Rev. 2016 Feb; 2016(1):1-2. PMID: 27454359.
      View in: PubMed
    3. Xiong W, Matheson CJ, Xu M, Backos DS, Mills TS, Salian-Mehta S, Kiseljak-Vassiliades K, Reigan P, Wierman ME. Structure-Based Screen Identification of a Mammalian Ste20-like Kinase 4 (MST4) Inhibitor with Therapeutic Potential for Pituitary Tumors. Mol Cancer Ther. 2016 Mar; 15(3):412-20. PMID: 26721946.
      View in: PubMed
    4. Shea KL, Gavin KM, Melanson EL, Gibbons E, Stavros A, Wolfe P, Kittelson JM, Vondracek SF, Schwartz RS, Wierman ME, Kohrt WM. Body composition and bone mineral density after ovarian hormone suppression with or without estradiol treatment. Menopause. 2015 Oct; 22(10):1045-52. PMID: 25783468; PMCID: PMC4760356 [Available on 10/01/16].
    5. Kiseljak-Vassiliades K, Xu M, Mills TS, Smith EE, Silveira LJ, Lillehei KO, Kerr JM, Kleinschmidt-DeMasters BK, Wierman ME. Differential somatostatin receptor (SSTR) 1-5 expression and downstream effectors in histologic subtypes of growth hormone pituitary tumors. Mol Cell Endocrinol. 2015 Dec 05; 417:73-83. PMID: 26391562; PMCID: PMC4641524 [Available on 12/05/16].
    6. Melanson EL, Gavin KM, Shea KL, Wolfe P, Wierman ME, Schwartz RS, Kohrt WM. Regulation of energy expenditure by estradiol in premenopausal women. J Appl Physiol (1985). 2015 Nov 01; 119(9):975-81. PMID: 26338457; PMCID: PMC4628992 [Available on 11/01/16].
    7. Wierman ME, Chin WW, Clemmons DR, Gagel RF, Larsen JL. Changing of the Guard. Endocr Rev. 2015 Aug; 36(4):345-6. PMID: 26240982.
      View in: PubMed
    8. Wierman ME. Risks of Different Testosterone Preparations: Too Much, Too Little, Just Right. JAMA Intern Med. 2015 Jul; 175(7):1197-8. PMID: 25961437.
      View in: PubMed
    9. Salian-Mehta S, Xu M, McKinsey TA, Tobet S, Wierman ME. Novel Interaction of Class IIb Histone Deacetylase 6 (HDAC6) with Class IIa HDAC9 Controls Gonadotropin Releasing Hormone (GnRH) Neuronal Cell Survival and Movement. J Biol Chem. 2015 May 29; 290(22):14045-56. PMID: 25873389; PMCID: PMC4447976.
    10. Xiong W, Knox AJ, Xu M, Kiseljak-Vassiliades K, Colgan SP, Brodsky KS, Kleinschmidt-Demasters BK, Lillehei KO, Wierman ME. Mammalian Ste20-like kinase 4 promotes pituitary cell proliferation and survival under hypoxia. Mol Endocrinol. 2015 Mar; 29(3):460-72. PMID: 25650755; PMCID: PMC4580653.
    11. Cefalu WT, Nair KS, Seaquist ER, Zierath J, Boulton AJ, LeRoith D, Harrell RM, Grunberger G, Wartofsky L, Gore AC, Wierman ME, Hammes SR, Lange CA, Santen RJ. Statement of principle. Horm Cancer. 2015 Feb; 6(1):1. PMID: 25410830.
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    12. Cefalu WT, Nair KS, Seaquist ER, Zierath J, Boulton AJ, LeRoith D, Harrell RM, Grunberger G, Wartofsky L, Gore AC, Wierman ME, Hammes SR, Lange CA, Santen RJ. Statement of principle. J Clin Endocrinol Metab. 2014 Dec; 99(12):4376. PMID: 25365410.
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    13. Wierman ME, Auchus RJ, Haisenleder DJ, Hall JE, Handelsman D, Hankinson S, Rosner W, Singh RJ, Sluss PM, Stanczyk FZ. Editorial: the new instructions to authors for the reporting of steroid hormone measurements. Mol Endocrinol. 2014 Dec; 28(12):1917. PMID: 25354217.
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    14. Wierman ME, Auchus RJ, Haisenleder DJ, Hall JE, Handelsman D, Hankinson S, Rosner W, Singh RJ, Sluss PM, Stanczyk FZ. Editorial: The new instructions to authors for the reporting of steroid hormone measurements. J Clin Endocrinol Metab. 2014 Dec; 99(12):4375. PMID: 25354278.
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    15. Cefalu WT, Nair KS, Seaquist ER, Zierath J, Boulton AJ, LeRoith D, Harrell RM, Grunberger G, Wartofsky L, Gore AC, Wierman ME, Hammes SR, Lange CA, Santen RJ. Statement of principle. Endocr Rev. 2014 Dec; 35(6):850. PMID: 25365740.
      View in: PubMed
    16. Wierman ME, Auchus RJ, Haisenleder DJ, Hall JE, Handelsman D, Hankinson S, Rosner W, Singh RJ, Sluss PM, Stanczyk FZ. Editorial: the new instructions to authors for the reporting of steroid hormone measurements. Endocrinology. 2014 Dec; 155(12):4603. PMID: 25354305.
      View in: PubMed
    17. Wierman ME, Auchus RJ, Haisenleder DJ, Hall JE, Handelsman D, Hankinson S, Rosner W, Singh RJ, Sluss PM, Stanczyk FZ. Editorial: The new instructions to authors for the reporting of steroid hormone measurements. Endocr Rev. 2014 Dec; 35(6):849. PMID: 25354232.
      View in: PubMed
    18. Wierman ME, Arlt W, Basson R, Davis SR, Miller KK, Murad MH, Rosner W, Santoro N. Androgen therapy in women: a reappraisal: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab. 2014 Oct; 99(10):3489-510. PMID: 25279570.
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    19. Sato J, Kinugasa M, Satomi-Kobayashi S, Hatakeyama K, Knox AJ, Asada Y, Wierman ME, Hirata K, Rikitake Y. Family with sequence similarity 5, member C (FAM5C) increases leukocyte adhesion molecules in vascular endothelial cells: implication in vascular inflammation. PLoS One. 2014; 9(9):e107236. PMID: 25251368; PMCID: PMC4175995.
    20. Kiseljak-Vassiliades K, Carlson NE, Borges MT, Kleinschmidt-DeMasters BK, Lillehei KO, Kerr JM, Wierman ME. Growth hormone tumor histological subtypes predict response to surgical and medical therapy. Endocrine. 2015 May; 49(1):231-41. PMID: 25129651; PMCID: PMC4331291.
    21. Ripley D, Wierman M, Gerber D, Weintraub A, Newman J. Comment on the decision to provide testosterone supplementation to patients with traumatic brain injury. PM R. 2014 Aug; 6(8):761. PMID: 25169710.
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    22. Salian-Mehta S, Xu M, Pierce A, Bliesner B, Tobet S, Wierman ME. Loss of Growth arrest specific gene 6 (Gas6) results in altered GnRH neuron migration, delayed vaginal opening and sexual maturation in mice. Mol Cell Endocrinol. 2014 Aug 05; 393(1-2):164-70. PMID: 24978606; PMCID: PMC4130768.
    23. Ho PM, Barón AE, Wierman ME. Deaths and cardiovascular events in men receiving testosterone--reply. JAMA. 2014 Mar 05; 311(9):964-5. PMID: 24595788.
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    24. Salian-Mehta S, Xu M, Knox AJ, Plummer L, Slavov D, Taylor M, Bevers S, Hodges RS, Crowley WF, Wierman ME. Functional consequences of AXL sequence variants in hypogonadotropic hypogonadism. J Clin Endocrinol Metab. 2014 Apr; 99(4):1452-60. PMID: 24476074; PMCID: PMC3973777.
    25. Vigen R, O'Donnell CI, Barón AE, Grunwald GK, Maddox TM, Bradley SM, Barqawi A, Woning G, Wierman ME, Plomondon ME, Rumsfeld JS, Ho PM. Association of testosterone therapy with mortality, myocardial infarction, and stroke in men with low testosterone levels. JAMA. 2013 Nov 06; 310(17):1829-36. PMID: 24193080.
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    26. Salian-Mehta S, Xu M, Wierman ME. AXL and MET crosstalk to promote gonadotropin releasing hormone (GnRH) neuronal cell migration and survival. Mol Cell Endocrinol. 2013 Jul 15; 374(1-2):92-100. PMID: 23648337; PMCID: PMC3690482.
    27. Weickhardt AJ, Doebele RC, Purcell WT, Bunn PA, Oton AB, Rothman MS, Wierman ME, Mok T, Popat S, Bauman J, Nieva J, Novello S, Ou SH, Camidge DR. Symptomatic reduction in free testosterone levels secondary to crizotinib use in male cancer patients. Cancer. 2013 Jul 01; 119(13):2383-90. PMID: 23585220; PMCID: PMC3686910.
    28. Rosner W, Hankinson SE, Sluss PM, Vesper HW, Wierman ME. Challenges to the measurement of estradiol: an endocrine society position statement. J Clin Endocrinol Metab. 2013 Apr; 98(4):1376-87. PMID: 23463657; PMCID: PMC3615207.
    29. Xu M, Knox AJ, Michaelis KA, Kiseljak-Vassiliades K, Kleinschmidt-DeMasters BK, Lillehei KO, Wierman ME. Reprimo (RPRM) is a novel tumor suppressor in pituitary tumors and regulates survival, proliferation, and tumorigenicity. Endocrinology. 2012 Jul; 153(7):2963-73. PMID: 22562171; PMCID: PMC4714648.
    30. Weickhardt AJ, Rothman MS, Salian-Mehta S, Kiseljak-Vassiliades K, Oton AB, Doebele RC, Wierman ME, Camidge DR. Rapid-onset hypogonadism secondary to crizotinib use in men with metastatic nonsmall cell lung cancer. Cancer. 2012 Nov 01; 118(21):5302-9. PMID: 22488744.
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    31. Kiseljak-Vassiliades K, Shafi S, Kerr JM, Phang TL, Kleinschmidt-DeMasters BK, Wierman ME. Clinical implications of growth hormone-secreting tumor subtypes. Endocrine. 2012 Aug; 42(1):18-28. PMID: 22434413.
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    32. Meditz AL, Moreau KL, MaWhinney S, Gozansky WS, Melander K, Kohrt WM, Wierman ME, Connick E. CCR5 expression is elevated on endocervical CD4+ T cells in healthy postmenopausal women. J Acquir Immune Defic Syndr. 2012 Mar 01; 59(3):221-8. PMID: 22083068; PMCID: PMC3288615.
    33. Wierman ME, Xu M, Pierce A, Bliesner B, Bliss SP, Roberson MS. Extracellular signal-regulated kinase 1 and 2 are not required for GnRH neuron development and normal female reproductive axis function in mice. Neuroendocrinology. 2012; 95(4):289-96. PMID: 22156655.
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    34. Michaelis KA, Knox AJ, Xu M, Kiseljak-Vassiliades K, Edwards MG, Geraci M, Kleinschmidt-DeMasters BK, Lillehei KO, Wierman ME. Identification of growth arrest and DNA-damage-inducible gene beta (GADD45beta) as a novel tumor suppressor in pituitary gonadotrope tumors. Endocrinology. 2011 Oct; 152(10):3603-13. PMID: 21810943; PMCID: PMC4714647.
    35. Rothman MS, Wierman ME. How should postmenopausal androgen excess be evaluated? Clin Endocrinol (Oxf). 2011 Aug; 75(2):160-4. PMID: 21521309.
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    36. Madsen H, Borges TM, Knox AJ, Michaelis KA, Xu M, Lillehei KO, Wierman ME, Kleinschmidt-DeMasters BK. Giant pituitary adenomas: pathologic-radiographic correlations and lack of role for p53 and MIB-1 labeling. Am J Surg Pathol. 2011 Aug; 35(8):1204-13. PMID: 21753697.
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    37. Pierce A, Xu M, Bliesner B, Liu Z, Richards J, Tobet S, Wierman ME. Hypothalamic but not pituitary or ovarian defects underlie the reproductive abnormalities in Axl/Tyro3 null mice. Mol Cell Endocrinol. 2011 Jun 06; 339(1-2):151-8. PMID: 21539887; PMCID: PMC3124083.
    38. Kerr JM, Wierman ME. Pituitary apoplexy. BMJ. 2011 Mar 17; 342:d1270. PMID: 21415110.
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    39. Rothman MS, Carlson NE, Xu M, Wang C, Swerdloff R, Lee P, Goh VH, Ridgway EC, Wierman ME. Reexamination of testosterone, dihydrotestosterone, estradiol and estrone levels across the menstrual cycle and in postmenopausal women measured by liquid chromatography-tandem mass spectrometry. Steroids. 2011 Jan; 76(1-2):177-82. PMID: 21070796; PMCID: PMC3005029.
    40. Lillehei KO, Widdel L, Astete CA, Wierman ME, Kleinschmidt-DeMasters BK, Kerr JM. Transsphenoidal resection of 82 Rathke cleft cysts: limited value of alcohol cauterization in reducing recurrence rates. J Neurosurg. 2011 Feb; 114(2):310-7. PMID: 20799861.
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    41. Wierman ME, Kiseljak-Vassiliades K, Tobet S. Gonadotropin-releasing hormone (GnRH) neuron migration: initiation, maintenance and cessation as critical steps to ensure normal reproductive function. Front Neuroendocrinol. 2011 Jan; 32(1):43-52. PMID: 20650288; PMCID: PMC3008544.
    42. Basson R, Wierman ME, van Lankveld J, Brotto L. Summary of the recommendations on sexual dysfunctions in women. J Sex Med. 2010 Jan; 7(1 Pt 2):314-26. PMID: 20092441.
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    43. Wierman ME, Nappi RE, Avis N, Davis SR, Labrie F, Rosner W, Shifren JL. Endocrine aspects of women's sexual function. J Sex Med. 2010 Jan; 7(1 Pt 2):561-85. PMID: 20092453.
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    44. Carlson NE, Brenner LA, Wierman ME, Harrison-Felix C, Morey C, Gallagher S, Ripley D. Hypogonadism on admission to acute rehabilitation is correlated with lower functional status at admission and discharge. Brain Inj. 2009 Apr; 23(4):336-44. PMID: 19330595.
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    45. Xu M, Shorts-Cary L, Knox AJ, Kleinsmidt-DeMasters B, Lillehei K, Wierman ME. Epidermal growth factor receptor pathway substrate 8 is overexpressed in human pituitary tumors: role in proliferation and survival. Endocrinology. 2009 May; 150(5):2064-71. PMID: 19116338.
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    46. Pierce A, Bliesner B, Xu M, Nielsen-Preiss S, Lemke G, Tobet S, Wierman ME. Axl and Tyro3 modulate female reproduction by influencing gonadotropin-releasing hormone neuron survival and migration. Mol Endocrinol. 2008 Nov; 22(11):2481-95. PMID: 18787040; PMCID: PMC2582545.
    47. Rothman MS, Wierman ME. Female hypogonadism: evaluation of the hypothalamic-pituitary-ovarian axis. Pituitary. 2008; 11(2):163-9. PMID: 18404388.
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    48. Wierman M, Basson R, Davis S, Khosla S, Miller K, Rosner W, Santoro N. Are the endocrine society's clinical practice guidelines on androgen therapy in women misguided? A commentary-response. J Sex Med. 2007 Nov; 4(6):1782-3; author reply 1784-5. PMID: 17970980.
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    49. Schwarting GA, Wierman ME, Tobet SA. Gonadotropin-releasing hormone neuronal migration. Semin Reprod Med. 2007 Sep; 25(5):305-12. PMID: 17710726.
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    50. Rothman MS, Wierman ME. The role of gonadotropin releasing hormone in normal and pathologic endocrine processes. Curr Opin Endocrinol Diabetes Obes. 2007 Aug; 14(4):306-10. PMID: 17940457.
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    51. Wierman ME, Kohrt WM. Vascular and metabolic effects of sex steroids: new insights into clinical trials. Reprod Sci. 2007 May; 14(4):300-14. PMID: 17644802.
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    52. Wierman ME. Sex steroid effects at target tissues: mechanisms of action. Adv Physiol Educ. 2007 Mar; 31(1):26-33. PMID: 17327579.
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    53. Nielsen-Preiss SM, Allen MP, Xu M, Linseman DA, Pawlowski JE, Bouchard RJ, Varnum BC, Heidenreich KA, Wierman ME. Adhesion-related kinase induction of migration requires phosphatidylinositol-3-kinase and ras stimulation of rac activity in immortalized gonadotropin-releasing hormone neuronal cells. Endocrinology. 2007 Jun; 148(6):2806-14. PMID: 17332061.
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    54. Rothman MS, Arciniegas DB, Filley CM, Wierman ME. The neuroendocrine effects of traumatic brain injury. J Neuropsychiatry Clin Neurosci. 2007; 19(4):363-72. PMID: 18070838.
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    55. Shorts-Cary L, Xu M, Ertel J, Kleinschmidt-Demasters BK, Lillehei K, Matsuoka I, Nielsen-Preiss S, Wierman ME. Bone morphogenetic protein and retinoic acid-inducible neural specific protein-3 is expressed in gonadotrope cell pituitary adenomas and induces proliferation, migration, and invasion. Endocrinology. 2007 Mar; 148(3):967-75. PMID: 17138656.
      View in: PubMed
    56. Wierman ME, Basson R, Davis SR, Khosla S, Miller KK, Rosner W, Santoro N. Androgen therapy in women: an Endocrine Society Clinical Practice guideline. J Clin Endocrinol Metab. 2006 Oct; 91(10):3697-710. PMID: 17018650.
      View in: PubMed
    57. Harrison GS, Wierman ME, Nett TM, Glode LM. Gonadotropin-releasing hormone and its receptor in normal and malignant cells. Endocr Relat Cancer. 2004 Dec; 11(4):725-48. PMID: 15613448.
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    58. Wierman ME, Pawlowski JE, Allen MP, Xu M, Linseman DA, Nielsen-Preiss S. Molecular mechanisms of gonadotropin-releasing hormone neuronal migration. Trends Endocrinol Metab. 2004 Apr; 15(3):96-102. PMID: 15046737.
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    59. Hirshman E, Merritt P, Wang CC, Wierman M, Budescu DV, Kohrt W, Templin JL, Bhasin S. Evidence that androgenic and estrogenic metabolites contribute to the effects of dehydroepiandrosterone on cognition in postmenopausal women. Horm Behav. 2004 Feb; 45(2):144-55. PMID: 15019802.
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    60. Shattuck TM, Välimäki S, Obara T, Gaz RD, Clark OH, Shoback D, Wierman ME, Tojo K, Robbins CM, Carpten JD, Farnebo LO, Larsson C, Arnold A. Somatic and germ-line mutations of the HRPT2 gene in sporadic parathyroid carcinoma. N Engl J Med. 2003 Oct 30; 349(18):1722-9. PMID: 14585940.
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    61. Shattuck TM, Kim TS, Costa J, Yandell DW, Imanishi Y, Palanisamy N, Gaz RD, Shoback D, Clark OH, Monchik JM, Wierman ME, Hollenberg A, Tojo K, Chaganti RS, Arnold A. Mutational analyses of RB and BRCA2 as candidate tumour suppressor genes in parathyroid carcinoma. Clin Endocrinol (Oxf). 2003 Aug; 59(2):180-9. PMID: 12864795.
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    62. Hirshman E, Wells E, Wierman ME, Anderson B, Butler A, Senholzi M, Fisher J. The effect of dehydroepiandrosterone (DHEA) on recognition memory decision processes and discrimination in postmenopausal women. Psychon Bull Rev. 2003 Mar; 10(1):125-34. PMID: 12747499.
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    63. Petroff BK, Croutch CR, Hunter DM, Wierman ME, Gao X. 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) stimulates gonadotropin secretion in the immature female Sprague-Dawley rat through a pentobarbital- and estradiol-sensitive mechanism but does not alter gonadotropin-releasing hormone (GnRH) secretion by immortalized GnRH neurons in vitro. Biol Reprod. 2003 Jun; 68(6):2100-6. PMID: 12606454.
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    64. Vazquez-Martinez R, Leclerc GM, Wierman ME, Boockfor FR. Episodic activation of the rat GnRH promoter: role of the homeoprotein oct-1. Mol Endocrinol. 2002 Sep; 16(9):2093-100. PMID: 12198245.
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    65. Allen MP, Xu M, Linseman DA, Pawlowski JE, Bokoch GM, Heidenreich KA, Wierman ME. Adhesion-related kinase repression of gonadotropin-releasing hormone gene expression requires Rac activation of the extracellular signal-regulated kinase pathway. J Biol Chem. 2002 Oct 11; 277(41):38133-40. PMID: 12138087.
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    66. Pawlowski JE, Ertel JR, Allen MP, Xu M, Butler C, Wilson EM, Wierman ME. Liganded androgen receptor interaction with beta-catenin: nuclear co-localization and modulation of transcriptional activity in neuronal cells. J Biol Chem. 2002 Jun 07; 277(23):20702-10. PMID: 11916967.
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    67. Allen MP, Linseman DA, Udo H, Xu M, Schaack JB, Varnum B, Kandel ER, Heidenreich KA, Wierman ME. Novel mechanism for gonadotropin-releasing hormone neuronal migration involving Gas6/Ark signaling to p38 mitogen-activated protein kinase. Mol Cell Biol. 2002 Jan; 22(2):599-613. PMID: 11756555; PMCID: PMC139735.
    68. Li M, Linseman DA, Allen MP, Meintzer MK, Wang X, Laessig T, Wierman ME, Heidenreich KA. Myocyte enhancer factor 2A and 2D undergo phosphorylation and caspase-mediated degradation during apoptosis of rat cerebellar granule neurons. J Neurosci. 2001 Sep 01; 21(17):6544-52. PMID: 11517243.
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    69. Allen MP, Xu M, Zeng C, Tobet SA, Wierman ME. Myocyte enhancer factors-2B and -2C are required for adhesion related kinase repression of neuronal gonadotropin releasing hormone gene expression. J Biol Chem. 2000 Dec 15; 275(50):39662-70. PMID: 10995769.
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    70. Allen MP, Zeng C, Schneider K, Xiong X, Meintzer MK, Bellosta P, Basilico C, Varnum B, Heidenreich KA, Wierman ME. Growth arrest-specific gene 6 (Gas6)/adhesion related kinase (Ark) signaling promotes gonadotropin-releasing hormone neuronal survival via extracellular signal-regulated kinase (ERK) and Akt. Mol Endocrinol. 1999 Feb; 13(2):191-201. PMID: 9973250.
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    71. Wierman ME. Advances in the diagnosis and management of impotence. Dis Mon. 1999 Jan; 45(1):1-20. PMID: 9987493.
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    72. Wierman ME. Advances in the diagnosis and management of impotence. Adv Intern Med. 1999; 44:1-17. PMID: 9929703.
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    73. Wierman ME, Cassel CK. Erectile dysfunction: a multifaceted disorder. Hosp Pract (1995). 1998 Oct 15; 33(10):65-74, 77-8, 83-9; discussion 89-90. PMID: 9793543.
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    74. Fang Z, Xiong X, James A, Gordon DF, Wierman ME. Identification of novel factors that regulate GnRH gene expression and neuronal migration. Endocrinology. 1998 Aug; 139(8):3654-7. PMID: 9681520.
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    75. Wierman ME, Xiong X, Kepa JK, Spaulding AJ, Jacobsen BM, Fang Z, Nilaver G, Ojeda SR. Repression of gonadotropin-releasing hormone promoter activity by the POU homeodomain transcription factor SCIP/Oct-6/Tst-1: a regulatory mechanism of phenotype expression? Mol Cell Biol. 1997 Mar; 17(3):1652-65. PMID: 9032292; PMCID: PMC231890.
    76. Kepa JK, Spaulding AJ, Jacobsen BM, Fang Z, Xiong X, Radovick S, Wierman ME. Structure of the distal human gonadotropin releasing hormone (hGnrh) gene promoter and functional analysis in Gt1-7 neuronal cells. Nucleic Acids Res. 1996 Sep 15; 24(18):3614-20. PMID: 8836191; PMCID: PMC146144.
    77. Kepa JK, Jacobsen BM, Boen EA, Prendergast P, Edwards DP, Takimoto G, Wierman ME. Direct binding of progesterone receptor to nonconsensus DNA sequences represses rat GnRH. Mol Cell Endocrinol. 1996 Mar 01; 117(1):27-39. PMID: 8734471.
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    78. Wierman ME, Fang Z, Kepa JK. GnRH gene expression in neuronal cell lines. Trends Endocrinol Metab. 1996 Mar; 7(2):60-5. PMID: 18406727.
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    79. Bruder JM, Spaulding AJ, Wierman ME. Phorbol ester inhibition of rat gonadotropin-releasing hormone promoter activity: role of Fos and Jun in the repression of transcription. Mol Endocrinol. 1996 Jan; 10(1):35-44. PMID: 8838143.
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    80. Wierman ME, Bruder JM, Kepa JK. Regulation of gonadotropin-releasing hormone (GnRH) gene expression in hypothalamic neuronal cells. Cell Mol Neurobiol. 1995 Feb; 15(1):79-88. PMID: 7648611.
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    81. Bruder JM, Samuels MH, Bremner WJ, Ridgway EC, Wierman ME. Hypothyroidism-induced macroorchidism: use of a gonadotropin-releasing hormone agonist to understand its mechanism and augment adult stature. J Clin Endocrinol Metab. 1995 Jan; 80(1):11-6. PMID: 7829598.
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    82. Cryns VL, Thor A, Xu HJ, Hu SX, Wierman ME, Vickery AL, Benedict WF, Arnold A. Loss of the retinoblastoma tumor-suppressor gene in parathyroid carcinoma. N Engl J Med. 1994 Mar 17; 330(11):757-61. PMID: 7906387.
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    83. Bruder JM, Wierman ME. Evidence for transcriptional inhibition of GnRH gene expression by phorbol ester at a proximal promoter region. Mol Cell Endocrinol. 1994 Mar; 99(2):177-82. PMID: 8206325.
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    84. Boepple PA, Frisch LS, Wierman ME, Hoffman WH, Crowley WF. The natural history of autonomous gonadal function, adrenarche, and central puberty in gonadotropin-independent precocious puberty. J Clin Endocrinol Metab. 1992 Dec; 75(6):1550-5. PMID: 1464663.
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    85. Bruder JM, Krebs WD, Nett TM, Wierman ME. Phorbol ester activation of the protein kinase C pathway inhibits gonadotropin-releasing hormone gene expression. Endocrinology. 1992 Dec; 131(6):2552-8. PMID: 1446598.
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    86. Wierman ME, Kepa JK, Sun W, Gordon DF, Wood WM. Estrogen negatively regulates rat gonadotropin releasing hormone (rGnRH) promoter activity in transfected placental cells. Mol Cell Endocrinol. 1992 Jul; 86(1-2):1-10. PMID: 1511775.
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    87. Kepa JK, Wang C, Neeley CI, Raynolds MV, Gordon DF, Wood WM, Wierman ME. Structure of the rat gonadotropin releasing hormone (rGnRH) gene promoter and functional analysis in hypothalamic cells. Nucleic Acids Res. 1992 Mar 25; 20(6):1393-9. PMID: 1561095; PMCID: PMC312188.
    88. Martin K, Santoro N, Hall J, Filicori M, Wierman M, Crowley WF. Clinical review 15: Management of ovulatory disorders with pulsatile gonadotropin-releasing hormone. J Clin Endocrinol Metab. 1990 Nov; 71(5):1081A-1081G. PMID: 2229271.
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    89. Wierman ME, Gharib SD, Wang C, LaRovere JM, Badger TM, Chin WW. Divergent regulation of gonadotropin subunit mRNA levels by androgens in the female rat. Biol Reprod. 1990 Aug; 43(2):191-5. PMID: 1696138.
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    90. Schlaff WD, Wierman ME. Endocrinology of male fertility and infertility. Curr Opin Obstet Gynecol. 1990 Jun; 2(3):412-7. PMID: 2102336.
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    91. Childs GV, Unabia G, Wierman ME, Gharib SD, Chin WW. Castration induces time-dependent changes in the follicle-stimulating hormone beta-subunit messenger ribonucleic acid-containing gonadotrope cell population. Endocrinology. 1990 Apr; 126(4):2205-13. PMID: 2108011.
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    92. Wierman ME, Wang C. Androgen selectively stimulates follicle-stimulating hormone-beta mRNA levels after gonadotropin-releasing hormone antagonist administration. Biol Reprod. 1990 Mar; 42(3):563-71. PMID: 2111188.
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    93. Gharib SD, Wierman ME, Shupnik MA, Chin WW. Molecular biology of the pituitary gonadotropins. Endocr Rev. 1990 Feb; 11(1):177-99. PMID: 2108012.
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    94. Gharib SD, Roy A, Wierman ME, Chin WW. Isolation and characterization of the gene encoding the beta-subunit of rat follicle-stimulating hormone. DNA. 1989 Jun; 8(5):339-49. PMID: 2504572.
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    95. Samuels MH, Wierman ME, Wang C, Ridgway EC. The effect of altered thyroid status on pituitary hormone messenger ribonucleic acid concentrations in the rat. Endocrinology. 1989 May; 124(5):2277-82. PMID: 2707156.
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    96. Wierman ME, Rivier JE, Wang C. Gonadotropin-releasing hormone-dependent regulation of gonadotropin subunit messenger ribonucleic acid levels in the rat. Endocrinology. 1989 Jan; 124(1):272-8. PMID: 2491805.
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    97. Wierman ME, Gharib SD, Chin WW. The structure and regulation of the pituitary gonadotrophin subunit genes. Baillieres Clin Endocrinol Metab. 1988 Nov; 2(4):869-89. PMID: 2478113.
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    98. Wierman ME, Gharib SD, LaRovere JM, Badger TM, Chin WW. Selective failure of androgens to regulate follicle stimulating hormone beta messenger ribonucleic acid levels in the male rat. Mol Endocrinol. 1988 Jun; 2(6):492-8. PMID: 2458524.
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    99. Childs GV, Lloyd JM, Unabia G, Gharib SD, Wierman ME, Chin WW. Detection of luteinizing hormone beta messenger ribonucleic acid (RNA) in individual gonadotropes after castration: use of a new in situ hybridization method with a photobiotinylated complementary RNA probe. Mol Endocrinol. 1987 Dec; 1(12):926-32. PMID: 3153470.
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    100. Gharib SD, Wierman ME, Badger TM, Chin WW. Sex steroid hormone regulation of follicle-stimulating hormone subunit messenger ribonucleic acid (mRNA) levels in the rat. J Clin Invest. 1987 Aug; 80(2):294-9. PMID: 3112183; PMCID: PMC442237.
    101. Hall DA, Crowley WF, Wierman ME, Simeone JF, McCarthy KA. Sonographic monitoring of LHRH analogue therapy in idiopathic precocious puberty in young girls. J Clin Ultrasound. 1986 Jun; 14(5):331-8. PMID: 3088048.
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    102. Boepple PA, Mansfield MJ, Wierman ME, Rudlin CR, Bode HH, Crigler JF, Crawford JD, Crowley WF. Use of a potent, long acting agonist of gonadotropin-releasing hormone in the treatment of precocious puberty. Endocr Rev. 1986 Feb; 7(1):24-33. PMID: 2937629.
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    103. Wierman ME, Beardsworth DE, Crawford JD, Crigler JF, Mansfield MJ, Bode HH, Boepple PA, Kushner DC, Crowley WF. Adrenarche and skeletal maturation during luteinizing hormone releasing hormone analogue suppression of gonadarche. J Clin Invest. 1986 Jan; 77(1):121-6. PMID: 2935557; PMCID: PMC423317.
    104. Santoro N, Wierman ME, Filicori M, Waldstreicher J, Crowley WF. Intravenous administration of pulsatile gonadotropin-releasing hormone in hypothalamic amenorrhea: effects of dosage. J Clin Endocrinol Metab. 1986 Jan; 62(1):109-16. PMID: 3079597.
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    105. Scheurich JW, Wierman ME, Brown BG, Ferro PS, Graham DY. Preparation for barium enema: comparison of a commercial formula diet and low-residue, clear-liquid diets in inpatients. South Med J. 1985 Jul; 78(7):838-40. PMID: 4012381.
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    106. Wierman ME, Beardsworth DE, Mansfield MJ, Badger TM, Crawford JD, Crigler JF, Bode HH, Loughlin JS, Kushner DC, Scully RE, et al. Puberty without gonadotropins. A unique mechanism of sexual development. N Engl J Med. 1985 Jan 10; 312(2):65-72. PMID: 3917301.
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