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James R Roede

TitleAsst Professor
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus

    Collapse Research 
    Collapse research activities and funding
    F31AA016710     (ROEDE, JAMES R)Dec 1, 2006 - Nov 30, 2009
    Characterizing the role of peroxiredoxin 6 in Alcoholic Liver Disease.
    Role: Principal Investigator

    F32ES019821     (ROEDE, JAMES R)Mar 1, 2011 - Feb 28, 2013
    Mechanism of Peroxiredoxin 3 in a Model of Pesticide-Mediated Neurodegeneration
    Role: Principal Investigator

    K99ES022266     (ROEDE, JAMES R)Sep 26, 2012 - Aug 31, 2013
    Altered transport and epigenomic changes in maneb-potentiated neurotoxicity
    Role: Principal Investigator

    R00ES022266     (ROEDE, JAMES R)Sep 16, 2013 - Aug 31, 2016
    Altered transport and epigenomic changes in maneb-potentiated neurotoxicity
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Coughlan C, Walker DI, Lohr KM, Richardson JR, Saba LM, Caudle WM, Fritz KS, Roede JR. Comparative Proteomic Analysis of Carbonylated Proteins from the Striatum and Cortex of Pesticide-Treated Mice. Parkinsons Dis. 2015; 2015:812532. PMID: 26345149; PMCID: PMC4546751.
    2. Harris PS, Roy SR, Coughlan C, Orlicky DJ, Liang Y, Shearn CT, Roede JR, Fritz KS. Chronic ethanol consumption induces mitochondrial protein acetylation and oxidative stress in the kidney. Redox Biol. 2015 Dec; 6:33-40. PMID: 26177469; PMCID: PMC4511634.
    3. Lin Z, Roede JR, He C, Jones DP, Filipov NM. Short-term oral atrazine exposure alters the plasma metabolome of male C57BL/6 mice and disrupts a-linolenate, tryptophan, tyrosine and other major metabolic pathways. Toxicology. 2014 Dec 04; 326:130-41. PMID: 25445803.
      View in: PubMed
    4. Roede JR, Uppal K, Park Y, Tran V, Jones DP. Transcriptome-metabolome wide association study (TMWAS) of maneb and paraquat neurotoxicity reveals network level interactions in toxicologic mechanism. Toxicol Rep. 2014; 1:435-444. PMID: 27722094.
      View in: PubMed
    5. Roede JR, Jones DP. Thiol-reactivity of the fungicide maneb. Redox Biol. 2014; 2:651-5. PMID: 24936438; PMCID: PMC4052523.
    6. Go YM, Roede JR, Orr M, Liang Y, Jones DP. Integrated redox proteomics and metabolomics of mitochondria to identify mechanisms of cd toxicity. Toxicol Sci. 2014 May; 139(1):59-73. PMID: 24496640; PMCID: PMC4007108.
    7. Go YM, Uppal K, Walker DI, Tran V, Dury L, Strobel FH, Baubichon-Cortay H, Pennell KD, Roede JR, Jones DP. Mitochondrial metabolomics using high-resolution Fourier-transform mass spectrometry. Methods Mol Biol. 2014; 1198:43-73. PMID: 25270922; PMCID: PMC4318503.
    8. Roede JR, Uppal K, Park Y, Lee K, Tran V, Walker D, Strobel FH, Rhodes SL, Ritz B, Jones DP. Serum metabolomics of slow vs. rapid motor progression Parkinson's disease: a pilot study. PLoS One. 2013; 8(10):e77629. PMID: 24167579; PMCID: PMC3805572.
    9. Go YM, Roede JR, Walker DI, Duong DM, Seyfried NT, Orr M, Liang Y, Pennell KD, Jones DP. Selective targeting of the cysteine proteome by thioredoxin and glutathione redox systems. Mol Cell Proteomics. 2013 Nov; 12(11):3285-96. PMID: 23946468; PMCID: PMC3820939.
    10. Roede JR, Uppal K, Liang Y, Promislow DE, Wachtman LM, Jones DP. Characterization of plasma thiol redox potential in a common marmoset model of aging. Redox Biol. 2013; 1:387-93. PMID: 24024176; PMCID: PMC3757708.
    11. Liang Y, Roede JR, Dikalov S, Miller NG, Dudley SC, Quyyumi A, Jones DP. Determination of ebselen-sensitive reactive oxygen metabolites (ebROM) in human serum based upon N,N'-diethyl-1,4-phenylenediamine oxidation. Clin Chim Acta. 2012 Dec 24; 414:1-6. PMID: 22687643; PMCID: PMC3662006.
    12. Roede JR, Park Y, Li S, Strobel FH, Jones DP. Detailed mitochondrial phenotyping by high resolution metabolomics. PLoS One. 2012; 7(3):e33020. PMID: 22412977; PMCID: PMC3295783.
    13. Roede JR, Go YM, Jones DP. Redox equivalents and mitochondrial bioenergetics. Methods Mol Biol. 2012; 810:249-80. PMID: 22057573.
      View in: PubMed
    14. Kunde SS, Roede JR, Vos MB, Orr ML, Go YM, Park Y, Ziegler TR, Jones DP. Hepatic oxidative stress in fructose-induced fatty liver is not caused by sulfur amino acid insufficiency. Nutrients. 2011 11; 3(11):987-1002. PMID: 22254090.
      View in: PubMed
    15. Orlicky DJ, Roede JR, Bales E, Greenwood C, Greenberg A, Petersen D, McManaman JL. Chronic ethanol consumption in mice alters hepatocyte lipid droplet properties. Alcohol Clin Exp Res. 2011 Jun; 35(6):1020-33. PMID: 21535024; PMCID: PMC4158406.
    16. Go YM, Kang SM, Roede JR, Orr M, Jones DP. Increased inflammatory signaling and lethality of influenza H1N1 by nuclear thioredoxin-1. PLoS One. 2011 Apr 15; 6(4):e18918. PMID: 21526215; PMCID: PMC3078150.
    17. Fritz KS, Galligan JJ, Smathers RL, Roede JR, Shearn CT, Reigan P, Petersen DR. 4-Hydroxynonenal inhibits SIRT3 via thiol-specific modification. Chem Res Toxicol. 2011 May 16; 24(5):651-62. PMID: 21449565; PMCID: PMC3113719.
    18. Roede JR, Hansen JM, Go YM, Jones DP. Maneb and paraquat-mediated neurotoxicity: involvement of peroxiredoxin/thioredoxin system. Toxicol Sci. 2011 Jun; 121(2):368-75. PMID: 21402726; PMCID: PMC3098961.
    19. Galligan JJ, Fritz KS, Tipney H, Smathers RL, Roede JR, Shearn CT, Hunter LE, Petersen DR. Profiling impaired hepatic endoplasmic reticulum glycosylation as a consequence of ethanol ingestion. J Proteome Res. 2011 Apr 01; 10(4):1837-47. PMID: 21319786; PMCID: PMC3501204.
    20. Backos DS, Fritz KS, Roede JR, Petersen DR, Franklin CC. Posttranslational modification and regulation of glutamate-cysteine ligase by the a,ß-unsaturated aldehyde 4-hydroxy-2-nonenal. Free Radic Biol Med. 2011 Jan 01; 50(1):14-26. PMID: 20970495; PMCID: PMC3014730.
    21. Roede JR, Jones DP. Reactive species and mitochondrial dysfunction: mechanistic significance of 4-hydroxynonenal. Environ Mol Mutagen. 2010 Jun; 51(5):380-90. PMID: 20544880.
      View in: PubMed
    22. Roede JR, Orlicky DJ, Fisher AB, Petersen DR. Overexpression of peroxiredoxin 6 does not prevent ethanol-mediated oxidative stress and may play a role in hepatic lipid accumulation. J Pharmacol Exp Ther. 2009 Jul; 330(1):79-88. PMID: 19386791; PMCID: PMC2700161.
    23. Stewart BJ, Roede JR, Doorn JA, Petersen DR. Lipid aldehyde-mediated cross-linking of apolipoprotein B-100 inhibits secretion from HepG2 cells. Biochim Biophys Acta. 2009 Aug; 1791(8):772-80. PMID: 19393338; PMCID: PMC2735725.
    24. Roede JR, Carbone DL, Doorn JA, Kirichenko OV, Reigan P, Petersen DR. In vitro and in silico characterization of peroxiredoxin 6 modified by 4-hydroxynonenal and 4-oxononenal. Chem Res Toxicol. 2008 Dec; 21(12):2289-99. PMID: 19548352.
      View in: PubMed
    25. Roede JR, Stewart BJ, Petersen DR. Decreased expression of peroxiredoxin 6 in a mouse model of ethanol consumption. Free Radic Biol Med. 2008 Dec 01; 45(11):1551-8. PMID: 18852041.
      View in: PubMed
    26. Roede J, Strutz J. [Timely therapy of chronic otitis media]. Z Arztl Fortbild (Jena). 1994 Jun; 88(5-6):367-71. PMID: 8091805.
      View in: PubMed
    27. Xu L, Probst R, Harris FP, Roede J. Peripheral analysis of frequency in human ears revealed by tone burst evoked otoacoustic emissions. Hear Res. 1994 Apr; 74(1-2):173-80. PMID: 8040086.
      View in: PubMed
    28. Roede J, Harris FP, Probst R, Xu L. Repeatability of distortion product otoacoustic emissions in normally hearing humans. Audiology. 1993 Sep-Oct; 32(5):273-81. PMID: 8216026.
      View in: PubMed
    29. Höhmann DH, Milewski C, Krieger U, Roede J. [Esthetic aspects of excision of basaliomas of the area of the head and neck]. Laryngorhinootologie. 1992 Jun; 71(6):311-4. PMID: 1637452.
      View in: PubMed
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