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James R Roede

TitleAssociate Professor
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOP-Administration
Phone303/724-1348

    Collapse Research 
    Collapse research activities and funding
    R21AA026928     (FRITZ, KRISTOFER S.)Sep 5, 2018 - Aug 31, 2021
    NIH
    Ethanol Metabolism Disrupts Hepatic Thiol Redox Signaling and Control
    Role: Co-Principal Investigator
    R01ES027593     (ROEDE, JAMES R)Mar 1, 2017 - Feb 28, 2026
    NIH
    Altered Hippocampal Neurogenesis and Cognition via Maneb-mediated Changes in the Thiol Redox Proteome.
    Role: Principal Investigator
    R00ES022266     (ROEDE, JAMES R)Sep 16, 2013 - Aug 31, 2017
    NIH
    Altered transport and epigenomic changes in maneb-potentiated neurotoxicity
    Role: Principal Investigator
    K99ES022266     (ROEDE, JAMES R)Sep 26, 2012 - Aug 31, 2013
    NIH
    Altered transport and epigenomic changes in maneb-potentiated neurotoxicity
    Role: Principal Investigator
    F32ES019821     (ROEDE, JAMES R)Mar 1, 2011 - Feb 28, 2013
    NIH
    Mechanism of Peroxiredoxin 3 in a Model of Pesticide-Mediated Neurodegeneration
    Role: Principal Investigator
    F31AA016710     (ROEDE, JAMES R)Dec 1, 2006 - Nov 30, 2009
    NIH
    Characterizing the role of peroxiredoxin 6 in Alcoholic Liver Disease.
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Sri Hari A, Banerji R, Liang LP, Fulton RE, Huynh CQ, Fabisiak T, McElroy PB, Roede JR, Patel M. Increasing glutathione levels by a novel posttranslational mechanism inhibits neuronal hyperexcitability. Redox Biol. 2023 11; 67:102895. PMID: 37769522.
      View in: PubMed
    2. Harris PS, McGinnis CD, Michel CR, Marentette JO, Reisdorph R, Roede JR, Fritz KS. Click chemistry-based thiol redox proteomics reveals significant cysteine reduction induced by chronic ethanol consumption. Redox Biol. 2023 08; 64:102792. PMID: 37390786.
      View in: PubMed
    3. Stem AD, Rogers KL, Roede JR, Roncal-Jimenez CA, Johnson RJ, Brown JM. Sugarcane ash and sugarcane ash-derived silica nanoparticles alter cellular metabolism in human proximal tubular kidney cells. Environ Pollut. 2023 Sep 01; 332:121951. PMID: 37301454.
      View in: PubMed
    4. Prutton KM, Marentette JO, Maclean KN, Roede JR. Characterization of mitochondrial and metabolic alterations induced by trisomy 21 during neural differentiation. Free Radic Biol Med. 2023 02 20; 196:11-21. PMID: 36638900.
      View in: PubMed
    5. Prutton KM, Marentette JO, Leifheit BA, Esquer H, LaBarbera DV, Anderson CC, Maclean KN, Roede JR. Oxidative stress as a candidate mechanism for accelerated neuroectodermal differentiation due to trisomy 21. Free Radic Biol Med. 2022 06; 186:32-42. PMID: 35537597.
      View in: PubMed
    6. Elajaili H, Hernandez-Lagunas L, Harris P, Sparagna GC, Jonscher R, Ohlstrom D, Sucharov CC, Bowler RP, Suliman H, Fritz KS, Roede JR, Nozik ES. Extracellular superoxide dismutase (EC-SOD) R213G variant reduces mitochondrial ROS and preserves mitochondrial function in bleomycin-induced lung injury: EC-SOD R213G variant and intracellular redox regulation. Adv Redox Res. 2022 Jul; 5. PMID: 38273965.
      View in: PubMed
    7. Harris PS, Michel CR, Yun Y, McGinnis CD, Assiri MA, Ahmadi AR, Sun Z, Roede JR, Burchill MA, Orlicky DJ, McCullough RL, Fritz KS. Proteomic analysis of alcohol-associated hepatitis reveals glycoprotein NMB (GPNMB) as a novel hepatic and serum biomarker. Alcohol. 2022 03; 99:35-48. PMID: 34923085.
      View in: PubMed
    8. Mendoza RP, Anderson CC, Fudge DH, Roede JR, Brown JM. Metabolic Consequences of IgE- and Non-IgE-Mediated Mast Cell Degranulation. J Immunol. 2021 12 01; 207(11):2637-2648. PMID: 34732470.
      View in: PubMed
    9. Anderson CC, Marentette JO, Prutton KM, Rauniyar AK, Reisz JA, D'Alessandro A, Maclean KN, Saba LM, Roede JR. Trisomy 21 results in modest impacts on mitochondrial function and central carbon metabolism. Free Radic Biol Med. 2021 08 20; 172:201-212. PMID: 34129926.
      View in: PubMed
    10. Maclean KN, Jiang H, Phinney WN, Mclagan BM, Roede JR, Stabler SP. Derangement of hepatic polyamine, folate, and methionine cycle metabolism in cystathionine beta-synthase-deficient homocystinuria in the presence and absence of treatment: Possible implications for pathogenesis. Mol Genet Metab. 2021 02; 132(2):128-138. PMID: 33483253.
      View in: PubMed
    11. Marentette JO, Anderson CC, Prutton KM, Jennings EQ, Rauniyar AK, Galligan JJ, Roede JR. Trisomy 21 impairs PGE2 production in dermal fibroblasts. Prostaglandins Other Lipid Mediat. 2021 Apr; 153:106524. PMID: 33418267.
      View in: PubMed
    12. Bok R, Guerra DD, Lorca RA, Wennersten SA, Harris PS, Rauniyar AK, Stabler SP, MacLean KN, Roede JR, Brown LD, Hurt KJ. Cystathionine ?-lyase promotes estrogen-stimulated uterine artery blood flow via glutathione homeostasis. Redox Biol. 2021 04; 40:101827. PMID: 33485059.
      View in: PubMed
    13. Anderson CC, Marentette JO, Rauniyar AK, Prutton KM, Khatri M, Matheson C, Reisz JA, Reigan P, D'Alessandro A, Roede JR. Maneb alters central carbon metabolism and thiol redox status in a toxicant model of Parkinson's disease. Free Radic Biol Med. 2021 01; 162:65-76. PMID: 33279619.
      View in: PubMed
    14. Anderson CC, Khatri M, Roede JR. Time-dependent simvastatin administration enhances doxorubicin toxicity in neuroblastoma. Toxicol Rep. 2020; 7:520-528. PMID: 32368502.
      View in: PubMed
    15. Kuzyk CL, Anderson CC, Roede JR. Simvastatin Induces Delayed Apoptosis Through Disruption of Glycolysis and Mitochondrial Impairment in Neuroblastoma Cells. Clin Transl Sci. 2020 05; 13(3):563-572. PMID: 31917509.
      View in: PubMed
    16. Gaffney DO, Jennings EQ, Anderson CC, Marentette JO, Shi T, Schou Oxvig AM, Streeter MD, Johannsen M, Spiegel DA, Chapman E, Roede JR, Galligan JJ. Non-enzymatic Lysine Lactoylation of Glycolytic Enzymes. Cell Chem Biol. 2020 02 20; 27(2):206-213.e6. PMID: 31767537.
      View in: PubMed
    17. Aivazidis S, Jain A, Rauniyar AK, Anderson CC, Marentette JO, Orlicky DJ, Fritz KS, Harris PS, Siegel D, Maclean KN, Roede JR. SNARE proteins rescue impaired autophagic flux in Down syndrome. PLoS One. 2019; 14(11):e0223254. PMID: 31714914.
      View in: PubMed
    18. Persaud I, Raghavendra AJ, Paruthi A, Alsaleh NB, Minarchick VC, Roede JR, Podila R, Brown JM. Defect-induced electronic states amplify the cellular toxicity of ZnO nanoparticles. Nanotoxicology. 2020 03; 14(2):145-161. PMID: 31553248.
      View in: PubMed
    19. Park YH, Kong T, Roede JR, Jones DP, Lee K. A biplot correlation range for group-wise metabolite selection in mass spectrometry. BioData Min. 2019; 12:4. PMID: 30740145.
      View in: PubMed
    20. Aivazidis S, Anderson CC, Roede JR. Toxicant-mediated redox control of proteostasis in neurodegeneration. Curr Opin Toxicol. 2019 Feb; 13:22-34. PMID: 31602419.
      View in: PubMed
    21. Anderson CC, Aivazidis S, Kuzyk CL, Jain A, Roede JR. Acute Maneb Exposure Significantly Alters Both Glycolysis and Mitochondrial Function in Neuroblastoma Cells. Toxicol Sci. 2018 09 01; 165(1):61-73. PMID: 29767788.
      View in: PubMed
    22. Petersen DR, Orlicky DJ, Roede JR, Shearn CT. Aberrant expression of redox regulatory proteins in patients with concomitant primary Sclerosing cholangitis/inflammatory bowel disease. Exp Mol Pathol. 2018 08; 105(1):32-36. PMID: 29852184.
      View in: PubMed
    23. Maclean KN, Jiang H, Aivazidis S, Kim E, Shearn CT, Harris PS, Petersen DR, Allen RH, Stabler SP, Roede JR. Taurine treatment prevents derangement of the hepatic ?-glutamyl cycle and methylglyoxal metabolism in a mouse model of classical homocystinuria: regulatory crosstalk between thiol and sulfinic acid metabolism. FASEB J. 2018 03; 32(3):1265-1280. PMID: 29101223.
      View in: PubMed
    24. Roede JR, Go YM, Jones DP. Redox Equivalents and Mitochondrial Bioenergetics. Methods Mol Biol. 2018; 1782:197-227. PMID: 29851002.
      View in: PubMed
    25. Shearn CT, Saba LM, Roede JR, Orlicky DJ, Shearn AH, Petersen DR. Differential carbonylation of proteins in end-stage human fatty and nonfatty NASH. Free Radic Biol Med. 2017 12; 113:280-290. PMID: 28988798.
      View in: PubMed
    26. Assiri MA, Roy SR, Harris PS, Ali H, Liang Y, Shearn CT, Orlicky DJ, Roede JR, Hirschey MD, Backos DS, Fritz KS. Chronic Ethanol Metabolism Inhibits Hepatic Mitochondrial Superoxide Dismutase via Lysine Acetylation. Alcohol Clin Exp Res. 2017 Oct; 41(10):1705-1714. PMID: 28804911.
      View in: PubMed
    27. Roede JR. Comment on: Extra-virgin olive oil ameliorates cognition and neuropathology of the 3xTg mice: role of autophagy. Ann Clin Transl Neurol. 2017 10; 4(10):762. PMID: 29046885.
      View in: PubMed
    28. Aivazidis S, Coughlan CM, Rauniyar AK, Jiang H, Liggett LA, Maclean KN, Roede JR. The burden of trisomy 21 disrupts the proteostasis network in Down syndrome. PLoS One. 2017; 12(4):e0176307. PMID: 28430800.
      View in: PubMed
    29. Coughlan C, Walker DI, Lohr KM, Richardson JR, Saba LM, Caudle WM, Fritz KS, Roede JR. Comparative Proteomic Analysis of Carbonylated Proteins from the Striatum and Cortex of Pesticide-Treated Mice. Parkinsons Dis. 2015; 2015:812532. PMID: 26345149.
      View in: PubMed
    30. Harris PS, Roy SR, Coughlan C, Orlicky DJ, Liang Y, Shearn CT, Roede JR, Fritz KS. Chronic ethanol consumption induces mitochondrial protein acetylation and oxidative stress in the kidney. Redox Biol. 2015 Dec; 6:33-40. PMID: 26177469.
      View in: PubMed
    31. Lin Z, Roede JR, He C, Jones DP, Filipov NM. Short-term oral atrazine exposure alters the plasma metabolome of male C57BL/6 mice and disrupts a-linolenate, tryptophan, tyrosine and other major metabolic pathways. Toxicology. 2014 Dec 04; 326:130-41. PMID: 25445803.
      View in: PubMed
    32. Roede JR, Uppal K, Park Y, Tran V, Jones DP. Transcriptome-metabolome wide association study (TMWAS) of maneb and paraquat neurotoxicity reveals network level interactions in toxicologic mechanism. Toxicol Rep. 2014; 1:435-444. PMID: 27722094.
      View in: PubMed
    33. Roede JR, Jones DP. Thiol-reactivity of the fungicide maneb. Redox Biol. 2014; 2:651-5. PMID: 24936438.
      View in: PubMed
    34. Go YM, Roede JR, Orr M, Liang Y, Jones DP. Integrated redox proteomics and metabolomics of mitochondria to identify mechanisms of cd toxicity. Toxicol Sci. 2014 May; 139(1):59-73. PMID: 24496640.
      View in: PubMed
    35. Go YM, Uppal K, Walker DI, Tran V, Dury L, Strobel FH, Baubichon-Cortay H, Pennell KD, Roede JR, Jones DP. Mitochondrial metabolomics using high-resolution Fourier-transform mass spectrometry. Methods Mol Biol. 2014; 1198:43-73. PMID: 25270922.
      View in: PubMed
    36. Roede JR, Uppal K, Park Y, Lee K, Tran V, Walker D, Strobel FH, Rhodes SL, Ritz B, Jones DP. Serum metabolomics of slow vs. rapid motor progression Parkinson's disease: a pilot study. PLoS One. 2013; 8(10):e77629. PMID: 24167579.
      View in: PubMed
    37. Go YM, Roede JR, Walker DI, Duong DM, Seyfried NT, Orr M, Liang Y, Pennell KD, Jones DP. Selective targeting of the cysteine proteome by thioredoxin and glutathione redox systems. Mol Cell Proteomics. 2013 Nov; 12(11):3285-96. PMID: 23946468.
      View in: PubMed
    38. Roede JR, Uppal K, Liang Y, Promislow DE, Wachtman LM, Jones DP. Characterization of plasma thiol redox potential in a common marmoset model of aging. Redox Biol. 2013; 1:387-93. PMID: 24024176.
      View in: PubMed
    39. Liang Y, Roede JR, Dikalov S, Miller NG, Dudley SC, Quyyumi A, Jones DP. Determination of ebselen-sensitive reactive oxygen metabolites (ebROM) in human serum based upon N,N'-diethyl-1,4-phenylenediamine oxidation. Clin Chim Acta. 2012 Dec 24; 414:1-6. PMID: 22687643.
      View in: PubMed
    40. Roede JR, Park Y, Li S, Strobel FH, Jones DP. Detailed mitochondrial phenotyping by high resolution metabolomics. PLoS One. 2012; 7(3):e33020. PMID: 22412977.
      View in: PubMed
    41. Roede JR, Go YM, Jones DP. Redox equivalents and mitochondrial bioenergetics. Methods Mol Biol. 2012; 810:249-80. PMID: 22057573.
      View in: PubMed
    42. Kunde SS, Roede JR, Vos MB, Orr ML, Go YM, Park Y, Ziegler TR, Jones DP. Hepatic oxidative stress in fructose-induced fatty liver is not caused by sulfur amino acid insufficiency. Nutrients. 2011 11; 3(11):987-1002. PMID: 22254090.
      View in: PubMed
    43. Orlicky DJ, Roede JR, Bales E, Greenwood C, Greenberg A, Petersen D, McManaman JL. Chronic ethanol consumption in mice alters hepatocyte lipid droplet properties. Alcohol Clin Exp Res. 2011 Jun; 35(6):1020-33. PMID: 21535024.
      View in: PubMed
    44. Go YM, Kang SM, Roede JR, Orr M, Jones DP. Increased inflammatory signaling and lethality of influenza H1N1 by nuclear thioredoxin-1. PLoS One. 2011 Apr 15; 6(4):e18918. PMID: 21526215.
      View in: PubMed
    45. Fritz KS, Galligan JJ, Smathers RL, Roede JR, Shearn CT, Reigan P, Petersen DR. 4-Hydroxynonenal inhibits SIRT3 via thiol-specific modification. Chem Res Toxicol. 2011 May 16; 24(5):651-62. PMID: 21449565.
      View in: PubMed
    46. Roede JR, Hansen JM, Go YM, Jones DP. Maneb and paraquat-mediated neurotoxicity: involvement of peroxiredoxin/thioredoxin system. Toxicol Sci. 2011 Jun; 121(2):368-75. PMID: 21402726.
      View in: PubMed
    47. Galligan JJ, Fritz KS, Tipney H, Smathers RL, Roede JR, Shearn CT, Hunter LE, Petersen DR. Profiling impaired hepatic endoplasmic reticulum glycosylation as a consequence of ethanol ingestion. J Proteome Res. 2011 Apr 01; 10(4):1837-47. PMID: 21319786.
      View in: PubMed
    48. Backos DS, Fritz KS, Roede JR, Petersen DR, Franklin CC. Posttranslational modification and regulation of glutamate-cysteine ligase by the a,?-unsaturated aldehyde 4-hydroxy-2-nonenal. Free Radic Biol Med. 2011 Jan 01; 50(1):14-26. PMID: 20970495.
      View in: PubMed
    49. Roede JR, Jones DP. Reactive species and mitochondrial dysfunction: mechanistic significance of 4-hydroxynonenal. Environ Mol Mutagen. 2010 Jun; 51(5):380-90. PMID: 20544880.
      View in: PubMed
    50. Roede JR, Orlicky DJ, Fisher AB, Petersen DR. Overexpression of peroxiredoxin 6 does not prevent ethanol-mediated oxidative stress and may play a role in hepatic lipid accumulation. J Pharmacol Exp Ther. 2009 Jul; 330(1):79-88. PMID: 19386791.
      View in: PubMed
    51. Stewart BJ, Roede JR, Doorn JA, Petersen DR. Lipid aldehyde-mediated cross-linking of apolipoprotein B-100 inhibits secretion from HepG2 cells. Biochim Biophys Acta. 2009 Aug; 1791(8):772-80. PMID: 19393338.
      View in: PubMed
    52. Roede JR, Carbone DL, Doorn JA, Kirichenko OV, Reigan P, Petersen DR. In vitro and in silico characterization of peroxiredoxin 6 modified by 4-hydroxynonenal and 4-oxononenal. Chem Res Toxicol. 2008 Dec; 21(12):2289-99. PMID: 19548352.
      View in: PubMed
    53. Roede JR, Stewart BJ, Petersen DR. Decreased expression of peroxiredoxin 6 in a mouse model of ethanol consumption. Free Radic Biol Med. 2008 Dec 01; 45(11):1551-8. PMID: 18852041.
      View in: PubMed
    54. Roede J, Strutz J. [Timely therapy of chronic otitis media]. Z Arztl Fortbild (Jena). 1994 Jun; 88(5-6):367-71. PMID: 8091805.
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    55. Xu L, Probst R, Harris FP, Roede J. Peripheral analysis of frequency in human ears revealed by tone burst evoked otoacoustic emissions. Hear Res. 1994 Apr; 74(1-2):173-80. PMID: 8040086.
      View in: PubMed
    56. Roede J, Harris FP, Probst R, Xu L. Repeatability of distortion product otoacoustic emissions in normally hearing humans. Audiology. 1993 Sep-Oct; 32(5):273-81. PMID: 8216026.
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    57. H?hmann DH, Milewski C, Krieger U, Roede J. [Esthetic aspects of excision of basaliomas of the area of the head and neck]. Laryngorhinootologie. 1992 Jun; 71(6):311-4. PMID: 1637452.
      View in: PubMed
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