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Xiao-Jing Wang

TitleProfessor
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM-Pathology

    Collapse Research 
    Collapse research activities and funding
    R41ES007597     (WANG, XIAO-JING)Sep 30, 1995 - Sep 29, 1996
    NIH/NIEHS
    CARCINOGENICITY ASSAY USING TRANSGENIC KERATINOCYTES
    Role: Principal Investigator

    R01CA079998     (WANG, XIAO-JING)Jan 1, 1999 - Apr 30, 2011
    NIH/NCI
    Role of TGF beta Signaling in skin carcinogenesis
    Role: Principal Investigator

    R01CA087849     (WANG, XIAO-JING)Jul 1, 2000 - Jul 31, 2013
    NIH/NCI
    Role of Smads in the epidermis and skin carcinogenesis
    Role: Principal Investigator

    R01DE015953     (WANG, XIAO-JING)Mar 1, 2004 - Jan 31, 2015
    NIH/NIDCR
    Role of TGFbeta signaling in HNSCC progression
    Role: Principal Investigator

    R01GM070966     (WANG, XIAO-JING)Apr 1, 2004 - Mar 31, 2009
    NIH/NIGMS
    Effects of altering TGF beta signaling on wound healing
    Role: Principal Investigator

    RC1DE020649     (WANG, XIAO-JING)Sep 17, 2009 - Aug 31, 2011
    NIH/NIDCR
    Identification of normal and cancer stem cells and their niche in oral mucosa
    Role: Principal Investigator

    R01AR061792     (WANG, XIAO-JING)Jul 18, 2011 - Jun 30, 2016
    NIH/NIAMS
    Effects of Altering TGF Beta Signaling on Wound Healing
    Role: Principal Investigator

    T32CA174648     (WANG, XIAO-JING)Apr 1, 2013 - Mar 31, 2018
    NIH/NCI
    Training in Translational Research of Lung, Head and Neck Cancer
    Role: Principal Investigator

    R01DE024371     (WANG, XIAO-JING)Aug 1, 2014 - Jul 31, 2018
    NIH/NIDCR
    Identifying oral cancer stem cell properties affected by the microenvironment
    Role: Principal Investigator

    R41AR067106     (WANG, XIAO-JING)Sep 1, 2014 - Aug 31, 2015
    NIH/NIAMS
    Testing Smad7-based biologics for treating chronic wounds
    Role: Principal Investigator

    R43DE024659     (TURNER, BRIAN CURTIS)Sep 15, 2014 - Feb 28, 2015
    NIH/NIDCR
    Smad7 use in oral mucositis treatment
    Role: Co-Principal Investigator

    I01BX003232     (WANG, XIAO-JING)Oct 1, 2016 - Sep 30, 2020
    VA
    Mechanisms of Breaking Indolence in Squamous Cell Carcinoma
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Malkoski SP, Haeger SM, Cleaver TG, Rodriguez KJ, Li H, Lu SL, Feser WJ, Barón AE, Merrick D, Lighthall JG, Ijichi H, Franklin W, Wang XJ. Loss of transforming growth factor beta type II receptor increases aggressive tumor behavior and reduces survival in lung adenocarcinoma and squamous cell carcinoma. Clin Cancer Res. 2012 Apr 15; 18(8):2173-83. PMID: 22399565; PMCID: PMC3328594.
    2. Malkoski SP, Wang XJ. Two sides of the story? Smad4 loss in pancreatic cancer versus head-and-neck cancer. FEBS Lett. 2012 Jul 04; 586(14):1984-92. PMID: 22321641; PMCID: PMC3285395.
    3. Han G, Li F, Singh TP, Wolf P, Wang XJ. The pro-inflammatory role of TGFß1: a paradox? Int J Biol Sci. 2012; 8(2):228-35. PMID: 22253566; PMCID: PMC3258562.
    4. Han G, Wang XJ. Roles of TGFß signaling Smads in squamous cell carcinoma. Cell Biosci. 2011 Dec 28; 1:41. PMID: 22204491; PMCID: PMC3285038.
    5. Minor J, Wang X, Zhang F, Song J, Jimeno A, Wang XJ, Lu X, Gross N, Kulesz-Martin M, Wang D, Lu SL. Methylation of microRNA-9 is a specific and sensitive biomarker for oral and oropharyngeal squamous cell carcinomas. Oral Oncol. 2012 Jan; 48(1):73-8. PMID: 22133638; PMCID: PMC3291120.
    6. Wang XI, Thomas J, Zhang S. Changing trends in human papillomavirus-associated head and neck squamous cell carcinoma. Ann Diagn Pathol. 2012 Jan; 16(1):7-12. PMID: 22001331.
      View in: PubMed
    7. Han G, Li F, Ten Dijke P, Wang XJ. Temporal smad7 transgene induction in mouse epidermis accelerates skin wound healing. Am J Pathol. 2011 Oct; 179(4):1768-79. PMID: 21944279; PMCID: PMC3181395.
    8. Compton AM, Moore-Medlin T, Herman-Ferdinandez L, Clark C, Caldito GC, Wang XI, Thomas J, Abreo FW, Nathan CO. Human papillomavirus in metastatic lymph nodes from unknown primary head and neck squamous cell carcinoma. Otolaryngol Head Neck Surg. 2011 Jul; 145(1):51-7. PMID: 21493313.
      View in: PubMed
    9. Deng Y, Deng H, Liu J, Han G, Malkoski S, Liu B, Zhao R, Wang XJ, Zhang Q. Transcriptional down-regulation of Brca1 and E-cadherin by CtBP1 in breast cancer. Mol Carcinog. 2012 Jun; 51(6):500-7. PMID: 21681822; PMCID: PMC3177013.
    10. Mitra D, Malkoski SP, Wang XJ. Cancer stem cells in head and neck cancer. Cancers (Basel). 2011 Jan 20; 3(1):415-27. PMID: 24212622; PMCID: PMC3756369.
    11. Deng Y, Liu J, Han G, Lu SL, Wang SY, Malkoski S, Tan AC, Deng C, Wang XJ, Zhang Q. Redox-dependent Brca1 transcriptional regulation by an NADH-sensor CtBP1. Oncogene. 2010 Dec 16; 29(50):6603-8. PMID: 20818429; PMCID: PMC3081720.
    12. Malkoski SP, Cleaver TG, Lu SL, Lighthall JG, Wang XJ. Keratin promoter based gene manipulation in the murine conducting airway. Int J Biol Sci. 2010 Jan 20; 6(1):68-79. PMID: 20140084; PMCID: PMC2815352.
    13. Han G, Williams CA, Salter K, Garl PJ, Li AG, Wang XJ. A role for TGFbeta signaling in the pathogenesis of psoriasis. J Invest Dermatol. 2010 Feb; 130(2):371-7. PMID: 19710682; PMCID: PMC2898194.
    14. Hoot KE, Lighthall J, Han G, Lu SL, Li A, Ju W, Kulesz-Martin M, Bottinger E, Wang XJ. Keratinocyte-specific Smad2 ablation results in increased epithelial-mesenchymal transition during skin cancer formation and progression. J Clin Invest. 2008 Aug; 118(8):2722-32. PMID: 18618014; PMCID: PMC2447925.
    15. Owens P, Bazzi H, Engelking E, Han G, Christiano AM, Wang XJ. Smad4-dependent desmoglein-4 expression contributes to hair follicle integrity. Dev Biol. 2008 Oct 01; 322(1):156-66. PMID: 18692037; PMCID: PMC2642977.
    16. Han G, Li AG, Liang YY, Owens P, He W, Lu S, Yoshimatsu Y, Wang D, Ten Dijke P, Lin X, Wang XJ. Smad7-induced beta-catenin degradation alters epidermal appendage development. Dev Cell. 2006 Sep; 11(3):301-12. PMID: 16950122.
      View in: PubMed
    17. Lu SL, Herrington H, Reh D, Weber S, Bornstein S, Wang D, Li AG, Tang CF, Siddiqui Y, Nord J, Andersen P, Corless CL, Wang XJ. Loss of transforming growth factor-beta type II receptor promotes metastatic head-and-neck squamous cell carcinoma. Genes Dev. 2006 May 15; 20(10):1331-42. PMID: 16702406; PMCID: PMC1472907.
    18. Han G, Lu SL, Li AG, He W, Corless CL, Kulesz-Martin M, Wang XJ. Distinct mechanisms of TGF-beta1-mediated epithelial-to-mesenchymal transition and metastasis during skin carcinogenesis. J Clin Invest. 2005 Jul; 115(7):1714-23. PMID: 15937546; PMCID: PMC1142114.
    19. Li AG, Wang D, Feng XH, Wang XJ. Latent TGFbeta1 overexpression in keratinocytes results in a severe psoriasis-like skin disorder. EMBO J. 2004 Apr 21; 23(8):1770-81. PMID: 15057277; PMCID: PMC394237.
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