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Matthew C Keller

TitleAssociate Professor
InstitutionUniversity of Colorado Boulder
DepartmentPsych-Psychology
Phone303/492-5799
ORCID ORCID Icon0000-0002-6075-9882 Additional info

    Collapse Research 
    Collapse research activities and funding
    K01MH085812     (KELLER, MATTHEW CHARLES)Jan 11, 2010 - Dec 31, 2015
    NIH/NIMH
    Evolutionary Roles of Homozygosity &Copy Number Variation in Mental Disorders
    Role: Principal Investigator

    R01MH100141     (KELLER, MATTHEW CHARLES)Feb 4, 2013 - Nov 30, 2017
    NIH/NIMH
    Estimating the frequencies and population specificities of risk alleles
    Role: Principal Investigator

    Collapse Bibliographic 
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Border R, Keller MC. Commentary: Fundamental problems with candidate gene-by-environment interaction studies - reflections on Moore and Thoemmes (2016). J Child Psychol Psychiatry. 2017 Mar; 58(3):328-330. PMID: 28194762.
      View in: PubMed
    2. Trampush JW, Yang ML, Yu J, Knowles E, Davies G, Liewald DC, Starr JM, Djurovic S, Melle I, Sundet K, Christoforou A, Reinvang I, DeRosse P, Lundervold AJ, Steen VM, Espeseth T, Räikkönen K, Widen E, Palotie A, Eriksson JG, Giegling I, Konte B, Roussos P, Giakoumaki S, Burdick KE, Payton A, Ollier W, Horan M, Chiba-Falek O, Attix DK, Need AC, Cirulli ET, Voineskos AN, Stefanis NC, Avramopoulos D, Hatzimanolis A, Arking DE, Smyrnis N, Bilder RM, Freimer NA, Cannon TD, London E, Poldrack RA, Sabb FW, Congdon E, Conley ED, Scult MA, Dickinson D, Straub RE, Donohoe G, Morris D, Corvin A, Gill M, Hariri AR, Weinberger DR, Pendleton N, Bitsios P, Rujescu D, Lahti J, Le Hellard S, Keller MC, Andreassen OA, Deary IJ, Glahn DC, Malhotra AK, Lencz T. GWAS meta-analysis reveals novel loci and genetic correlates for general cognitive function: a report from the COGENT consortium. Mol Psychiatry. 2017 Mar; 22(3):336-345. PMID: 28093568.
      View in: PubMed
    3. Liu M, Malone SM, Vaidyanathan U, Keller MC, Abecasis G, McGue M, Iacono WG, Vrieze SI. Psychophysiological endophenotypes to characterize mechanisms of known schizophrenia genetic loci. Psychol Med. 2017 Apr; 47(6):1116-1125. PMID: 27995817.
      View in: PubMed
    4. Tahmasbi R, Keller MC. GeneEvolve: a fast and memory efficient forward-time simulator of realistic whole-genome sequence and SNP data. Bioinformatics. 2017 Jan 15; 33(2):294-296. PMID: 27659450.
      View in: PubMed
    5. Palmer RH, Nugent NR, Brick LA, Bidwell CL, McGeary JE, Keller MC, Knopik VS. Evidence of Shared Genome-Wide Additive Genetic Effects on Interpersonal Trauma Exposure and Generalized Vulnerability to Drug Dependence in a Population of Substance Users. J Trauma Stress. 2016 Jun; 29(3):197-204. PMID: 27214850.
      View in: PubMed
    6. Otowa T, Hek K, Lee M, Byrne EM, Mirza SS, Nivard MG, Bigdeli T, Aggen SH, Adkins D, Wolen A, Fanous A, Keller MC, Castelao E, Kutalik Z, der Auwera SV, Homuth G, Nauck M, Teumer A, Milaneschi Y, Hottenga JJ, Direk N, Hofman A, Uitterlinden A, Mulder CL, Henders AK, Medland SE, Gordon S, Heath AC, Madden PA, Pergadia ML, van der Most PJ, Nolte IM, van Oort FV, Hartman CA, Oldehinkel AJ, Preisig M, Grabe HJ, Middeldorp CM, Penninx BW, Boomsma D, Martin NG, Montgomery G, Maher BS, van den Oord EJ, Wray NR, Tiemeier H, Hettema JM. Meta-analysis of genome-wide association studies of anxiety disorders. Mol Psychiatry. 2016 Oct; 21(10):1391-9. PMID: 26754954.
      View in: PubMed
    7. Lee SH, Byrne EM, Hultman CM, Kähler A, Vinkhuyzen AA, Ripke S, Andreassen OA, Frisell T, Gusev A, Hu X, Karlsson R, Mantzioris VX, McGrath JJ, Mehta D, Stahl EA, Zhao Q, Kendler KS, Sullivan PF, Price AL, O'Donovan M, Okada Y, Mowry BJ, Raychaudhuri S, Wray NR. New data and an old puzzle: the negative association between schizophrenia and rheumatoid arthritis. Int J Epidemiol. 2015 Oct; 44(5):1706-21. PMID: 26286434.
      View in: PubMed
    8. Howrigan DP, Simonson MA, Davies G, Harris SE, Tenesa A, Starr JM, Liewald DC, Deary IJ, McRae A, Wright MJ, Montgomery GW, Hansell N, Martin NG, Payton A, Horan M, Ollier WE, Abdellaoui A, Boomsma DI, DeRosse P, Knowles EE, Glahn DC, Djurovic S, Melle I, Andreassen OA, Christoforou A, Steen VM, Hellard SL, Sundet K, Reinvang I, Espeseth T, Lundervold AJ, Giegling I, Konte B, Hartmann AM, Rujescu D, Roussos P, Giakoumaki S, Burdick KE, Bitsios P, Donohoe G, Corley RP, Visscher PM, Pendleton N, Malhotra AK, Neale BM, Lencz T, Keller MC. Genome-wide autozygosity is associated with lower general cognitive ability. Mol Psychiatry. 2016 Jun; 21(6):837-43. PMID: 26390830.
      View in: PubMed
    9. Haysom HJ, Mitchem DG, Lee AJ, Wright MJ, Martin NG, Keller MC, Zietsch BP. A test of the facultative calibration/reactive heritability model of extraversion. Evol Hum Behav. 2015 Sep; 36(5):414-419. PMID: 26880866.
      View in: PubMed
    10. Yang J, Bakshi A, Zhu Z, Hemani G, Vinkhuyzen AA, Lee SH, Robinson MR, Perry JR, Nolte IM, van Vliet-Ostaptchouk JV, Snieder H. Genetic variance estimation with imputed variants finds negligible missing heritability for human height and body mass index. Nat Genet. 2015 Oct; 47(10):1114-20. PMID: 26323059.
      View in: PubMed
    11. Lee AJ, Mitchem DG, Wright MJ, Martin NG, Keller MC, Zietsch BP. Facial averageness and genetic quality: Testing heritability, genetic correlation with attractiveness, and the paternal age effect. Evol Hum Behav. 2016 Jan 01; 37(1):61-66. PMID: 26858521.
      View in: PubMed
    12. Palmer RH, McGeary JE, Heath AC, Keller MC, Brick LA, Knopik VS. Shared additive genetic influences on DSM-IV criteria for alcohol dependence in subjects of European ancestry. Addiction. 2015 Dec; 110(12):1922-31. PMID: 26211938.
      View in: PubMed
    13. Keller MC, Visscher PM. Genetic variation links creativity to psychiatric disorders. Nat Neurosci. 2015 Jul; 18(7):928-9. PMID: 26108717.
      View in: PubMed
    14. Trampush JW, Lencz T, Knowles E, Davies G, Guha S, Pe'er I, Liewald DC, Starr JM, Djurovic S, Melle I, Sundet K, Christoforou A, Reinvang I, Mukherjee S, DeRosse P, Lundervold A, Steen VM, John M, Espeseth T, Räikkönen K, Widen E, Palotie A, Eriksson JG, Giegling I, Konte B, Ikeda M, Roussos P, Giakoumaki S, Burdick KE, Payton A, Ollier W, Horan M, Scult M, Dickinson D, Straub RE, Donohoe G, Morris D, Corvin A, Gill M, Hariri A, Weinberger DR, Pendleton N, Iwata N, Darvasi A, Bitsios P, Rujescu D, Lahti J, Le Hellard S, Keller MC, Andreassen OA, Deary IJ, Glahn DC, Malhotra AK. Independent evidence for an association between general cognitive ability and a genetic locus for educational attainment. Am J Med Genet B Neuropsychiatr Genet. 2015 Jul; 168B(5):363-73. PMID: 25951819.
      View in: PubMed
    15. Mitchem DG, Zietsch BP, Wright MJ, Martin NG, Hewitt JK, Keller MC. NO RELATIONSHIP BETWEEN INTELLIGENCE AND FACIAL ATTRACTIVENESS IN A LARGE, GENETICALLY INFORMATIVE SAMPLE. Evol Hum Behav. 2015 May 01; 36(3):240-247. PMID: 25937789.
      View in: PubMed
    16. Zietsch BP, de Candia TR, Keller MC. Evolutionary behavioral genetics. Curr Opin Behav Sci. 2015 Apr; 2:73-80. PMID: 25587556.
      View in: PubMed
    17. Derringer J, Corley RP, Haberstick BC, Young SE, Demmitt BA, Howrigan DP, Kirkpatrick RM, Iacono WG, McGue M, Keller MC, Brown S, Tapert S, Hopfer CJ, Stallings MC, Crowley TJ, Rhee SH, Krauter K, Hewitt JK, McQueen MB. Genome-Wide Association Study of Behavioral Disinhibition in a Selected Adolescent Sample. Behav Genet. 2015 Jul; 45(4):375-81. PMID: 25637581.
      View in: PubMed
    18. Palmer RH, Brick L, Nugent NR, Bidwell LC, McGeary JE, Knopik VS, Keller MC. Examining the role of common genetic variants on alcohol, tobacco, cannabis and illicit drug dependence: genetics of vulnerability to drug dependence. Addiction. 2015 Mar; 110(3):530-7. PMID: 25424661.
      View in: PubMed
    19. Dick DM, Agrawal A, Keller MC, Adkins A, Aliev F, Monroe S, Hewitt JK, Kendler KS, Sher KJ. Candidate gene-environment interaction research: reflections and recommendations. Perspect Psychol Sci. 2015 Jan; 10(1):37-59. PMID: 25620996.
      View in: PubMed
    20. Verweij KJ, Abdellaoui A, Veijola J, Sebert S, Koiranen M, Keller MC, Järvelin MR, Zietsch BP. The association of genotype-based inbreeding coefficient with a range of physical and psychological human traits. PLoS One. 2014; 9(7):e103102. PMID: 25062308.
      View in: PubMed
    21. Gratten J, Wray NR, Keller MC, Visscher PM. Large-scale genomics unveils the genetic architecture of psychiatric disorders. Nat Neurosci. 2014 Jun; 17(6):782-90. PMID: 24866044.
      View in: PubMed
    22. Simonson MA, McQueen MB, Keller MC. Whole-genome pathway analysis on 132,497 individuals identifies novel gene-sets associated with body mass index. PLoS One. 2014; 9(1):e78546. PMID: 24497910.
      View in: PubMed
    23. Power RA, Keller MC, Ripke S, Abdellaoui A, Wray NR, Sullivan PF. A recessive genetic model and runs of homozygosity in major depressive disorder. Am J Med Genet B Neuropsychiatr Genet. 2014 Mar; 165B(2):157-66. PMID: 24482242.
      View in: PubMed
    24. Lee AJ, Mitchem DG, Wright MJ, Martin NG, Keller MC, Zietsch BP. Genetic factors that increase male facial masculinity decrease facial attractiveness of female relatives. Psychol Sci. 2014 Feb; 25(2):476-84. PMID: 24379153.
      View in: PubMed
    25. Lencz T, Knowles E, Davies G, Guha S, Liewald DC, Starr JM, Djurovic S, Melle I, Sundet K, Christoforou A, Reinvang I, Mukherjee S, DeRosse P, Lundervold A, Steen VM, John M, Espeseth T, Räikkönen K, Widen E, Palotie A, Eriksson JG, Giegling I, Konte B, Ikeda M, Roussos P, Giakoumaki S, Burdick KE, Payton A, Ollier W, Horan M, Donohoe G, Morris D, Corvin A, Gill M, Pendleton N, Iwata N, Darvasi A, Bitsios P, Rujescu D, Lahti J, Hellard SL, Keller MC, Andreassen OA, Deary IJ, Glahn DC, Malhotra AK. Molecular genetic evidence for overlap between general cognitive ability and risk for schizophrenia: a report from the Cognitive Genomics consorTium (COGENT). Mol Psychiatry. 2014 Feb; 19(2):168-74. PMID: 24342994.
      View in: PubMed
    26. Mitchem DG, Purkey AM, Grebe NM, Carey G, Garver-Apgar CE, Bates TC, Arden R, Hewitt JK, Medland SE, Martin NG, Zietsch BP, Keller MC. Estimating the sex-specific effects of genes on facial attractiveness and sexual dimorphism. Behav Genet. 2014 May; 44(3):270-81. PMID: 24213680.
      View in: PubMed
    27. Keller MC. Gene × environment interaction studies have not properly controlled for potential confounders: the problem and the (simple) solution. Biol Psychiatry. 2014 Jan 01; 75(1):18-24. PMID: 24135711.
      View in: PubMed
    28. de Candia TR, Lee SH, Yang J, Browning BL, Gejman PV, Levinson DF, Mowry BJ, Hewitt JK, Goddard ME, O'Donovan MC, Purcell SM, Posthuma D. Additive genetic variation in schizophrenia risk is shared by populations of African and European descent. Am J Hum Genet. 2013 Sep 05; 93(3):463-70. PMID: 23954163.
      View in: PubMed
    29. Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs. Nat Genet. 2013 Sep; 45(9):984-94. PMID: 23933821.
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    30. Brant AM, Munakata Y, Boomsma DI, Defries JC, Haworth CM, Keller MC, Martin NG, McGue M, Petrill SA, Plomin R, Wadsworth SJ, Wright MJ, Hewitt JK. The nature and nurture of high IQ: an extended sensitive period for intellectual development. Psychol Sci. 2013 Aug; 24(8):1487-95. PMID: 23818653.
      View in: PubMed
    31. Keller MC, Garver-Apgar CE, Wright MJ, Martin NG, Corley RP, Stallings MC, Hewitt JK, Zietsch BP. The genetic correlation between height and IQ: shared genes or assortative mating? PLoS Genet. 2013 Apr; 9(4):e1003451. PMID: 23593038.
      View in: PubMed
    32. Verweij KJ, Yang J, Lahti J, Veijola J, Hintsanen M, Pulkki-Råback L, Heinonen K, Pouta A, Pesonen AK, Widen E, Taanila A, Isohanni M, Miettunen J, Palotie A, Penke L, Service SK, Heath AC, Montgomery GW, Raitakari O, Kähönen M, Viikari J, Räikkönen K, Eriksson JG, Keltikangas-Järvinen L, Lehtimäki T, Martin NG, Järvelin MR, Visscher PM, Keller MC, Zietsch BP. Maintenance of genetic variation in human personality: testing evolutionary models by estimating heritability due to common causal variants and investigating the effect of distant inbreeding. Evolution. 2012 Oct; 66(10):3238-51. PMID: 23025612.
      View in: PubMed
    33. Keller MC, Simonson MA, Ripke S, Neale BM, Gejman PV, Howrigan DP, Lee SH, Lencz T, Levinson DF, Sullivan PF. Runs of homozygosity implicate autozygosity as a schizophrenia risk factor. PLoS Genet. 2012; 8(4):e1002656. PMID: 22511889.
      View in: PubMed
    34. Lee SH, DeCandia TR, Ripke S, Yang J. Estimating the proportion of variation in susceptibility to schizophrenia captured by common SNPs. Nat Genet. 2012 Feb 19; 44(3):247-50. PMID: 22344220.
      View in: PubMed
    35. Howrigan DP, Simonson MA, Kamens HM, Stephens SH, Wills AG, Ehringer MA, Keller MC, McQueen MB. Mutational load analysis of unrelated individuals. BMC Proc. 2011 Nov 29; 5 Suppl 9:S55. PMID: 22373138.
      View in: PubMed
    36. Simonson MA, Wills AG, Keller MC, McQueen MB. Recent methods for polygenic analysis of genome-wide data implicate an important effect of common variants on cardiovascular disease risk. BMC Med Genet. 2011 Oct 26; 12:146. PMID: 22029572.
      View in: PubMed
    37. Howrigan DP, Simonson MA, Keller MC. Detecting autozygosity through runs of homozygosity: a comparison of three autozygosity detection algorithms. BMC Genomics. 2011 Sep 23; 12:460. PMID: 21943305.
      View in: PubMed
    38. Duncan LE, Keller MC. A critical review of the first 10 years of candidate gene-by-environment interaction research in psychiatry. Am J Psychiatry. 2011 Oct; 168(10):1041-9. PMID: 21890791.
      View in: PubMed
    39. Keller MC, Visscher PM, Goddard ME. Quantification of inbreeding due to distant ancestors and its detection using dense single nucleotide polymorphism data. Genetics. 2011 Sep; 189(1):237-49. PMID: 21705750.
      View in: PubMed
    40. Keller MC, Medland SE, Duncan LE. Are extended twin family designs worth the trouble? A comparison of the bias, precision, and accuracy of parameters estimated in four twin family models. Behav Genet. 2010 May; 40(3):377-93. PMID: 20013306.
      View in: PubMed
    41. Keller MC, McRae AF, McGaughran JM, Visscher PM, Martin NG, Montgomery GW. Non-pathological paternal isodisomy of chromosome 2 detected from a genome-wide SNP scan. Am J Med Genet A. 2009 Aug; 149A(8):1823-6. PMID: 19610117.
      View in: PubMed
    42. Medland SE, Keller MC. Modeling extended twin family data II: power associated with different family structures. Twin Res Hum Genet. 2009 Feb; 12(1):19-25. PMID: 19210176.
      View in: PubMed
    43. Maes HH, Neale MC, Medland SE, Keller MC, Martin NG, Heath AC, Eaves LJ. Flexible Mx specification of various extended twin kinship designs. Twin Res Hum Genet. 2009 Feb; 12(1):26-34. PMID: 19210177.
      View in: PubMed
    44. Keller MC, Medland SE, Duncan LE, Hatemi PK, Neale MC, Maes HH, Eaves LJ. Modeling extended twin family data I: description of the Cascade model. Twin Res Hum Genet. 2009 Feb; 12(1):8-18. PMID: 19210175.
      View in: PubMed
    45. Ybarra O, Burnstein E, Winkielman P, Keller MC, Manis M, Chan E, Rodriguez J. Mental exercising through simple socializing: social interaction promotes general cognitive functioning. Pers Soc Psychol Bull. 2008 Feb; 34(2):248-59. PMID: 18212333.
      View in: PubMed
    46. Keller MC, Neale MC, Kendler KS. Association of different adverse life events with distinct patterns of depressive symptoms. Am J Psychiatry. 2007 Oct; 164(10):1521-9; quiz 1622. PMID: 17898343.
      View in: PubMed
    47. Keller MC, Nesse RM. The evolutionary significance of depressive symptoms: different adverse situations lead to different depressive symptom patterns. J Pers Soc Psychol. 2006 Aug; 91(2):316-30. PMID: 16881767.
      View in: PubMed
    48. Keller MC, Miller G. Resolving the paradox of common, harmful, heritable mental disorders: which evolutionary genetic models work best? Behav Brain Sci. 2006 Aug; 29(4):385-404; discussion 405-52. PMID: 17094843.
      View in: PubMed
    49. Cannon TD, Keller MC. Endophenotypes in the genetic analyses of mental disorders. Annu Rev Clin Psychol. 2006; 2:267-90. PMID: 17716071.
      View in: PubMed
    50. Keller MC, Coventry WL, Heath AC, Martin NG. Widespread evidence for non-additive genetic variation in Cloninger's and Eysenck's personality dimensions using a twin plus sibling design. Behav Genet. 2005 Nov; 35(6):707-21. PMID: 16273321.
      View in: PubMed
    51. Keller MC, Fredrickson BL, Ybarra O, Côté S, Johnson K, Mikels J, Conway A, Wager T. A warm heart and a clear head. The contingent effects of weather on mood and cognition. Psychol Sci. 2005 Sep; 16(9):724-31. PMID: 16137259.
      View in: PubMed
    52. Keller MC, Coventry WL. Quantifying and addressing parameter indeterminacy in the classical twin design. Twin Res Hum Genet. 2005 Jun; 8(3):201-13. PMID: 15989748.
      View in: PubMed
    53. Coventry WL, Keller MC. Estimating the extent of parameter bias in the classical twin design: a comparison of parameter estimates from extended twin-family and classical twin designs. Twin Res Hum Genet. 2005 Jun; 8(3):214-23. PMID: 15989749.
      View in: PubMed
    54. Wager TD, Keller MC, Lacey SC, Jonides J. Increased sensitivity in neuroimaging analyses using robust regression. Neuroimage. 2005 May 15; 26(1):99-113. PMID: 15862210.
      View in: PubMed
    55. Keller MC, Nesse RM. Is low mood an adaptation? Evidence for subtypes with symptoms that match precipitants. J Affect Disord. 2005 May; 86(1):27-35. PMID: 15820268.
      View in: PubMed
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