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Ellen L. Burnham

TitleAssociate Professor
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM-MED
Address2RC2
Research 2
12700 East 19th Avenue - Mail Stop 8619
Aurora CO 80045
Phone303/724-6078

     Biography 
     awards and honors
    2013Professional Leadership Award, University of Colorado
    2008Giles F. Filley Memorial Award in Respiratory Physiology and Medicine, American Physiological Society
    1995Alpha Omega Alpha Honor Society, University of Texas-Southwestern Medical School
    1991Phi Beta Kappa, Texas Christian University

     Overview 
     overview
    I am a pulmonary and critical care physician who also performs clinical and translational research. Our group's research focuses on the effect of alcohol and other drug consumption on the development of pneumonia and lung injury. Along with local and national collaborators, we have formed a consortium to enable translational investigations in this area, and have developed a biorepository to facilitate these investigations. Please see our consortium's website: CoPARC Other research interests of mine include junior faculty development, specifically, understanding and developing elements of the mentor-mentee relationship to promote career success. I am an Associate Program Director for the CCTSI's KL2 Mentored Career Development program that supports this role.
    Finally, I am the Medical Director of the University of Colorado's Medical ICU, where I am actively involved in multidisciplinary quality initiatives relevant to care of critically ill patients.


     Bibliographic 
     selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Riches DW, Burnham EL, Moss M, Downey GP, Schmidt EP. Introduction to the 57th annual Thomas L. Petty aspen lung conference: rebuilding the injured lung. Ann Am Thorac Soc. 2015 Mar; 12 Suppl 1:S1-2.
      View in: PubMed
    2. Burnham EL, Hyzy RC, Paine R, Kelly AM, Quint LE, Lynch D, Curran-Everett D, Moss M, Standiford TJ. Detection of Fibroproliferation by Chest High-Resolution CT Scan in Resolving ARDS. Chest. 2014 Nov 1; 146(5):1196-204.
      View in: PubMed
    3. Pfund C, House SC, Asquith P, Fleming MF, Buhr KA, Burnham EL, Eichenberger Gilmore JM, Huskins WC, McGee R, Schurr K, Shapiro ED, Spencer KC, Sorkness CA. Training mentors of clinical and translational research scholars: a randomized controlled trial. Acad Med. 2014 May; 89(5):774-82.
      View in: PubMed
    4. Tanaka T, Doe JM, Horstmann SA, Ahmad S, Ahmad A, Min SJ, Reynolds PR, Suram S, Gaydos J, Burnham EL, Vandivier RW. Neuroendocrine signaling via the serotonin transporter regulates clearance of apoptotic cells. J Biol Chem. 2014 Apr 11; 289(15):10466-75.
      View in: PubMed
    5. Burnham EL. 24/7 attendings: "helicoptering" the housestaff? Pediatrics. 2014 Jan; 133(1):131-3.
      View in: PubMed
    6. Smart A, Thompson BT, Needham DM, Hopkins RO, Williams A, Burnham EL, Moss M. Surrogate consent for genetic testing, the reconsent process, and consent for long-term outcomes in acute respiratory distress syndrome trials. Am J Respir Crit Care Med. 2013 Dec 1; 188(11):1370-3.
      View in: PubMed
    7. Macht M, King CJ, Wimbish T, Clark BJ, Benson AB, Burnham EL, Williams A, Moss M. Post-extubation dysphagia is associated with longer hospitalization in survivors of critical illness with neurologic impairment. Crit Care. 2013; 17(3):R119.
      View in: PubMed
    8. Clark BJ, Williams A, Feemster LM, Bradley KA, Macht M, Moss M, Burnham EL. Alcohol screening scores and 90-day outcomes in patients with acute lung injury. Crit Care Med. 2013 Jun; 41(6):1518-25.
      View in: PubMed
    9. Clark BJ, Bull TM, Benson AB, Stream AR, Macht M, Gaydos J, Meadows C, Burnham EL, Moss M. Growth differentiation factor-15 and prognosis in acute respiratory distress syndrome: a retrospective cohort study. Crit Care. 2013; 17(3):R92.
      View in: PubMed
    10. Clark BJ, Keniston A, Douglas IS, Beresford T, Macht M, Williams A, Jones J, Burnham EL, Moss M. Healthcare utilization in medical intensive care unit survivors with alcohol withdrawal. Alcohol Clin Exp Res. 2013 Sep; 37(9):1536-43.
      View in: PubMed
    11. Burnham EL, Kovacs EJ, Davis CS. Pulmonary cytokine composition differs in the setting of alcohol use disorders and cigarette smoking. Am J Physiol Lung Cell Mol Physiol. 2013 Jun 15; 304(12):L873-82.
      View in: PubMed
    12. Burnham EL, Janssen WJ, Riches DW, Moss M, Downey GP. The fibroproliferative response in acute respiratory distress syndrome: mechanisms and clinical significance. Eur Respir J. 2014 Jan; 43(1):276-85.
      View in: PubMed
    13. Burnham EL, Hyzy RC, Paine R, Coley C, Kelly AM, Quint LE, Lynch D, Janssen WJ, Moss M, Standiford TJ. Chest CT features are associated with poorer quality of life in acute lung injury survivors. Crit Care Med. 2013 Feb; 41(2):445-56.
      View in: PubMed
    14. Lara AR, Cosgrove GP, Janssen WJ, Huie TJ, Burnham EL, Heinz DE, Curran-Everett D, Sahin H, Schwarz MI, Cool CD, Groshong SD, Geraci MW, Tuder RM, Hyde DM, Henson PM. Increased lymphatic vessel length is associated with the fibroblast reticulum and disease severity in usual interstitial pneumonia and nonspecific interstitial pneumonia. Chest. 2012 Dec; 142(6):1569-76.
      View in: PubMed
    15. Fleming M, Burnham EL, Huskins WC. Mentoring translational science investigators. JAMA. 2012 Nov 21; 308(19):1981-2.
      View in: PubMed
    16. Macht M, Wimbish T, Clark BJ, Benson AB, Burnham EL, Williams A, Moss M. Diagnosis and treatment of post-extubation dysphagia: results from a national survey. J Crit Care. 2012 Dec; 27(6):578-86.
      View in: PubMed
    17. Finigan JH, Mishra R, Vasu VT, Silveira LJ, Nethery DE, Standiford TJ, Burnham EL, Moss M, Kern JA. Bronchoalveolar lavage neuregulin-1 is elevated in acute lung injury and correlates with inflammation. Eur Respir J. 2013 Feb; 41(2):396-401.
      View in: PubMed
    18. Albright JM, Davis CS, Bird MD, Ramirez L, Kim H, Burnham EL, Gamelli RL, Kovacs EJ. The acute pulmonary inflammatory response to the graded severity of smoke inhalation injury. Crit Care Med. 2012 Apr; 40(4):1113-21.
      View in: PubMed
    19. Burnham EL, McCord JM, Bose S, Brown LA, House R, Moss M, Gaydos J. Protandim does not influence alveolar epithelial permeability or intrapulmonary oxidative stress in human subjects with alcohol use disorders. Am J Physiol Lung Cell Mol Physiol. 2012 Apr 1; 302(7):L688-99.
      View in: PubMed
    20. Baker TA, Davis CS, Bach HH, Romero J, Burnham EL, Kovacs EJ, Gamelli RL, Majetschak M. Ubiquitin and stromal cell-derived factor-1a in bronchoalveolar lavage fluid after burn and inhalation injury. J Burn Care Res. 2012 Jan-Feb; 33(1):57-64.
      View in: PubMed
    21. Paine R, Standiford TJ, Dechert RE, Moss M, Martin GS, Rosenberg AL, Thannickal VJ, Burnham EL, Brown MB, Hyzy RC. A randomized trial of recombinant human granulocyte-macrophage colony stimulating factor for patients with acute lung injury. Crit Care Med. 2012 Jan; 40(1):90-7.
      View in: PubMed
    22. Fisichella PM, Davis CS, Lundberg PW, Lowery E, Burnham EL, Alex CG, Ramirez L, Pelletiere K, Love RB, Kuo PC, Kovacs EJ. The protective role of laparoscopic antireflux surgery against aspiration of pepsin after lung transplantation. Surgery. 2011 Oct; 150(4):598-606.
      View in: PubMed
    23. Macht M, Wimbish T, Clark BJ, Benson AB, Burnham EL, Williams A, Moss M. Postextubation dysphagia is persistent and associated with poor outcomes in survivors of critical illness. Crit Care. 2011; 15(5):R231.
      View in: PubMed
    24. Clark BJ, Smart A, House R, Douglas I, Burnham EL, Moss M. Severity of acute illness is associated with baseline readiness to change in medical intensive care unit patients with unhealthy alcohol use. Alcohol Clin Exp Res. 2012 Mar; 36(3):544-51.
      View in: PubMed
    25. Malcolm KC, Kret JE, Young RL, Poch KR, Caceres SM, Douglas IS, Coldren CD, Burnham EL, Moss M, Nick JA. Bacteria-specific neutrophil dysfunction associated with interferon-stimulated gene expression in the acute respiratory distress syndrome. PLoS One. 2011; 6(7):e21958.
      View in: PubMed
    26. Burnham EL, Schiro S, Fleming M. Mentoring K scholars: strategies to support research mentors. Clin Transl Sci. 2011 Jun; 4(3):199-203.
      View in: PubMed
    27. Majka S, Burnham E, Stenmark KR. Cell-based therapies in pulmonary hypertension: who, what, and when? Am J Physiol Lung Cell Mol Physiol. 2011 Jul; 301(1):L9-L11.
      View in: PubMed
    28. Burnham EL, Fleming M. Selection of research mentors for K-funded scholars. Clin Transl Sci. 2011 Apr; 4(2):87-92.
      View in: PubMed
    29. Burnham EL, Phang TL, House R, Vandivier RW, Moss M, Gaydos J. Alveolar macrophage gene expression is altered in the setting of alcohol use disorders. Alcohol Clin Exp Res. 2011 Feb; 35(2):284-94.
      View in: PubMed
    30. Burnham EL, Gaydos J, Hess E, House R, Cooper J. Alcohol use disorders affect antimicrobial proteins and anti-pneumococcal activity in epithelial lining fluid obtained via bronchoalveolar lavage. Alcohol Alcohol. 2010 Sep-Oct; 45(5):414-21.
      View in: PubMed
    31. Boé DM, Richens TR, Horstmann SA, Burnham EL, Janssen WJ, Henson PM, Moss M, Vandivier RW. Acute and chronic alcohol exposure impair the phagocytosis of apoptotic cells and enhance the pulmonary inflammatory response. Alcohol Clin Exp Res. 2010 Oct; 34(10):1723-32.
      View in: PubMed
    32. Burnham EL, Moss M, Geraci MW. The case for 24/7 in-house intensivist coverage. Am J Respir Crit Care Med. 2010 Jun 1; 181(11):1159-60.
      View in: PubMed
    33. Burnham EL, Mealer M, Gaydos J, Majka S, Moss M. Acute lung injury but not sepsis is associated with increased colony formation by peripheral blood mononuclear cells. Am J Respir Cell Mol Biol. 2010 Sep; 43(3):326-33.
      View in: PubMed
    34. Boé DM, Vandivier RW, Burnham EL, Moss M. Alcohol abuse and pulmonary disease. J Leukoc Biol. 2009 Nov; 86(5):1097-104.
      View in: PubMed
    35. Mealer M, Burnham EL, Goode CJ, Rothbaum B, Moss M. The prevalence and impact of post traumatic stress disorder and burnout syndrome in nurses. Depress Anxiety. 2009; 26(12):1118-26.
      View in: PubMed
    36. Graham BB, Burnham EL, Janssen JS, Janssen WJ. Dyspnea, chest pain, and altered mental status in a 33-year-old carpenter. Chest. 2008 Nov; 134(5):1074-9.
      View in: PubMed
    37. Majka SM, Skokan M, Wheeler L, Harral J, Gladson S, Burnham E, Loyd JE, Stenmark KR, Varella-Garcia M, West J. Evidence for cell fusion is absent in vascular lesions associated with pulmonary arterial hypertension. Am J Physiol Lung Cell Mol Physiol. 2008 Dec; 295(6):L1028-39.
      View in: PubMed
    38. de Wit M, Gennings C, Zilberberg M, Burnham EL, Moss M, Balster RL. Drug withdrawal, cocaine and sedative use disorders increase the need for mechanical ventilation in medical patients. Addiction. 2008 Sep; 103(9):1500-8.
      View in: PubMed
    39. Burnham EL. Identification of risky alcohol consumption in the preoperative assessment: opportunity to diagnose and intervene. Anesthesiology. 2008 Aug; 109(2):169-70.
      View in: PubMed
    40. Burnham EL, Halkar R, Burks M, Moss M. The effects of alcohol abuse on pulmonary alveolar-capillary barrier function in humans. Alcohol Alcohol. 2009 Jan-Feb; 44(1):8-12.
      View in: PubMed
    41. Burnham EL. Circulating progenitors in lung injury: a novel therapy for acute respiratory distress syndrome? Anesthesiology. 2008 Mar; 108(3):354-6.
      View in: PubMed
    42. Martin J, Helm K, Ruegg P, Varella-Garcia M, Burnham E, Majka S. Adult lung side population cells have mesenchymal stem cell potential. Cytotherapy. 2008; 10(2):140-51.
      View in: PubMed
    43. Yeh MY, Burnham EL, Moss M, Brown LA. Non-invasive evaluation of pulmonary glutathione in the exhaled breath condensate of otherwise healthy alcoholics. Respir Med. 2008 Feb; 102(2):248-55.
      View in: PubMed
    44. de Wit M, Best AM, Gennings C, Burnham EL, Moss M. Alcohol use disorders increase the risk for mechanical ventilation in medical patients. Alcohol Clin Exp Res. 2007 Jul; 31(7):1224-30.
      View in: PubMed
    45. Yeh MY, Burnham EL, Moss M, Brown LA. Chronic alcoholism alters systemic and pulmonary glutathione redox status. Am J Respir Crit Care Med. 2007 Aug 1; 176(3):270-6.
      View in: PubMed
    46. Burnham EL, Moss M, Ritzenthaler JD, Roman J. Increased fibronectin expression in lung in the setting of chronic alcohol abuse. Alcohol Clin Exp Res. 2007 Apr; 31(4):675-83.
      View in: PubMed
    47. Moss M, Burnham EL. Alcohol abuse in the critically ill patient. Lancet. 2006 Dec 23; 368(9554):2231-42.
      View in: PubMed
    48. Burnham E, Moss M. Progenitor cells in acute lung injury. Minerva Anestesiol. 2006 Jun; 72(6):369-74.
      View in: PubMed
    49. Khan J, Burnham EL, Moss M. Acquired weakness in the ICU: critical illness myopathy and polyneuropathy. Minerva Anestesiol. 2006 Jun; 72(6):401-6.
      View in: PubMed
    50. Esper A, Burnham EL, Moss M. The effect of alcohol abuse on ARDS and multiple organ dysfunction. Minerva Anestesiol. 2006 Jun; 72(6):375-81.
      View in: PubMed
    51. Burnham EL, Moss M, Ziegler TR. Myopathies in critical illness: characterization and nutritional aspects. J Nutr. 2005 Jul; 135(7):1818S-1823S.
      View in: PubMed
    52. Burnham EL, Taylor WR, Quyyumi AA, Rojas M, Brigham KL, Moss M. Increased circulating endothelial progenitor cells are associated with survival in acute lung injury. Am J Respir Crit Care Med. 2005 Oct 1; 172(7):854-60.
      View in: PubMed
    53. Burnham EL, Moss M, Harris F, Brown LA. Elevated plasma and lung endothelial selectin levels in patients with acute respiratory distress syndrome and a history of chronic alcohol abuse. Crit Care Med. 2004 Mar; 32(3):675-9.
      View in: PubMed
    54. Burnham EL, Brown LA, Halls L, Moss M. Effects of chronic alcohol abuse on alveolar epithelial barrier function and glutathione homeostasis. Alcohol Clin Exp Res. 2003 Jul; 27(7):1167-72.
      View in: PubMed
    55. Moss M, Burnham EL. Chronic alcohol abuse, acute respiratory distress syndrome, and multiple organ dysfunction. Crit Care Med. 2003 Apr; 31(4 Suppl):S207-12.
      View in: PubMed
    56. Moss M, Parsons PE, Steinberg KP, Hudson LD, Guidot DM, Burnham EL, Eaton S, Cotsonis GA. Chronic alcohol abuse is associated with an increased incidence of acute respiratory distress syndrome and severity of multiple organ dysfunction in patients with septic shock. Crit Care Med. 2003 Mar; 31(3):869-77.
      View in: PubMed
    57. Schortgen F, Brochard L, Burnham E, Martin GS. Pro/con clinical debate: Hydroxyethylstarches should be avoided in septic patients. Crit Care. 2003 Aug; 7(4):279-81.
      View in: PubMed
    58. Burnham E, Moss M. A potential new therapy for sepsis: learning from experience. Crit Care Med. 2001 Mar; 29(3):690-1.
      View in: PubMed
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