Colorado PROFILES, The Colorado Clinical and Translational Sciences Institute (CCTSI)
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Last Name
Institution

Sergejs Berdnikovs

TitleProfessor
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM-MED

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Berdnikovs S, Newcomb DC, Haruna NF, McKernan KE, Kuehnle SN, Gebretsadik T, McKennan C, Ma S, Cephus JY, Rosas-Salazar C, Anderson LJ, Gern JE, Hartert T. Single-cell profiling demonstrates the combined effect of wheeze phenotype and infant viral infection on airway epithelial development. Sci Adv. 2025 May 23; 11(21):eadr9995. PMID: 40408478.
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    2. Drake LY, Stelzig KE, Hernandez-Botero AM, Berdnikovs S, Chiarella SE. Sex differences in lung B cell responses in a murine model of asthma. Int Arch Allergy Immunol. 2025 Apr 29; 1-19. PMID: 40300587.
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    3. Haruna NF, Politanska Y, Connelly AR, O'Connor K, Bhattacharya S, Miklaszewski GE, P?rez-Leonor XG, Rerko G, Hentenaar IT, Nguyen DC, Lamothe Molina PA, Bochner BS, Abdala-Valencia H, Gill MA, Lee FE, Berdnikovs S. scRNA-seq profiling of human granulocytes reveals expansion of developmentally flexible neutrophil precursors with mixed neutrophil and eosinophil properties in asthma. J Leukoc Biol. 2024 Nov 04; 116(5):1184-1197. PMID: 38814679.
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    4. Lang A, Gadd S, Gunderman L, Lippner E, Devonshire A, Schipma MJ, Berdnikovs S, Kumar R. Whole Blood Transcriptomics Identifies Differences in Innate Immune Pathway Expression in Infants at Risk for Peanut Allergy. Clin Exp Allergy. 2025 Jan; 55(1):100-103. PMID: 39415357.
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    5. Berdnikovs S, Newcomb DC, Hartert TV. How early life respiratory viral infections impact airway epithelial development and may lead to asthma. Front Pediatr. 2024; 12:1441293. PMID: 39156016.
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    6. Haruna NF, Berdnikovs S, Nie Z. Eosinophil biology from the standpoint of metabolism: implications for metabolic disorders and asthma. J Leukoc Biol. 2024 Jul 25; 116(2):288-296. PMID: 38700084.
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    7. Berdnikovs S, Newcomb DC, McKernan KE, Kuehnle SN, Haruna NF, Gebretsadik T, McKennan C, Ma S, Cephus JY, Rosas-Salazar C, Anderson LJ, Gern JE, Hartert T. Single cell profiling to determine influence of wheeze and early-life viral infection on developmental programming of airway epithelium. bioRxiv. 2024 Jul 11. PMID: 39026695.
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    8. Chhiba KD, Kuang FL, Berdnikovs S, Kato A, Bochner BS. Little to no mRNA for the a- or ?-chains of FceRI in human eosinophils. J Allergy Clin Immunol. 2024 02; 153(2):533-534. PMID: 37988049.
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    9. Chiarella SE, Cuervo-Pardo L, Coden ME, Jeong BM, Doan TC, Connelly AR, Rodriguez RI, Queener AM, Berdnikovs S. Sex differences in a murine model of asthma are time and tissue compartment dependent. PLoS One. 2023; 18(10):e0271281. PMID: 37819947.
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    10. Wang W, Bale S, Wei J, Yalavarthi B, Bhattacharyya D, Yan JJ, Abdala-Valencia H, Xu D, Sun H, Marangoni RG, Herzog E, Berdnikovs S, Miller SD, Sawalha AH, Tsou PS, Awaji K, Yamashita T, Sato S, Asano Y, Tiruppathi C, Yeldandi A, Schock BC, Bhattacharyya S, Varga J. Author Correction: Fibroblast A20 governs fibrosis susceptibility and its repression by DREAM promotes fibrosis in multiple organs. Nat Commun. 2023 Jan 31; 14(1):523. PMID: 36720888.
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    11. Wang W, Bale S, Wei J, Yalavarthi B, Bhattacharyya D, Yan JJ, Abdala-Valencia H, Xu D, Sun H, Marangoni RG, Herzog E, Berdnikovs S, Miller SD, Sawalha AH, Tsou PS, Awaji K, Yamashita T, Sato S, Asano Y, Tiruppathi C, Yeldandi A, Schock BC, Bhattacharyya S, Varga J. Fibroblast A20 governs fibrosis susceptibility and its repression by DREAM promotes fibrosis in multiple organs. Nat Commun. 2022 10 26; 13(1):6358. PMID: 36289219.
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    12. Snyder BM, Gebretsadik T, Turi KN, McKennan C, Havstad S, Jackson DJ, Ober C, Lynch S, McCauley K, Seroogy CM, Zoratti EM, Khurana Hershey GK, Berdnikovs S, Cunningham G, Summar ML, Gern JE, Hartert TV. Association of citrulline concentration at birth with lower respiratory tract infection in infancy: Findings from a multi-site birth cohort study. Front Pediatr. 2022; 10:979777. PMID: 36324820.
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    13. Bravo-Solarte DC, Stelzig KE, Cuervo-Pardo L, Berdnikovs S, Chiarella SE. Genomic evidence for dysregulated glutamine metabolism in?the asthmatic airway epithelium. Clin Transl Allergy. 2022 Jul; 12(7):e12178. PMID: 35813976.
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    14. Chirkova T, Rosas-Salazar C, Gebretsadik T, Jadhao SJ, Chappell JD, Peebles RS, Dupont WD, Newcomb DC, Berdnikovs S, Gergen PJ, Hartert TV, Anderson LJ. Effect of Infant RSV Infection on Memory T Cell Responses at Age 2-3 Years. Front Immunol. 2022; 13:826666. PMID: 35371035.
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    15. Berdnikovs S, Newcomb DC, Gebretsadik T, Snyder BM, Wiggins DA, Poleon KS, Hartert TV. Cellular and systemic energy metabolic dysregulation in asthma development-a hypothesis-generating approach. J Allergy Clin Immunol. 2022 05; 149(5):1802-1806.e2. PMID: 34740605.
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    16. Connelly AR, Jeong BM, Coden ME, Cao JY, Chirkova T, Rosas-Salazar C, Cephus JY, Anderson LJ, Newcomb DC, Hartert TV, Berdnikovs S. Metabolic Reprogramming of Nasal Airway Epithelial Cells Following Infant Respiratory Syncytial Virus Infection. Viruses. 2021 10 13; 13(10). PMID: 34696488.
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    17. Wechsler ME, Munitz A, Ackerman SJ, Drake MG, Jackson DJ, Wardlaw AJ, Dougan SK, Berdnikovs S, Schleich F, Matucci A, Chanez P, Prazma CM, Howarth P, Weller PF, Merkel PA. Eosinophils in Health and Disease: A State-of-the-Art Review. Mayo Clin Proc. 2021 10; 96(10):2694-2707. PMID: 34538424.
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    18. Coden ME, Loffredo LF, Abdala-Valencia H, Berdnikovs S. Comparative Study of SARS-CoV-2, SARS-CoV-1, MERS-CoV, HCoV-229E and Influenza Host Gene Expression in Asthma: Importance of Sex, Disease Severity, and Epithelial Heterogeneity. Viruses. 2021 06 05; 13(6). PMID: 34198852.
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    19. Queener AM, Chiarella SE, Cuervo-Pardo L, Coden ME, Abdala-Valencia H, Berdnikovs S. Metabolism of Epithelial Cells in Health and Allergic Disease: Collegium Internationale Allergologicum Update 2021. Int Arch Allergy Immunol. 2021; 182(8):663-678. PMID: 34077948.
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    20. Berdnikovs S. The twilight zone: plasticity and mixed ontogeny of neutrophil and eosinophil granulocyte subsets. Semin Immunopathol. 2021 06; 43(3):337-346. PMID: 34009400.
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    21. Jeong BM, Walker MT, Rodriguez R, Coden ME, Nagasaka R, Doan TC, Politanska Y, Abdala-Valencia H, Berdnikovs S. More than neutrophils: Lin(+)Ly6G(+)IL-5Ra(+) multipotent myeloid cells (MMCs) are dominant in normal murine bone marrow and retain capacity to differentiate into eosinophils and monocytes. J Leukoc Biol. 2022 01; 111(1):113-122. PMID: 33857341.
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    22. Coden ME, Walker MT, Jeong BM, Connelly AR, Nagasaka R, Berdnikovs S. Beyond Il-5: Metabolic Reprogramming and Stromal Support Are Prerequisite for Generation and Survival of Long-Lived Eosinophil. Cells. 2021 04 06; 10(4). PMID: 33917349.
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    23. Casalino-Matsuda SM, Berdnikovs S, Wang N, Nair A, Gates KL, Beitel GJ, Sporn PHS. Hypercapnia selectively modulates LPS-induced changes in innate immune and DNA replication-related gene transcription in the macrophage. Interface Focus. 2021 Apr 06; 11(2):20200039. PMID: 33633835.
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    24. Takahashi T, Kato A, Suh LA, Carter RG, Stevens WW, Price CPE, Norton JE, Weibman AR, Harris KE, Peters AT, Grammer LC, Welch K, Shintani-Smith S, Conley DB, Berdnikovs S, Tan BK, Kern RC, Schleimer RP. Integrin ?6 microparticles in nasal lavage fluids; potential new biomarkers for basal cell activation in chronic rhinosinusitis. Allergy. 2020 12; 75(12):3261-3264. PMID: 32455472.
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    25. Bharat A, Angulo M, Sun H, Akbarpour M, Alberro A, Cheng Y, Shigemura M, Berdnikovs S, Welch LC, Kanter JA, Budinger GRS, Lecuona E, Sznajder JI. High CO2 Levels Impair Lung Wound Healing. Am J Respir Cell Mol Biol. 2020 08; 63(2):244-254. PMID: 32275835.
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    26. Stelzig KE, Canepa-Escaro F, Schiliro M, Berdnikovs S, Prakash YS, Chiarella SE. Estrogen regulates the expression of SARS-CoV-2 receptor ACE2 in differentiated airway epithelial cells. Am J Physiol Lung Cell Mol Physiol. 2020 06 01; 318(6):L1280-L1281. PMID: 32432918.
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    27. Coden ME, Berdnikovs S. Eosinophils in wound healing and epithelial remodeling: Is coagulation a missing link? J Leukoc Biol. 2020 07; 108(1):93-103. PMID: 32170876.
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    28. Loffredo LF, Coden ME, Jeong BM, Walker MT, Anekalla KR, Doan TC, Rodriguez R, Browning M, Nam K, Lee JJ, Abdala-Valencia H, Berdnikovs S. Eosinophil accumulation in postnatal lung is specific to the primary septation phase of development. Sci Rep. 2020 03 10; 10(1):4425. PMID: 32157178.
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    29. Loffredo LF, Coden ME, Berdnikovs S. Endocrine Disruptor Bisphenol A (BPA) Triggers Systemic Para-Inflammation and is Sufficient to Induce Airway Allergic Sensitization in Mice. Nutrients. 2020 01 28; 12(2). PMID: 32012983.
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    30. Hsu CL, Chhiba KD, Krier-Burris R, Hosakoppal S, Berdnikovs S, Miller ML, Bryce PJ. Allergic inflammation is initiated by IL-33-dependent crosstalk between mast cells and basophils. PLoS One. 2020; 15(1):e0226701. PMID: 31940364.
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    31. Coden ME, Loffredo LF, Walker MT, Jeong BM, Nam K, Bochner BS, Abdala-Valencia H, Berdnikovs S. Fibrinogen Is a Specific Trigger for Cytolytic Eosinophil Degranulation. J Immunol. 2020 01 15; 204(2):438-448. PMID: 31818982.
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    32. Shigemura M, Lecuona E, Angulo M, Dada LA, Edwards MB, Welch LC, Casalino-Matsuda SM, Sporn PHS, Vad?sz I, Helenius IT, Nader GA, Gruenbaum Y, Sharabi K, Cummins E, Taylor C, Bharat A, Gottardi CJ, Beitel GJ, Kaminski N, Budinger GRS, Berdnikovs S, Sznajder JI. Elevated CO2 regulates the Wnt signaling pathway in mammals, Drosophila melanogaster and Caenorhabditis elegans. Sci Rep. 2019 12 03; 9(1):18251. PMID: 31796806.
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    33. Patel NB, Ostilla LA, Cuervo-Pardo L, Berdnikovs S, Chiarella SE. Gene expression of TMEM178, which encodes a negative regulator of NFATc1, decreases with the progression of asthma severity. Clin Transl Allergy. 2019; 9:38. PMID: 31406566.
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    34. Doan TC, Jeong BM, Coden ME, Loffredo LF, Bhattacharyya S, Chiarella SE, Varga J, Abdala-Valencia H, Berdnikovs S. Matrix protein tenascin-C expands and reversibly blocks maturation of murine eosinophil progenitors. J Allergy Clin Immunol. 2018 08; 142(2):695-698.e4. PMID: 29705244.
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    35. Abdala-Valencia H, Coden ME, Chiarella SE, Jacobsen EA, Bochner BS, Lee JJ, Berdnikovs S. Shaping eosinophil identity in the tissue contexts of development, homeostasis, and disease. J Leukoc Biol. 2018 07; 104(1):95-108. PMID: 29656559.
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    36. Misharin AV, Morales-Nebreda L, Reyfman PA, Cuda CM, Walter JM, McQuattie-Pimentel AC, Chen CI, Anekalla KR, Joshi N, Williams KJN, Abdala-Valencia H, Yacoub TJ, Chi M, Chiu S, Gonzalez-Gonzalez FJ, Gates K, Lam AP, Nicholson TT, Homan PJ, Soberanes S, Dominguez S, Morgan VK, Saber R, Shaffer A, Hinchcliff M, Marshall SA, Bharat A, Berdnikovs S, Bhorade SM, Bartom ET, Morimoto RI, Balch WE, Sznajder JI, Chandel NS, Mutlu GM, Jain M, Gottardi CJ, Singer BD, Ridge KM, Bagheri N, Shilatifard A, Budinger GRS, Perlman H. Monocyte-derived alveolar macrophages drive lung fibrosis and persist in the lung over the life span. J Exp Med. 2017 Aug 07; 214(8):2387-2404. PMID: 28694385.
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    37. Loffredo LF, Abdala-Valencia H, Anekalla KR, Cuervo-Pardo L, Gottardi CJ, Berdnikovs S. Beyond epithelial-to-mesenchymal transition: Common suppression of differentiation programs underlies epithelial barrier dysfunction in mild, moderate, and severe asthma. Allergy. 2017 Dec; 72(12):1988-2004. PMID: 28599074.
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    38. Gonsalves N, Berdnikovs S, Schroeder H, Zalewski A, Bryce PJ. Gender-specific differences in the molecular signatures of adult Eosinophilic Oesophagitis. Clin Exp Allergy. 2017 07; 47(7):969-971. PMID: 28580626.
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    39. Schleimer RP, Berdnikovs S. Etiology of epithelial barrier dysfunction in patients with type 2 inflammatory diseases. J Allergy Clin Immunol. 2017 Jun; 139(6):1752-1761. PMID: 28583447.
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    40. Chhiba KD, Hsu CL, Berdnikovs S, Bryce PJ. Transcriptional Heterogeneity of Mast Cells and Basophils upon Activation. J Immunol. 2017 06 15; 198(12):4868-4878. PMID: 28476932.
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    41. Takahashi T, Kato A, Berdnikovs S, Stevens WW, Suh LA, Norton JE, Carter RG, Harris KE, Peters AT, Hulse KE, Grammer LC, Welch KC, Shintani-Smith S, Tan BK, Conley DB, Kern RC, Bochner BS, Schleimer RP. Microparticles in nasal lavage fluids in chronic rhinosinusitis: Potential biomarkers for diagnosis of aspirin-exacerbated respiratory disease. J Allergy Clin Immunol. 2017 Sep; 140(3):720-729. PMID: 28238741.
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    42. Sennello JA, Misharin AV, Flozak AS, Berdnikovs S, Cheresh P, Varga J, Kamp DW, Budinger GR, Gottardi CJ, Lam AP. Lrp5/?-Catenin Signaling Controls Lung Macrophage Differentiation and Inhibits Resolution of Fibrosis. Am J Respir Cell Mol Biol. 2017 Feb; 56(2):191-201. PMID: 27668462.
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    43. Johnston LK, Hsu CL, Krier-Burris RA, Chhiba KD, Chien KB, McKenzie A, Berdnikovs S, Bryce PJ. IL-33 Precedes IL-5 in Regulating Eosinophil Commitment and Is Required for Eosinophil Homeostasis. J Immunol. 2016 11 01; 197(9):3445-3453. PMID: 27683753.
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    44. Carr TF, Berdnikovs S, Simon HU, Bochner BS, Rosenwasser LJ. Eosinophilic bioactivities in severe asthma. World Allergy Organ J. 2016; 9:21. PMID: 27386041.
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    45. Abdala Valencia H, Loffredo LF, Misharin AV, Berdnikovs S. Phenotypic plasticity and targeting of Siglec-F(high) CD11c(low) eosinophils to the airway in a murine model of asthma. Allergy. 2016 Feb; 71(2):267-71. PMID: 26414117.
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    46. Stevens WW, Ocampo CJ, Berdnikovs S, Sakashita M, Mahdavinia M, Suh L, Takabayashi T, Norton JE, Hulse KE, Conley DB, Chandra RK, Tan BK, Peters AT, Grammer LC, Kato A, Harris KE, Carter RG, Fujieda S, Kern RC, Schleimer RP. Cytokines in Chronic Rhinosinusitis. Role in Eosinophilia and Aspirin-exacerbated Respiratory Disease. Am J Respir Crit Care Med. 2015 Sep 15; 192(6):682-94. PMID: 26067893.
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    47. Abdala-Valencia H, Bryce PJ, Schleimer RP, Wechsler JB, Loffredo LF, Cook-Mills JM, Hsu CL, Berdnikovs S. Tetraspanin CD151 Is a Negative Regulator of FceRI-Mediated Mast Cell Activation. J Immunol. 2015 Aug 15; 195(4):1377-87. PMID: 26136426.
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    48. Misharin AV, Cuda CM, Saber R, Turner JD, Gierut AK, Haines GK, Berdnikovs S, Filer A, Clark AR, Buckley CD, Mutlu GM, Budinger GR, Perlman H. Nonclassical Ly6C(-) monocytes drive the development of inflammatory arthritis in mice. Cell Rep. 2014 Oct 23; 9(2):591-604. PMID: 25373902.
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    49. Abdala-Valencia H, Berdnikovs S, Soveg FW, Cook-Mills JM. a-Tocopherol supplementation of allergic female mice inhibits development of CD11c+CD11b+ dendritic cells in utero and allergic inflammation in neonates. Am J Physiol Lung Cell Mol Physiol. 2014 Sep 15; 307(6):L482-96. PMID: 25015974.
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    50. McErlean P, Berdnikovs S, Favoreto S, Shen J, Biyasheva A, Barbeau R, Eisley C, Barczak A, Ward T, Schleimer RP, Erle DJ, Boushey HA, Avila PC. Asthmatics with exacerbation during acute respiratory illness exhibit unique transcriptional signatures within the nasal mucosa. Genome Med. 2014; 6(1):1. PMID: 24433494.
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    51. Abdala-Valencia H, Berdnikovs S, Cook-Mills JM. Vitamin E isoforms as modulators of lung inflammation. Nutrients. 2013 Oct 31; 5(11):4347-63. PMID: 24184873.
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    52. Berdnikovs S, Abdala-Valencia H, Cook-Mills JM. Endothelial cell PTP1B regulates leukocyte recruitment during allergic inflammation. Am J Physiol Lung Cell Mol Physiol. 2013 Feb 15; 304(4):L240-9. PMID: 23275627.
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    53. Marchese ME, Berdnikovs S, Cook-Mills JM. Distinct sites within the vascular cell adhesion molecule-1 (VCAM-1) cytoplasmic domain regulate VCAM-1 activation of calcium fluxes versus Rac1 during leukocyte transendothelial migration. Biochemistry. 2012 Oct 16; 51(41):8235-46. PMID: 22970700.
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    54. Abdala-Valencia H, Berdnikovs S, McCary CA, Urick D, Mahadevia R, Marchese ME, Swartz K, Wright L, Mutlu GM, Cook-Mills JM. Inhibition of allergic inflammation by supplementation with 5-hydroxytryptophan. Am J Physiol Lung Cell Mol Physiol. 2012 Oct 15; 303(8):L642-60. PMID: 22842218.
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    55. Abdala-Valencia H, Berdnikovs S, Cook-Mills JM. Vitamin E isoforms differentially regulate intercellular adhesion molecule-1 activation of PKCa in human microvascular endothelial cells. PLoS One. 2012; 7(7):e41054. PMID: 22815910.
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    56. Berdnikovs S, Pavlov VI, Abdala-Valencia H, McCary CA, Klumpp DJ, Tremblay ML, Cook-Mills JM. PTP1B deficiency exacerbates inflammation and accelerates leukocyte trafficking in vivo. J Immunol. 2012 Jan 15; 188(2):874-84. PMID: 22156494.
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    57. Abdala-Valencia H, Berdnikovs S, Cook-Mills JM. Mechanisms for vascular cell adhesion molecule-1 activation of ERK1/2 during leukocyte transendothelial migration. PLoS One. 2011; 6(10):e26706. PMID: 22031842.
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    58. McCary CA, Abdala-Valencia H, Berdnikovs S, Cook-Mills JM. Supplemental and highly elevated tocopherol doses differentially regulate allergic inflammation: reversibility of a-tocopherol and ?-tocopherol's effects. J Immunol. 2011 Mar 15; 186(6):3674-85. PMID: 21317387.
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    59. Berdnikovs S, Abdala-Valencia H, McCary C, Somand M, Cole R, Garcia A, Bryce P, Cook-Mills JM. Isoforms of vitamin E have opposing immunoregulatory functions during inflammation by regulating leukocyte recruitment. J Immunol. 2009 Apr 01; 182(7):4395-405. PMID: 19299740.
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    60. Berdnikovs S, Bernstein M, Metzler A, German RZ. Pelvic growth: ontogeny of size and shape sexual dimorphism in rat pelves. J Morphol. 2007 Jan; 268(1):12-22. PMID: 17154287.
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