Colorado PROFILES, The Colorado Clinical and Translational Sciences Institute (CCTSI)
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Boris Draznin

TitleProfessor
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM-MED
Phone303/724-2605

     Bibliographic 
     selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Grodzinsky A, Arnold SV, Jacob D, Draznin B, Kosiborod M. THE IMPACT OF CARDIOVASCULAR DRUGS ON GLYCEMIC CONTROL: A REVIEW. Endocr Pract. 2017 Mar; 23(3):363-371.
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    2. Wang YJ, Seggelke S, Hawkins RM, Gibbs J, Lindsay M, Hazlett I, Low Wang CC, Rasouli N, Young KA, Draznin B. IMPACT OF GLUCOSE MANAGEMENT TEAM ON OUTCOMES OF HOSPITALIZARON IN PATIENTS WITH TYPE 2 DIABETES ADMITTED TO THE MEDICAL SERVICE. Endocr Pract. 2016 Dec; 22(12):1401-1405.
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    3. Low Wang CC, Draznin B. USE OF NPH INSULIN FOR GLUCOCORTICOID-INDUCED HYPERGLYCEMIA. Endocr Pract. 2016 Feb; 22(2):271-3.
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    4. Klonoff DC, Draznin B, Drincic A, Dungan K, Gianchandani R, Inzucchi SE, Nichols JH, Rice MJ, Seley JJ. PRIDE Statement on the Need for a Moratorium on the CMS Plan to Cite Hospitals for Performing Point-of-Care Capillary Blood Glucose Monitoring on Critically Ill Patients. J Clin Endocrinol Metab. 2015 Oct; 100(10):3607-12.
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    5. Hellman R, Draznin B. Do we need to broaden the scope of inpatient diabetes education to include our faculty? Endocr Pract. 2015 Apr; 21(4):448-9.
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    6. Draznin B, Wang Y, Seggelke S, Hawkins RM, Gibbs J, Bridenstine M, Rasouli N, Wang CL. Glycemic control and outcomes of hospitalization in noncritically ill patients with type 2 diabetes admitted with cardiac problems or infections. Endocr Pract. 2014 Dec; 20(12):1303-8.
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    7. Maturu A, Michels A, Draznin B. Multiple Disease Associations in Autoimmune Polyglandular Syndrome Type II. Endocr Pract. 2014 Dec; 20(12):e250-5.
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    8. Seggelke SA, Hawkins RM, Gibbs J, Rasouli N, Wang CC, Draznin B. Effect of glargine insulin delivery method (pen device versus vial/syringe) on glycemic control and patient preferences in patients with type 1 and type 2 diabetes. Endocr Pract. 2014 Jun; 20(6):536-9.
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    9. Seggelke SA, Hawkins RM, Gibbs J, Rasouli N, Wang C, Draznin B. Transitional care clinic for uninsured and medicaid-covered patients with diabetes mellitus discharged from the hospital: a pilot quality improvement study. Hosp Pract (1995). 2014 Feb; 42(1):46-51.
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    10. Draznin B, Gilden J, Golden SH, Inzucchi S. Response to comment on: Draznin et al. Pathways to quality inpatient management of hyperglycemia and diabetes: a call to action. Diabetes Care 2013;36:1807-1814. Diabetes Care. 2013 Dec; 36(12):e220.
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    11. Draznin B, Gilden J, Golden SH, Inzucchi SE. Pathways to quality inpatient management of hyperglycemia and diabetes: a call to action. Diabetes Care. 2013 Jul; 36(7):1807-14.
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    12. Low Wang CC, Lu L, Leitner JW, Sarraf M, Gianani R, Draznin B, Greyson CR, Reusch JE, Schwartz GG. Arterial insulin resistance in Yucatan micropigs with diet-induced obesity and metabolic syndrome. J Diabetes Complications. 2013 Jul-Aug; 27(4):307-15.
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    13. Low Wang CC, Draznin B. Practical approach to management of inpatient hyperglycemia in select patient populations. Hosp Pract (1995). 2013 Apr; 41(2):45-53.
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    14. Wang CC, Adochio RL, Leitner JW, Abeyta IM, Draznin B, Cornier MA. Acute effects of different diet compositions on skeletal muscle insulin signalling in obese individuals during caloric restriction. Metabolism. 2013 Apr; 62(4):595-603.
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    15. Rasouli N, Seggelke S, Gibbs J, Hawkins RM, Casciano ML, Cohlmia E, Taylor-Cousar J, Wang C, Pereira R, Hsia E, Draznin B. Cystic fibrosis-related diabetes in adults: inpatient management of 121 patients during 410 admissions. J Diabetes Sci Technol. 2012 Sep 01; 6(5):1038-44.
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    16. Hsia E, Seggelke S, Gibbs J, Hawkins RM, Cohlmia E, Rasouli N, Wang C, Kam I, Draznin B. Subcutaneous administration of glargine to diabetic patients receiving insulin infusion prevents rebound hyperglycemia. J Clin Endocrinol Metab. 2012 Sep; 97(9):3132-7.
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    17. Draznin B, Wang C, Adochio R, Leitner JW, Cornier MA. Effect of dietary macronutrient composition on AMPK and SIRT1 expression and activity in human skeletal muscle. Horm Metab Res. 2012 Sep; 44(9):650-5.
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    18. Bergouignan A, Gozansky WS, Barry DW, Leitner W, MacLean PS, Hill JO, Draznin B, Melanson EL. Increasing dietary fat elicits similar changes in fat oxidation and markers of muscle oxidative capacity in lean and obese humans. PLoS One. 2012; 7(1):e30164.
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    19. Hsia E, Seggelke SA, Gibbs J, Rasouli N, Draznin B. Comparison of 70/30 biphasic insulin with glargine/lispro regimen in non-critically ill diabetic patients on continuous enteral nutrition therapy. Nutr Clin Pract. 2011 Dec; 26(6):714-7.
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    20. Hsia E, Draznin B. Intensive control of diabetes in the hospital: why, how, and what is in the future? J Diabetes Sci Technol. 2011 Nov 01; 5(6):1596-601.
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    21. Draznin B. Mechanism of the mitogenic influence of hyperinsulinemia. Diabetol Metab Syndr. 2011 Jun 13; 3(1):10.
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    22. Seggelke SA, Gibbs J, Draznin B. Pilot study of using neutral protamine Hagedorn insulin to counteract the effect of methylprednisolone in hospitalized patients with diabetes. J Hosp Med. 2011 Mar; 6(3):175-6.
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    23. Nadeau KJ, Regensteiner JG, Bauer TA, Brown MS, Dorosz JL, Hull A, Zeitler P, Draznin B, Reusch JE. Insulin resistance in adolescents with type 1 diabetes and its relationship to cardiovascular function. J Clin Endocrinol Metab. 2010 Feb; 95(2):513-21.
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    24. Lee J, Xu Y, Lu L, Bergman B, Leitner JW, Greyson C, Draznin B, Schwartz GG. Multiple abnormalities of myocardial insulin signaling in a porcine model of diet-induced obesity. Am J Physiol Heart Circ Physiol. 2010 Feb; 298(2):H310-9.
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    25. Draznin B. Mitogenic action of insulin: friend, foe or 'frenemy'? Diabetologia. 2010 Feb; 53(2):229-33.
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    26. Adochio RL, Leitner JW, Gray K, Draznin B, Cornier MA. Early responses of insulin signaling to high-carbohydrate and high-fat overfeeding. Nutr Metab (Lond). 2009 Sep 28; 6:37.
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    27. Moriarty MW, McCurdy CE, Janssen RC, Shaw T, Leitner JW, Friedman JE, Draznin B. In vivo knockdown of p85alpha with an antisense oligonucleotide improves insulin sensitivity in Lep(ob/ob) and diet-induced obese mice. Horm Metab Res. 2009 Oct; 41(10):757-61.
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    28. Nadeau KJ, Zeitler PS, Bauer TA, Brown MS, Dorosz JL, Draznin B, Reusch JE, Regensteiner JG. Insulin resistance in adolescents with type 2 diabetes is associated with impaired exercise capacity. J Clin Endocrinol Metab. 2009 Oct; 94(10):3687-95.
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    29. Kim T, Wayne Leitner J, Adochio R, Draznin B. Knockdown of JNK rescues 3T3-L1 adipocytes from insulin resistance induced by mitochondrial dysfunction. Biochem Biophys Res Commun. 2009 Jan 23; 378(4):772-6.
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    30. Adochio R, Leitner JW, Hedlund R, Draznin B. Rescuing 3T3-L1 adipocytes from insulin resistance induced by stimulation of Akt-mammalian target of rapamycin/p70 S6 kinase (S6K1) pathway and serine phosphorylation of insulin receptor substrate-1: effect of reduced expression of p85alpha subunit of phosphatidylinositol 3-kinase and S6K1 kinase. Endocrinology. 2009 Mar; 150(3):1165-73.
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    31. Pereira RI, Leitner JW, Erickson C, Draznin B. Pioglitazone acutely stimulates adiponectin secretion from mouse and human adipocytes via activation of the phosphatidylinositol 3'-kinase. Life Sci. 2008 Nov 07; 83(19-20):638-43.
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    32. Muntoni S, Muntoni S, Draznin B. Effects of chronic hyperinsulinemia in insulin-resistant patients. Curr Diab Rep. 2008 Jun; 8(3):233-8.
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    33. Accurso A, Bernstein RK, Dahlqvist A, Draznin B, Feinman RD, Fine EJ, Gleed A, Jacobs DB, Larson G, Lustig RH, Manninen AH, McFarlane SI, Morrison K, Nielsen JV, Ravnskov U, Roth KS, Silvestre R, Sowers JR, Sundberg R, Volek JS, Westman EC, Wood RJ, Wortman J, Vernon MC. Dietary carbohydrate restriction in type 2 diabetes mellitus and metabolic syndrome: time for a critical appraisal. Nutr Metab (Lond). 2008 Apr 08; 5:9.
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    34. Nadeau KJ, Ehlers LB, Aguirre LE, Reusch JE, Draznin B. Discordance between intramuscular triglyceride and insulin sensitivity in skeletal muscle of Zucker diabetic rats after treatment with fenofibrate and rosiglitazone. Diabetes Obes Metab. 2007 Sep; 9(5):714-23.
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    35. Reusch JE, Draznin BB. Atherosclerosis in diabetes and insulin resistance. Diabetes Obes Metab. 2007 Jul; 9(4):455-63.
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    36. Wang CC, Sorribas V, Sharma G, Levi M, Draznin B. Insulin attenuates vascular smooth muscle calcification but increases vascular smooth muscle cell phosphate transport. Atherosclerosis. 2007 Nov; 195(1):e65-75.
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    37. del Rincon JP, Iida K, Gaylinn BD, McCurdy CE, Leitner JW, Barbour LA, Kopchick JJ, Friedman JE, Draznin B, Thorner MO. Growth hormone regulation of p85alpha expression and phosphoinositide 3-kinase activity in adipose tissue: mechanism for growth hormone-mediated insulin resistance. Diabetes. 2007 Jun; 56(6):1638-46.
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    38. Thureen P, Reece M, Rodden D, Barbour L, Chappell J, Leitner JW, Jones RO, Draznin B. Increased farnesylation of p21-Ras and neonatal macrosomia in women with gestational diabetes. J Pediatr. 2006 Dec; 149(6):871-3.
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    39. Draznin B. Molecular mechanisms of insulin resistance: serine phosphorylation of insulin receptor substrate-1 and increased expression of p85alpha: the two sides of a coin. Diabetes. 2006 Aug; 55(8):2392-7.
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    40. Wang CC, Sharma G, Draznin B. Early growth response gene-1 expression in vascular smooth muscle cells effects of insulin and oxidant stress. Am J Hypertens. 2006 Apr; 19(4):366-72.
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    41. Cornier MA, Bessesen DH, Gurevich I, Leitner JW, Draznin B. Nutritional upregulation of p85alpha expression is an early molecular manifestation of insulin resistance. Diabetologia. 2006 Apr; 49(4):748-54.
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    42. Nadeau KJ, Ehlers LB, Aguirre LE, Moore RL, Jew KN, Ortmeyer HK, Hansen BC, Reusch JE, Draznin B. Exercise training and calorie restriction increase SREBP-1 expression and intramuscular triglyceride in skeletal muscle. Am J Physiol Endocrinol Metab. 2006 Jul; 291(1):E90-8.
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    43. Pereira RI, Draznin B. Inhibition of the phosphatidylinositol 3'-kinase signaling pathway leads to decreased insulin-stimulated adiponectin secretion from 3T3-L1 adipocytes. Metabolism. 2005 Dec; 54(12):1636-43.
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    44. Barbour LA, Mizanoor Rahman S, Gurevich I, Leitner JW, Fischer SJ, Roper MD, Knotts TA, Vo Y, McCurdy CE, Yakar S, Leroith D, Kahn CR, Cantley LC, Friedman JE, Draznin B. Increased P85alpha is a potent negative regulator of skeletal muscle insulin signaling and induces in vivo insulin resistance associated with growth hormone excess. J Biol Chem. 2005 Nov 11; 280(45):37489-94.
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    45. Cornier MA, Donahoo WT, Pereira R, Gurevich I, Westergren R, Enerback S, Eckel PJ, Goalstone ML, Hill JO, Eckel RH, Draznin B. Insulin sensitivity determines the effectiveness of dietary macronutrient composition on weight loss in obese women. Obes Res. 2005 Apr; 13(4):703-9.
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    46. Wang CC, Goalstone ML, Draznin B. Molecular mechanisms of insulin resistance that impact cardiovascular biology. Diabetes. 2004 Nov; 53(11):2735-40.
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    47. Nadeau KJ, Leitner JW, Gurerich I, Draznin B. Insulin regulation of sterol regulatory element-binding protein-1 expression in L-6 muscle cells and 3T3 L1 adipocytes. J Biol Chem. 2004 Aug 13; 279(33):34380-7.
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    48. Finlayson CA, Chappell J, Leitner JW, Goalstone ML, Garrity M, Nawaz S, Ciaraldi TP, Draznin B. Enhanced insulin signaling via Shc in human breast cancer. Metabolism. 2003 Dec; 52(12):1606-11.
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    49. Barbour LA, Shao J, Qiao L, Leitner W, Anderson M, Friedman JE, Draznin B. Human placental growth hormone increases expression of the p85 regulatory unit of phosphatidylinositol 3-kinase and triggers severe insulin resistance in skeletal muscle. Endocrinology. 2004 Mar; 145(3):1144-50.
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    50. Wang CC, Gurevich I, Draznin B. Insulin affects vascular smooth muscle cell phenotype and migration via distinct signaling pathways. Diabetes. 2003 Oct; 52(10):2562-9.
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    51. Golovchenko I, Yang CH, Goalstone ML, Draznin B. Garlic extract methylallyl thiosulfinate blocks insulin potentiation of platelet-derived growth factor-stimulated migration of vascular smooth muscle cells. Metabolism. 2003 Feb; 52(2):254-9.
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    52. Barbour LA, Shao J, Qiao L, Pulawa LK, Jensen DR, Bartke A, Garrity M, Draznin B, Friedman JE. Human placental growth hormone causes severe insulin resistance in transgenic mice. Am J Obstet Gynecol. 2002 Mar; 186(3):512-7.
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    53. Shao J, Yamashita H, Qiao L, Draznin B, Friedman JE. Phosphatidylinositol 3-kinase redistribution is associated with skeletal muscle insulin resistance in gestational diabetes mellitus. Diabetes. 2002 Jan; 51(1):19-29.
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    54. Montagnani M, Golovchenko I, Kim I, Koh GY, Goalstone ML, Mundhekar AN, Johansen M, Kucik DF, Quon MJ, Draznin B. Inhibition of phosphatidylinositol 3-kinase enhances mitogenic actions of insulin in endothelial cells. J Biol Chem. 2002 Jan 18; 277(3):1794-9.
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    55. Chappell J, Leitner JW, Solomon S, Golovchenko I, Goalstone ML, Draznin B. Effect of insulin on cell cycle progression in MCF-7 breast cancer cells. Direct and potentiating influence. J Biol Chem. 2001 Oct 12; 276(41):38023-8.
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    56. Stephens E, Thureen PJ, Goalstone ML, Anderson MS, Leitner JW, Hay WW, Draznin B. Fetal hyperinsulinemia increases farnesylation of p21 Ras in fetal tissues. Am J Physiol Endocrinol Metab. 2001 Aug; 281(2):E217-23.
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    57. Klemm DJ, Leitner JW, Watson P, Nesterova A, Reusch JE, Goalstone ML, Draznin B. Insulin-induced adipocyte differentiation. Activation of CREB rescues adipogenesis from the arrest caused by inhibition of prenylation. J Biol Chem. 2001 Jul 27; 276(30):28430-5.
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    58. Goalstone ML, Leitner JW, Berhanu P, Sharma PM, Olefsky JM, Draznin B. Insulin signals to prenyltransferases via the Shc branch of intracellular signaling. J Biol Chem. 2001 Apr 20; 276(16):12805-12.
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    59. Golovchenko I, Goalstone ML, Watson P, Brownlee M, Draznin B. Hyperinsulinemia enhances transcriptional activity of nuclear factor-kappaB induced by angiotensin II, hyperglycemia, and advanced glycosylation end products in vascular smooth muscle cells. Circ Res. 2000 Oct 27; 87(9):746-52.
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    60. Chappell J, Golovchenko I, Wall K, Stjernholm R, Leitner JW, Goalstone M, Draznin B. Potentiation of Rho-A-mediated lysophosphatidic acid activity by hyperinsulinemia. J Biol Chem. 2000 Oct 13; 275(41):31792-7.
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    61. Draznin B, Miles P, Kruszynska Y, Olefsky J, Friedman J, Golovchenko I, Stjernholm R, Wall K, Reitman M, Accili D, Cooksey R, McClain D, Goalstone M. Effects of insulin on prenylation as a mechanism of potentially detrimental influence of hyperinsulinemia. Endocrinology. 2000 Apr; 141(4):1310-6.
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    62. Goalstone ML, Wall K, Leitner JW, Kurowski T, Ruderman N, Pan SJ, Ivy JL, Moller DE, Draznin B. Increased amounts of farnesylated p21Ras in tissues of hyperinsulinaemic animals. Diabetologia. 1999 Mar; 42(3):310-6.
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    63. Goalstone ML, Leitner JW, Golovchenko I, Stjernholm MR, Cormont M, Le Marchand-Brustel Y, Draznin B. Insulin promotes phosphorylation and activation of geranylgeranyltransferase II. Studies with geranylgeranylation of rab-3 and rab-4. J Biol Chem. 1999 Jan 29; 274(5):2880-4.
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    64. Goalstone ML, Draznin B. Effect of insulin on farnesyltransferase gene transcription and mRNA stability. Biochem Biophys Res Commun. 1999 Jan 08; 254(1):243-7.
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    65. Goalstone ML, Natarajan R, Standley PR, Walsh MF, Leitner JW, Carel K, Scott S, Nadler J, Sowers JR, Draznin B. Insulin potentiates platelet-derived growth factor action in vascular smooth muscle cells. Endocrinology. 1998 Oct; 139(10):4067-72.
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    66. Goalstone ML, Natarajan R, Standley PR, Walsh MF, Leitner JW, Carel K, Scott S, Nadler J, Sowers JR, Draznin B. Insulin Potentiates Platelet-Derived Growth Factor Action in Vascular Smooth Muscle Cells* * This work was supported by grants from the VA Research Service, the NIH (HL-48920 to R.N., HD-24497-06 to J.S.), PO-1-HL-55798 (to J.N. and R.N.), jointly funded by the NIH and the Juvenile Diabetes Foundation, the American Heart Association, a fellowship support from the American Heart Association (to M.G.), HealthONE Foundation: Diabetes and Endocrine Research and Education Fund, and Foundation for Biomedical Education and Research. Endocrinology. 1998 Oct 01; 139(10):4067-4072.
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    67. Goalstone ML, Leitner JW, Wall K, Dolgonos L, Rother KI, Accili D, Draznin B. Effect of insulin on farnesyltransferase. Specificity of insulin action and potentiation of nuclear effects of insulin-like growth factor-1, epidermal growth factor, and platelet-derived growth factor. J Biol Chem. 1998 Sep 11; 273(37):23892-6.
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    68. Goalstone ML, Draznin B. What does insulin do to Ras? Cell Signal. 1998 May; 10(5):297-301.
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    69. Sowers JR, Draznin B. Insulin, cation metabolism and insulin resistance. J Basic Clin Physiol Pharmacol. 1998; 9(2-4):223-33.
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    70. Goalstone M, Carel K, Leitner JW, Draznin B. Insulin stimulates the phosphorylation and activity of farnesyltransferase via the Ras-mitogen-activated protein kinase pathway. Endocrinology. 1997 Dec; 138(12):5119-24.
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    71. Goalstone M, Leitner JW, Draznin B. GTP loading of farnesylated p21Ras by insulin at the plasma membrane. Biochem Biophys Res Commun. 1997 Oct 09; 239(1):42-5.
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    72. Goalstone ML, Draznin B. Insulin signaling. West J Med. 1997 Sep; 167(3):166-73.
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    73. Leitner JW, Kline T, Carel K, Goalstone M, Draznin B. Hyperinsulinemia potentiates activation of p21Ras by growth factors. Endocrinology. 1997 May; 138(5):2211-4.
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    74. Carel K, Kummer JL, Schubert C, Leitner W, Heidenreich KA, Draznin B. Insulin stimulates mitogen-activated protein kinase by a Ras-independent pathway in 3T3-L1 adipocytes. J Biol Chem. 1996 Nov 29; 271(48):30625-30.
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    75. Goalstone ML, Draznin B. Effect of insulin on farnesyltransferase activity in 3T3-L1 adipocytes. J Biol Chem. 1996 Nov 01; 271(44):27585-9.
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    76. Draznin B. Insulin signaling network -- waiting for Copernicus. Endocrinology. 1996 Jul; 137(7):2647-8.
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    77. Schubert C, Carel K, DePaolo D, Leitner W, Draznin B. Interactions of protein kinase C with insulin signaling. Influence on GAP and Sos activities. J Biol Chem. 1996 Jun 28; 271(26):15311-4.
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    78. Carel K, DePaolo D, Reusch JE, Leitner JW, Draznin B. Reduced phosphorylation of mitogen-activated protein kinase kinase in response to insulin in cells with truncated C-terminal domain of insulin receptor. Endocrinology. 1996 Jun; 137(6):2362-6.
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    79. Sasaoka T, Langlois WJ, Bai F, Rose DW, Leitner JW, Decker SJ, Saltiel A, Gill GN, Kobayashi M, Draznin B, Olefsky JM. Involvement of ErbB2 in the signaling pathway leading to cell cycle progression from a truncated epidermal growth factor receptor lacking the C-terminal autophosphorylation sites. J Biol Chem. 1996 Apr 05; 271(14):8338-44.
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    80. Draznin B. Academic medicine is ill: diagnosis and prognosis. Acad Med. 1996 Apr; 71(4):314-6.
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    81. DePaolo D, Reusch JE, Carel K, Bhuripanyo P, Leitner JW, Draznin B. Functional interactions of phosphatidylinositol 3-kinase with GTPase-activating protein in 3T3-L1 adipocytes. Mol Cell Biol. 1996 Apr; 16(4):1450-7.
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    82. Langlois J, Leitner W, Medh J, Sasaoka T, Olefsky JM, Draznin B. Mechanism of activation of guanine nucleotide exchange factor by insulin. Endocrine. 1995 Jul; 3(7):475-9.
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    83. Jhun BH, Haruta T, Meinkoth JL, Leitner W, Draznin B, Saltiel AR, Pang L, Sasaoka T, Olefsky JM. Signal transduction pathways leading to insulin-induced early gene induction. Biochemistry. 1995 Jun 27; 34(25):7996-8004.
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    84. Reusch JE, Hsieh P, Bhuripanyo P, Carel K, Leitner JW, Olefsky JM, Draznin B. Insulin inhibits nuclear phosphatase activity: requirement for the C-terminal domain of the insulin receptor. Endocrinology. 1995 Jun; 136(6):2464-9.
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    85. Reusch JE, Bhuripanyo P, Carel K, Leitner JW, Hsieh P, DePaolo D, Draznin B. Differential requirement for p21ras activation in the metabolic signaling by insulin. J Biol Chem. 1995 Feb 03; 270(5):2036-40.
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    86. Sasaoka T, Langlois WJ, Leitner JW, Draznin B, Olefsky JM. The signaling pathway coupling epidermal growth factor receptors to activation of p21ras. J Biol Chem. 1994 Dec 23; 269(51):32621-5.
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    87. Robinson LJ, Leitner W, Draznin B, Heidenreich KA. Evidence that p21ras mediates the neurotrophic effects of insulin and insulin-like growth factor I in chick forebrain neurons. Endocrinology. 1994 Dec; 135(6):2568-73.
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    88. Reusch JE, Hsieh P, Klemm D, Hoeffler J, Draznin B. Insulin inhibits dephosphorylation of adenosine 3',5'-monophosphate response element-binding protein/activating transcription factor-1: effect on nuclear phosphoserine phosphatase-2a. Endocrinology. 1994 Dec; 135(6):2418-22.
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    89. Langlois WJ, Medh J, Leitner JW, Sasaoka T, Olefsky JM, Draznin B. Insulin and epidermal growth factor influence guanine nucleotide-releasing factor by distinct mechanisms. Endocrinology. 1994 Dec; 135(6):2412-7.
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    90. Sasaoka T, Rose DW, Jhun BH, Saltiel AR, Draznin B, Olefsky JM. Evidence for a functional role of Shc proteins in mitogenic signaling induced by insulin, insulin-like growth factor-1, and epidermal growth factor. J Biol Chem. 1994 May 06; 269(18):13689-94.
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    91. Sasaoka T, Draznin B, Leitner JW, Langlois WJ, Olefsky JM. Shc is the predominant signaling molecule coupling insulin receptors to activation of guanine nucleotide releasing factor and p21ras-GTP formation. J Biol Chem. 1994 Apr 08; 269(14):10734-8.
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    92. Jhun BH, Meinkoth JL, Leitner JW, Draznin B, Olefsky JM. Insulin and insulin-like growth factor-I signal transduction requires p21ras. J Biol Chem. 1994 Feb 25; 269(8):5699-704.
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    93. Begum N, Robinson LJ, Draznin B, Heidenreich KA. Protein phosphatase-1 and -2a activities in cultured fetal chick neurons: differential regulation by insulin and insulin-like growth factor-I. Endocrinology. 1993 Nov; 133(5):2085-90.
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    94. Draznin B, Chang L, Leitner JW, Takata Y, Olefsky JM. Insulin activates p21Ras and guanine nucleotide releasing factor in cells expressing wild type and mutant insulin receptors. J Biol Chem. 1993 Sep 25; 268(27):19998-20001.
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    95. Draznin B. Cytosolic calcium and insulin resistance. Am J Kidney Dis. 1993 Jun; 21(6 Suppl 3):32-8.
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    96. Begum N, Olefsky JM, Draznin B. Mechanism of impaired metabolic signaling by a truncated human insulin receptor. Decreased activation of protein phosphatase 1 by insulin. J Biol Chem. 1993 Apr 15; 268(11):7917-22.
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    97. Reusch JE, Sussman KE, Draznin B. Inverse relationship between GLUT-4 phosphorylation and its intrinsic activity. J Biol Chem. 1993 Feb 15; 268(5):3348-51.
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    98. Begum N, Leitner W, Reusch JE, Sussman KE, Draznin B. GLUT-4 phosphorylation and its intrinsic activity. Mechanism of Ca(2+)-induced inhibition of insulin-stimulated glucose transport. J Biol Chem. 1993 Feb 15; 268(5):3352-6.
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    99. Begum N, Draznin B. Effect of streptozotocin-induced diabetes on GLUT-4 phosphorylation in rat adipocytes. J Clin Invest. 1992 Oct; 90(4):1254-62.
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    100. Byyny RL, LoVerde M, Lloyd S, Mitchell W, Draznin B. Cytosolic calcium and insulin resistance in elderly patients with essential hypertension. Am J Hypertens. 1992 Jul; 5(7):459-64.
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    101. Begum N, Sussman KE, Draznin B. Calcium-induced inhibition of phosphoserine phosphatase in insulin target cells is mediated by the phosphorylation and activation of inhibitor 1. J Biol Chem. 1992 Mar 25; 267(9):5959-63.
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    102. Begum N, Graham AL, Sussman KE, Draznin B. Role of cAMP in mediating effects of fasting on dephosphorylation of insulin receptor. Am J Physiol. 1992 Feb; 262(2 Pt 1):E142-9.
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    103. Nishida K, Ohara T, Johnson J, Wallner JS, Wilk J, Sherman N, Kawakami K, Sussman KE, Draznin B. Na+/K(+)-ATPase activity and its alpha II subunit gene expression in rat skeletal muscle: influence of diabetes, fasting, and refeeding. Metabolism. 1992 Jan; 41(1):56-63.
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    104. Metz S, Holmes D, Robertson RP, Leitner W, Draznin B. Gene expression of type I phospholipase A2 in pancreatic beta cells. Regulation of mRNA levels by starvation or glucose excess. FEBS Lett. 1991 Dec 16; 295(1-3):110-2.
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    105. Reusch JE, Begum N, Sussman KE, Draznin B. Regulation of GLUT-4 phosphorylation by intracellular calcium in adipocytes. Endocrinology. 1991 Dec; 129(6):3269-73.
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    106. Begum N, Sussman KE, Draznin B. Differential effects of diabetes on adipocyte and liver phosphotyrosine and phosphoserine phosphatase activities. Diabetes. 1991 Dec; 40(12):1620-9.
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    107. Ohara T, Sussman KE, Draznin B. Effect of diabetes on cytosolic free Ca2+ and Na(+)-K(+)-ATPase in rat aorta. Diabetes. 1991 Nov; 40(11):1560-3.
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    108. Begum N, Sussman KE, Draznin B. High levels of cytosolic free calcium inhibit dephosphorylation of insulin receptor and glycogen synthase. Cell Calcium. 1991 Jun; 12(6):423-30.
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    109. Draznin B. Cytosolic calcium: a new factor in insulin resistance? Diabetes Res Clin Pract. 1991 Mar; 11(3):141-5.
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    110. Murakami K, Wilk J, Nishida K, Sussman KE, Draznin B. Hep-G2 glucose transporter gene polymorphism in Caucasian, black, Hispanic and Japanese patients with NIDDM. Diabetes Res Clin Pract. 1990 May-Jun; 9(2):115-21.
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    111. Segal S, Lloyd S, Sherman N, Sussman K, Draznin B. Postprandial changes in cytosolic free calcium and glucose uptake in adipocytes in obesity and non-insulin-dependent diabetes mellitus. Horm Res. 1990; 34(1):39-44.
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    112. Draznin B, Lewis D, Houlder N, Sherman N, Adamo M, Garvey WT, LeRoith D, Sussman K. Mechanism of insulin resistance induced by sustained levels of cytosolic free calcium in rat adipocytes. Endocrinology. 1989 Nov; 125(5):2341-9.
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    113. Wang Y, Goodman M, Lumerman J, Sussman KE, Dahl R, Lafferty KJ, Draznin B. In vivo administration of interleukin-1 inhibits glucose-stimulated insulin release. Diabetes Res Clin Pract. 1989 Sep 18; 7(3):205-11.
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    114. Draznin B, Sussman KE, Eckel RH, Kao M, Yost T, Sherman NA. Possible role of cytosolic free calcium concentrations in mediating insulin resistance of obesity and hyperinsulinemia. J Clin Invest. 1988 Dec; 82(6):1848-52.
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    115. Draznin B. Intracellular calcium, insulin secretion, and action. Am J Med. 1988 Nov 28; 85(5A):44-58.
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    116. Draznin B, Metz SA, Sussman KE, Leitner JW. Cyclosporin-induced inhibition of insulin release. Possible role of voltage-dependent calcium transport channels. Biochem Pharmacol. 1988 Oct 15; 37(20):3941-5.
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    117. Draznin B, Leitner JW, Sussman KE, Sherman NA. Insulin and glucose modulate protein kinase C activity in rat adipocytes. Biochem Biophys Res Commun. 1988 Oct 14; 156(1):570-5.
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    118. Draznin B, Sussman KE, Leitner JW, Metz SA. Glyburide increases cytosolic-free calcium concentrations in normal rat pancreatic islet cells. Metabolism. 1988 Jul; 37(7):660-3.
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    119. Draznin B, Sussman KE, Kao M, Sherman N. Relationship between cytosolic free calcium concentration and 2-deoxyglucose uptake in adipocytes isolated from 2- and 12-month-old rats. Endocrinology. 1988 Jun; 122(6):2578-83.
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    120. Glugla M, Draznin B. Treatment of impotence with vacuum-operated erection assistance device. Diabetes Care. 1988 May; 11(5):445-6.
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    121. Draznin B, Dahl R, Sherman N, Sussman KE, Staehelin LA. Exocytosis in normal anterior pituitary cells. Quantitative correlation between growth hormone release and the morphological features of exocytosis. J Clin Invest. 1988 Apr; 81(4):1042-50.
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    122. Draznin B, Sussman K, Kao M, Lewis D, Sherman N. The existence of an optimal range of cytosolic free calcium for insulin-stimulated glucose transport in rat adipocytes. J Biol Chem. 1987 Oct 25; 262(30):14385-8.
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    123. Draznin B, Metz SA, Sussman KE, Leitner JW. Measurement of cytosolic free calcium concentration in relation to insulin release in normal rat pancreatic islets. Diabetes Res Clin Pract. 1987 Sep-Oct; 3(5):291-5.
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    124. Sussman KE, Leitner JW, Draznin B. Cytosolic free-calcium concentrations in normal pancreatic islet cells. Effect of secretagogues and somatostatin. Diabetes. 1987 May; 36(5):571-7.
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    125. Draznin B, Kao M, Sussman KE. Insulin and glyburide increase cytosolic free-Ca2+ concentration in isolated rat adipocytes. Diabetes. 1987 Feb; 36(2):174-8.
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    126. Metz SA, Draznin B, Sussman KE, Leitner JW. Unmasking of arachidonate-induced insulin release by removal of extracellular calcium. Arachidonic acid mobilizes cellular calcium in rat islets of Langerhans. Biochem Biophys Res Commun. 1987 Jan 15; 142(1):251-8.
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    127. Draznin B, Steiner C, Sherman N, Sussman K. Somatostatin inhibits fusion of pituitary secretion vesicles with the plasma membranes. Biochem Biophys Res Commun. 1986 Sep 14; 139(2):673-8.
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    128. Goodman M, Leitner JW, Sussman KE, Draznin B. Insulin secretion in aging: studies with sequential gating of secretion vesicle margination and lysis. Endocrinology. 1986 Aug; 119(2):827-32.
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    129. Draznin B, Goodman M, Leitner JW, Sussman KE. Feedback inhibition of insulin on insulin secretion in isolated pancreatic islets. Endocrinology. 1986 Mar; 118(3):1054-8.
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    130. Trowbridge M, Draznin B. Insulin internalization and intracellular protein degradation: a quantitative correlation. Horm Metab Res. 1986 Mar; 18(3):156-8.
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    131. Steiner C, Dahl R, Sherman N, Trowbridge M, Vatter A, Robbins R, Draznin B. Somatostatin receptors are biologically active before they are inserted into the plasma membrane. Endocrinology. 1986 Feb; 118(2):766-72.
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    132. Draznin B, Steinberg JP, Leitner JW, Sussman KE. The nature of insulin secretory defect in aging rats. Diabetes. 1985 Nov; 34(11):1168-73.
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    133. Draznin B, Sherman N, Sussman K, Dahl R, Vatter A. Internalization and cellular processing of somatostatin in primary culture of rat anterior pituitary cells. Endocrinology. 1985 Sep; 117(3):960-6.
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    134. Draznin B, Leitner JW, Sussman KE. A unique control mechanism in the regulation of insulin secretion. Secretagogue-induced somatostatin receptor recruitment. J Clin Invest. 1985 May; 75(5):1510-6.
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    135. Draznin B, Steinberg JP, Goodman M, Leitner JW, Sussman KE. Control of secretion vesicle margination and lysis by glucose, IBMX, and glyburide. Am J Physiol. 1985 Mar; 248(3 Pt 1):E375-80.
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    136. Draznin B, Mehler PS, Leitner JW, Sussman KE, Dahl R, Vatter A, Melmed S. Localization of somatostatin receptors in secretion vesicles in anterior pituitary cells and pancreatic islets. J Recept Res. 1985; 5(1):83-103.
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    137. Trowbridge M, Sussman A, Ferguson L, Draznin B, Neufeld N, Begum N, Tepperman H, Tepperman J. Mechanisms of the fasting-induced dissociation of insulin binding from its action in isolated rat hepatocytes. Mol Cell Biochem. 1984 Apr; 62(1):25-36.
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    138. Steinberg JP, Leitner JW, Draznin B, Sussman KE. Calmodulin and cyclic AMP. Possible different sites of action of these two regulatory agents in exocytotic hormone release. Diabetes. 1984 Apr; 33(4):339-45.
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    139. Draznin B, Trowbridge M, Ferguson L. Quantitative studies of the rate of insulin internalization in isolated rat hepatocytes. Biochem J. 1984 Mar 01; 218(2):307-12.
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    140. Rifkin RM, Todd WW, Toothaker DR, Sussman A, Trowbridge M, Draznin B. Effects of in vivo and in vitro alcohol administration on insulin binding and glycogenesis in isolated rat hepatocytes. Ann Nutr Metab. 1983; 27(4):313-9.
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    141. Trowbridge M, Draznin B. Effect of fasting on insulin's ability to inhibit intracellular proteolysis. Horm Metab Res. 1983 Jan; 15(1):48-9.
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    142. Sussman KE, Draznin B, Leitner JW, Mehler PS. The endocrine secretion granule revisited- postulating new functions. Metabolism. 1982 Sep; 31(9):959-67.
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    143. Sussman KE, Mehler PS, Leitner JW, Draznin B. Role of the secretion vesicle in the transport of receptors: modulation of somatostatin binding to pancreatic islets. Endocrinology. 1982 Jul; 111(1):316-23.
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    144. Draznin B, Leitner JW, Sussman KE. Kinetics of somatostatin receptor migration in isolated pancreatic islets. Diabetes. 1982 May; 31(5 Pt 1):467-9.
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    145. Schalch DS, Burstein PJ, Tewel SJ, Draznin B, Emler CA. The effect of renal impairment on growth in the rat: relationship to malnutrition and serum somatomedin levels. Endocrinology. 1981 May; 108(5):1683-9.
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    146. Miller LL, Schalch DS, Draznin B. Role of the liver in regulating somatomedin activity: effects of streptozotocin diabetes and starvation on the synthesis and release of insulin-like growth factor and its carrier protein by the isolated perfused rat liver. Endocrinology. 1981 Apr; 108(4):1265-71.
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    147. Draznin B, Todd WW, Leitner JW, Toothaker DR. Lysosomal and non-lysosomal pathways of intracellular insulin degradation in isolated rat hepatocytes. Horm Res. 1981; 15(4):252-62.
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    148. Draznin B, Solomons CC, Toothaker DR, Sussman KE. Energy-dependent steps in insulin-hepatocyte interaction. Endocrinology. 1981 Jan; 108(1):8-17.
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    149. Draznin B, Solomons CC, Emler CA, Schalch DS, Sussman KE. Decreased insulin binding and degradation associated with depressed intracellular ATP content. Diabetes. 1980 Mar; 29(3):221-6.
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    150. Draznin B, Burstein PJ, Heinrich UE, Johnson CB, Emler CA, Schalch DS. Insulin-like growth factor and its carrier protein in hypopituitary and hypothyroid children and adults. Clin Endocrinol (Oxf). 1980 Feb; 12(2):137-42.
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    151. Burstein PJ, Draznin B, Johnson CJ, Schalch DS. The effect of hypothyroidism on growth, serum growth hormone, the growth hormone-dependent somatomedin, insulin-like growth factor, and its carrier protein in rats. Endocrinology. 1979 Apr; 104(4):1107-11.
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    152. Schalch DS, Heinrich UE, Draznin B, Johnson CJ, Miller LL. Role of the liver in regulating somatomedin activity: hormonal effects on the synthesis and release of insulin-like growth factor and its carrier protein by the isolated perfused rat liver. Endocrinology. 1979 Apr; 104(4):1143-51.
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    153. Draznin B, Ayalon D, Hoerer E, Oberman Z, Harell A, Ravid R, Laurian L. Effect of diphenylhydantoin on patterns of insulin secretion in obese subjects. Acta Diabetol Lat. 1977 Jan-Apr; 14(1-2):51-61.
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