Colorado PROFILES, The Colorado Clinical and Translational Sciences Institute (CCTSI)
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Last Name
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Amanda J Law

TitleProfessor
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM-PSYCH
Phone303/724-7915
    Other Positions
    TitleAssoc Chair
    InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
    DepartmentSOM-PSYCH
    DivisionGeneral Operations

    TitleDivision Head
    InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
    DepartmentSOM-PSYCH
    DivisionGeneral Operations


    Collapse Research 
    Collapse research activities and funding
    R01HD112364     (LAW, AMANDA JAYNE)Sep 1, 2023 - Jun 30, 2028
    NIH
    Neuregulin/Alpha7nAChR Signaling, the GABAergic Switch and Neurodevelopmental Risk: Mechanisms of Gestational Choline Supplementation.
    Role: Principal Investigator
    R01MH103716     (LAW, AMANDA JAYNE)Sep 12, 2014 - Jul 31, 2020
    NIH
    Targets for treating schizophrenia: AKT in neurodevelopment and cognition.
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Kim BJH, Ji MY, Chen JCC, Correia JA, Law AJJ, Kow CY. Use of oxygen therapy for pneumocephalus: a systematic review. Neurosurg Rev. 2024 Jan 04; 47(1):30. PMID: 38172487.
      View in: PubMed
    2. Hoffman MC, Hunter SJ, D'Alessandro A, Christians U, Law AJ, Freedman R. Maternal Plasma Choline during Gestation and Small for Gestational Age Infants. Am J Perinatol. 2024 05; 41(S 01):e939-e948. PMID: 36584689.
      View in: PubMed
    3. Hunter SK, Freedman R, Law AJ, Christians U, Holzman JBW, Johnson Z, Hoffman MC. Maternal corticosteroids and depression during gestation and decreased fetal heart rate variability. Neuroreport. 2021 10 06; 32(14):1170-1174. PMID: 34284445.
      View in: PubMed
    4. Hunter SK, Hoffman MC, McCarthy L, D'Alessandro A, Wyrwa A, Noonan K, Christians U, Nakimuli-Mpungu E, Zeisel SH, Law AJ, Freedman R. Black American Maternal Prenatal Choline, Offspring Gestational Age at Birth, and Developmental Predisposition to Mental Illness. Schizophr Bull. 2021 07 08; 47(4):896-905. PMID: 33184653.
      View in: PubMed
    5. Hunter SK, Hoffman MC, McCarthy L, D'Alessandro A, Wyrwa A, Noonan K, Christians U, Nakimuli-Mpungu E, Zeisel SH, Law AJ, Freedman R. Targeting Treatments to Health Disparities. Schizophr Bull. 2021 07 08; 47(4):886-887. PMID: 33940629.
      View in: PubMed
    6. Hunter SK, Hoffman MC, D'Alessandro A, Walker VK, Balser M, Noonan K, Law AJ, Freedman R. Maternal prenatal choline and inflammation effects on 4-year-olds' performance on the Wechsler Preschool and Primary Scale of Intelligence-IV. J Psychiatr Res. 2021 09; 141:50-56. PMID: 34174557.
      View in: PubMed
    7. Freedman R, Hunter SK, Law AJ, Hoffman MC. Prenatal prevention of psychiatric illness and childhood development population-wide. World Psychiatry. 2021 Jun; 20(2):226-227. PMID: 34002528.
      View in: PubMed
    8. Hoffman MC, Freedman R, Law AJ, Clark AM, Hunter SK. Maternal nutrients and effects of gestational COVID-19 infection on fetal brain development. Clin Nutr ESPEN. 2021 06; 43:1-8. PMID: 34024500.
      View in: PubMed
    9. Freedman R, Hunter SK, Law AJ, Clark AM, Roberts A, Hoffman MC. Choline, folic acid, Vitamin D, and fetal brain development in the psychosis spectrum. Schizophr Res. 2022 09; 247:16-25. PMID: 33838984.
      View in: PubMed
    10. Hunter SK, Hoffman MC, D'Alessandro A, Wyrwa A, Noonan K, Zeisel SH, Law AJ, Freedman R. Prenatal choline, cannabis, and infection, and their association with offspring development of attention and social problems through 4 years of age. Psychol Med. 2022 10; 52(14):3019-3028. PMID: 33491615.
      View in: PubMed
    11. Palumbo S, Paterson C, Yang F, Hood VL, Law AJ. PKB?/AKT2 deficiency impacts brain mTOR signaling, prefrontal cortical physiology, hippocampal plasticity and select murine behaviors. Mol Psychiatry. 2021 02; 26(2):411-428. PMID: 33328589.
      View in: PubMed
    12. Freedman R, Hunter SK, Noonan K, Wyrwa A, Christians U, Law AJ, Hoffman MC. Maternal Prenatal Depression in Pregnancies With Female and Male Fetuses and Developmental Associations With C-reactive Protein and Cortisol. Biol Psychiatry Cogn Neurosci Neuroimaging. 2021 03; 6(3):310-320. PMID: 33060035.
      View in: PubMed
    13. Freedman R, Hunter SK, Law AJ, D'Alessandro A, Noonan K, Wyrwa A, Camille Hoffman M. Maternal choline and respiratory coronavirus effects on fetal brain development. J Psychiatr Res. 2020 09; 128:1-4. PMID: 32474140.
      View in: PubMed
    14. Paterson C, Cumming B, Law AJ. Temporal Dynamics of the Neuregulin-ErbB Network in the Murine Prefrontal Cortex across the Lifespan. Cereb Cortex. 2020 05 14; 30(5):3325-3339. PMID: 31897479.
      View in: PubMed
    15. Hood VL, Paterson C, Law AJ. PI3Kinase-p110d Overexpression Impairs Dendritic Morphogenesis and Increases Dendritic Spine Density. Front Mol Neurosci. 2020; 13:29. PMID: 32180704.
      View in: PubMed
    16. Hunter SK, Hoffman MC, D'Alessandro A, Noonan K, Wyrwa A, Freedman R, Law AJ. Male fetus susceptibility to maternal inflammation: C-reactive protein and brain development. Psychol Med. 2021 02; 51(3):450-459. PMID: 31787129.
      View in: PubMed
    17. Hood VL, Berger R, Freedman R, Law AJ. Transcription of PIK3CD in human brain and schizophrenia: regulation by proinflammatory cytokines. Hum Mol Genet. 2019 10 01; 28(19):3188-3198. PMID: 31211828.
      View in: PubMed
    18. Howell KR, Law AJ. Neurodevelopmental concepts of schizophrenia in the genome-wide association era: AKT/mTOR signaling as a pathological mediator of genetic and environmental programming during development. Schizophr Res. 2020 03; 217:95-104. PMID: 31522868.
      View in: PubMed
    19. Pacheco A, Berger R, Freedman R, Law AJ. A VNTR Regulates miR-137 Expression Through Novel Alternative Splicing and Contributes to Risk for Schizophrenia. Sci Rep. 2019 08 13; 9(1):11793. PMID: 31409837.
      View in: PubMed
    20. Freedman R, Hunter SK, Law AJ, Wagner BD, D'Alessandro A, Christians U, Noonan K, Wyrwa A, Hoffman MC. Higher Gestational Choline Levels in Maternal Infection Are Protective for Infant Brain Development. J Pediatr. 2019 05; 208:198-206.e2. PMID: 30879727.
      View in: PubMed
    21. Deakin IH, Godlewska BR, Walker MA, Huang GJ, Schwab MH, Nave KA, Law AJ, Harrison PJ. Altered hippocampal gene expression and structure in transgenic mice overexpressing neuregulin 1 (Nrg1) type I. Transl Psychiatry. 2018 10 22; 8(1):229. PMID: 30348978.
      View in: PubMed
    22. Paterson C, Law AJ. Toward Better Strategies for Understanding Disrupted Cortical Excitatory/Inhibitory Balance in Schizophrenia. Biol Psychiatry. 2018 04 15; 83(8):632-634. PMID: 29559094.
      View in: PubMed
    23. Howell KR, Floyd K, Law AJ. PKB?/AKT3 loss-of-function causes learning and memory deficits and deregulation of AKT/mTORC2 signaling: Relevance for schizophrenia. PLoS One. 2017; 12(5):e0175993. PMID: 28467426.
      View in: PubMed
    24. Paterson C, Wang Y, Hyde TM, Weinberger DR, Kleinman JE, Law AJ. Temporal, Diagnostic, and Tissue-Specific Regulation of NRG3 Isoform Expression in Human Brain Development and Affective Disorders. Am J Psychiatry. 2017 03 01; 174(3):256-265. PMID: 27771971.
      View in: PubMed
    25. Papaleo F, Yang F, Paterson C, Palumbo S, Carr GV, Wang Y, Floyd K, Huang W, Thomas CJ, Chen J, Weinberger DR, Law AJ. Behavioral, Neurophysiological, and Synaptic Impairment in a Transgenic Neuregulin1 (NRG1-IV) Murine Schizophrenia Model. J Neurosci. 2016 04 27; 36(17):4859-75. PMID: 27122041.
      View in: PubMed
    26. Ross RG, Hunter SK, Hoffman MC, McCarthy L, Chambers BM, Law AJ, Leonard S, Zerbe GO, Freedman R. Perinatal Phosphatidylcholine Supplementation and Early Childhood Behavior Problems: Evidence for CHRNA7 Moderation. Am J Psychiatry. 2016 05 01; 173(5):509-16. PMID: 26651393.
      View in: PubMed
    27. Jenkins AK, Paterson C, Wang Y, Hyde TM, Kleinman JE, Law AJ. Neurexin 1 (NRXN1) splice isoform expression during human neocortical development and aging. Mol Psychiatry. 2016 May; 21(5):701-6. PMID: 26216298.
      View in: PubMed
    28. Paterson C, Wang Y, Kleinman JE, Law AJ. Effects of schizophrenia risk variation in the NRG1 gene on NRG1-IV splicing during fetal and early postnatal human neocortical development. Am J Psychiatry. 2014 Sep; 171(9):979-89. PMID: 24935406.
      View in: PubMed
    29. Paterson C, Law AJ. Transient overexposure of neuregulin 3 during early postnatal development impacts selective behaviors in adulthood. PLoS One. 2014; 9(8):e104172. PMID: 25093331.
      View in: PubMed
    30. Law AJ. Genetic mouse models of neuregulin 1: gene dosage effects, isoform-specific functions, and relevance to schizophrenia. Biol Psychiatry. 2014 Jul 15; 76(2):89-90. PMID: 24948382.
      View in: PubMed
    31. Morita Y, Callicott JH, Testa LR, Mighdoll MI, Dickinson D, Chen Q, Tao R, Lipska BK, Kolachana B, Law AJ, Ye T, Straub RE, Weinberger DR, Kleinman JE, Hyde TM. Characteristics of the cation cotransporter NKCC1 in human brain: alternate transcripts, expression in development, and potential relationships to brain function and schizophrenia. J Neurosci. 2014 Apr 02; 34(14):4929-40. PMID: 24695712.
      View in: PubMed
    32. Jenkins A, Apud JA, Zhang F, Decot H, Weinberger DR, Law AJ. Identification of candidate single-nucleotide polymorphisms in NRXN1 related to antipsychotic treatment response in patients with schizophrenia. Neuropsychopharmacology. 2014 Aug; 39(9):2170-8. PMID: 24633560.
      View in: PubMed
    33. Tost H, Callicott JH, Rasetti R, Vakkalanka R, Mattay VS, Weinberger DR, Law AJ. Effects of neuregulin 3 genotype on human prefrontal cortex physiology. J Neurosci. 2014 Jan 15; 34(3):1051-6. PMID: 24431462.
      View in: PubMed
    34. Gothelf D, Law AJ, Frisch A, Chen J, Zarchi O, Michaelovsky E, Ren-Patterson R, Lipska BK, Carmel M, Kolachana B, Weizman A, Weinberger DR. Biological effects of COMT haplotypes and psychosis risk in 22q11.2 deletion syndrome. Biol Psychiatry. 2014 Mar 01; 75(5):406-13. PMID: 23992923.
      View in: PubMed
    35. Law AJ, Wang Y, Sei Y, O'Donnell P, Piantadosi P, Papaleo F, Straub RE, Huang W, Thomas CJ, Vakkalanka R, Besterman AD, Lipska BK, Hyde TM, Harrison PJ, Kleinman JE, Weinberger DR. Neuregulin 1-ErbB4-PI3K signaling in schizophrenia and phosphoinositide 3-kinase-p110d inhibition as a potential therapeutic strategy. Proc Natl Acad Sci U S A. 2012 Jul 24; 109(30):12165-70. PMID: 22689948.
      View in: PubMed
    36. Marder SR, Roth B, Sullivan PF, Scolnick EM, Nestler EJ, Geyer MA, Welnberger DR, Karayiorgou M, Guidotti A, Gingrich J, Akbarian S, Buchanan RW, Lieberman JA, Conn PJ, Haggarty SJ, Law AJ, Campbell B, Krystal JH, Moghaddam B, Sawa A, Saw A, Caron MG, George SR, Allen JA, Solis M. Advancing drug discovery for schizophrenia. Ann N Y Acad Sci. 2011 Oct; 1236:30-43. PMID: 22032400.
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    37. Deakin IH, Nissen W, Law AJ, Lane T, Kanso R, Schwab MH, Nave KA, Lamsa KP, Paulsen O, Bannerman DM, Harrison PJ. Transgenic overexpression of the type I isoform of neuregulin 1 affects working memory and hippocampal oscillations but not long-term potentiation. Cereb Cortex. 2012 Jul; 22(7):1520-9. PMID: 21878485.
      View in: PubMed
    38. Marenco S, Geramita M, van der Veen JW, Barnett AS, Kolachana B, Shen J, Weinberger DR, Law AJ. Genetic association of ErbB4 and human cortical GABA levels in vivo. J Neurosci. 2011 Aug 10; 31(32):11628-32. PMID: 21832192.
      View in: PubMed
    39. Hyde TM, Lipska BK, Ali T, Mathew SV, Law AJ, Metitiri OE, Straub RE, Ye T, Colantuoni C, Herman MM, Bigelow LB, Weinberger DR, Kleinman JE. Expression of GABA signaling molecules KCC2, NKCC1, and GAD1 in cortical development and schizophrenia. J Neurosci. 2011 Jul 27; 31(30):11088-95. PMID: 21795557.
      View in: PubMed
    40. Kleinman JE, Law AJ, Lipska BK, Hyde TM, Ellis JK, Harrison PJ, Weinberger DR. Genetic neuropathology of schizophrenia: new approaches to an old question and new uses for postmortem human brains. Biol Psychiatry. 2011 Jan 15; 69(2):140-5. PMID: 21183009.
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    41. Nicodemus KK, Law AJ, Radulescu E, Luna A, Kolachana B, Vakkalanka R, Rujescu D, Giegling I, Straub RE, McGee K, Gold B, Dean M, Muglia P, Callicott JH, Tan HY, Weinberger DR. Biological validation of increased schizophrenia risk with NRG1, ERBB4, and AKT1 epistasis via functional neuroimaging in healthy controls. Arch Gen Psychiatry. 2010 Oct; 67(10):991-1001. PMID: 20921115.
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    42. Tan W, Dean M, Law AJ. Molecular cloning and characterization of the human ErbB4 gene: identification of novel splice isoforms in the developing and adult brain. PLoS One. 2010 Sep 23; 5(9):e12924. PMID: 20886074.
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    43. Kao WT, Wang Y, Kleinman JE, Lipska BK, Hyde TM, Weinberger DR, Law AJ. Common genetic variation in Neuregulin 3 (NRG3) influences risk for schizophrenia and impacts NRG3 expression in human brain. Proc Natl Acad Sci U S A. 2010 Aug 31; 107(35):15619-24. PMID: 20713722.
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    44. Arabadzisz D, Diaz-Heijtz R, Knuesel I, Weber E, Pilloud S, Dettling AC, Feldon J, Law AJ, Harrison PJ, Pryce CR. Primate early life stress leads to long-term mild hippocampal decreases in corticosteroid receptor expression. Biol Psychiatry. 2010 Jun 01; 67(11):1106-9. PMID: 20132928.
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    45. Deakin IH, Law AJ, Oliver PL, Schwab MH, Nave KA, Harrison PJ, Bannerman DM. Behavioural characterization of neuregulin 1 type I overexpressing transgenic mice. Neuroreport. 2009 Nov 25; 20(17):1523-8. PMID: 19829162.
      View in: PubMed
    46. Nicodemus KK, Law AJ, Luna A, Vakkalanka R, Straub RE, Kleinman JE, Weinberger DR. A 5' promoter region SNP in NRG1 is associated with schizophrenia risk and type III isoform expression. Mol Psychiatry. 2009 Aug; 14(8):741-3. PMID: 19626024.
      View in: PubMed
    47. Law AJ, Pei Q, Feldon J, Pryce CR, Harrison PJ. Gene expression in the anterior cingulate cortex and amygdala of adolescent marmoset monkeys following parental separations in infancy. Int J Neuropsychopharmacol. 2009 Jul; 12(6):761-72. PMID: 19102816.
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    48. Law AJ, Pei Q, Walker M, Gordon-Andrews H, Weickert CS, Feldon J, Pryce CR, Harrison PJ. Early parental deprivation in the marmoset monkey produces long-term changes in hippocampal expression of genes involved in synaptic plasticity and implicated in mood disorder. Neuropsychopharmacology. 2009 May; 34(6):1381-94. PMID: 18615010.
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    49. Chong VZ, Thompson M, Beltaifa S, Webster MJ, Law AJ, Weickert CS. Elevated neuregulin-1 and ErbB4 protein in the prefrontal cortex of schizophrenic patients. Schizophr Res. 2008 Mar; 100(1-3):270-80. PMID: 18243664.
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    50. Mathew SV, Law AJ, Lipska BK, D?vila-Garc?a MI, Zamora ED, Mitkus SN, Vakkalanka R, Straub RE, Weinberger DR, Kleinman JE, Hyde TM. Alpha7 nicotinic acetylcholine receptor mRNA expression and binding in postmortem human brain are associated with genetic variation in neuregulin 1. Hum Mol Genet. 2007 Dec 01; 16(23):2921-32. PMID: 17884806.
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    51. Tan W, Wang Y, Gold B, Chen J, Dean M, Harrison PJ, Weinberger DR, Law AJ. Molecular cloning of a brain-specific, developmentally regulated neuregulin 1 (NRG1) isoform and identification of a functional promoter variant associated with schizophrenia. J Biol Chem. 2007 Aug 17; 282(33):24343-51. PMID: 17565985.
      View in: PubMed
    52. Law AJ, Kleinman JE, Weinberger DR, Weickert CS. Disease-associated intronic variants in the ErbB4 gene are related to altered ErbB4 splice-variant expression in the brain in schizophrenia. Hum Mol Genet. 2007 Jan 15; 16(2):129-41. PMID: 17164265.
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    53. Law AJ, Lipska BK, Weickert CS, Hyde TM, Straub RE, Hashimoto R, Harrison PJ, Kleinman JE, Weinberger DR. Neuregulin 1 transcripts are differentially expressed in schizophrenia and regulated by 5' SNPs associated with the disease. Proc Natl Acad Sci U S A. 2006 Apr 25; 103(17):6747-52. PMID: 16618933.
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    54. Harrison PJ, Law AJ. Neuregulin 1 and schizophrenia: genetics, gene expression, and neurobiology. Biol Psychiatry. 2006 Jul 15; 60(2):132-40. PMID: 16442083.
      View in: PubMed
    55. Law AJ, Weickert CS, Hyde TM, Kleinman JE, Harrison PJ. Reduced spinophilin but not microtubule-associated protein 2 expression in the hippocampal formation in schizophrenia and mood disorders: molecular evidence for a pathology of dendritic spines. Am J Psychiatry. 2004 Oct; 161(10):1848-55. PMID: 15465982.
      View in: PubMed
    56. Law AJ, Hutchinson LJ, Burnet PW, Harrison PJ. Antipsychotics increase microtubule-associated protein 2 mRNA but not spinophilin mRNA in rat hippocampus and cortex. J Neurosci Res. 2004 May 01; 76(3):376-82. PMID: 15079866.
      View in: PubMed
    57. Law AJ, Shannon Weickert C, Hyde TM, Kleinman JE, Harrison PJ. Neuregulin-1 (NRG-1) mRNA and protein in the adult human brain. Neuroscience. 2004; 127(1):125-36. PMID: 15219675.
      View in: PubMed
    58. Law AJ, Weickert CS, Webster MJ, Herman MM, Kleinman JE, Harrison PJ. Changes in NMDA receptor subunit mRNAs and cyclophilin mRNA during development of the human hippocampus. Ann N Y Acad Sci. 2003 Nov; 1003:426-30. PMID: 14684479.
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    59. Law AJ, Harrison PJ. The distribution and morphology of prefrontal cortex pyramidal neurons identified using anti-neurofilament antibodies SMI32, N200 and FNP7. Normative data and a comparison in subjects with schizophrenia, bipolar disorder or major depression. J Psychiatr Res. 2003 Nov-Dec; 37(6):487-99. PMID: 14563380.
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    60. Harrison PJ, Law AJ, Eastwood SL. Glutamate receptors and transporters in the hippocampus in schizophrenia. Ann N Y Acad Sci. 2003 Nov; 1003:94-101. PMID: 14684437.
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    61. Law AJ, Weickert CS, Webster MJ, Herman MM, Kleinman JE, Harrison PJ. Expression of NMDA receptor NR1, NR2A and NR2B subunit mRNAs during development of the human hippocampal formation. Eur J Neurosci. 2003 Sep; 18(5):1197-205. PMID: 12956718.
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    62. Law A. Schizophrenia, IV: neuregulin-1 in the human brain. Am J Psychiatry. 2003 Aug; 160(8):1392. PMID: 12900297.
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    63. Eastwood SL, Law AJ, Everall IP, Harrison PJ. The axonal chemorepellant semaphorin 3A is increased in the cerebellum in schizophrenia and may contribute to its synaptic pathology. Mol Psychiatry. 2003 Feb; 8(2):148-55. PMID: 12610647.
      View in: PubMed
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