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Steven M Anderson

TitleWorking ORP Retiree - Faculty
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM-Pathology
Phone303/724-3742

    Collapse Research 
    Collapse research activities and funding
    R01CA245143     (FINDLAY, VICTORIA JANE)Jul 1, 2020 - Jun 30, 2025
    NIH
    Lifestyle associated reactive metabolites and their negative impact on breast cancer risk
    Role: Co-Principal Investigator
    R01CA138482     (ANDERSON, STEVEN M)Sep 15, 2011 - Jul 31, 2015
    NIH
    Is GLUT1 required for tumor growth and the Warburg Effect?
    Role: Principal Investigator
    T36GM095349     (LAAKSO, JOSEPH M)Mar 1, 2011 - Feb 28, 2017
    NIH
    Endocrine Network for Undergraduate Research and Carrier Development Opportunitie
    Role: Co-Principal Investigator
    R13CA128408     (ANDERSON, STEVEN M)May 1, 2007 - Apr 30, 2010
    NIH
    MAMMARY GLAND BIOLOGY GRC
    Role: Principal Investigator
    R01DE016354     (ANDERSON, STEVEN M)Jul 7, 2006 - Apr 30, 2011
    NIH
    Salivary Acinar Cell Apoptosis: Regulation of p53 by Akt
    Role: Principal Investigator
    R01DK063674     (ANDERSON, STEVEN M)Jul 1, 2003 - Apr 30, 2007
    NIH
    Regulation of Akt and glucose transport by prolactin
    Role: Principal Investigator
    F33CA093037     (ANDERSON, STEVEN M)Sep 1, 2001
    NIH
    Identification of Substrates and Genes Regulated by Akt
    Role: Principal Investigator
    T35HL007961     (FLORES, SONIA CASTRO)Jun 1, 2000 - May 31, 2011
    NIH
    Biomedical Research Internship Program for Undergraduate
    Role: Co-Principal Investigator
    R01CA085736     (ANDERSON, STEVEN M)Mar 10, 2000 - Feb 28, 2005
    NIH
    INDUCTION OF MAMMARY CANCER BY SIGNALING MOLECULES
    Role: Principal Investigator
    R01DK053858     (ANDERSON, STEVEN M)Jun 1, 1998 - May 31, 2003
    NIH
    SIGNAL TRANSDUCTION BY THE PROLACTIN RECEPTOR
    Role: Principal Investigator
    R01GM055754     (ANDERSON, STEVEN M)Mar 1, 1998 - Feb 28, 2003
    NIH
    SRC-LIKE KINASES IN INTERLEUKIN-3 RECEPTOR SIGNALING
    Role: Principal Investigator
    R01DK048879     (ANDERSON, STEVEN M)Sep 30, 1994 - Aug 31, 1997
    NIH
    ACTIVATION OF JAK2 TYROSINE KINASE IN BREAST CANCER
    Role: Principal Investigator
    R01CA045241     (ANDERSON, STEVEN M)Aug 1, 1987 - Jul 31, 2000
    NIH
    MODULATION OF HEMATOPOIETIC STEM CELL PROLIFERATION
    Role: Principal Investigator
    R29CA045241     (ANDERSON, STEVEN M)Aug 1, 1987 - Jul 31, 1992
    NIH
    MODULATION OF HEMATOPOIETIC STEM CELL PROLIFERATION
    Role: Principal Investigator
    P01HD038129     (ANDERSON, STEVEN M)Jul 31, 2016
    NIH
    Functional Development of the Mammary Gland
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. Wellberg EA, Corleto KA, Checkley LA, Jindal S, Johnson G, Higgins JA, Obeid S, Anderson SM, Thor AD, Schedin PJ, MacLean PS, Giles ED. Preventing ovariectomy-induced weight gain decreases tumor burden in rodent models of obesity and postmenopausal breast cancer. Breast Cancer Res. 2022 06 20; 24(1):42. PMID: 35725493.
      View in: PubMed
    2. Li K, Ji X, Seeley R, Lee WC, Shi Y, Song F, Liao X, Song C, Huang X, Rux D, Cao J, Luo X, Anderson SM, Huang W, Long F. Impaired glucose metabolism underlies articular cartilage degeneration in osteoarthritis. FASEB J. 2022 06; 36(6):e22377. PMID: 35608871.
      View in: PubMed
    3. DeLuca KF, Mick JE, Ide AH, Lima WC, Sherman L, Schaller KL, Anderson SM, Zhao N, Stasevich TJ, Varma D, Nilsson J, DeLuca JG. Generation and diversification of recombinant monoclonal antibodies. Elife. 2021 12 31; 10. PMID: 34970967.
      View in: PubMed
    4. Ward AV, Anderson SM, Sartorius CA. Advances in Analyzing the Breast Cancer Lipidome and Its Relevance to Disease Progression and Treatment. J Mammary Gland Biol Neoplasia. 2021 12; 26(4):399-417. PMID: 34914014.
      View in: PubMed
    5. Grinman DY, Careaga VP, Wellberg EA, Dansey MV, Kordon EC, Anderson SM, Maier MS, Burton G, MacLean PS, Rudolph MC, Pecci A. Liver X receptor-a activation enhances cholesterol secretion in lactating mammary epithelium. Am J Physiol Endocrinol Metab. 2019 06 01; 316(6):E1136-E1145. PMID: 30964702.
      View in: PubMed
    6. Wellberg EA, Kabos P, Gillen AE, Jacobsen BM, Brechbuhl HM, Johnson SJ, Rudolph MC, Edgerton SM, Thor AD, Anderson SM, Elias A, Zhou XK, Iyengar NM, Morrow M, Falcone DJ, El-Hely O, Dannenberg AJ, Sartorius CA, MacLean PS. FGFR1 underlies obesity-associated progression of estrogen receptor-positive breast cancer after estrogen deprivation. JCI Insight. 2018 07 26; 3(14). PMID: 30046001.
      View in: PubMed
    7. Giles ED, Jindal S, Wellberg EA, Schedin T, Anderson SM, Thor AD, Edwards DP, MacLean PS, Schedin P. Metformin inhibits stromal aromatase expression and tumor progression in a rodent model of postmenopausal breast cancer. Breast Cancer Res. 2018 06 14; 20(1):50. PMID: 29898754.
      View in: PubMed
    8. Wellberg EA, Checkley LA, Giles ED, Johnson SJ, Oljira R, Wahdan-Alaswad R, Foright RM, Dooley G, Edgerton SM, Jindal S, Johnson GC, Richer JK, Kabos P, Thor AD, Schedin P, MacLean PS, Anderson SM. The Androgen Receptor Supports Tumor Progression After the Loss of Ovarian Function in a Preclinical Model of Obesity and Breast Cancer. Horm Cancer. 2017 12; 8(5-6):269-285. PMID: 28741260.
      View in: PubMed
    9. Checkley LA, Rudolph MC, Wellberg EA, Giles ED, Wahdan-Alaswad RS, Houck JA, Edgerton SM, Thor AD, Schedin P, Anderson SM, MacLean PS. Metformin Accumulation Correlates with Organic Cation Transporter 2 Protein Expression and Predicts Mammary Tumor Regression In Vivo. Cancer Prev Res (Phila). 2017 Mar; 10(3):198-207. PMID: 28154203.
      View in: PubMed
    10. Wellberg EA, Johnson S, Finlay-Schultz J, Lewis AS, Terrell KL, Sartorius CA, Abel ED, Muller WJ, Anderson SM. The glucose transporter GLUT1 is required for ErbB2-induced mammary tumorigenesis. Breast Cancer Res. 2016 12 20; 18(1):131. PMID: 27998284.
      View in: PubMed
    11. Heinz RE, Rudolph MC, Ramanathan P, Spoelstra NS, Butterfield KT, Webb PG, Babbs BL, Gao H, Chen S, Gordon MA, Anderson SM, Neville MC, Gu H, Richer JK. Constitutive expression of microRNA-150 in mammary epithelium suppresses secretory activation and impairs de novo lipogenesis. Development. 2016 11 15; 143(22):4236-4248. PMID: 27729410.
      View in: PubMed
    12. Wellberg EA, Rudolph MC, Lewis AS, Padilla-Just N, Jedlicka P, Anderson SM. Modulation of tumor fatty acids, through overexpression or loss of thyroid hormone responsive protein spot 14 is associated with altered growth and metastasis. Breast Cancer Res. 2014 Dec 04; 16(6):481. PMID: 25472762.
      View in: PubMed
    13. Wahdan-Alaswad RS, Cochrane DR, Spoelstra NS, Howe EN, Edgerton SM, Anderson SM, Thor AD, Richer JK. Metformin-induced killing of triple-negative breast cancer cells is mediated by reduction in fatty acid synthase via miRNA-193b. Horm Cancer. 2014 Dec; 5(6):374-89. PMID: 25213330.
      View in: PubMed
    14. Wellberg EA, Anderson SM. FASNating targets of metformin in breast cancer stem-like cells. Horm Cancer. 2014 Dec; 5(6):358-62. PMID: 25172609.
      View in: PubMed
    15. Macintyre AN, Gerriets VA, Nichols AG, Michalek RD, Rudolph MC, Deoliveira D, Anderson SM, Abel ED, Chen BJ, Hale LP, Rathmell JC. The glucose transporter Glut1 is selectively essential for CD4 T cell activation and effector function. Cell Metab. 2014 Jul 01; 20(1):61-72. PMID: 24930970.
      View in: PubMed
    16. Rudolph MC, Wellberg EA, Lewis AS, Terrell KL, Merz AL, Maluf NK, Serkova NJ, Anderson SM. Thyroid hormone responsive protein Spot14 enhances catalysis of fatty acid synthase in lactating mammary epithelium. J Lipid Res. 2014 06; 55(6):1052-65. PMID: 24771867.
      View in: PubMed
    17. Wie SM, Adwan TS, DeGregori J, Anderson SM, Reyland ME. Inhibiting tyrosine phosphorylation of protein kinase Cd (PKCd) protects the salivary gland from radiation damage. J Biol Chem. 2014 Apr 11; 289(15):10900-10908. PMID: 24569990.
      View in: PubMed
    18. Schmidt JW, Wehde BL, Sakamoto K, Triplett AA, Anderson SM, Tsichlis PN, Leone G, Wagner KU. Stat5 regulates the phosphatidylinositol 3-kinase/Akt1 pathway during mammary gland development and tumorigenesis. Mol Cell Biol. 2014 Apr; 34(7):1363-77. PMID: 24469394.
      View in: PubMed
    19. Wahdan-Alaswad R, Fan Z, Edgerton SM, Liu B, Deng XS, Arnadottir SS, Richer JK, Anderson SM, Thor AD. Glucose promotes breast cancer aggression and reduces metformin efficacy. Cell Cycle. 2013 Dec 15; 12(24):3759-69. PMID: 24107633.
      View in: PubMed
    20. Pereira RO, Wende AR, Olsen C, Soto J, Rawlings T, Zhu Y, Anderson SM, Abel ED. Inducible overexpression of GLUT1 prevents mitochondrial dysfunction and attenuates structural remodeling in pressure overload but does not prevent left ventricular dysfunction. J Am Heart Assoc. 2013 Sep 19; 2(5):e000301. PMID: 24052497.
      View in: PubMed
    21. Neville MC, Webb P, Ramanathan P, Mannino MP, Pecorini C, Monks J, Anderson SM, MacLean P. The insulin receptor plays an important role in secretory differentiation in the mammary gland. Am J Physiol Endocrinol Metab. 2013 Nov 01; 305(9):E1103-14. PMID: 23982156.
      View in: PubMed
    22. Giles ED, Wellberg EA, Astling DP, Anderson SM, Thor AD, Jindal S, Tan AC, Schedin PS, Maclean PS. Obesity and overfeeding affecting both tumor and systemic metabolism activates the progesterone receptor to contribute to postmenopausal breast cancer. Cancer Res. 2012 Dec 15; 72(24):6490-501. PMID: 23222299.
      View in: PubMed
    23. Neville MC, Anderson SM, McManaman JL, Badger TM, Bunik M, Contractor N, Crume T, Dabelea D, Donovan SM, Forman N, Frank DN, Friedman JE, German JB, Goldman A, Hadsell D, Hambidge M, Hinde K, Horseman ND, Hovey RC, Janoff E, Krebs NF, Lebrilla CB, Lemay DG, MacLean PS, Meier P, Morrow AL, Neu J, Nommsen-Rivers LA, Raiten DJ, Rijnkels M, Seewaldt V, Shur BD, VanHouten J, Williamson P. Lactation and neonatal nutrition: defining and refining the critical questions. J Mammary Gland Biol Neoplasia. 2012 Jun; 17(2):167-88. PMID: 22752723.
      View in: PubMed
    24. Rudolph MC, Karl Maluf N, Wellberg EA, Johnson CA, Murphy RC, Anderson SM. Mammalian fatty acid synthase activity from crude tissue lysates tracing ??C-labeled substrates using gas chromatography-mass spectrometry. Anal Biochem. 2012 Sep 15; 428(2):158-66. PMID: 22728958.
      View in: PubMed
    25. Young CD, Lewis AS, Rudolph MC, Ruehle MD, Jackman MR, Yun UJ, Ilkun O, Pereira R, Abel ED, Anderson SM. Modulation of glucose transporter 1 (GLUT1) expression levels alters mouse mammary tumor cell growth in vitro and in vivo. PLoS One. 2011; 6(8):e23205. PMID: 21826239.
      View in: PubMed
    26. Yuan T, Wang Y, Pao L, Anderson SM, Gu H. Lactation defect in a widely used MMTV-Cre transgenic line of mice. PLoS One. 2011 Apr 29; 6(4):e19233. PMID: 21559430.
      View in: PubMed
    27. Rudolph MC, Russell TD, Webb P, Neville MC, Anderson SM. Prolactin-mediated regulation of lipid biosynthesis genes in vivo in the lactating mammary epithelial cell. Am J Physiol Endocrinol Metab. 2011 Jun; 300(6):E1059-68. PMID: 21467304.
      View in: PubMed
    28. Rudolph MC, Monks J, Burns V, Phistry M, Marians R, Foote MR, Bauman DE, Anderson SM, Neville MC. Sterol regulatory element binding protein and dietary lipid regulation of fatty acid synthesis in the mammary epithelium. Am J Physiol Endocrinol Metab. 2010 Dec; 299(6):E918-27. PMID: 20739508.
      View in: PubMed
    29. Garc?a-Mart?nez JM, Calcabrini A, Gonz?lez L, Mart?n-Forero E, Agull?-Ortu?o MT, Simon V, Watkin H, Anderson SM, Roche S, Mart?n-P?rez J. A non-catalytic function of the Src family tyrosine kinases controls prolactin-induced Jak2 signaling. Cell Signal. 2010 Mar; 22(3):415-26. PMID: 19892015.
      View in: PubMed
    30. Nelson AC, Lyons TR, Young CD, Hansen KC, Anderson SM, Holt JT. AKT regulates BRCA1 stability in response to hormone signaling. Mol Cell Endocrinol. 2010 May 05; 319(1-2):129-42. PMID: 20085797.
      View in: PubMed
    31. Rudolph MC, Wellberg EA, Anderson SM. Adipose-depleted mammary epithelial cells and organoids. J Mammary Gland Biol Neoplasia. 2009 Dec; 14(4):381-6. PMID: 19953310.
      View in: PubMed
    32. Young CD, Anderson SM. Rah, rah, ROS: metabolic changes caused by loss of adhesion induce cell death. Breast Cancer Res. 2009; 11(6):307. PMID: 19930622.
      View in: PubMed
    33. Limesand KH, Said S, Anderson SM. Suppression of radiation-induced salivary gland dysfunction by IGF-1. PLoS One. 2009; 4(3):e4663. PMID: 19252741.
      View in: PubMed
    34. Young CD, Nolte EC, Lewis A, Serkova NJ, Anderson SM. Activated Akt1 accelerates MMTV-c-ErbB2 mammary tumourigenesis in mice without activation of ErbB3. Breast Cancer Res. 2008; 10(4):R70. PMID: 18700973.
      View in: PubMed
    35. Young CD, Anderson SM. Sugar and fat - that's where it's at: metabolic changes in tumors. Breast Cancer Res. 2008; 10(1):202. PMID: 18304378.
      View in: PubMed
    36. Watkin H, Richert MM, Lewis A, Terrell K, McManaman JP, Anderson SM. Lactation failure in Src knockout mice is due to impaired secretory activation. BMC Dev Biol. 2008 Jan 23; 8:6. PMID: 18215306.
      View in: PubMed
    37. Rudolph MC, Neville MC, Anderson SM. Lipid synthesis in lactation: diet and the fatty acid switch. J Mammary Gland Biol Neoplasia. 2007 Dec; 12(4):269-81. PMID: 18027074.
      View in: PubMed
    38. Lyons TR, Thorburn J, Ryan PW, Thorburn A, Anderson SM, Kassenbrock CK. Regulation of the Pro-apoptotic scaffolding protein POSH by Akt. J Biol Chem. 2007 Jul 27; 282(30):21987-97. PMID: 17535800.
      View in: PubMed
    39. Anderson SM, Rudolph MC, McManaman JL, Neville MC. Key stages in mammary gland development. Secretory activation in the mammary gland: it's not just about milk protein synthesis! Breast Cancer Res. 2007; 9(1):204. PMID: 17338830.
      View in: PubMed
    40. Rudolph MC, McManaman JL, Phang T, Russell T, Kominsky DJ, Serkova NJ, Stein T, Anderson SM, Neville MC. Metabolic regulation in the lactating mammary gland: a lipid synthesizing machine. Physiol Genomics. 2007 Feb 12; 28(3):323-36. PMID: 17105756.
      View in: PubMed
    41. Palmer CA, Neville MC, Anderson SM, McManaman JL. Analysis of lactation defects in transgenic mice. J Mammary Gland Biol Neoplasia. 2006 Oct; 11(3-4):269-82. PMID: 17136614.
      View in: PubMed
    42. Limesand KH, Schwertfeger KL, Anderson SM. MDM2 is required for suppression of apoptosis by activated Akt1 in salivary acinar cells. Mol Cell Biol. 2006 Dec; 26(23):8840-56. PMID: 16982679.
      View in: PubMed
    43. Buser AC, Gass-Handel EK, Wyszomierski SL, Doppler W, Leonhardt SA, Schaack J, Rosen JM, Watkin H, Anderson SM, Edwards DP. Progesterone receptor repression of prolactin/signal transducer and activator of transcription 5-mediated transcription of the beta-casein gene in mammary epithelial cells. Mol Endocrinol. 2007 Jan; 21(1):106-25. PMID: 16973758.
      View in: PubMed
    44. Reddy JC, Reimann JD, Anderson SM, Klein PM. Concordance between central and local laboratory HER2 testing from a community-based clinical study. Clin Breast Cancer. 2006 Jun; 7(2):153-7. PMID: 16800975.
      View in: PubMed
    45. Humphries MJ, Limesand KH, Schneider JC, Nakayama KI, Anderson SM, Reyland ME. Suppression of apoptosis in the protein kinase Cdelta null mouse in vivo. J Biol Chem. 2006 Apr 07; 281(14):9728-37. PMID: 16452485.
      View in: PubMed
    46. Kassenbrock CK, Anderson SM. Regulation of ubiquitin protein ligase activity in c-Cbl by phosphorylation-induced conformational change and constitutive activation by tyrosine to glutamate point mutations. J Biol Chem. 2004 Jul 02; 279(27):28017-27. PMID: 15117950.
      View in: PubMed
    47. Kelher MR, Ambruso DR, Elzi DJ, Anderson SM, Paterson AJ, Thurman GW, Silliman CC. Formyl-Met-Leu-Phe induces calcium-dependent tyrosine phosphorylation of Rel-1 in neutrophils. Cell Calcium. 2003 Dec; 34(6):445-55. PMID: 14572803.
      View in: PubMed
    48. Schwertfeger KL, McManaman JL, Palmer CA, Neville MC, Anderson SM. Expression of constitutively activated Akt in the mammary gland leads to excess lipid synthesis during pregnancy and lactation. J Lipid Res. 2003 Jun; 44(6):1100-12. PMID: 12700340.
      View in: PubMed
    49. Sun W, Wei X, Kesavan K, Garrington TP, Fan R, Mei J, Anderson SM, Gelfand EW, Johnson GL. MEK kinase 2 and the adaptor protein Lad regulate extracellular signal-regulated kinase 5 activation by epidermal growth factor via Src. Mol Cell Biol. 2003 Apr; 23(7):2298-308. PMID: 12640115.
      View in: PubMed
    50. Limesand KH, Barzen KA, Sanders LA, Sclafani RA, Raynolds MV, Reyland ME, Anderson SM, Quissell DO. Characterization of rat parotid and submandibular acinar cell apoptosis in primary culture. In Vitro Cell Dev Biol Anim. 2003 Mar-Apr; 39(3-4):170-7. PMID: 14505429.
      View in: PubMed
    51. Kassenbrock CK, Hunter S, Garl P, Johnson GL, Anderson SM. Inhibition of Src family kinases blocks epidermal growth factor (EGF)-induced activation of Akt, phosphorylation of c-Cbl, and ubiquitination of the EGF receptor. J Biol Chem. 2002 Jul 12; 277(28):24967-75. PMID: 11994282.
      View in: PubMed
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