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Monika R Fleshner

TitleProfessor
InstitutionUniversity of Colorado Boulder
DepartmentIntegrative Physiology
Phone303/492-1483

    Collapse Research 
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    R03MH060301     (FLESHNER, MONIKA R)Jul 1, 1999 - Jun 30, 2000
    NIH/NIMH
    STRESS, EXERCISE AND INNATE IMMUNITY
    Role: Principal Investigator

    R03AI045576     (FLESHNER, MONIKA R)Sep 30, 1999 - Sep 29, 2001
    NIH/NIAID
    EXERCISE PREVENTS THE IMMUNOSUPPRESSIVE EFFECT OF STRESS
    Role: Principal Investigator

    R01AI048555     (FLESHNER, MONIKA R)Dec 15, 2000 - Nov 30, 2004
    NIH/NIAID
    EXERCISE, STRESS AND IMMUNITY--PHYSIOLOGICAL MECHANISMS
    Role: Principal Investigator

    R01MH068283     (FLESHNER, MONIKA R)Jun 1, 2003 - Jan 31, 2016
    NIH/NIMH
    The Neurobiology of the Stress Resistant Brain
    Role: Principal Investigator

    R01AI057797     (FLESHNER, MONIKA R)Jun 1, 2004 - May 31, 2010
    NIH/NIAID
    Stress, Heat-Shock Proteins, and Innate Immunity
    Role: Principal Investigator

    R01DE021966     (WATKINS, LINDA)Sep 1, 2011 - Aug 31, 2016
    NIH/NIDCR
    Preventing Transition of Acute-to-Chronic Neuropathic Pain: Models, Mechanisms &
    Role: Co-Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Lloyd BA, Hake HS, Ishiwata T, Farmer CE, Loetz EC, Fleshner M, Bland ST, Greenwood BN. Exercise increases mTOR signaling in brain regions involved in cognition and emotional behavior. Behav Brain Res. 2017 Apr 14; 323:56-67. PMID: 28130174.
      View in: PubMed
    2. Thompson RS, Roller R, Mika A, Greenwood BN, Knight R, Chichlowski M, Berg BM, Fleshner M. Dietary Prebiotics and Bioactive Milk Fractions Improve NREM Sleep, Enhance REM Sleep Rebound and Attenuate the Stress-Induced Decrease in Diurnal Temperature and Gut Microbial Alpha Diversity. Front Behav Neurosci. 2016; 10:240. PMID: 28119579.
      View in: PubMed
    3. Speaker KJ, Paton MM, Cox SS, Fleshner M. A Single Bout of Fasting (24?h) Reduces Basal Cytokine Expression and Minimally Impacts the Sterile Inflammatory Response in the White Adipose Tissue of Normal Weight F344 Rats. Mediators Inflamm. 2016; 2016:1698071. PMID: 28077915.
      View in: PubMed
    4. Mika A, Day HE, Martinez A, Rumian NL, Greenwood BN, Chichlowski M, Berg BM, Fleshner M. Early life diets with prebiotics and bioactive milk fractions attenuate the impact of stress on learned helplessness behaviours and alter gene expression within neural circuits important for stress resistance. Eur J Neurosci. 2017 Feb; 45(3):342-357. PMID: 27763700.
      View in: PubMed
    5. Mika A, Rumian N, Loughridge AB, Fleshner M. Exercise and Prebiotics Produce Stress Resistance: Converging Impacts on Stress-Protective and Butyrate-Producing Gut Bacteria. Int Rev Neurobiol. 2016; 131:165-191. PMID: 27793217.
      View in: PubMed
    6. Grace PM, Fabisiak TJ, Green-Fulgham SM, Anderson ND, Strand KA, Kwilasz AJ, Galer EL, Walker FR, Greenwood BN, Maier SF, Fleshner M, Watkins LR. Prior voluntary wheel running attenuates neuropathic pain. Pain. 2016 09; 157(9):2012-23. PMID: 27355182; PMCID: PMC4988888 [Available on 09/01/17].
    7. Fleshner M, Frank M, Maier SF. Danger Signals and Inflammasomes: Stress-Evoked Sterile Inflammation in Mood Disorders. Neuropsychopharmacology. 2017 Jan; 42(1):36-45. PMID: 27412959.
      View in: PubMed
    8. Reber SO, Siebler PH, Donner NC, Morton JT, Smith DG, Kopelman JM, Lowe KR, Wheeler KJ, Fox JH, Hassell JE, Greenwood BN, Jansch C, Lechner A, Schmidt D, Uschold-Schmidt N, Füchsl AM, Langgartner D, Walker FR, Hale MW, Lopez Perez G, Van Treuren W, González A, Halweg-Edwards AL, Fleshner M, Raison CL, Rook GA, Peddada SD, Knight R, Lowry CA. Immunization with a heat-killed preparation of the environmental bacterium Mycobacterium vaccae promotes stress resilience in mice. Proc Natl Acad Sci U S A. 2016 May 31; 113(22):E3130-9. PMID: 27185913; PMCID: PMC4896712.
    9. Fleshner M, Olivier KN, Shaw PA, Adjemian J, Strollo S, Claypool RJ, Folio L, Zelazny A, Holland SM, Prevots DR. Mortality among patients with pulmonary non-tuberculous mycobacteria disease. Int J Tuberc Lung Dis. 2016 May; 20(5):582-7. PMID: 27084809.
      View in: PubMed
    10. Thompson RS, Roller R, Greenwood BN, Fleshner M. Wheel running improves REM sleep and attenuates stress-induced flattening of diurnal rhythms in F344 rats. Stress. 2016 05; 19(3):312-24. PMID: 27124542.
      View in: PubMed
    11. Seetharaman S, Fleshner M, Park CR, Diamond DM. Influence of daily social stimulation on behavioral and physiological outcomes in an animal model of PTSD. Brain Behav. 2016 May; 6(5):e00458. PMID: 27110436; PMCID: PMC4834360.
    12. Grace P, Strand K, Galer E, Anderson N, Fabisiak T, Fulgham S, Greenwood B, Fleshner M, Maier S, Watkins L. (464) Prior voluntary wheel running is protective for neuropathic-like pain. J Pain. 2016 Apr; 17(4S):S90. PMID: 28162718.
      View in: PubMed
    13. Herrera JJ, Fedynska S, Ghasem PR, Wieman T, Clark PJ, Gray N, Loetz E, Campeau S, Fleshner M, Greenwood BN. Neurochemical and behavioural indices of exercise reward are independent of exercise controllability. Eur J Neurosci. 2016 May; 43(9):1190-202. PMID: 26833814; PMCID: PMC4918765 [Available on 05/01/17].
    14. Mika A, Fleshner M. Early-life exercise may promote lasting brain and metabolic health through gut bacterial metabolites. Immunol Cell Biol. 2016 Feb; 94(2):151-7. PMID: 26647967.
      View in: PubMed
    15. Clark PJ, Amat J, McConnell SO, Ghasem PR, Greenwood BN, Maier SF, Fleshner M. Running Reduces Uncontrollable Stress-Evoked Serotonin and Potentiates Stress-Evoked Dopamine Concentrations in the Rat Dorsal Striatum. PLoS One. 2015; 10(11):e0141898. PMID: 26555633; PMCID: PMC4640857.
    16. Mika A, Bouchet CA, Bunker P, Hellwinkel JE, Spence KG, Day HE, Campeau S, Fleshner M, Greenwood BN. Voluntary exercise during extinction of auditory fear conditioning reduces the relapse of fear associated with potentiated activity of striatal direct pathway neurons. Neurobiol Learn Mem. 2015 Nov; 125:224-35. PMID: 26454156; PMCID: PMC4648665 [Available on 11/01/16].
    17. Mika A, Van Treuren W, González A, Herrera JJ, Knight R, Fleshner M. Exercise is More Effective at Altering Gut Microbial Composition and Producing Stable Changes in Lean Mass in Juvenile versus Adult Male F344 Rats. PLoS One. 2015; 10(5):e0125889. PMID: 26016739; PMCID: PMC4446322.
    18. Zoladz PR, Park CR, Fleshner M, Diamond DM. Psychosocial predator-based animal model of PTSD produces physiological and behavioral sequelae and a traumatic memory four months following stress onset. Physiol Behav. 2015 Aug 01; 147:183-92. PMID: 25911267.
      View in: PubMed
    19. Wright KP, Drake AL, Frey DJ, Fleshner M, Desouza CA, Gronfier C, Czeisler CA. Influence of sleep deprivation and circadian misalignment on cortisol, inflammatory markers, and cytokine balance. Brain Behav Immun. 2015 Jul; 47:24-34. PMID: 25640603.
      View in: PubMed
    20. van Praag H, Fleshner M, Schwartz MW, Mattson MP. Exercise, energy intake, glucose homeostasis, and the brain. J Neurosci. 2014 Nov 12; 34(46):15139-49. PMID: 25392482; PMCID: PMC4228123.
    21. Beninson LA, Fleshner M. Exosomes in fetal bovine serum dampen primary macrophage IL-1ß response to lipopolysaccharide (LPS) challenge. Immunol Lett. 2015 Feb; 163(2):187-92. PMID: 25455591.
      View in: PubMed
    22. Greenwood BN, Thompson RS, Opp MR, Fleshner M. Repeated exposure to conditioned fear stress increases anxiety and delays sleep recovery following exposure to an acute traumatic stressor. Front Psychiatry. 2014; 5:146. PMID: 25368585; PMCID: PMC4202708.
    23. Beninson LA, Brown PN, Loughridge AB, Saludes JP, Maslanik T, Hills AK, Woodworth T, Craig W, Yin H, Fleshner M. Acute stressor exposure modifies plasma exosome-associated heat shock protein 72 (Hsp72) and microRNA (miR-142-5p and miR-203). PLoS One. 2014; 9(9):e108748. PMID: 25259839; PMCID: PMC4178201.
    24. Clark PJ, Ghasem PR, Mika A, Day HE, Herrera JJ, Greenwood BN, Fleshner M. Wheel running alters patterns of uncontrollable stress-induced cfos mRNA expression in rat dorsal striatum direct and indirect pathways: A possible role for plasticity in adenosine receptors. Behav Brain Res. 2014 Oct 01; 272:252-63. PMID: 25017571; PMCID: PMC4196684.
    25. Thompson RS, Strong PV, Clark PJ, Maslanik TM, Wright KP, Greenwood BN, Fleshner M. Repeated fear-induced diurnal rhythm disruptions predict PTSD-like sensitized physiological acute stress responses in F344 rats. Acta Physiol (Oxf). 2014 Jun; 211(2):447-65. PMID: 24447583.
      View in: PubMed
    26. Beninson LA, Fleshner M. Exosomes: an emerging factor in stress-induced immunomodulation. Semin Immunol. 2014 Oct; 26(5):394-401. PMID: 24405946.
      View in: PubMed
    27. Fleshner M, Greenwood BN, Yirmiya R. Neuronal-glial mechanisms of exercise-evoked stress robustness. Curr Top Behav Neurosci. 2014; 18:1-12. PMID: 24481547.
      View in: PubMed
    28. Cox SS, Speaker KJ, Beninson LA, Craig WC, Paton MM, Fleshner M. Adrenergic and glucocorticoid modulation of the sterile inflammatory response. Brain Behav Immun. 2014 Feb; 36:183-92. PMID: 24321216.
      View in: PubMed
    29. Speaker KJ, Cox SS, Paton MM, Serebrakian A, Maslanik T, Greenwood BN, Fleshner M. Six weeks of voluntary wheel running modulates inflammatory protein (MCP-1, IL-6, and IL-10) and DAMP (Hsp72) responses to acute stress in white adipose tissue of lean rats. Brain Behav Immun. 2014 Jul; 39:87-98. PMID: 24246250; PMCID: PMC4301739.
    30. Saludes JP, Morton LA, Coulup SK, Fiorini Z, Cook BM, Beninson L, Chapman ER, Fleshner M, Yin H. Multivalency amplifies the selection and affinity of bradykinin-derived peptides for lipid nanovesicles. Mol Biosyst. 2013 Aug; 9(8):2005-9. PMID: 23715428; PMCID: PMC3764994.
    31. Loughridge AB, Greenwood BN, Day HE, McQueen MB, Fleshner M. Microarray analyses reveal novel targets of exercise-induced stress resistance in the dorsal raphe nucleus. Front Behav Neurosci. 2013; 7:37. PMID: 23717271; PMCID: PMC3650681.
    32. Thompson RS, Christianson JP, Maslanik TM, Maier SF, Greenwood BN, Fleshner M. Effects of stressor controllability on diurnal physiological rhythms. Physiol Behav. 2013 Mar 15; 112-113:32-9. PMID: 23454291; PMCID: PMC3637963.
    33. Zoladz PR, Fleshner M, Diamond DM. Differential effectiveness of tianeptine, clonidine and amitriptyline in blocking traumatic memory expression, anxiety and hypertension in an animal model of PTSD. Prog Neuropsychopharmacol Biol Psychiatry. 2013 Jul 01; 44:1-16. PMID: 23318688.
      View in: PubMed
    34. Maslanik T, Tannura K, Mahaffey L, Loughridge AB, Beninson L, Benninson L, Ursell L, Greenwood BN, Knight R, Fleshner M. Commensal bacteria and MAMPs are necessary for stress-induced increases in IL-1ß and IL-18 but not IL-6, IL-10 or MCP-1. PLoS One. 2012; 7(12):e50636. PMID: 23236381; PMCID: PMC3517493.
    35. Greenwood BN, Spence KG, Crevling DM, Clark PJ, Craig WC, Fleshner M. Exercise-induced stress resistance is independent of exercise controllability and the medial prefrontal cortex. Eur J Neurosci. 2013 Feb; 37(3):469-78. PMID: 23121339; PMCID: PMC4285393.
    36. Morton LA, Yang H, Saludes JP, Fiorini Z, Beninson L, Chapman ER, Fleshner M, Xue D, Yin H. MARCKS-ED peptide as a curvature and lipid sensor. ACS Chem Biol. 2013 Jan 18; 8(1):218-25. PMID: 23075500; PMCID: PMC3548944.
    37. Maslanik T, Mahaffey L, Tannura K, Beninson L, Greenwood BN, Fleshner M. The inflammasome and danger associated molecular patterns (DAMPs) are implicated in cytokine and chemokine responses following stressor exposure. Brain Behav Immun. 2013 Feb; 28:54-62. PMID: 23103443.
      View in: PubMed
    38. Greenwood BN, Strong PV, Loughridge AB, Day HE, Clark PJ, Mika A, Hellwinkel JE, Spence KG, Fleshner M. 5-HT2C receptors in the basolateral amygdala and dorsal striatum are a novel target for the anxiolytic and antidepressant effects of exercise. PLoS One. 2012; 7(9):e46118. PMID: 23049953; PMCID: PMC3458100.
    39. Foley TE, Brooks LR, Gilligan LJ, Burghardt PR, Koch LG, Britton SL, Fleshner M. Brain activation patterns at exhaustion in rats that differ in inherent exercise capacity. PLoS One. 2012; 7(9):e45415. PMID: 23028992; PMCID: PMC3444461.
    40. Fleshner M. Stress-evoked sterile inflammation, danger associated molecular patterns (DAMPs), microbial associated molecular patterns (MAMPs) and the inflammasome. Brain Behav Immun. 2013 Jan; 27(1):1-7. PMID: 22964544.
      View in: PubMed
    41. Hutchinson MR, Northcutt AL, Hiranita T, Wang X, Lewis SS, Thomas J, van Steeg K, Kopajtic TA, Loram LC, Sfregola C, Galer E, Miles NE, Bland ST, Amat J, Rozeske RR, Maslanik T, Chapman TR, Strand KA, Fleshner M, Bachtell RK, Somogyi AA, Yin H, Katz JL, Rice KC, Maier SF, Watkins LR. Opioid activation of toll-like receptor 4 contributes to drug reinforcement. J Neurosci. 2012 Aug 15; 32(33):11187-200. PMID: 22895704; PMCID: PMC3454463.
    42. Saludes JP, Morton LA, Ghosh N, Beninson LA, Chapman ER, Fleshner M, Yin H. Detection of highly curved membrane surfaces using a cyclic peptide derived from synaptotagmin-I. ACS Chem Biol. 2012 Oct 19; 7(10):1629-35. PMID: 22769435; PMCID: PMC3477269.
    43. Speaker KJ, Fleshner M. Interleukin-1 beta: a potential link between stress and the development of visceral obesity. BMC Physiol. 2012 Jun 27; 12:8. PMID: 22738239; PMCID: PMC3404929.
    44. Thompson RS, Strong PV, Fleshner M. Physiological consequences of repeated exposures to conditioned fear. Behav Sci (Basel). 2012 Jun; 2(2):57-78. PMID: 25379216; PMCID: PMC4217585.
    45. Greenwood BN, Loughridge AB, Sadaoui N, Christianson JP, Fleshner M. The protective effects of voluntary exercise against the behavioral consequences of uncontrollable stress persist despite an increase in anxiety following forced cessation of exercise. Behav Brain Res. 2012 Aug 01; 233(2):314-21. PMID: 22610051; PMCID: PMC3402647.
    46. Zoladz PR, Fleshner M, Diamond DM. Psychosocial animal model of PTSD produces a long-lasting traumatic memory, an increase in general anxiety and PTSD-like glucocorticoid abnormalities. Psychoneuroendocrinology. 2012 Sep; 37(9):1531-45. PMID: 22421563.
      View in: PubMed
    47. Campisi J, Sharkey C, Johnson JD, Asea A, Maslanik T, Bernstein-Hanley I, Fleshner M. Stress-induced facilitation of host response to bacterial challenge in F344 rats is dependent on extracellular heat shock protein 72 and independent of alpha beta T cells. Stress. 2012 Nov; 15(6):637-46. PMID: 22217161.
      View in: PubMed
    48. Strong PV, Christianson JP, Loughridge AB, Amat J, Maier SF, Fleshner M, Greenwood BN. 5-hydroxytryptamine 2C receptors in the dorsal striatum mediate stress-induced interference with negatively reinforced instrumental escape behavior. Neuroscience. 2011 Dec 01; 197:132-44. PMID: 21958863; PMCID: PMC3235414.
    49. Hains LE, Loram LC, Taylor FR, Strand KA, Wieseler JL, Barrientos RM, Young JJ, Frank MG, Sobesky J, Martin TJ, Eisenach JC, Maier SF, Johnson JD, Fleshner M, Watkins LR. Prior laparotomy or corticosterone potentiates lipopolysaccharide-induced fever and sickness behaviors. J Neuroimmunol. 2011 Oct 28; 239(1-2):53-60. PMID: 21907418; PMCID: PMC3205218.
    50. Maslanik T, Bernstein-Hanley I, Helwig B, Fleshner M. The impact of acute-stressor exposure on splenic innate immunity: a gene expression analysis. Brain Behav Immun. 2012 Jan; 26(1):142-9. PMID: 21893187.
      View in: PubMed
    51. Fleshner M, Maier SF, Lyons DM, Raskind MA. The neurobiology of the stress-resistant brain. Stress. 2011 Sep; 14(5):498-502. PMID: 21790482; PMCID: PMC3287388.
    52. Greenwood BN, Fleshner M. Exercise, stress resistance, and central serotonergic systems. Exerc Sport Sci Rev. 2011 Jul; 39(3):140-9. PMID: 21508844; PMCID: PMC4303035.
    53. Zoladz PR, Park CR, Halonen JD, Salim S, Alzoubi KH, Srivareerat M, Fleshner M, Alkadhi KA, Diamond DM. Differential expression of molecular markers of synaptic plasticity in the hippocampus, prefrontal cortex, and amygdala in response to spatial learning, predator exposure, and stress-induced amnesia. Hippocampus. 2012 Mar; 22(3):577-89. PMID: 21538655.
      View in: PubMed
    54. Rozeske RR, Greenwood BN, Fleshner M, Watkins LR, Maier SF. Voluntary wheel running produces resistance to inescapable stress-induced potentiation of morphine conditioned place preference. Behav Brain Res. 2011 Jun 01; 219(2):378-81. PMID: 21262267; PMCID: PMC3062637.
    55. Walsh NP, Gleeson M, Shephard RJ, Gleeson M, Woods JA, Bishop NC, Fleshner M, Green C, Pedersen BK, Hoffman-Goetz L, Rogers CJ, Northoff H, Abbasi A, Simon P. Position statement. Part one: Immune function and exercise. Exerc Immunol Rev. 2011; 17:6-63. PMID: 21446352.
      View in: PubMed
    56. Fleshner M. The gut microbiota: a new player in the innate immune stress response? Brain Behav Immun. 2011 Mar; 25(3):395-6. PMID: 21168480.
      View in: PubMed
    57. Greenwood BN, Foley TE, Le TV, Strong PV, Loughridge AB, Day HE, Fleshner M. Long-term voluntary wheel running is rewarding and produces plasticity in the mesolimbic reward pathway. Behav Brain Res. 2011 Mar 01; 217(2):354-62. PMID: 21070820; PMCID: PMC3021978.
    58. Campeau S, Nyhuis TJ, Sasse SK, Kryskow EM, Herlihy L, Masini CV, Babb JA, Greenwood BN, Fleshner M, Day HE. Hypothalamic pituitary adrenal axis responses to low-intensity stressors are reduced after voluntary wheel running in rats. J Neuroendocrinol. 2010 Aug; 22(8):872-88. PMID: 20406350; PMCID: PMC4469265.
    59. Greenwood BN, Strong PV, Fleshner M. Lesions of the basolateral amygdala reverse the long-lasting interference with shuttle box escape produced by uncontrollable stress. Behav Brain Res. 2010 Jul 29; 211(1):71-6. PMID: 20226213; PMCID: PMC2862138.
    60. Campeau S, Nyhuis TJ, Kryskow EM, Masini CV, Babb JA, Sasse SK, Greenwood BN, Fleshner M, Day HE. Stress rapidly increases alpha 1d adrenergic receptor mRNA in the rat dentate gyrus. Brain Res. 2010 Apr 06; 1323:109-18. PMID: 20138850; PMCID: PMC2888891.
    61. Christianson JP, Ragole T, Amat J, Greenwood BN, Strong PV, Paul ED, Fleshner M, Watkins LR, Maier SF. 5-hydroxytryptamine 2C receptors in the basolateral amygdala are involved in the expression of anxiety after uncontrollable traumatic stress. Biol Psychiatry. 2010 Feb 15; 67(4):339-45. PMID: 19914601; PMCID: PMC3278236.
    62. Greenwood BN, Strong PV, Foley TE, Fleshner M. A behavioral analysis of the impact of voluntary physical activity on hippocampus-dependent contextual conditioning. Hippocampus. 2009 Oct; 19(10):988-1001. PMID: 19115374; PMCID: PMC3287390.
    63. Zoladz PR, Park CR, Muñoz C, Fleshner M, Diamond DM. Tianeptine: an antidepressant with memory-protective properties. Curr Neuropharmacol. 2008 Dec; 6(4):311-21. PMID: 19587852; PMCID: PMC2701287.
    64. Strong PV, Greenwood BN, Fleshner M. The effects of the selective 5-HT(2C) receptor antagonist SB 242084 on learned helplessness in male Fischer 344 rats. Psychopharmacology (Berl). 2009 May; 203(4):665-75. PMID: 19037632.
      View in: PubMed
    65. Sasse SK, Greenwood BN, Masini CV, Nyhuis TJ, Fleshner M, Day HE, Campeau S. Chronic voluntary wheel running facilitates corticosterone response habituation to repeated audiogenic stress exposure in male rats. Stress. 2008 Nov; 11(6):425-37. PMID: 19065456; PMCID: PMC2600621.
    66. Zoladz PR, Conrad CD, Fleshner M, Diamond DM. Acute episodes of predator exposure in conjunction with chronic social instability as an animal model of post-traumatic stress disorder. Stress. 2008 Jul; 11(4):259-81. PMID: 18574787; PMCID: PMC2535807.
    67. Johnson JD, Cortez V, Kennedy SL, Foley TE, Hanson H, Fleshner M. Role of central beta-adrenergic receptors in regulating proinflammatory cytokine responses to a peripheral bacterial challenge. Brain Behav Immun. 2008 Oct; 22(7):1078-86. PMID: 18468841; PMCID: PMC2603469.
    68. Greenwood BN, Strong PV, Brooks L, Fleshner M. Anxiety-like behaviors produced by acute fluoxetine administration in male Fischer 344 rats are prevented by prior exercise. Psychopharmacology (Berl). 2008 Aug; 199(2):209-22. PMID: 18454279; PMCID: PMC4356177.
    69. Park CR, Zoladz PR, Conrad CD, Fleshner M, Diamond DM. Acute predator stress impairs the consolidation and retrieval of hippocampus-dependent memory in male and female rats. Learn Mem. 2008 Apr; 15(4):271-80. PMID: 18391188; PMCID: PMC2327269.
    70. Grant RW, Mariani RA, Vieira VJ, Fleshner M, Smith TP, Keylock KT, Lowder TW, McAuley E, Hu L, Chapman-Novakofski K, Woods JA. Cardiovascular exercise intervention improves the primary antibody response to keyhole limpet hemocyanin (KLH) in previously sedentary older adults. Brain Behav Immun. 2008 Aug; 22(6):923-32. PMID: 18295445; PMCID: PMC2576741.
    71. Greenwood BN, Fleshner M. Exercise, learned helplessness, and the stress-resistant brain. Neuromolecular Med. 2008; 10(2):81-98. PMID: 18300002.
      View in: PubMed
    72. Foley TE, Fleshner M. Neuroplasticity of dopamine circuits after exercise: implications for central fatigue. Neuromolecular Med. 2008; 10(2):67-80. PMID: 18274707.
      View in: PubMed
    73. Brown DA, Johnson MS, Armstrong CJ, Lynch JM, Caruso NM, Ehlers LB, Fleshner M, Spencer RL, Moore RL. Short-term treadmill running in the rat: what kind of stressor is it? J Appl Physiol (1985). 2007 Dec; 103(6):1979-85. PMID: 17916671.
      View in: PubMed
    74. Greenwood BN, Strong PV, Dorey AA, Fleshner M. Therapeutic effects of exercise: wheel running reverses stress-induced interference with shuttle box escape. Behav Neurosci. 2007 Oct; 121(5):992-1000. PMID: 17907830.
      View in: PubMed
    75. Campbell AM, Park CR, Zoladz PR, Muñoz C, Fleshner M, Diamond DM. Pre-training administration of tianeptine, but not propranolol, protects hippocampus-dependent memory from being impaired by predator stress. Eur Neuropsychopharmacol. 2008 Feb; 18(2):87-98. PMID: 17566714.
      View in: PubMed
    76. Frey DJ, Fleshner M, Wright KP. The effects of 40 hours of total sleep deprivation on inflammatory markers in healthy young adults. Brain Behav Immun. 2007 Nov; 21(8):1050-7. PMID: 17524614.
      View in: PubMed
    77. Greenwood BN, Strong PV, Foley TE, Thompson RS, Fleshner M. Learned helplessness is independent of levels of brain-derived neurotrophic factor in the hippocampus. Neuroscience. 2007 Feb 23; 144(4):1193-208. PMID: 17161541; PMCID: PMC1847581.
    78. Foley TE, Greenwood BN, Day HE, Koch LG, Britton SL, Fleshner M. Elevated central monoamine receptor mRNA in rats bred for high endurance capacity: implications for central fatigue. Behav Brain Res. 2006 Nov 01; 174(1):132-42. PMID: 16934883.
      View in: PubMed
    79. Park CR, Campbell AM, Woodson JC, Smith TP, Fleshner M, Diamond DM. Permissive influence of stress in the expression of a U-shaped relationship between serum corticosterone levels and spatial memory errors in rats. Dose Response. 2006 Jun 20; 4(1):55-74. PMID: 18648634; PMCID: PMC2477653.
    80. Nickerson M, Kennedy SL, Johnson JD, Fleshner M. Sexual dimorphism of the intracellular heat shock protein 72 response. J Appl Physiol (1985). 2006 Aug; 101(2):566-75. PMID: 16690792.
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    81. Ganter MT, Ware LB, Howard M, Roux J, Gartland B, Matthay MA, Fleshner M, Pittet JF. Extracellular heat shock protein 72 is a marker of the stress protein response in acute lung injury. Am J Physiol Lung Cell Mol Physiol. 2006 Sep; 291(3):L354-61. PMID: 16679378; PMCID: PMC2765126.
    82. Dishman RK, Berthoud HR, Booth FW, Cotman CW, Edgerton VR, Fleshner MR, Gandevia SC, Gomez-Pinilla F, Greenwood BN, Hillman CH, Kramer AF, Levin BE, Moran TH, Russo-Neustadt AA, Salamone JD, Van Hoomissen JD, Wade CE, York DA, Zigmond MJ. Neurobiology of exercise. Obesity (Silver Spring). 2006 Mar; 14(3):345-56. PMID: 16648603.
      View in: PubMed
    83. Smith TP, Kennedy SL, Smith M, Orent S, Fleshner M. Physiological improvements and health benefits during an exercise-based comprehensive rehabilitation program in medically complex patients. Exerc Immunol Rev. 2006; 12:86-96. PMID: 17201074.
      View in: PubMed
    84. Johnson JD, Fleshner M. Releasing signals, secretory pathways, and immune function of endogenous extracellular heat shock protein 72. J Leukoc Biol. 2006 Mar; 79(3):425-34. PMID: 16387837.
      View in: PubMed
    85. Johnson JD, Campisi J, Sharkey CM, Kennedy SL, Nickerson M, Greenwood BN, Fleshner M. Catecholamines mediate stress-induced increases in peripheral and central inflammatory cytokines. Neuroscience. 2005; 135(4):1295-307. PMID: 16165282.
      View in: PubMed
    86. Nickerson M, Elphick GF, Campisi J, Greenwood BN, Fleshner M. Physical activity alters the brain Hsp72 and IL-1beta responses to peripheral E. coli challenge. Am J Physiol Regul Integr Comp Physiol. 2005 Dec; 289(6):R1665-74. PMID: 16081876.
      View in: PubMed
    87. Fleshner M, Johnson JD. Endogenous extra-cellular heat shock protein 72: releasing signal(s) and function. Int J Hyperthermia. 2005 Aug; 21(5):457-71. PMID: 16048842.
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    88. Kennedy SL, Nickerson M, Campisi J, Johnson JD, Smith TP, Sharkey C, Fleshner M. Splenic norepinephrine depletion following acute stress suppresses in vivo antibody response. J Neuroimmunol. 2005 Aug; 165(1-2):150-60. PMID: 15978673.
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    89. Johnson JD, Campisi J, Sharkey CM, Kennedy SL, Nickerson M, Fleshner M. Adrenergic receptors mediate stress-induced elevations in extracellular Hsp72. J Appl Physiol (1985). 2005 Nov; 99(5):1789-95. PMID: 16037404.
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    90. Fleshner M. Physical activity and stress resistance: sympathetic nervous system adaptations prevent stress-induced immunosuppression. Exerc Sport Sci Rev. 2005 Jul; 33(3):120-6. PMID: 16006819.
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    91. Fleshner M. Translational research using in vivo measures of primary antibody responses. Brain Behav Immun. 2005 Jul; 19(4):309-10. PMID: 15944069.
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    92. Greenwood BN, Foley TE, Day HE, Burhans D, Brooks L, Campeau S, Fleshner M. Wheel running alters serotonin (5-HT) transporter, 5-HT1A, 5-HT1B, and alpha 1b-adrenergic receptor mRNA in the rat raphe nuclei. Biol Psychiatry. 2005 Mar 01; 57(5):559-68. PMID: 15737672.
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    93. Greenwood BN, Foley TE, Burhans D, Maier SF, Fleshner M. The consequences of uncontrollable stress are sensitive to duration of prior wheel running. Brain Res. 2005 Feb 08; 1033(2):164-78. PMID: 15694921.
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    94. Kennedy SL, Smith TP, Fleshner M. Resting cellular and physiological effects of freewheel running. Med Sci Sports Exerc. 2005 Jan; 37(1):79-83. PMID: 15632672.
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    95. Fleshner M, Campisi J, Amiri L, Diamond DM. Cat exposure induces both intra- and extracellular Hsp72: the role of adrenal hormones. Psychoneuroendocrinology. 2004 Oct; 29(9):1142-52. PMID: 15219638.
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    96. Johnston IN, Milligan ED, Wieseler-Frank J, Frank MG, Zapata V, Campisi J, Langer S, Martin D, Green P, Fleshner M, Leinwand L, Maier SF, Watkins LR. A role for proinflammatory cytokines and fractalkine in analgesia, tolerance, and subsequent pain facilitation induced by chronic intrathecal morphine. J Neurosci. 2004 Aug 18; 24(33):7353-65. PMID: 15317861.
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    97. Holguin A, O'Connor KA, Biedenkapp J, Campisi J, Wieseler-Frank J, Milligan ED, Hansen MK, Spataro L, Maksimova E, Bravmann C, Martin D, Fleshner M, Maier SF, Watkins LR. HIV-1 gp120 stimulates proinflammatory cytokine-mediated pain facilitation via activation of nitric oxide synthase-I (nNOS). Pain. 2004 Aug; 110(3):517-30. PMID: 15288392.
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    98. Smith TP, Kennedy SL, Fleshner M. Influence of age and physical activity on the primary in vivo antibody and T cell-mediated responses in men. J Appl Physiol (1985). 2004 Aug; 97(2):491-8. PMID: 15247195.
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    99. Christou EA, Jakobi JM, Critchlow A, Fleshner M, Enoka RM. The 1- to 2-Hz oscillations in muscle force are exacerbated by stress, especially in older adults. J Appl Physiol (1985). 2004 Jul; 97(1):225-35. PMID: 15220319.
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    100. Day HE, Greenwood BN, Hammack SE, Watkins LR, Fleshner M, Maier SF, Campeau S. Differential expression of 5HT-1A, alpha 1b adrenergic, CRF-R1, and CRF-R2 receptor mRNA in serotonergic, gamma-aminobutyric acidergic, and catecholaminergic cells of the rat dorsal raphe nucleus. J Comp Neurol. 2004 Jun 28; 474(3):364-78. PMID: 15174080; PMCID: PMC2430888.
    101. Fleshner M, Laudenslager ML. Psychoneuroimmunology: then and now. Behav Cogn Neurosci Rev. 2004 Jun; 3(2):114-30. PMID: 15537988.
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    102. Gazda LS, Smith T, Watkins LR, Maier SF, Fleshner M. Stressor exposure produces long-term reductions in antigen-specific T and B cell responses. Stress. 2003 Dec; 6(4):259-67. PMID: 14660058.
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    103. Woodson JC, Macintosh D, Fleshner M, Diamond DM. Emotion-induced amnesia in rats: working memory-specific impairment, corticosterone-memory correlation, and fear versus arousal effects on memory. Learn Mem. 2003 Sep-Oct; 10(5):326-36. PMID: 14557605; PMCID: PMC217998.
    104. Sorensen B, Streib JE, Strand M, Make B, Giclas PC, Fleshner M, Jones JF. Complement activation in a model of chronic fatigue syndrome. J Allergy Clin Immunol. 2003 Aug; 112(2):397-403. PMID: 12897748.
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    105. Campisi J, Hansen MK, O'Connor KA, Biedenkapp JC, Watkins LR, Maier SF, Fleshner M. Circulating cytokines and endotoxin are not necessary for the activation of the sickness or corticosterone response produced by peripheral E. coli challenge. J Appl Physiol (1985). 2003 Nov; 95(5):1873-82. PMID: 12871965.
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    106. Greenwood BN, Foley TE, Day HE, Campisi J, Hammack SH, Campeau S, Maier SF, Fleshner M. Freewheel running prevents learned helplessness/behavioral depression: role of dorsal raphe serotonergic neurons. J Neurosci. 2003 Apr 01; 23(7):2889-98. PMID: 12684476.
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    107. Elphick GF, Wieseler-Frank J, Greenwood BN, Campisi J, Fleshner M. B-1 cell (CD5+/CD11b+) numbers and nIgM levels are elevated in physically active vs. sedentary rats. J Appl Physiol (1985). 2003 Jul; 95(1):199-206. PMID: 12651863.
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    108. Fleshner M, Campisi J, Johnson JD. Can exercise stress facilitate innate immunity? A functional role for stress-induced extracellular Hsp72. Exerc Immunol Rev. 2003; 9:6-24. PMID: 14686090.
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    109. Greenwood BN, Kennedy S, Smith TP, Campeau S, Day HE, Fleshner M. Voluntary freewheel running selectively modulates catecholamine content in peripheral tissue and c-Fos expression in the central sympathetic circuit following exposure to uncontrollable stress in rats. Neuroscience. 2003; 120(1):269-81. PMID: 12849759.
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    110. Campisi J, Leem TH, Fleshner M. Stress-induced extracellular Hsp72 is a functionally significant danger signal to the immune system. Cell Stress Chaperones. 2003; 8(3):272-86. PMID: 14984061; PMCID: PMC514881.
    111. Campisi J, Leem TH, Fleshner M. Acute stress decreases inflammation at the site of infection. A role for nitric oxide. Physiol Behav. 2002 Nov; 77(2-3):291-9. PMID: 12419405.
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    112. Campisi J, Leem TH, Greenwood BN, Hansen MK, Moraska A, Higgins K, Smith TP, Fleshner M. Habitual physical activity facilitates stress-induced HSP72 induction in brain, peripheral, and immune tissues. Am J Physiol Regul Integr Comp Physiol. 2003 Feb; 284(2):R520-30. PMID: 12399251.
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    113. Elphick GF, Greenwood BN, Campisi J, Fleshner M. Increased serum nIgM in voluntarily physically active rats: a potential role for B-1 cells. J Appl Physiol (1985). 2003 Feb; 94(2):660-7. PMID: 12391051.
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    114. Campisi J, Fleshner M. Role of extracellular HSP72 in acute stress-induced potentiation of innate immunity in active rats. J Appl Physiol (1985). 2003 Jan; 94(1):43-52. PMID: 12391077.
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    115. Moraska A, Campisi J, Nguyen KT, Maier SF, Watkins LR, Fleshner M. Elevated IL-1beta contributes to antibody suppression produced by stress. J Appl Physiol (1985). 2002 Jul; 93(1):207-15. PMID: 12070207.
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    116. Fleshner M, Campisi J, Deak T, Greenwood BN, Kintzel JA, Leem TH, Smith TP, Sorensen B. Acute stressor exposure facilitates innate immunity more in physically active than in sedentary rats. Am J Physiol Regul Integr Comp Physiol. 2002 Jun; 282(6):R1680-6. PMID: 12010750.
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    117. Mazzeo RS, Donovan D, Fleshner M, Butterfield GE, Zamudio S, Wolfel EE, Moore LG. Interleukin-6 response to exercise and high-altitude exposure: influence of alpha-adrenergic blockade. J Appl Physiol (1985). 2001 Nov; 91(5):2143-9. PMID: 11641355.
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    118. Moraska A, Fleshner M. Voluntary physical activity prevents stress-induced behavioral depression and anti-KLH antibody suppression. Am J Physiol Regul Integr Comp Physiol. 2001 Aug; 281(2):R484-9. PMID: 11448851.
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    119. Noteboom JT, Fleshner M, Enoka RM. Activation of the arousal response can impair performance on a simple motor task. J Appl Physiol (1985). 2001 Aug; 91(2):821-31. PMID: 11457799.
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    120. Fleshner M, Deak T, Nguyen KT, Watkins LR, Maier SF. Endogenous glucocorticoids play a positive regulatory role in the anti-keyhole limpet hemocyanin in vivo antibody response. J Immunol. 2001 Mar 15; 166(6):3813-9. PMID: 11238624.
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    121. Rachal Pugh C, Fleshner M, Watkins LR, Maier SF, Rudy JW. The immune system and memory consolidation: a role for the cytokine IL-1beta. Neurosci Biobehav Rev. 2001 Jan; 25(1):29-41. PMID: 11166076.
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    122. Hansen MK, Nguyen KT, Goehler LE, Gaykema RP, Fleshner M, Maier SF, Watkins LR. Effects of vagotomy on lipopolysaccharide-induced brain interleukin-1beta protein in rats. Auton Neurosci. 2000 Dec 20; 85(1-3):119-26. PMID: 11189018.
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    123. Pecaut MJ, Simske SJ, Fleshner M. Spaceflight induces changes in splenocyte subpopulations: effectiveness of ground-based models. Am J Physiol Regul Integr Comp Physiol. 2000 Dec; 279(6):R2072-8. PMID: 11080071.
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    124. Colagiovanni DB, Suniga MA, Frazier JL, Edwards CK, Fleshner M, McCay JA, White KL, Shopp GM. TNF-alpha blockade by a dimeric TNF type I receptor molecule selectively inhibits adaptive immune responses. Immunopharmacol Immunotoxicol. 2000 Nov; 22(4):627-51. PMID: 11105778.
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    125. Moraska A, Deak T, Spencer RL, Roth D, Fleshner M. Treadmill running produces both positive and negative physiological adaptations in Sprague-Dawley rats. Am J Physiol Regul Integr Comp Physiol. 2000 Oct; 279(4):R1321-9. PMID: 11004000.
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    126. Fleshner M. Exercise and neuroendocrine regulation of antibody production: protective effect of physical activity on stress-induced suppression of the specific antibody response. Int J Sports Med. 2000 May; 21 Suppl 1:S14-9. PMID: 10893019.
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    127. Nguyen KT, Deak T, Will MJ, Hansen MK, Hunsaker BN, Fleshner M, Watkins LR, Maier SF. Timecourse and corticosterone sensitivity of the brain, pituitary, and serum interleukin-1beta protein response to acute stress. Brain Res. 2000 Mar 24; 859(2):193-201. PMID: 10719064.
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    128. Hansen MK, Nguyen KT, Fleshner M, Goehler LE, Gaykema RP, Maier SF, Watkins LR. Effects of vagotomy on serum endotoxin, cytokines, and corticosterone after intraperitoneal lipopolysaccharide. Am J Physiol Regul Integr Comp Physiol. 2000 Feb; 278(2):R331-6. PMID: 10666132.
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    129. Todd P, Pecaut MJ, Fleshner M. Combined effects of space flight factors and radiation on humans. Mutat Res. 1999 Dec 06; 430(2):211-9. PMID: 10631335.
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    130. Pugh CR, Nguyen KT, Gonyea JL, Fleshner M, Wakins LR, Maier SF, Rudy JW. Role of interleukin-1 beta in impairment of contextual fear conditioning caused by social isolation. Behav Brain Res. 1999 Dec; 106(1-2):109-18. PMID: 10595426.
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    131. Diamond DM, Fleshner M, Rose GM. The enhancement of hippocampal primed burst potentiation by dehydroepiandrosterone sulfate (DHEAS) is blocked by psychological stress. Stress. 1999 Dec; 3(2):107-21. PMID: 10938573.
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    132. Deak T, Nguyen KT, Cotter CS, Fleshner M, Watkins LR, Maier SF, Spencer RL. Long-term changes in mineralocorticoid and glucocorticoid receptor occupancy following exposure to an acute stressor. Brain Res. 1999 Nov 20; 847(2):211-20. PMID: 10575090.
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    133. Deak T, Nguyen KT, Fleshner M, Watkins LR, Maier SF. Acute stress may facilitate recovery from a subcutaneous bacterial challenge. Neuroimmunomodulation. 1999 Sep-Oct; 6(5):344-54. PMID: 10474053.
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    134. Mesches MH, Fleshner M, Heman KL, Rose GM, Diamond DM. Exposing rats to a predator blocks primed burst potentiation in the hippocampus in vitro. J Neurosci. 1999 Jul 15; 19(14):RC18. PMID: 10407060.
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    135. Noble EG, Moraska A, Mazzeo RS, Roth DA, Olsson MC, Moore RL, Fleshner M. Differential expression of stress proteins in rat myocardium after free wheel or treadmill run training. J Appl Physiol (1985). 1999 May; 86(5):1696-701. PMID: 10233137.
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    136. Milligan ED, Nguyen KT, Deak T, Hinde JL, Fleshner M, Watkins LR, Maier SF. The long term acute phase-like responses that follow acute stressor exposure are blocked by alpha-melanocyte stimulating hormone. Brain Res. 1998 Nov 09; 810(1-2):48-58. PMID: 9813238.
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    137. Fleshner M, Nguyen KT, Cotter CS, Watkins LR, Maier SF. Acute stressor exposure both suppresses acquired immunity and potentiates innate immunity. Am J Physiol. 1998 Sep; 275(3 Pt 2):R870-8. PMID: 9728086.
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    138. Gaykema RP, Goehler LE, Tilders FJ, Bol JG, McGorry M, Fleshner M, Maier SF, Watkins LR. Bacterial endotoxin induces fos immunoreactivity in primary afferent neurons of the vagus nerve. Neuroimmunomodulation. 1998 Sep-Oct; 5(5):234-40. PMID: 9730691.
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    139. Pugh CR, Kumagawa K, Fleshner M, Watkins LR, Maier SF, Rudy JW. Selective effects of peripheral lipopolysaccharide administration on contextual and auditory-cue fear conditioning. Brain Behav Immun. 1998 Sep; 12(3):212-29. PMID: 9769157.
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    140. Fleshner M, Goehler LE, Schwartz BA, McGorry M, Martin D, Maier SF, Watkins LR. Thermogenic and corticosterone responses to intravenous cytokines (IL-1beta and TNF-alpha) are attenuated by subdiaphragmatic vagotomy. J Neuroimmunol. 1998 Jun 15; 86(2):134-41. PMID: 9663558.
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    141. Maier SF, Goehler LE, Fleshner M, Watkins LR. The role of the vagus nerve in cytokine-to-brain communication. Ann N Y Acad Sci. 1998 May 01; 840:289-300. PMID: 9629257.
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    142. Nguyen KT, Deak T, Owens SM, Kohno T, Fleshner M, Watkins LR, Maier SF. Exposure to acute stress induces brain interleukin-1beta protein in the rat. J Neurosci. 1998 Mar 15; 18(6):2239-46. PMID: 9482808.
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    143. Deak T, Meriwether JL, Fleshner M, Spencer RL, Abouhamze A, Moldawer LL, Grahn RE, Watkins LR, Maier SF. Evidence that brief stress may induce the acute phase response in rats. Am J Physiol. 1997 Dec; 273(6 Pt 2):R1998-2004. PMID: 9435654.
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    144. Milligan ED, McGorry MM, Fleshner M, Gaykema RP, Goehler LE, Watkins LR, Maier SF. Subdiaphragmatic vagotomy does not prevent fever following intracerebroventricular prostaglandin E2: further evidence for the importance of vagal afferents in immune-to-brain communication. Brain Res. 1997 Aug 22; 766(1-2):240-3. PMID: 9359608.
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    145. Pugh CR, Tremblay D, Fleshner M, Rudy JW. A selective role for corticosterone in contextual-fear conditioning. Behav Neurosci. 1997 Jun; 111(3):503-11. PMID: 9189265.
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    146. Fleshner M, Pugh CR, Tremblay D, Rudy JW. DHEA-S selectively impairs contextual-fear conditioning: support for the antiglucocorticoid hypothesis. Behav Neurosci. 1997 Jun; 111(3):512-7. PMID: 9189266.
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    147. Fleshner M, Silbert L, Deak T, Goehler LE, Martin D, Watkins LR, Maier SF. TNF-alpha-induced corticosterone elevation but not serum protein or corticosteroid binding globulin reduction is vagally mediated. Brain Res Bull. 1997; 44(6):701-6. PMID: 9421133.
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    148. Pugh CR, Fleshner M, Rudy JW. Type II glucocorticoid receptor antagonists impair contextual but not auditory-cue fear conditioning in juvenile rats. Neurobiol Learn Mem. 1997 Jan; 67(1):75-9. PMID: 9013504.
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    149. Fleshner M, Brennan FX, Nguyen K, Watkins LR, Maier SF. RU-486 blocks differentially suppressive effect of stress on in vivo anti-KLH immunoglobulin response. Am J Physiol. 1996 Nov; 271(5 Pt 2):R1344-52. PMID: 8945973.
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    150. Diamond DM, Fleshner M, Ingersoll N, Rose GM. Psychological stress impairs spatial working memory: relevance to electrophysiological studies of hippocampal function. Behav Neurosci. 1996 Aug; 110(4):661-72. PMID: 8864259.
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    151. Lockwood LL, Silbert LH, Fleshner MR, McNeal C, Watkins LR, Laudenslager ML, Rice KC, Weber RJ, Maier SF. Morphine-induced alterations in antibody levels: receptor and immune mechanisms. J Pharmacol Exp Ther. 1996 Aug; 278(2):689-96. PMID: 8768720.
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    152. Bennett MC, Mlady GW, Fleshner M, Rose GM. Synergy between chronic corticosterone and sodium azide treatments in producing a spatial learning deficit and inhibiting cytochrome oxidase activity. Proc Natl Acad Sci U S A. 1996 Feb 06; 93(3):1330-4. PMID: 8577764; PMCID: PMC40080.
    153. Diamond DM, Branch BJ, Fleshner M. The neurosteroid dehydroepiandrosterone sulfate (DHEAS) enhances hippocampal primed burst, but not long-term, potentiation. Neurosci Lett. 1996 Jan 05; 202(3):204-8. PMID: 8848267.
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    154. Brennan FX, Fleshner M, Watkins LR, Maier SF. Macrophage stimulation reduces the cholesterol levels of stressed and unstressed rats. Life Sci. 1996; 58(20):1771-6. PMID: 8637401.
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    155. Diamond DM, Branch BJ, Fleshner M, Rose GM. Effects of dehydroepiandrosterone sulfate and stress on hippocampal electrophysiological plasticity. Ann N Y Acad Sci. 1995 Dec 29; 774:304-7. PMID: 8597472.
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    156. Fleshner M, Deak T, Spencer RL, Laudenslager ML, Watkins LR, Maier SF. A long-term increase in basal levels of corticosterone and a decrease in corticosteroid-binding globulin after acute stressor exposure. Endocrinology. 1995 Dec; 136(12):5336-42. PMID: 7588279.
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    157. Fleshner M, Hermann J, Lockwood LL, Laudenslager ML, Watkins LR, Maier SF. Stressed rats fail to expand the CD45RC+CD4+ (Th1-like) T cell subset in response to KLH: possible involvement of IFN-gamma. Brain Behav Immun. 1995 Jun; 9(2):101-12. PMID: 7549034.
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    158. Fleshner M, Goehler LE, Hermann J, Relton JK, Maier SF, Watkins LR. Interleukin-1 beta induced corticosterone elevation and hypothalamic NE depletion is vagally mediated. Brain Res Bull. 1995; 37(6):605-10. PMID: 7670884.
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    159. Fleshner M, Bellgrau D, Watkins LR, Laudenslager ML, Maier SF. Stress-induced reduction in the rat mixed lymphocyte reaction is due to macrophages and not to changes in T cell phenotypes. J Neuroimmunol. 1995 Jan; 56(1):45-52. PMID: 7822481.
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    160. Maier SF, Watkins LR, Fleshner M. Psychoneuroimmunology. The interface between behavior, brain, and immunity. Am Psychol. 1994 Dec; 49(12):1004-17. PMID: 7818221.
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    161. Sutton LC, Fleshner M, Mazzeo R, Maier SF, Watkins LR. A permissive role of corticosterone in an opioid form of stress-induced analgesia: blockade of opiate analgesia is not due to stress-induced hormone release. Brain Res. 1994 Nov 07; 663(1):19-29. PMID: 7850467.
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    162. Diamond DM, Fleshner M, Rose GM. Psychological stress repeatedly blocks hippocampal primed burst potentiation in behaving rats. Behav Brain Res. 1994 May 30; 62(1):1-9. PMID: 7917027.
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    163. Lockwood LL, Silbert LH, Fleshner M, Laudenslager ML, Watkins LR, Maier SF. Morphine-induced decreases in in vivo antibody responses. Brain Behav Immun. 1994 Mar; 8(1):24-36. PMID: 8003769.
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    164. Fleshner M, Brohm MM, Laudenslager ML, Watkins LR, Maier SF. Modulation of the in vivo antibody response by a benzodiazepine inverse agonist (DMCM) administered centrally or peripherally. Physiol Behav. 1993 Dec; 54(6):1149-54. PMID: 8295955.
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    165. Thomas-Dobersen DA, Butler-Simon N, Fleshner M. Evaluation of a weight management intervention program in adolescents with insulin-dependent diabetes mellitus. J Am Diet Assoc. 1993 May; 93(5):535-40. PMID: 8315162.
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    166. Grisel JE, Fleshner M, Watkins LR, Maier SF. Opioid and nonopioid interactions in two forms of stress-induced analgesia. Pharmacol Biochem Behav. 1993 May; 45(1):161-72. PMID: 8516354.
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    167. Fleshner M, Watkins LR, Lockwood LL, Grahn RE, Gerhardt G, Meaney MJ, Laudenslager ML, Maier SF. Blockade of the hypothalamic-pituitary-adrenal response to stress by intraventricular injection of dexamethasone: a method for studying the stress-induced peripheral effects of glucocorticoids. Psychoneuroendocrinology. 1993; 18(4):251-63. PMID: 8391148.
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    168. Fleshner M, Watkins LR, Lockwood LL, Bellgrau D, Laudenslager ML, Maier SF. Specific changes in lymphocyte subpopulations: a potential mechanism for stress-induced immunomodulation. J Neuroimmunol. 1992 Dec; 41(2):131-42. PMID: 1469075.
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    169. Diamond DM, Bennett MC, Fleshner M, Rose GM. Inverted-U relationship between the level of peripheral corticosterone and the magnitude of hippocampal primed burst potentiation. Hippocampus. 1992 Oct; 2(4):421-30. PMID: 1308198.
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    170. Fleshner M, Watkins LR, Redd JM, Kruse CA, Bellgrau D. A 9L gliosarcoma transplantation model for studying adoptive immunotherapy into the brains of conscious rats. Cell Transplant. 1992; 1(4):307-12. PMID: 1344303.
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    171. Barnes CA, Forster MJ, Fleshner M, Ahanotu EN, Laudenslager ML, Mazzeo RS, Maier SF, Lal H. Exercise does not modify spatial memory, brain autoimmunity, or antibody response in aged F-344 rats. Neurobiol Aging. 1991 Jan-Feb; 12(1):47-53. PMID: 2002883.
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    172. Watkins LR, Thurston CL, Fleshner M. Phenylephrine-induced antinociception: investigations of potential neural and endocrine bases. Brain Res. 1990 Oct 01; 528(2):273-84. PMID: 2271928.
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    173. Engstrom DA, Bennett MC, Stevens KE, Wilson RL, Diamond DM, Fleshner M, Rose GM. Modulation of hippocampal primed burst potentiation by anesthesia. Brain Res. 1990 Jun 25; 521(1-2):148-52. PMID: 2207654.
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    174. Diamond DM, Bennett MC, Engstrom DA, Fleshner M, Rose GM. Adrenalectomy reduces the threshold for hippocampal primed burst potentiation in the anesthetized rat. Brain Res. 1989 Jul 17; 492(1-2):356-60. PMID: 2752305.
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    175. Fleshner M, Laudenslager ML, Simons L, Maier SF. Reduced serum antibodies associated with social defeat in rats. Physiol Behav. 1989 Jun; 45(6):1183-7. PMID: 2813542.
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    176. Laudenslager ML, Fleshner M, Hofstadter P, Held PE, Simons L, Maier SF. Suppression of specific antibody production by inescapable shock: stability under varying conditions. Brain Behav Immun. 1988 Jun; 2(2):92-101. PMID: 3148338.
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