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Steven J Coultrap

TitleResearch Instructor
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM-PHARM General Operations
Phone303/724-3611

    Collapse Research 
    Collapse research activities and funding
    F32AA005606     (COULTRAP, STEVEN J)Mar 1, 2001
    NIH
    NMDA RECEPTOR EXPRESSION DIFFERENCES IN ILS AND ISS MICE
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Tullis JE, Larsen ME, Rumian NL, Freund RK, Boxer EE, Brown CN, Coultrap SJ, Schulman H, Aoto J, Dell'Acqua ML, Bayer KU. LTP induction by structural rather than enzymatic functions of CaMKII. Nature. 2023 Sep; 621(7977):146-153. PMID: 37648853.
      View in: PubMed
    2. Rumian NL, Freund RK, Dell'Acqua ML, Coultrap SJ, Bayer KU. Decreased nitrosylation of CaMKII causes aging-associated impairments in memory and synaptic plasticity in mice. Sci Signal. 2023 07 25; 16(795):eade5892. PMID: 37490545.
      View in: PubMed
    3. Brown CN, Rumian NL, Tullis JE, Coultrap SJ, Bayer KU. A?-induced synaptic impairments require CaMKII activity that is stimulated by indirect signaling events. iScience. 2022 Jun 17; 25(6):104368. PMID: 35620430.
      View in: PubMed
    4. Buonarati OR, Miller AP, Coultrap SJ, Bayer KU, Reichow SL. Conserved and divergent features of neuronal CaMKII holoenzyme structure, function, and high-order assembly. Cell Rep. 2021 12 28; 37(13):110168. PMID: 34965414.
      View in: PubMed
    5. Tullis JE, Buonarati OR, Coultrap SJ, Bourke AM, Tiemeier EL, Kennedy MJ, Herson PS, Bayer KU. GluN2B S1303 phosphorylation by CaMKII or DAPK1: no indication for involvement in ischemia or LTP. iScience. 2021 Oct 22; 24(10):103214. PMID: 34704002.
      View in: PubMed
    6. Brown CN, Cook SG, Allen HF, Crosby KC, Singh T, Coultrap SJ, Bayer KU. Characterization of six CaMKIIa variants found in patients with schizophrenia. iScience. 2021 Oct 22; 24(10):103184. PMID: 34667946.
      View in: PubMed
    7. Cook SG, Buonarati OR, Coultrap SJ, Bayer KU. CaMKII holoenzyme mechanisms that govern the LTP versus LTD decision. Sci Adv. 2021 04; 7(16). PMID: 33853773.
      View in: PubMed
    8. Buonarati OR, Cook SG, Goodell DJ, Chalmers NE, Rumian NL, Tullis JE, Restrepo S, Coultrap SJ, Quillinan N, Herson PS, Bayer KU. CaMKII versus DAPK1 Binding to GluN2B in Ischemic Neuronal Cell Death after Resuscitation from Cardiac Arrest. Cell Rep. 2020 01 07; 30(1):1-8.e4. PMID: 31914378.
      View in: PubMed
    9. Opazo P, Viana da Silva S, Carta M, Breillat C, Coultrap SJ, Grillo-Bosch D, Sainlos M, Coussen F, Bayer KU, Mulle C, Choquet D. CaMKII Metaplasticity Drives A? Oligomer-Mediated Synaptotoxicity. Cell Rep. 2018 06 12; 23(11):3137-3145. PMID: 29898386.
      View in: PubMed
    10. Myers JB, Zaegel V, Coultrap SJ, Miller AP, Bayer KU, Reichow SL. Publisher Correction: The CaMKII holoenzyme structure in activation-competent conformations. Nat Commun. 2018 05 25; 9:16180. PMID: 29799013.
      View in: PubMed
    11. Cook SG, Bourke AM, O'Leary H, Zaegel V, Lasda E, Mize-Berge J, Quillinan N, Tucker CL, Coultrap SJ, Herson PS, Bayer KU. Analysis of the CaMKIIa and ? splice-variant distribution among brain regions reveals isoform-specific differences in holoenzyme formation. Sci Rep. 2018 04 03; 8(1):5448. PMID: 29615706.
      View in: PubMed
    12. Woolfrey KM, O'Leary H, Goodell DJ, Robertson HR, Horne EA, Coultrap SJ, Dell'Acqua ML, Bayer KU. CaMKII regulates the depalmitoylation and synaptic removal of the scaffold protein AKAP79/150 to mediate structural long-term depression. J Biol Chem. 2018 02 02; 293(5):1551-1567. PMID: 29196604.
      View in: PubMed
    13. Goodell DJ, Zaegel V, Coultrap SJ, Hell JW, Bayer KU. DAPK1 Mediates LTD by Making CaMKII/GluN2B Binding LTP Specific. Cell Rep. 2017 06 13; 19(11):2231-2243. PMID: 28614711.
      View in: PubMed
    14. Myers JB, Zaegel V, Coultrap SJ, Miller AP, Bayer KU, Reichow SL. The CaMKII holoenzyme structure in activation-competent conformations. Nat Commun. 2017 06 07; 8:15742. PMID: 28589927.
      View in: PubMed
    15. Deng G, Orfila JE, Dietz RM, Moreno-Garcia M, Rodgers KM, Coultrap SJ, Quillinan N, Traystman RJ, Bayer KU, Herson PS. Autonomous CaMKII Activity as a Drug Target for Histological and Functional Neuroprotection after Resuscitation from Cardiac Arrest. Cell Rep. 2017 01 31; 18(5):1109-1117. PMID: 28147268.
      View in: PubMed
    16. Coultrap SJ, Zaegel V, Bayer KU. CaMKII isoforms differ in their specific requirements for regulation by nitric oxide. FEBS Lett. 2014 Dec 20; 588(24):4672-6. PMID: 25447522.
      View in: PubMed
    17. Coultrap SJ, Bayer KU. Nitric oxide induces Ca2+-independent activity of the Ca2+/calmodulin-dependent protein kinase II (CaMKII). J Biol Chem. 2014 Jul 11; 289(28):19458-65. PMID: 24855644.
      View in: PubMed
    18. Barcomb K, Buard I, Coultrap SJ, Kulbe JR, O'Leary H, Benke TA, Bayer KU. Autonomous CaMKII requires further stimulation by Ca2+/calmodulin for enhancing synaptic strength. FASEB J. 2014 Aug; 28(8):3810-9. PMID: 24843070.
      View in: PubMed
    19. Goodell DJ, Eliseeva TA, Coultrap SJ, Bayer KU. CaMKII binding to GluN2B is differentially affected by macromolecular crowding reagents. PLoS One. 2014; 9(5):e96522. PMID: 24796865.
      View in: PubMed
    20. Coultrap SJ, Freund RK, O'Leary H, Sanderson JL, Roche KW, Dell'Acqua ML, Bayer KU. Autonomous CaMKII mediates both LTP and LTD using a mechanism for differential substrate site selection. Cell Rep. 2014 Feb 13; 6(3):431-7. PMID: 24485660.
      View in: PubMed
    21. Kulbe JR, Mulcahy Levy JM, Coultrap SJ, Thorburn A, Bayer KU. Excitotoxic glutamate insults block autophagic flux in hippocampal neurons. Brain Res. 2014 Jan 13; 1542:12-9. PMID: 24505621.
      View in: PubMed
    22. Barcomb K, Coultrap SJ, Bayer KU. Enzymatic activity of CaMKII is not required for its interaction with the glutamate receptor subunit GluN2B. Mol Pharmacol. 2013 Dec; 84(6):834-43. PMID: 24056996.
      View in: PubMed
    23. Coultrap SJ, Bayer KU. CaMKII regulation in information processing and storage. Trends Neurosci. 2012 Oct; 35(10):607-18. PMID: 22717267.
      View in: PubMed
    24. Wu PH, Coultrap S, Pinnix C, Davies KD, Tailor R, Ang KK, Browning MD, Grosshans DR. Radiation induces acute alterations in neuronal function. PLoS One. 2012; 7(5):e37677. PMID: 22662188.
      View in: PubMed
    25. Coultrap SJ, Barcomb K, Bayer KU. A significant but rather mild contribution of T286 autophosphorylation to Ca2+/CaM-stimulated CaMKII activity. PLoS One. 2012; 7(5):e37176. PMID: 22615928.
      View in: PubMed
    26. Coultrap SJ, Bayer KU. Improving a natural CaMKII inhibitor by random and rational design. PLoS One. 2011; 6(10):e25245. PMID: 21984908.
      View in: PubMed
    27. O'Leary H, Liu WH, Rorabaugh JM, Coultrap SJ, Bayer KU. Nucleotides and phosphorylation bi-directionally modulate Ca2+/calmodulin-dependent protein kinase II (CaMKII) binding to the N-methyl-D-aspartate (NMDA) receptor subunit GluN2B. J Biol Chem. 2011 Sep 09; 286(36):31272-81. PMID: 21768120.
      View in: PubMed
    28. Coultrap SJ, Vest RS, Ashpole NM, Hudmon A, Bayer KU. CaMKII in cerebral ischemia. Acta Pharmacol Sin. 2011 Jul; 32(7):861-72. PMID: 21685929.
      View in: PubMed
    29. Wu PH, Coultrap SJ, Browning MD, Proctor WR. Functional adaptation of the N-methyl-D-aspartate receptor to inhibition by ethanol is modulated by striatal-enriched protein tyrosine phosphatase and p38 mitogen-activated protein kinase. Mol Pharmacol. 2011 Sep; 80(3):529-37. PMID: 21680777.
      View in: PubMed
    30. Wu PH, Coultrap S, Browning MD, Proctor WR. Correlated changes in NMDA receptor phosphorylation, functional activity, and sedation by chronic ethanol consumption. J Neurochem. 2010 Dec; 115(5):1112-22. PMID: 20831600.
      View in: PubMed
    31. Buard I, Coultrap SJ, Freund RK, Lee YS, Dell'Acqua ML, Silva AJ, Bayer KU. CaMKII "autonomy" is required for initiating but not for maintaining neuronal long-term information storage. J Neurosci. 2010 Jun 16; 30(24):8214-20. PMID: 20554872.
      View in: PubMed
    32. Vest RS, O'Leary H, Coultrap SJ, Kindy MS, Bayer KU. Effective post-insult neuroprotection by a novel Ca(2+)/ calmodulin-dependent protein kinase II (CaMKII) inhibitor. J Biol Chem. 2010 Jul 02; 285(27):20675-82. PMID: 20424167.
      View in: PubMed
    33. Coultrap SJ, Buard I, Kulbe JR, Dell'Acqua ML, Bayer KU. CaMKII autonomy is substrate-dependent and further stimulated by Ca2+/calmodulin. J Biol Chem. 2010 Jun 04; 285(23):17930-7. PMID: 20353941.
      View in: PubMed
    34. Davies KD, Goebel-Goody SM, Coultrap SJ, Browning MD. Long term synaptic depression that is associated with GluR1 dephosphorylation but not alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor internalization. J Biol Chem. 2008 Nov 28; 283(48):33138-46. PMID: 18819923.
      View in: PubMed
    35. Coultrap SJ, Bickford PC, Browning MD. Blueberry-enriched diet ameliorates age-related declines in NMDA receptor-dependent LTP. Age (Dordr). 2008 Dec; 30(4):263-72. PMID: 19424850.
      View in: PubMed
    36. Hellier JL, Grosshans DR, Coultrap SJ, Jones JP, Dobelis P, Browning MD, Staley KJ. NMDA receptor trafficking at recurrent synapses stabilizes the state of the CA3 network. J Neurophysiol. 2007 Nov; 98(5):2818-26. PMID: 17728388.
      View in: PubMed
    37. Davies KD, Alvestad RM, Coultrap SJ, Browning MD. alphaCaMKII autophosphorylation levels differ depending on subcellular localization. Brain Res. 2007 Jul 16; 1158:39-49. PMID: 17559813.
      View in: PubMed
    38. Cornejo BJ, Mesches MH, Coultrap S, Browning MD, Benke TA. A single episode of neonatal seizures permanently alters glutamatergic synapses. Ann Neurol. 2007 May; 61(5):411-26. PMID: 17323345.
      View in: PubMed
    39. Goebel SM, Alvestad RM, Coultrap SJ, Browning MD. Tyrosine phosphorylation of the N-methyl-D-aspartate receptor is enhanced in synaptic membrane fractions of the adult rat hippocampus. Brain Res Mol Brain Res. 2005 Dec 07; 142(1):65-79. PMID: 16257472.
      View in: PubMed
    40. Williams B, Nelson M, Granholm AC, Coultrap S, Browning M, Curtis M. Altered NGF response but not release in the aged septo-hippocampal cholinergic system. Exp Neurol. 2005 Nov; 196(1):30-40. PMID: 16137678.
      View in: PubMed
    41. Coultrap SJ, Nixon KM, Alvestad RM, Valenzuela CF, Browning MD. Differential expression of NMDA receptor subunits and splice variants among the CA1, CA3 and dentate gyrus of the adult rat. Brain Res Mol Brain Res. 2005 Apr 27; 135(1-2):104-11. PMID: 15857673.
      View in: PubMed
    42. Gemma C, Stellwagen H, Fister M, Coultrap SJ, Mesches MH, Browning MD, Bickford PC. Rosiglitazone improves contextual fear conditioning in aged rats. Neuroreport. 2004 Oct 05; 15(14):2255-9. PMID: 15371745.
      View in: PubMed
    43. Alvestad RM, Grosshans DR, Coultrap SJ, Nakazawa T, Yamamoto T, Browning MD. Tyrosine dephosphorylation and ethanol inhibition of N-Methyl-D-aspartate receptor function. J Biol Chem. 2003 Mar 28; 278(13):11020-5. PMID: 12536146.
      View in: PubMed
    44. Grosshans DR, Clayton DA, Coultrap SJ, Browning MD. LTP leads to rapid surface expression of NMDA but not AMPA receptors in adult rat CA1. Nat Neurosci. 2002 Jan; 5(1):27-33. PMID: 11740502.
      View in: PubMed
    45. Coultrap SJ, Sun H, Tenner TE, Machu TK. Competitive antagonism of the mouse 5-hydroxytryptamine3 receptor by bisindolylmaleimide I, a "selective" protein kinase C inhibitor. J Pharmacol Exp Ther. 1999 Jul; 290(1):76-82. PMID: 10381762.
      View in: PubMed
    46. Machu TK, Coultrap SJ, Waugh MD, Hamilton ME. Mutation of putative phosphorylation sites in the 5-hydroxytryptamine3 receptor does not eliminate its modulation by ethanol. Alcohol Clin Exp Res. 1999 Jan; 23(1):12-7. PMID: 10029198.
      View in: PubMed
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